TY  - JOUR
AU  - Šukalović, Vladimir
AU  - Šoškić, Vukić
AU  - Ignjatović, Đurđica
AU  - Andrić, Deana
AU  - Penjišević, Jelena
AU  - Kostić-Rajačić, Slađana
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1646
AB  - The dopaminergic receptor system has been the focus for the development of new pharmacotherapeutic agents targeting a number of central nervous system related disorders, such as drug addiction, schizophrenia, depression, and Parkinson's disease, to name just a few. To date, the crystal structure for the human D2 receptor is not known, despite its vital function and importance as a therapeutic target. Herein, a recent advancement in the determination of key receptor ligand interactions for the available arylpiperazine-like ligands, using a D2 receptor model based on the crystal structure of the D3 receptor is presented. To determine key interactions responsible for high dopaminergic activity, computer-docking analysis was used together with experimental data. A total of 4 dopaminergic ligands showing moderate to high affinity were tested and the obtained results rationalized using ligand structures docked into the proposed D2 receptor model.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides
VL  - 79
IS  - 12
SP  - 1461
EP  - 1467
DO  - 10.2298/JSC140423070S
ER  - 

@article{
author = "Šukalović, Vladimir and Šoškić, Vukić and Ignjatović, Đurđica and Andrić, Deana and Penjišević, Jelena and Kostić-Rajačić, Slađana",
year = "2014",
abstract = "The dopaminergic receptor system has been the focus for the development of new pharmacotherapeutic agents targeting a number of central nervous system related disorders, such as drug addiction, schizophrenia, depression, and Parkinson's disease, to name just a few. To date, the crystal structure for the human D2 receptor is not known, despite its vital function and importance as a therapeutic target. Herein, a recent advancement in the determination of key receptor ligand interactions for the available arylpiperazine-like ligands, using a D2 receptor model based on the crystal structure of the D3 receptor is presented. To determine key interactions responsible for high dopaminergic activity, computer-docking analysis was used together with experimental data. A total of 4 dopaminergic ligands showing moderate to high affinity were tested and the obtained results rationalized using ligand structures docked into the proposed D2 receptor model.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides",
volume = "79",
number = "12",
pages = "1461-1467",
doi = "10.2298/JSC140423070S"
}

Šukalović, V., Šoškić, V., Ignjatović, Đ., Andrić, D., Penjišević, J.,& Kostić-Rajačić, S.. (2014). Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(12), 1461-1467.
https://doi.org/10.2298/JSC140423070S

Šukalović V, Šoškić V, Ignjatović Đ, Andrić D, Penjišević J, Kostić-Rajačić S. Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides. in Journal of the Serbian Chemical Society. 2014;79(12):1461-1467.
doi:10.2298/JSC140423070S .

Šukalović, Vladimir, Šoškić, Vukić, Ignjatović, Đurđica, Andrić, Deana, Penjišević, Jelena, Kostić-Rajačić, Slađana, "Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides" in Journal of the Serbian Chemical Society, 79, no. 12 (2014):1461-1467,
https://doi.org/10.2298/JSC140423070S . .

TY  - JOUR
AU  - Šukalović, Vladimir
AU  - Bogdan, Anca Elena
AU  - Tovilović, Gordana
AU  - Ignjatović, Đurđica
AU  - Andrić, Deana
AU  - Kostić-Rajačić, Slađana
AU  - Šoškić, Vukić
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1413
AB  - The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Archiv der Pharmazie
T1  - N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling
VL  - 346
IS  - 10
SP  - 708
EP  - 717
DO  - 10.1002/ardp.201300189
ER  - 

@article{
author = "Šukalović, Vladimir and Bogdan, Anca Elena and Tovilović, Gordana and Ignjatović, Đurđica and Andrić, Deana and Kostić-Rajačić, Slađana and Šoškić, Vukić",
year = "2013",
abstract = "The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Archiv der Pharmazie",
title = "N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling",
volume = "346",
number = "10",
pages = "708-717",
doi = "10.1002/ardp.201300189"
}

