Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes
Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa
2008
Autori
Grgurić-Šipka, SanjaAlshtewi, Mohamed Al. Arbi M.
Jeremić, Dejan
Kaluđerović, Goran N.
Gomez-Ruiz, Santiago
Žižak, Željko S.
Juranić, Zorica D.
Sabo, Tibor
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.
Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa.
Ključne reči:
ruthenium(II) complexes / p-cymene / p-cymene / K-3-thiosemicarbazone / K3-thiosemicarbazone / N-methylpiperazine / N-methylpiperazine / cytotoxic activity / cytotoxic activityIzvor:
Journal of the Serbian Chemical Society, 2008, 73, 6, 619-630Izdavač:
- Serbian Chemical Soc, Belgrade
Finansiranje / projekti:
- Sinteza, karakterizacija i aktivnost organskih i koordinacionih jedinjenja i njihova primena u (bio)nanotehnologiji (RS-MESTD-MPN2006-2010-142010)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-MPN2006-2010-145006)
DOI: 10.2298/JSC0806619G
ISSN: 0352-5139
WoS: 000258789700003
Scopus: 2-s2.0-47049083285
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Grgurić-Šipka, Sanja AU - Alshtewi, Mohamed Al. Arbi M. AU - Jeremić, Dejan AU - Kaluđerović, Goran N. AU - Gomez-Ruiz, Santiago AU - Žižak, Željko S. AU - Juranić, Zorica D. AU - Sabo, Tibor PY - 2008 UR - https://cherry.chem.bg.ac.rs/handle/123456789/966 AB - Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present. AB - Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes T1 - Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa VL - 73 IS - 6 SP - 619 EP - 630 DO - 10.2298/JSC0806619G ER -
@article{ author = "Grgurić-Šipka, Sanja and Alshtewi, Mohamed Al. Arbi M. and Jeremić, Dejan and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Žižak, Željko S. and Juranić, Zorica D. and Sabo, Tibor", year = "2008", abstract = "Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present., Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes, Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa", volume = "73", number = "6", pages = "619-630", doi = "10.2298/JSC0806619G" }
Grgurić-Šipka, S., Alshtewi, M. Al. A. M., Jeremić, D., Kaluđerović, G. N., Gomez-Ruiz, S., Žižak, Ž. S., Juranić, Z. D.,& Sabo, T.. (2008). Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 73(6), 619-630. https://doi.org/10.2298/JSC0806619G
Grgurić-Šipka S, Alshtewi MAAM, Jeremić D, Kaluđerović GN, Gomez-Ruiz S, Žižak ŽS, Juranić ZD, Sabo T. Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes. in Journal of the Serbian Chemical Society. 2008;73(6):619-630. doi:10.2298/JSC0806619G .
Grgurić-Šipka, Sanja, Alshtewi, Mohamed Al. Arbi M., Jeremić, Dejan, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Žižak, Željko S., Juranić, Zorica D., Sabo, Tibor, "Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes" in Journal of the Serbian Chemical Society, 73, no. 6 (2008):619-630, https://doi.org/10.2298/JSC0806619G . .