The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos
Primena DP polarografije za određivanje cinka i sadržaja cink-piritiona u šamponima protiv peruti
Апстракт
Commercially formulated anti-dandruff shampoos contain zinc pyrithione (ZPT) as an active ingredient that has antifungal, antibacterial and anti-seborrheic properties. The determination of ZPT concentration in commercial anti-dandruff shampoos by differential pulse polarography (DPP) was based on the electrochemical reduction of zinc ions in ammoniacal buffer pH 10.2, and the linear dependence of the reduction differential pulse peak current at the potential - 1.33 V vs. concentration of zinc. Using the calibration curve method, it was found that the range of linearity for the determination of zinc concentration was from 1.28 x 10-5 to 1.39 x 10-4 mol L‒1 (linear regression equation: I = - 0.097 + 6.635 x 105c). Surface active ingredients and micro-components in the shampoos did not exert a polarographic interference for the determination of zinc and did not affect the indirect determination of the content of the active ingredient ZPT. The concentrations of zinc in the analyzed anti-da...ndruff shampoo samples were determined by the standard addition method, resulting in 4.20 x 10‒2 mol L‒1, 1.76 x 10‒1 mol L‒1 and 1.82 x 10‒1 mol L‒1. The results of DPP determinations of zinc and ZPT show that the content of ZPT was 0.28%, 1.15% i.e. 1.19% and was below the maximum recommended level of ZPT in anti-dandruff shampoos. This simple and sensitive differential pulse polarography method is suitable for a routine and rapid control of the active ingredient content, as well as for the quality control of anti-dandruff shampoos.
Aktivni sastojak komercijalno formulisanih šampona protiv peruti je cink-pirition, koji ima antifungalno, antibakterijsko i antiseboreično dejstvo. Određivanje cink-piritiona u šamponima protiv peruti primenom metode diferencijalne pulsne polarografije zasnivalo se na elektrohemijskoj redukciji jona cinka u amonijačnom puferu pH 10,2 i linearnoj zavisnosti intenziteta struje pika na redukcionom potencijalu - 1,33 V i koncentracije cinka. Metodom kalibracione krive je određen opseg linearnosti za određivanje koncentracije cinka od 1,28 x 10‒5 do 1,39 x 10‒4 mol L-1 i dobijena je linearna regresiona jednačina I = - 0,097 + 6,635 x 105c. Utvrđeno je da površinski aktivne komponente u matriksu šampona ne pokazuju polarografsku interferenciju i ne utiču na određivanje koncentracije cinka i sadržaja cink-piritiona u analiziranim šamponima. Koncentracije cinka u analiziranim uzorcima šampona određene su metodom standardnog dodatka i iznose 4,20 x 10‒2 mol L-1, 1,76 ' 10‒1 mol L-1 i 1,82 x 10‒...1 mol L-1. Rezultati polarografskog određivanja cinka i sadržaja cink-piritiona pokazuju da su dobijene vrednosti cink-piritiona 0,28%, 1,15% i 1,19% ispod maksimalno preporučenog sadržaja cink-piritiona u šamponima protiv peruti. Ova jednostavna i osetljiva metoda diferencijalno pulsne polarografije pogodna je za rutinsko i brzo određivanje sadržaja aktivnog sastojka i kontrolu kvaliteta šampona protiv peruti.
