Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen
Samo za registrovane korisnike
2024
Autori
Đurašinović, TatjanaLopandić, Zorana
![](/themes/MirageCherry/images/orcid.png)
Protić-Rosić, Isidora
![](/themes/MirageCherry/images/orcid.png)
Nešić, Andrijana
![](/themes/MirageCherry/images/orcid.png)
Trbojević-Ivić, Jovana
![](/themes/MirageCherry/images/orcid.png)
Jappe, Uta
Gavrović-Jankulović, Marija
Članak u časopisu (Objavljena verzija)
![](/themes/MirageCherry//images/creativecommons/arr.png)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Banana allergy is often associated with the pollen and latex allergies, which led us to the hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.
Ključne reči:
Banana / Food allergy / Recombinant allergen / Cross-reactivity / Panallergen / Epitope mappingIzvor:
Food Chemistry, 2024, 437, 137782-Izdavač:
- Elsevier
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200168 (Univerzitet u Beogradu, Hemijski fakultet) (RS-MESTD-inst-2020-200168)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200288)
Kolekcije
Institucija/grupa
Inovacioni centar / Innovation CentreTY - JOUR AU - Đurašinović, Tatjana AU - Lopandić, Zorana AU - Protić-Rosić, Isidora AU - Nešić, Andrijana AU - Trbojević-Ivić, Jovana AU - Jappe, Uta AU - Gavrović-Jankulović, Marija PY - 2024 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6338 AB - Banana allergy is often associated with the pollen and latex allergies, which led us to the hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons, while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis. PB - Elsevier T2 - Food Chemistry T1 - Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen VL - 437 SP - 137782 DO - 10.1016/j.foodchem.2023.137782 ER -
@article{ author = "Đurašinović, Tatjana and Lopandić, Zorana and Protić-Rosić, Isidora and Nešić, Andrijana and Trbojević-Ivić, Jovana and Jappe, Uta and Gavrović-Jankulović, Marija", year = "2024", abstract = "Banana allergy is often associated with the pollen and latex allergies, which led us to the hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons, while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.", publisher = "Elsevier", journal = "Food Chemistry", title = "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen", volume = "437", pages = "137782", doi = "10.1016/j.foodchem.2023.137782" }
Đurašinović, T., Lopandić, Z., Protić-Rosić, I., Nešić, A., Trbojević-Ivić, J., Jappe, U.,& Gavrović-Jankulović, M.. (2024). Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry Elsevier., 437, 137782. https://doi.org/10.1016/j.foodchem.2023.137782
Đurašinović T, Lopandić Z, Protić-Rosić I, Nešić A, Trbojević-Ivić J, Jappe U, Gavrović-Jankulović M. Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry. 2024;437:137782. doi:10.1016/j.foodchem.2023.137782 .
Đurašinović, Tatjana, Lopandić, Zorana, Protić-Rosić, Isidora, Nešić, Andrijana, Trbojević-Ivić, Jovana, Jappe, Uta, Gavrović-Jankulović, Marija, "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen" in Food Chemistry, 437 (2024):137782, https://doi.org/10.1016/j.foodchem.2023.137782 . .