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Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum
dc.creator | Jankovic, S.M. | |
dc.creator | Beleslin, D. | |
dc.creator | Ivanović, Milovan | |
dc.creator | Kouvelas, D. | |
dc.creator | Argyriou, A. | |
dc.creator | Đorđević, S. | |
dc.creator | Mirtsou-Fidani, V. | |
dc.date.accessioned | 2018-11-22T00:01:26Z | |
dc.date.available | 2018-11-22T00:01:26Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0354-2440 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/45 | |
dc.description.abstract | Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable. | en |
dc.rights | restrictedAccess | |
dc.source | Archives of Gastroenterohepatology | |
dc.subject | Analogues | en |
dc.subject | Fentanyl | en |
dc.subject | Ileum | en |
dc.subject | Rat | en |
dc.title | Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.volume | 16 | |
dc.citation.issue | 2 | |
dc.citation.spage | 29 | |
dc.citation.epage | 32 | |
dc.citation.other | 16(2): 29-32 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-0031054326 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cherry_45 |
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