Кључне речи:
zinc pyrithione / anti-dandruff shampoo / differential pulse polarography / cink-pirition / šampon protiv peruti / diferencijalno pulsna polarografijaИзвор:
Facta Universitatis: Series Physics, Chemistry and Technology, 2015, 13, 3, 181-190Финансирање / пројекти:
- Динамика нелинеарних физичкохемијских и биохемијских система са моделирањем и предвиђањем њихових понашања под неравнотежним условима (RS-MESTD-Basic Research (BR or ON)-172015)
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Blagojević, Slavica M. AU - Pastor, Ferenc AU - Borić, Ivan AU - Erić, Nataša M. AU - Sužnjević, Desanka Ž. PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/83 AB - Commercially formulated anti-dandruff shampoos contain zinc pyrithione (ZPT) as an active ingredient that has antifungal, antibacterial and anti-seborrheic properties. The determination of ZPT concentration in commercial anti-dandruff shampoos by differential pulse polarography (DPP) was based on the electrochemical reduction of zinc ions in ammoniacal buffer pH 10.2, and the linear dependence of the reduction differential pulse peak current at the potential - 1.33 V vs. concentration of zinc. Using the calibration curve method, it was found that the range of linearity for the determination of zinc concentration was from 1.28 x 10-5 to 1.39 x 10-4 mol L‒1 (linear regression equation: I = - 0.097 + 6.635 x 105c). Surface active ingredients and micro-components in the shampoos did not exert a polarographic interference for the determination of zinc and did not affect the indirect determination of the content of the active ingredient ZPT. The concentrations of zinc in the analyzed anti-dandruff shampoo samples were determined by the standard addition method, resulting in 4.20 x 10‒2 mol L‒1, 1.76 x 10‒1 mol L‒1 and 1.82 x 10‒1 mol L‒1. The results of DPP determinations of zinc and ZPT show that the content of ZPT was 0.28%, 1.15% i.e. 1.19% and was below the maximum recommended level of ZPT in anti-dandruff shampoos. This simple and sensitive differential pulse polarography method is suitable for a routine and rapid control of the active ingredient content, as well as for the quality control of anti-dandruff shampoos. AB - Aktivni sastojak komercijalno formulisanih šampona protiv peruti je cink-pirition, koji ima antifungalno, antibakterijsko i antiseboreično dejstvo. Određivanje cink-piritiona u šamponima protiv peruti primenom metode diferencijalne pulsne polarografije zasnivalo se na elektrohemijskoj redukciji jona cinka u amonijačnom puferu pH 10,2 i linearnoj zavisnosti intenziteta struje pika na redukcionom potencijalu - 1,33 V i koncentracije cinka. Metodom kalibracione krive je određen opseg linearnosti za određivanje koncentracije cinka od 1,28 x 10‒5 do 1,39 x 10‒4 mol L-1 i dobijena je linearna regresiona jednačina I = - 0,097 + 6,635 x 105c. Utvrđeno je da površinski aktivne komponente u matriksu šampona ne pokazuju polarografsku interferenciju i ne utiču na određivanje koncentracije cinka i sadržaja cink-piritiona u analiziranim šamponima. Koncentracije cinka u analiziranim uzorcima šampona određene su metodom standardnog dodatka i iznose 4,20 x 10‒2 mol L-1, 1,76 ' 10‒1 mol L-1 i 1,82 x 10‒1 mol L-1. Rezultati polarografskog određivanja cinka i sadržaja cink-piritiona pokazuju da su dobijene vrednosti cink-piritiona 0,28%, 1,15% i 1,19% ispod maksimalno preporučenog sadržaja cink-piritiona u šamponima protiv peruti. Ova jednostavna i osetljiva metoda diferencijalno pulsne polarografije pogodna je za rutinsko i brzo određivanje sadržaja aktivnog sastojka i kontrolu kvaliteta šampona protiv peruti. T2 - Facta Universitatis: Series Physics, Chemistry and Technology T1 - The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos T1 - Primena DP polarografije za određivanje cinka i sadržaja cink-piritiona u šamponima protiv peruti VL - 13 IS - 3 SP - 181 EP - 190 DO - 10.2298/FUPCT1503181B ER -
