TY  - JOUR
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Željković, Milica
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Đurđić, Slađana Z.
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3815
AB  - Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells’ proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.
PB  - Elsevier
T2  - Environmental Toxicology and Pharmacology
T1  - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity
VL  - 75
DO  - 10.1016/j.etap.2020.103326
ER  - 

@article{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Željković, Milica and Popović, Dušanka and Zolotarevski, Lidija and Đurđić, Slađana Z. and Mutić, Jelena and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2020",
abstract = "Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells’ proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.",
publisher = "Elsevier",
journal = "Environmental Toxicology and Pharmacology",
title = "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity",
volume = "75",
doi = "10.1016/j.etap.2020.103326"
}

Tucović, D., Mirkov, I., Kulaš, J., Željković, M., Popović, D., Zolotarevski, L., Đurđić, S. Z., Mutić, J., Kataranovski, M.,& Popov Aleksandrov, A.. (2020). Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity. in Environmental Toxicology and Pharmacology
Elsevier., 75.
https://doi.org/10.1016/j.etap.2020.103326

Tucović D, Mirkov I, Kulaš J, Željković M, Popović D, Zolotarevski L, Đurđić SZ, Mutić J, Kataranovski M, Popov Aleksandrov A. Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity. in Environmental Toxicology and Pharmacology. 2020;75.
doi:10.1016/j.etap.2020.103326 .

Tucović, Dina, Mirkov, Ivana, Kulaš, Jelena, Željković, Milica, Popović, Dušanka, Zolotarevski, Lidija, Đurđić, Slađana Z., Mutić, Jelena, Kataranovski, Milena, Popov Aleksandrov, Aleksandra, "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity" in Environmental Toxicology and Pharmacology, 75 (2020),
https://doi.org/10.1016/j.etap.2020.103326 . .