Šukalović, V., Bogdan, A. E., Tovilović, G., Ignjatović, Đ., Andrić, D., Kostić-Rajačić, S.,& Šoškić, V.. (2013). N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. in Archiv der Pharmazie
Wiley-V C H Verlag Gmbh, Weinheim., 346(10), 708-717.
https://doi.org/10.1002/ardp.201300189

Šukalović V, Bogdan AE, Tovilović G, Ignjatović Đ, Andrić D, Kostić-Rajačić S, Šoškić V. N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. in Archiv der Pharmazie. 2013;346(10):708-717.
doi:10.1002/ardp.201300189 .

Šukalović, Vladimir, Bogdan, Anca Elena, Tovilović, Gordana, Ignjatović, Đurđica, Andrić, Deana, Kostić-Rajačić, Slađana, Šoškić, Vukić, "N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling" in Archiv der Pharmazie, 346, no. 10 (2013):708-717,
https://doi.org/10.1002/ardp.201300189 . .

TY  - DATA
AU  - Šukalović, Vladimir
AU  - Bogdan, Anca Elena
AU  - Tovilović, Gordana
AU  - Ignjatović, Đurđica
AU  - Andrić, Deana
AU  - Kostić-Rajačić, Slađana
AU  - Šoškić, Vukić
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3511
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Archiv der Pharmazie
T1  - Supplementary data for article: Šukalović, V.; Bogdan, A. E.; Tovilovic, G.; Ignjatovic, D.; Andrić, D.; Kostić-Rajačić, S.; Šoškić, V. N-{[2-(4-Phenyl-Piperazin-1-Yl)-Ethyl]-Phenyl}-Arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. Archiv der Pharmazie 2013, 346 (10), 708–717. https://doi.org/10.1002/ardp.201300189
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3511
ER  - 

@misc{
author = "Šukalović, Vladimir and Bogdan, Anca Elena and Tovilović, Gordana and Ignjatović, Đurđica and Andrić, Deana and Kostić-Rajačić, Slađana and Šoškić, Vukić",
year = "2013",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Archiv der Pharmazie",
title = "Supplementary data for article: Šukalović, V.; Bogdan, A. E.; Tovilovic, G.; Ignjatovic, D.; Andrić, D.; Kostić-Rajačić, S.; Šoškić, V. N-{[2-(4-Phenyl-Piperazin-1-Yl)-Ethyl]-Phenyl}-Arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. Archiv der Pharmazie 2013, 346 (10), 708–717. https://doi.org/10.1002/ardp.201300189",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3511"
}

Šukalović, V., Bogdan, A. E., Tovilović, G., Ignjatović, Đ., Andrić, D., Kostić-Rajačić, S.,& Šoškić, V.. (2013). Supplementary data for article: Šukalović, V.; Bogdan, A. E.; Tovilovic, G.; Ignjatovic, D.; Andrić, D.; Kostić-Rajačić, S.; Šoškić, V. N-{[2-(4-Phenyl-Piperazin-1-Yl)-Ethyl]-Phenyl}-Arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. Archiv der Pharmazie 2013, 346 (10), 708–717. https://doi.org/10.1002/ardp.201300189. in Archiv der Pharmazie
Wiley-V C H Verlag Gmbh, Weinheim..
https://hdl.handle.net/21.15107/rcub_cherry_3511

Šukalović V, Bogdan AE, Tovilović G, Ignjatović Đ, Andrić D, Kostić-Rajačić S, Šoškić V. Supplementary data for article: Šukalović, V.; Bogdan, A. E.; Tovilovic, G.; Ignjatovic, D.; Andrić, D.; Kostić-Rajačić, S.; Šoškić, V. N-{[2-(4-Phenyl-Piperazin-1-Yl)-Ethyl]-Phenyl}-Arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. Archiv der Pharmazie 2013, 346 (10), 708–717. https://doi.org/10.1002/ardp.201300189. in Archiv der Pharmazie. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3511 .

