Приказ основних података о документу
Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
dc.creator | Araškov, Jovana | |
dc.creator | Nikolić, Milan | |
dc.creator | Armaković, Stevan | |
dc.creator | Armaković, Sanja | |
dc.creator | Rodić, Marko | |
dc.creator | Višnjevac, Aleksandar | |
dc.creator | Padrón, José M. | |
dc.creator | Todorović, Tamara | |
dc.creator | Filipović, Nenad R. | |
dc.date.accessioned | 2021-09-01T11:28:56Z | |
dc.date.available | 2021-09-01T11:28:56Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0022286021006451 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/4539 | |
dc.description.abstract | To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | Spanish Government financial support through project PGC2018-094503-B-C22 (MCIU/AEI/FEDER, UE). | |
dc.relation.isreferencedby | https://cherry.chem.bg.ac.rs/handle/123456789/4540 | |
dc.rights | restrictedAccess | |
dc.source | Journal of Molecular Structure | |
dc.subject | Antioxidant activity | |
dc.subject | Antiproliferative activity | |
dc.subject | DFT | |
dc.subject | Drug likeness parameters | |
dc.subject | Hydrazonyl‒thiazoles | |
dc.subject | Single crystal X-ray analysis | |
dc.title | Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres | |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Николић, Милан; Филиповић, Ненад Р.; Aрашков, Јована Б.; Aрмаковић, Сања; Тодоровић, Тамара Р.; Aрмаковић, Стеван; Вишњевац, Aлександар; Падрóн, Јосé М.; Родић, Марко; | |
dc.citation.volume | 1240 | |
dc.citation.spage | 130512 | |
dc.identifier.wos | 000664244900012 | |
dc.identifier.doi | 10.1016/j.molstruc.2021.130512 | |
dc.citation.rank | M22~ | |
dc.description.other | Supplementary material: [https://cherry.chem.bg.ac.rs/handle/123456789/4540] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85105531083 |