Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents
Abstract
Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.
Keywords:
thin-layer chromatography / salting-out / ACE inhibitors / polyacrylonitrile sorbent / silica-gel / celluloseSource:
Chromatographia, 2001, 53, SPEC. ISSPublisher:
- Vieweg, Wiesbaden
DOI: 10.1007/BF02490373
ISSN: 0009-5893
WoS: 000170083800057
Scopus: 2-s2.0-0034936228
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aleksic, MB AU - Agbaba, Danica G. AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav Lj. PY - 2001 UR - https://cherry.chem.bg.ac.rs/handle/123456789/465 AB - Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed. PB - Vieweg, Wiesbaden T2 - Chromatographia T1 - Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents VL - 53 IS - SPEC. ISS DO - 10.1007/BF02490373 ER -
@article{ author = "Aleksic, MB and Agbaba, Danica G. and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.", year = "2001", abstract = "Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.", publisher = "Vieweg, Wiesbaden", journal = "Chromatographia", title = "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents", volume = "53", number = "SPEC. ISS", doi = "10.1007/BF02490373" }
Aleksic, M., Agbaba, D. G., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2001). Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia Vieweg, Wiesbaden., 53(SPEC. ISS). https://doi.org/10.1007/BF02490373
Aleksic M, Agbaba DG, Milojković-Opsenica D, Tešić ŽL. Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia. 2001;53(SPEC. ISS). doi:10.1007/BF02490373 .
Aleksic, MB, Agbaba, Danica G., Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents" in Chromatographia, 53, no. SPEC. ISS (2001), https://doi.org/10.1007/BF02490373 . .