Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid
Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline
2009
Authors
Drazici, BrankaPopovic, Gordana
Jelić, Ratomir
Sladić, Dušan
Mitić, Dragana
Anđelković, Katarina K.
Tešić, Živoslav Lj.
Article (Published version)
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Show full item recordAbstract
Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'(2)-bis-[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl(2)(H(2)O)], [Fe(L2)Cl(H(2)O)](2+), [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+), which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25 degrees C at a constant ionic strength of 0.10 mol/dm(3) (Na(2)SO(4)). The results showed that at pH lt 8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+) have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed.
U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH lt 8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.
Keywords:
metal complexes / d-metals / d-metals / hydrazone / hydrazone / acid-base equilibria / acid-base equilibria / potentiometry / potentiometrySource:
Journal of the Serbian Chemical Society, 2009, 74, 3, 269-277Publisher:
- Serbian Chemical Soc, Belgrade
Funding / projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-MESTD-MPN2006-2010-142062)
DOI: 10.2298/JSC0903269D
ISSN: 0352-5139
WoS: 000264850000005
Scopus: 2-s2.0-68949129340
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Drazici, Branka AU - Popovic, Gordana AU - Jelić, Ratomir AU - Sladić, Dušan AU - Mitić, Dragana AU - Anđelković, Katarina K. AU - Tešić, Živoslav Lj. PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/622 AB - Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'(2)-bis-[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl(2)(H(2)O)], [Fe(L2)Cl(H(2)O)](2+), [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+), which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25 degrees C at a constant ionic strength of 0.10 mol/dm(3) (Na(2)SO(4)). The results showed that at pH lt 8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+) have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed. AB - U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH lt 8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid T1 - Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline VL - 74 IS - 3 SP - 269 EP - 277 DO - 10.2298/JSC0903269D ER -
@article{ author = "Drazici, Branka and Popovic, Gordana and Jelić, Ratomir and Sladić, Dušan and Mitić, Dragana and Anđelković, Katarina K. and Tešić, Živoslav Lj.", year = "2009", abstract = "Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'(2)-bis-[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl(2)(H(2)O)], [Fe(L2)Cl(H(2)O)](2+), [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+), which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25 degrees C at a constant ionic strength of 0.10 mol/dm(3) (Na(2)SO(4)). The results showed that at pH lt 8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H(2)O)(3)](+) and [Zn(L2)(H(2)O)(2)](2+) have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed., U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH lt 8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid, Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline", volume = "74", number = "3", pages = "269-277", doi = "10.2298/JSC0903269D" }
Drazici, B., Popovic, G., Jelić, R., Sladić, D., Mitić, D., Anđelković, K. K.,& Tešić, Ž. Lj.. (2009). Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 74(3), 269-277. https://doi.org/10.2298/JSC0903269D
Drazici B, Popovic G, Jelić R, Sladić D, Mitić D, Anđelković KK, Tešić ŽL. Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society. 2009;74(3):269-277. doi:10.2298/JSC0903269D .
Drazici, Branka, Popovic, Gordana, Jelić, Ratomir, Sladić, Dušan, Mitić, Dragana, Anđelković, Katarina K., Tešić, Živoslav Lj., "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid" in Journal of the Serbian Chemical Society, 74, no. 3 (2009):269-277, https://doi.org/10.2298/JSC0903269D . .