Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes
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2007
Authors
Gomez-Ruiz, SantiagoKaluđerović, Goran N.
Polo-Ceron, Dorian
Prashar, Sanjiv
Fajardo, Mariano
Žižak, Žejko S.
Juranić, Zorica D.
Sabo, Tibor
Article (Published version)
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Show full item recordAbstract
The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.
Keywords:
ansa-titanocene compounds / antitumoural activity / adenocarcinoma HeLa / human myelogenous leukemia K562 / human malignant melanoma Fem-xSource:
Inorganic Chemistry Communications, 2007, 10, 7, 748-752Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
DOI: 10.1016/j.inoche.2007.03.016
ISSN: 1387-7003
WoS: 000247795000004
Scopus: 2-s2.0-34250199041
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gomez-Ruiz, Santiago AU - Kaluđerović, Goran N. AU - Polo-Ceron, Dorian AU - Prashar, Sanjiv AU - Fajardo, Mariano AU - Žižak, Žejko S. AU - Juranić, Zorica D. AU - Sabo, Tibor PY - 2007 UR - https://cherry.chem.bg.ac.rs/handle/123456789/847 AB - The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved. PB - Elsevier Science Bv, Amsterdam T2 - Inorganic Chemistry Communications T1 - Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes VL - 10 IS - 7 SP - 748 EP - 752 DO - 10.1016/j.inoche.2007.03.016 ER -
@article{ author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Polo-Ceron, Dorian and Prashar, Sanjiv and Fajardo, Mariano and Žižak, Žejko S. and Juranić, Zorica D. and Sabo, Tibor", year = "2007", abstract = "The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Inorganic Chemistry Communications", title = "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes", volume = "10", number = "7", pages = "748-752", doi = "10.1016/j.inoche.2007.03.016" }
Gomez-Ruiz, S., Kaluđerović, G. N., Polo-Ceron, D., Prashar, S., Fajardo, M., Žižak, Ž. S., Juranić, Z. D.,& Sabo, T.. (2007). Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications Elsevier Science Bv, Amsterdam., 10(7), 748-752. https://doi.org/10.1016/j.inoche.2007.03.016
Gomez-Ruiz S, Kaluđerović GN, Polo-Ceron D, Prashar S, Fajardo M, Žižak ŽS, Juranić ZD, Sabo T. Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications. 2007;10(7):748-752. doi:10.1016/j.inoche.2007.03.016 .
Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Polo-Ceron, Dorian, Prashar, Sanjiv, Fajardo, Mariano, Žižak, Žejko S., Juranić, Zorica D., Sabo, Tibor, "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes" in Inorganic Chemistry Communications, 10, no. 7 (2007):748-752, https://doi.org/10.1016/j.inoche.2007.03.016 . .