TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Zečević, Nebojša
AU  - Mihailović, Mladen
AU  - Jagodić, Jovana
AU  - Đurđić, Slađana Z.
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5630
AB  - Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary material for: Stojsavljević, A.; Zečević, N.; Mihailović, M.; Jagodić, J.; Đurđić, S.; Perović, M.; Manojlović, D. D. Elemental Profiling of Human Semen with Confirmed Normozoospermia: Baseline Levels for 44 Elements. Journal of Trace Elements in Medicine and Biology 2022, 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081.
VL  - 74
SP  - 127081
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5630
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Zečević, Nebojša and Mihailović, Mladen and Jagodić, Jovana and Đurđić, Slađana Z. and Perović, Milan and Manojlović, Dragan D.",
year = "2022",
abstract = "Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary material for: Stojsavljević, A.; Zečević, N.; Mihailović, M.; Jagodić, J.; Đurđić, S.; Perović, M.; Manojlović, D. D. Elemental Profiling of Human Semen with Confirmed Normozoospermia: Baseline Levels for 44 Elements. Journal of Trace Elements in Medicine and Biology 2022, 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081.",
volume = "74",
pages = "127081",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5630"
}

Stojsavljević, A., Zečević, N., Mihailović, M., Jagodić, J., Đurđić, S. Z., Perović, M.,& Manojlović, D. D.. (2022). Supplementary material for: Stojsavljević, A.; Zečević, N.; Mihailović, M.; Jagodić, J.; Đurđić, S.; Perović, M.; Manojlović, D. D. Elemental Profiling of Human Semen with Confirmed Normozoospermia: Baseline Levels for 44 Elements. Journal of Trace Elements in Medicine and Biology 2022, 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081.. in Journal of Trace Elements in Medicine and Biology
Elsevier., 74, 127081.
https://hdl.handle.net/21.15107/rcub_cherry_5630

Stojsavljević A, Zečević N, Mihailović M, Jagodić J, Đurđić SZ, Perović M, Manojlović DD. Supplementary material for: Stojsavljević, A.; Zečević, N.; Mihailović, M.; Jagodić, J.; Đurđić, S.; Perović, M.; Manojlović, D. D. Elemental Profiling of Human Semen with Confirmed Normozoospermia: Baseline Levels for 44 Elements. Journal of Trace Elements in Medicine and Biology 2022, 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081.. in Journal of Trace Elements in Medicine and Biology. 2022;74:127081.
https://hdl.handle.net/21.15107/rcub_cherry_5630 .

Stojsavljević, Aleksandar, Zečević, Nebojša, Mihailović, Mladen, Jagodić, Jovana, Đurđić, Slađana Z., Perović, Milan, Manojlović, Dragan D., "Supplementary material for: Stojsavljević, A.; Zečević, N.; Mihailović, M.; Jagodić, J.; Đurđić, S.; Perović, M.; Manojlović, D. D. Elemental Profiling of Human Semen with Confirmed Normozoospermia: Baseline Levels for 44 Elements. Journal of Trace Elements in Medicine and Biology 2022, 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081." in Journal of Trace Elements in Medicine and Biology, 74 (2022):127081,
https://hdl.handle.net/21.15107/rcub_cherry_5630 .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Ristić‑Medić, Danijela
AU  - Krstić, Đurđa D.
AU  - Rovčanin, Branislav
AU  - Radjen, Slavica
AU  - Terzić, Brankica
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5195
AB  - The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still
unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al,
Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-dialysis patients with
stage 3 CKD (PD group). Comparisons were made between groups of patients and healthy individuals from the control group
(CG). The levels of Al, Mn, Co, Ni, Cu, As, Se, Sr, and Pb were higher, while the levels of Cr, Zn, Rb, Cd, and U were lower
in HD patients than in our CG. Higher levels of Al and Se, as well as lower levels of As, Sr, Zn, Rb, and U were significant
and distinguished HD from PD. Among other analyzed elements, Co, Se, and U are the only trace elements that did not
distinguish PD from CG at a statistically significant level. The HD group had lower serum U levels than the PD group, and
this could be a result of hemodialysis. This study also revealed that the Cu/Zn ratio could be used as a marker for early and
late detection of renal failure. Marked changes of essential and toxic trace element levels in sera indicate additional pathophysiological
events in CKD, which could additionally contribute to the preexisting increased morbidity of HD patients.
Measurement of trace elements in HD patients should be performed routinely.
PB  - Springer
T2  - Biological Trace Element Research
T1  - Circulatory Imbalance of Essential and Toxic Trace Elements in Pre‑dialysis and Hemodialysis Patients
VL  - 200
SP  - 3117
EP  - 3125
DO  - 10.1007/s12011-021-02940-7
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Ristić‑Medić, Danijela and Krstić, Đurđa D. and Rovčanin, Branislav and Radjen, Slavica and Terzić, Brankica and Manojlović, Dragan D.",
year = "2022",
abstract = "The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still
unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al,
Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-dialysis patients with
stage 3 CKD (PD group). Comparisons were made between groups of patients and healthy individuals from the control group
(CG). The levels of Al, Mn, Co, Ni, Cu, As, Se, Sr, and Pb were higher, while the levels of Cr, Zn, Rb, Cd, and U were lower
in HD patients than in our CG. Higher levels of Al and Se, as well as lower levels of As, Sr, Zn, Rb, and U were significant
and distinguished HD from PD. Among other analyzed elements, Co, Se, and U are the only trace elements that did not
distinguish PD from CG at a statistically significant level. The HD group had lower serum U levels than the PD group, and
this could be a result of hemodialysis. This study also revealed that the Cu/Zn ratio could be used as a marker for early and
late detection of renal failure. Marked changes of essential and toxic trace element levels in sera indicate additional pathophysiological
events in CKD, which could additionally contribute to the preexisting increased morbidity of HD patients.
Measurement of trace elements in HD patients should be performed routinely.",
publisher = "Springer",
journal = "Biological Trace Element Research",
title = "Circulatory Imbalance of Essential and Toxic Trace Elements in Pre‑dialysis and Hemodialysis Patients",
volume = "200",
pages = "3117-3125",
doi = "10.1007/s12011-021-02940-7"
}

Stojsavljević, A., Ristić‑Medić, D., Krstić, Đ. D., Rovčanin, B., Radjen, S., Terzić, B.,& Manojlović, D. D.. (2022). Circulatory Imbalance of Essential and Toxic Trace Elements in Pre‑dialysis and Hemodialysis Patients. in Biological Trace Element Research
Springer., 200, 3117-3125.
https://doi.org/10.1007/s12011-021-02940-7

Stojsavljević A, Ristić‑Medić D, Krstić ĐD, Rovčanin B, Radjen S, Terzić B, Manojlović DD. Circulatory Imbalance of Essential and Toxic Trace Elements in Pre‑dialysis and Hemodialysis Patients. in Biological Trace Element Research. 2022;200:3117-3125.
doi:10.1007/s12011-021-02940-7 .

Stojsavljević, Aleksandar, Ristić‑Medić, Danijela, Krstić, Đurđa D., Rovčanin, Branislav, Radjen, Slavica, Terzić, Brankica, Manojlović, Dragan D., "Circulatory Imbalance of Essential and Toxic Trace Elements in Pre‑dialysis and Hemodialysis Patients" in Biological Trace Element Research, 200 (2022):3117-3125,
https://doi.org/10.1007/s12011-021-02940-7 . .