Synthesis of (-)-cytoxazone and (+)-epi-cytoxazone: The chiral pool approach

dc.creator	Tokic-Vujosevic, Z
dc.creator	Petrović, G.
dc.creator	Rakic, B
dc.creator	Matović, Radomir
dc.creator	Saičić, Radomir
dc.date.accessioned	2018-11-22T00:08:04Z
dc.date.available	2018-11-22T00:08:04Z
dc.date.issued	2005
dc.identifier.issn	0039-7911
dc.identifier.uri	https://cherry.chem.bg.ac.rs/handle/123456789/688
dc.description.abstract	Immunomodulator (-)-cytoxazone and its epimer (+)-epi-cytoxazone were synthesized starting from (D)-(-)-4-hydroxyphenylglycine. Homologation of the amino acid was achieved via the corresponding aldehyde, by a cyanohydrin reaction. The racemization of highly sensible amido aldehyde was efficiently suppressed when the oxidation of the parent aminoalcohol was performed by a modified Dess-Martin procedure.	en
dc.publisher	Marcel Dekker Inc, New York
dc.rights	restrictedAccess
dc.source	Synthetic Communications
dc.subject	amino alcohols	en
dc.subject	cyanohydrins	en
dc.subject	cytoxazone	en
dc.subject	oxazolines	en
dc.title	Synthesis of (-)-cytoxazone and (+)-epi-cytoxazone: The chiral pool approach	en
dc.type	article
dc.rights.license	ARR
dcterms.abstract	Саичић, Радомир; Ракиц, Б; Токиц-Вујосевиц, З; Матовиц, Р; Петровиц, Г;
dc.citation.volume	35
dc.citation.issue	3
dc.citation.spage	435
dc.citation.epage	447
dc.identifier.wos	000227372500012
dc.identifier.doi	10.1081/SCC-200048953
dc.citation.other	35(3): 435-447
dc.citation.rank	M23
dc.type.version	publishedVersion	en
dc.identifier.scopus	2-s2.0-14644411112

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