@article{ author = "Blagojević, Slavica M. and Pastor, Ferenc and Borić, Ivan and Erić, Nataša M. and Sužnjević, Desanka Ž.", year = "2015", abstract = "Commercially formulated anti-dandruff shampoos contain zinc pyrithione (ZPT) as an active ingredient that has antifungal, antibacterial and anti-seborrheic properties. The determination of ZPT concentration in commercial anti-dandruff shampoos by differential pulse polarography (DPP) was based on the electrochemical reduction of zinc ions in ammoniacal buffer pH 10.2, and the linear dependence of the reduction differential pulse peak current at the potential - 1.33 V vs. concentration of zinc. Using the calibration curve method, it was found that the range of linearity for the determination of zinc concentration was from 1.28 x 10-5 to 1.39 x 10-4 mol L‒1 (linear regression equation: I = - 0.097 + 6.635 x 105c). Surface active ingredients and micro-components in the shampoos did not exert a polarographic interference for the determination of zinc and did not affect the indirect determination of the content of the active ingredient ZPT. The concentrations of zinc in the analyzed anti-dandruff shampoo samples were determined by the standard addition method, resulting in 4.20 x 10‒2 mol L‒1, 1.76 x 10‒1 mol L‒1 and 1.82 x 10‒1 mol L‒1. The results of DPP determinations of zinc and ZPT show that the content of ZPT was 0.28%, 1.15% i.e. 1.19% and was below the maximum recommended level of ZPT in anti-dandruff shampoos. This simple and sensitive differential pulse polarography method is suitable for a routine and rapid control of the active ingredient content, as well as for the quality control of anti-dandruff shampoos., Aktivni sastojak komercijalno formulisanih šampona protiv peruti je cink-pirition, koji ima antifungalno, antibakterijsko i antiseboreično dejstvo. Određivanje cink-piritiona u šamponima protiv peruti primenom metode diferencijalne pulsne polarografije zasnivalo se na elektrohemijskoj redukciji jona cinka u amonijačnom puferu pH 10,2 i linearnoj zavisnosti intenziteta struje pika na redukcionom potencijalu - 1,33 V i koncentracije cinka. Metodom kalibracione krive je određen opseg linearnosti za određivanje koncentracije cinka od 1,28 x 10‒5 do 1,39 x 10‒4 mol L-1 i dobijena je linearna regresiona jednačina I = - 0,097 + 6,635 x 105c. Utvrđeno je da površinski aktivne komponente u matriksu šampona ne pokazuju polarografsku interferenciju i ne utiču na određivanje koncentracije cinka i sadržaja cink-piritiona u analiziranim šamponima. Koncentracije cinka u analiziranim uzorcima šampona određene su metodom standardnog dodatka i iznose 4,20 x 10‒2 mol L-1, 1,76 ' 10‒1 mol L-1 i 1,82 x 10‒1 mol L-1. Rezultati polarografskog određivanja cinka i sadržaja cink-piritiona pokazuju da su dobijene vrednosti cink-piritiona 0,28%, 1,15% i 1,19% ispod maksimalno preporučenog sadržaja cink-piritiona u šamponima protiv peruti. Ova jednostavna i osetljiva metoda diferencijalno pulsne polarografije pogodna je za rutinsko i brzo određivanje sadržaja aktivnog sastojka i kontrolu kvaliteta šampona protiv peruti.", journal = "Facta Universitatis: Series Physics, Chemistry and Technology", title = "The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos, Primena DP polarografije za određivanje cinka i sadržaja cink-piritiona u šamponima protiv peruti", volume = "13", number = "3", pages = "181-190", doi = "10.2298/FUPCT1503181B" }
Blagojević, S. M., Pastor, F., Borić, I., Erić, N. M.,& Sužnjević, D. Ž.. (2015). The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos. in Facta Universitatis: Series Physics, Chemistry and Technology, 13(3), 181-190. https://doi.org/10.2298/FUPCT1503181B
Blagojević SM, Pastor F, Borić I, Erić NM, Sužnjević DŽ. The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos. in Facta Universitatis: Series Physics, Chemistry and Technology. 2015;13(3):181-190. doi:10.2298/FUPCT1503181B .
Blagojević, Slavica M., Pastor, Ferenc, Borić, Ivan, Erić, Nataša M., Sužnjević, Desanka Ž., "The application of DP polarography for the determination of zinc and content of zinc pyrithione in anti-dandruff shampoos" in Facta Universitatis: Series Physics, Chemistry and Technology, 13, no. 3 (2015):181-190, https://doi.org/10.2298/FUPCT1503181B . .