Estimation of the hydrophobicity of tris-beta-diketonato complexes from reversed-phase thin-layer chromatographic data

Abstract

Experimental R(M) values for two series of beta-diketonato complexes, M(acac)(3-n)(phacphac)(n) and M(acae)(3-n)(phSacphSac)(n), where M represents cobalt(III) or chromium(III), have been determined by reversed-phase thin-layer chromatography on RP-18 silica with binary tetrahydrofuran-water, acetonitrile-water, and acetone-water mobile phases. R(M)(0) values were determined for the different mobile phase mixtures by linear extrapolation to 0% (v/v) organic modifier. Lipophilicity C(0) was calculated as the ratio of the intercept and slope values. Chromatographically obtained lipophilicity was correlated with calculated Clog P values.