New applications of advanced instrumental techniques for the characterization of food allergenic proteins
Authors
Benedé, SaraLozano-Ojalvo, Daniel
Cristobal, Susana
Costa, Joana
D’Auria, Enza
Ćirković-Veličković, Tanja
Garrido-Arandia, María
Karakaya, Sibel
Mafra, Isabel
Mazzucchelli, Gabriel
Picariello, Gianluca
Romero-Sahagun, Alejandro
Villa, Caterina
Roncada, Paola
Molina, Elena
Article (Published version)
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Show full item recordAbstract
Current approaches based on electrophoretic, chromatographic or immunochemical principles have allowed characterizing multiple allergens, mapping their epitopes, studying their mechanisms of action, developing detection and diagnostic methods and therapeutic strategies for the food and pharmaceutical industry. However, some of the common structural features related to the allergenic potential of food proteins remain unknown, or the pathological mechanism of food allergy is not yet fully understood. In addition, it is also necessary to evaluate new allergens from novel protein sources that may pose a new risk for consumers. Technological development has allowed the expansion of advanced technologies for which their whole potential has not been entirely exploited and could provide novel contributions to still unexplored molecular traits underlying both the structure of food allergens and the mechanisms through which they sensitize or elicit adverse responses in human subjects, as well as... improving analytical techniques for their detection. This review presents cutting-edge instrumental techniques recently applied when studying structural and functional aspects of proteins, mechanism of action and interaction between biomolecules. We also exemplify their role in the food allergy research and discuss their new possible applications in several areas of the food allergy field.
Keywords:
bioactive thermal proteome profiling / cryo-electron microscopy / cytometry by time-of-flight / Food allergens / mass spectrometry / microfluidics / RNA sequencing / solid-state nuclear magnetic resonance / surface plasmon resonance / X-ray free-electron lasers crystallographySource:
Critical Reviews in Food Science and Nutrition, 2022, 62, 31Publisher:
- Taylor & Francis Group
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics (EU-810752)
- Spanish Ministry of Science and Innovation (AGL2017-88964R)
- Allerscreening Project (H2020-NMBP-X-KET-2017. 768641 - AllerScreening)
- COST Action FA1402
- Fundac¸~ao para a Ci^encia e Tecnologia under the Partnership Agreement UIDB 50006/2020
- AlleRiskAssess - PTDC/BAA-AGR/31720/2017
- FCT for the research contract (SFRH/BPD/102404/2014)
- BOF StG No. 01N01718
- Serbian Academy of Sciences and Arts GA No. F26
- POPH-QREN - FCT grant PD/BD/114576/2016
DOI: 10.1080/10408398.2021.1931806
ISSN: 1040-8398
WoS: 000656931700001
Scopus: 2-s2.0-85107344954
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Benedé, Sara AU - Lozano-Ojalvo, Daniel AU - Cristobal, Susana AU - Costa, Joana AU - D’Auria, Enza AU - Ćirković-Veličković, Tanja AU - Garrido-Arandia, María AU - Karakaya, Sibel AU - Mafra, Isabel AU - Mazzucchelli, Gabriel AU - Picariello, Gianluca AU - Romero-Sahagun, Alejandro AU - Villa, Caterina AU - Roncada, Paola AU - Molina, Elena PY - 2022 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4548 AB - Current approaches based on electrophoretic, chromatographic or immunochemical principles have allowed characterizing multiple allergens, mapping their epitopes, studying their mechanisms of action, developing detection and diagnostic methods and therapeutic strategies for the food and pharmaceutical industry. However, some of the common structural features related to the allergenic potential of food proteins remain unknown, or the pathological mechanism of food allergy is not yet fully understood. In addition, it is also necessary to evaluate new allergens from novel protein sources that may pose a new risk for consumers. Technological development has allowed the expansion of advanced technologies for which their whole potential has not been entirely exploited and could provide novel contributions to still unexplored molecular traits underlying