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Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents
dc.creator | Stevanović, Nevena | |
dc.creator | Mazzeo, Paolo Pio | |
dc.creator | Bacchi, Alessia | |
dc.creator | Matić, Ivana Z. | |
dc.creator | Đorđić Crnogorac, Marija | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Vujčić, Miroslava | |
dc.creator | Novaković, Irena T. | |
dc.creator | Radanović, Dušanka D. | |
dc.creator | Šumar-Ristović, Maja | |
dc.creator | Sladić, Dušan | |
dc.creator | Čobeljić, Božidar | |
dc.creator | Anđelković, Katarina K. | |
dc.date.accessioned | 2021-10-18T08:20:15Z | |
dc.date.available | 2021-10-18T08:20:15Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0949-8257 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/4673 | |
dc.description.abstract | In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested. | |
dc.language | en | |
dc.publisher | Springer | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation.isreferencedby | https://cherry.chem.bg.ac.rs/handle/123456789/4675 | |
dc.rights | restrictedAccess | |
dc.source | JBIC Journal of Biological Inorganic Chemistry | |
dc.subject | Hydrazone complexes | |
dc.subject | X-ray | |
dc.subject | Antimicrobial activity | |
dc.subject | Cytotoxic activity | |
dc.subject | ROS | |
dc.subject | DNA-binding experiments | |
dc.title | Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents | |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Чобељић, Божидар; Aнђелковић, Катарина К.; Ђорђић Црногорац, Марија; Маззео, Паоло Пио; Стевановић, Невена; Сладић, Душан; Новаковић, Ирена; Радановић, Душанка; Вујчић, Мирослава; Матић, Ивана З.; Баццхи, Aлессиа; Станојковић, Татјана; Шумар-Ристовић, Маја; | |
dc.citation.volume | 26 | |
dc.citation.spage | 863 | |
dc.citation.epage | 880 | |
dc.identifier.wos | 000695511900001 | |
dc.identifier.doi | 10.1007/s00775-021-01893-5 | |
dc.citation.rank | M21~ | |
dc.description.other | Supplementary material: [https://cherry.chem.bg.ac.rs/handle/123456789/4675] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85114304815 |