TY  - JOUR
AU  - Todorović, Nevena M.
AU  - Stefanović, Milutin
AU  - Tinant, B
AU  - Declercq, JP
AU  - Makler, MT
AU  - Šolaja, Bogdan A.
PY  - 1996
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2582
AB  - Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5 alpha- and 5 beta-cholestan-3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5 beta-cholestane-3 alpha,3 beta-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC50 = 155 nM. (C) 1996 by Elsevier Science Inc.
PB  - Elsevier Science Inc, New York
T2  - Steroids
T1  - Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
VL  - 61
IS  - 12
SP  - 688
EP  - 696
DO  - 10.1016/S0039-128X(96)00203-6
ER  - 

@article{
author = "Todorović, Nevena M. and Stefanović, Milutin and Tinant, B and Declercq, JP and Makler, MT and Šolaja, Bogdan A.",
year = "1996",
abstract = "Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5 alpha- and 5 beta-cholestan-3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5 beta-cholestane-3 alpha,3 beta-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC50 = 155 nM. (C) 1996 by Elsevier Science Inc.",
publisher = "Elsevier Science Inc, New York",
journal = "Steroids",
title = "Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity",
volume = "61",
number = "12",
pages = "688-696",
doi = "10.1016/S0039-128X(96)00203-6"
}

Todorović, N. M., Stefanović, M., Tinant, B., Declercq, J., Makler, M.,& Šolaja, B. A.. (1996). Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity. in Steroids
Elsevier Science Inc, New York., 61(12), 688-696.
https://doi.org/10.1016/S0039-128X(96)00203-6

Todorović NM, Stefanović M, Tinant B, Declercq J, Makler M, Šolaja BA. Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity. in Steroids. 1996;61(12):688-696.
doi:10.1016/S0039-128X(96)00203-6 .

Todorović, Nevena M., Stefanović, Milutin, Tinant, B, Declercq, JP, Makler, MT, Šolaja, Bogdan A., "Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity" in Steroids, 61, no. 12 (1996):688-696,
https://doi.org/10.1016/S0039-128X(96)00203-6 . .