Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?
Samo za registrovane korisnike
2006
Autori
Nikolić, MilanVranić, Danijela
Spiric, Aurelija
Batas, Valentina
Nikolić-Kokić, Aleksandra
Radetic, Petar
Turubatovic, Lazar
Blagojević, Duško P.
Jones, David R.
Niketić, Vesna
Spasić, Mihajlo B.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The concept of an anti-oxidant defence system as a means to prevent oxidative cell damage implies balanced activities of anti-oxidant defence enzymes. As well as positive correlations between anti-oxidant enzyme activities in human erythrocytes, it has been observed that sometimes when glutathione peroxidase activity is increased, CuZn-superoxide dismutase activity is decreased. In our current study we have examined the plasma lipid profile and the anti-oxidant defence enzymes in erythrocytes from humans, pigs, and bulls. We found that a negative correlation existed between CuZn-superoxide dismutase and glutathione peroxidase activities in human erythrocytes when the concentrations of both plasma triglycerides and total cholesterol were high. This correlation was also found in pig erythrocytes, but not in bull erythrocytes. We propose that cholesterol could affect membrane lipid peroxiclation and superoxide generation in erythrocytes via the recently found fraction of cholesterol bound... to haemoglobin, termed haemoglobin-cholesterol. (c) 2006 Elsevier Inc. All rights reserved.
Ključne reči:
anti-oxidant defence / erythrocytes / cholesterol / haemoglobin / humans / pigs / bulls / plasma lipidsIzvor:
Biochemical and Biophysical Research Communications, 2006, 348, 1, 265-270Izdavač:
- Academic Press Inc Elsevier Science, San Diego
Finansiranje / projekti:
- Hemijske i biohemijske konsekvence metal-ligand interakcija, II. deo (RS-MESTD-MPN2006-2010-142017)
- Uloga redoks aktivnih supstanci u procesima održavanja homeostaze živih sistema (RS-MESTD-MPN2006-2010-143034)
DOI: 10.1016/j.bbrc.2006.06.199
ISSN: 0006-291X
PubMed: 16876118
WoS: 000239796100037
Scopus: 2-s2.0-33746738084
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Nikolić, Milan AU - Vranić, Danijela AU - Spiric, Aurelija AU - Batas, Valentina AU - Nikolić-Kokić, Aleksandra AU - Radetic, Petar AU - Turubatovic, Lazar AU - Blagojević, Duško P. AU - Jones, David R. AU - Niketić, Vesna AU - Spasić, Mihajlo B. PY - 2006 UR - https://cherry.chem.bg.ac.rs/handle/123456789/797 AB - The concept of an anti-oxidant defence system as a means to prevent oxidative cell damage implies balanced activities of anti-oxidant defence enzymes. As well as positive correlations between anti-oxidant enzyme activities in human erythrocytes, it has been observed that sometimes when glutathione peroxidase activity is increased, CuZn-superoxide dismutase activity is decreased. In our current study we have examined the plasma lipid profile and the anti-oxidant defence enzymes in erythrocytes from humans, pigs, and bulls. We found that a negative correlation existed between CuZn-superoxide dismutase and glutathione peroxidase activities in human erythrocytes when the concentrations of both plasma triglycerides and total cholesterol were high. This correlation was also found in pig erythrocytes, but not in bull erythrocytes. We propose that cholesterol could affect membrane lipid peroxiclation and superoxide generation in erythrocytes via the recently found fraction of cholesterol bound to haemoglobin, termed haemoglobin-cholesterol. (c) 2006 Elsevier Inc. All rights reserved. PB - Academic Press Inc Elsevier Science, San Diego T2 - Biochemical and Biophysical Research Communications T1 - Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities? VL - 348 IS - 1 SP - 265 EP - 270 DO - 10.1016/j.bbrc.2006.06.199 ER -
@article{ author = "Nikolić, Milan and Vranić, Danijela and Spiric, Aurelija and Batas, Valentina and Nikolić-Kokić, Aleksandra and Radetic, Petar and Turubatovic, Lazar and Blagojević, Duško P. and Jones, David R. and Niketić, Vesna and Spasić, Mihajlo B.", year = "2006", abstract = "The concept of an anti-oxidant defence system as a means to prevent oxidative cell damage implies balanced activities of anti-oxidant defence enzymes. As well as positive correlations between anti-oxidant enzyme activities in human erythrocytes, it has been observed that sometimes when glutathione peroxidase activity is increased, CuZn-superoxide dismutase activity is decreased. In our current study we have examined the plasma lipid profile and the anti-oxidant defence enzymes in erythrocytes from humans, pigs, and bulls. We found that a negative correlation existed between CuZn-superoxide dismutase and glutathione peroxidase activities in human erythrocytes when the concentrations of both plasma triglycerides and total cholesterol were high. This correlation was also found in pig erythrocytes, but not in bull erythrocytes. We propose that cholesterol could affect membrane lipid peroxiclation and superoxide generation in erythrocytes via the recently found fraction of cholesterol bound to haemoglobin, termed haemoglobin-cholesterol. (c) 2006 Elsevier Inc. All rights reserved.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Biochemical and Biophysical Research Communications", title = "Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?", volume = "348", number = "1", pages = "265-270", doi = "10.1016/j.bbrc.2006.06.199" }
Nikolić, M., Vranić, D., Spiric, A., Batas, V., Nikolić-Kokić, A., Radetic, P., Turubatovic, L., Blagojević, D. P., Jones, D. R., Niketić, V.,& Spasić, M. B.. (2006). Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?. in Biochemical and Biophysical Research Communications Academic Press Inc Elsevier Science, San Diego., 348(1), 265-270. https://doi.org/10.1016/j.bbrc.2006.06.199
Nikolić M, Vranić D, Spiric A, Batas V, Nikolić-Kokić A, Radetic P, Turubatovic L, Blagojević DP, Jones DR, Niketić V, Spasić MB. Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?. in Biochemical and Biophysical Research Communications. 2006;348(1):265-270. doi:10.1016/j.bbrc.2006.06.199 .
Nikolić, Milan, Vranić, Danijela, Spiric, Aurelija, Batas, Valentina, Nikolić-Kokić, Aleksandra, Radetic, Petar, Turubatovic, Lazar, Blagojević, Duško P., Jones, David R., Niketić, Vesna, Spasić, Mihajlo B., "Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?" in Biochemical and Biophysical Research Communications, 348, no. 1 (2006):265-270, https://doi.org/10.1016/j.bbrc.2006.06.199 . .