both the structure of food allergens and the mechanisms through which they sensitize or elicit adverse responses in human subjects, as well as improving analytical techniques for their detection. This review presents cutting-edge instrumental techniques recently applied when studying structural and functional aspects of proteins, mechanism of action and interaction between biomolecules. We also exemplify their role in the food allergy research and discuss their new possible applications in several areas of the food allergy field. PB - Taylor & Francis Group T2 - Critical Reviews in Food Science and Nutrition T1 - New applications of advanced instrumental techniques for the characterization of food allergenic proteins VL - 62 IS - 31 DO - 10.1080/10408398.2021.1931806 ER -
@article{ author = "Benedé, Sara and Lozano-Ojalvo, Daniel and Cristobal, Susana and Costa, Joana and D’Auria, Enza and Ćirković-Veličković, Tanja and Garrido-Arandia, María and Karakaya, Sibel and Mafra, Isabel and Mazzucchelli, Gabriel and Picariello, Gianluca and Romero-Sahagun, Alejandro and Villa, Caterina and Roncada, Paola and Molina, Elena", year = "2022", abstract = "Current approaches based on electrophoretic, chromatographic or immunochemical principles have allowed characterizing multiple allergens, mapping their epitopes, studying their mechanisms of action, developing detection and diagnostic methods and therapeutic strategies for the food and pharmaceutical industry. However, some of the common structural features related to the allergenic potential of food proteins remain unknown, or the pathological mechanism of food allergy is not yet fully understood. In addition, it is also necessary to evaluate new allergens from novel protein sources that may pose a new risk for consumers. Technological development has allowed the expansion of advanced technologies for which their whole potential has not been entirely exploited and could provide novel contributions to still unexplored molecular traits underlying both the structure of food allergens and the mechanisms through which they sensitize or elicit adverse responses in human subjects, as well as improving analytical techniques for their detection. This review presents cutting-edge instrumental techniques recently applied when studying structural and functional aspects of proteins, mechanism of action and interaction between biomolecules. We also exemplify their role in the food allergy research and discuss their new possible applications in several areas of the food allergy field.", publisher = "Taylor & Francis Group", journal = "Critical Reviews in Food Science and Nutrition", title = "New applications of advanced instrumental techniques for the characterization of food allergenic proteins", volume = "62", number = "31", doi = "10.1080/10408398.2021.1931806" }
Benedé, S., Lozano-Ojalvo, D., Cristobal, S., Costa, J., D’Auria, E., Ćirković-Veličković, T., Garrido-Arandia, M., Karakaya, S., Mafra, I., Mazzucchelli, G., Picariello, G., Romero-Sahagun, A., Villa, C., Roncada, P.,& Molina, E.. (2022). New applications of advanced instrumental techniques for the characterization of food allergenic proteins. in Critical Reviews in Food Science and Nutrition Taylor & Francis Group., 62(31). https://doi.org/10.1080/10408398.2021.1931806
Benedé S, Lozano-Ojalvo D, Cristobal S, Costa J, D’Auria E, Ćirković-Veličković T, Garrido-Arandia M, Karakaya S, Mafra I, Mazzucchelli G, Picariello G, Romero-Sahagun A, Villa C, Roncada P, Molina E. New applications of advanced instrumental techniques for the characterization of food allergenic proteins. in Critical Reviews in Food Science and Nutrition. 2022;62(31). doi:10.1080/10408398.2021.1931806 .
Benedé, Sara, Lozano-Ojalvo, Daniel, Cristobal, Susana, Costa, Joana, D’Auria, Enza, Ćirković-Veličković, Tanja, Garrido-Arandia, María, Karakaya, Sibel, Mafra, Isabel, Mazzucchelli, Gabriel, Picariello, Gianluca, Romero-Sahagun, Alejandro, Villa, Caterina, Roncada, Paola, Molina, Elena, "New applications of advanced instrumental techniques for the characterization of food allergenic proteins" in Critical Reviews in Food Science and Nutrition, 62, no. 31 (2022), https://doi.org/10.1080/10408398.2021.1931806 . .