Šukalović, Vladimir, Bogdan, Anca Elena, Tovilović, Gordana, Ignjatović, Đurđica, Andrić, Deana, Kostić-Rajačić, Slađana, Šoškić, Vukić, "Supplementary data for article: Šukalović, V.; Bogdan, A. E.; Tovilovic, G.; Ignjatovic, D.; Andrić, D.; Kostić-Rajačić, S.; Šoškić, V. N-{[2-(4-Phenyl-Piperazin-1-Yl)-Ethyl]-Phenyl}-Arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. Archiv der Pharmazie 2013, 346 (10), 708–717. https://doi.org/10.1002/ardp.201300189" in Archiv der Pharmazie (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3511 .

TY  - JOUR
AU  - Ignjatović, Đurđica
AU  - Milutinovic, Danijela Vojnovic
AU  - Nikolić-Kokić, Aleksandra
AU  - Slavic, Marija
AU  - Andrić, Deana
AU  - Tomic, Mirko
AU  - Kostić-Rajačić, Slađana
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1289
AB  - A group of sixteen arylpiperazines had been previously synthesized and evaluated for atypical antipsychotic activity. Here we examined these compounds for their neuroprotective capacity. The affinity and agonist/antagonist action of the arylpiperazines at dopamine hD(2S) receptors were determined in vitro on membranes from stably transfected CHO-hD(2S) cell line. The assays for cell viability and antioxidative capacity (total glutathione and total superoxide dismutase activity), amount of nitric oxide and superoxide radicals, as well as influence on prosurvival pathways (Akt and ERK), were performed on the human neuroblastoma cell line SH-SY5Y. Cell death was induced by oxidative or nitrosative stress, or by growing cells in the medium deprived of serum. Only four of the arylpiperazines exhibited notable neuroprotection against cell death induced by sodium nitroprusside. Two of these arylpiperazines induced elevations of pAkt, while two other compounds reduced the levels of pErk, whereas these actions are considered to support the cell survival. The benzimidazole heteroaryl-group, that mimics catechol moiety of the dopamine molecule, might be the prerequisite structure for the neuroprotective action of these ligands. It is postulated that neuroprotection was acquired also by elevation of endogenous glutathione or total superoxide dismutase activity. (C) 2012 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - European Journal of Pharmacology
T1  - The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside
VL  - 683
IS  - 1-3
SP  - 93
EP  - 100
DO  - 10.1016/j.ejphar.2012.03.011
ER  - 

@article{
author = "Ignjatović, Đurđica and Milutinovic, Danijela Vojnovic and Nikolić-Kokić, Aleksandra and Slavic, Marija and Andrić, Deana and Tomic, Mirko and Kostić-Rajačić, Slađana",
year = "2012",
abstract = "A group of sixteen arylpiperazines had been previously synthesized and evaluated for atypical antipsychotic activity. Here we examined these compounds for their neuroprotective capacity. The affinity and agonist/antagonist action of the arylpiperazines at dopamine hD(2S) receptors were determined in vitro on membranes from stably transfected CHO-hD(2S) cell line. The assays for cell viability and antioxidative capacity (total glutathione and total superoxide dismutase activity), amount of nitric oxide and superoxide radicals, as well as influence on prosurvival pathways (Akt and ERK), were performed on the human neuroblastoma cell line SH-SY5Y. Cell death was induced by oxidative or nitrosative stress, or by growing cells in the medium deprived of serum. Only four of the arylpiperazines exhibited notable neuroprotection against cell death induced by sodium nitroprusside. Two of these arylpiperazines induced elevations of pAkt, while two other compounds reduced the levels of pErk, whereas these actions are considered to support the cell survival. The benzimidazole heteroaryl-group, that mimics catechol moiety of the dopamine molecule, might be the prerequisite structure for the neuroprotective action of these ligands. It is postulated that neuroprotection was acquired also by elevation of endogenous glutathione or total superoxide dismutase activity. (C) 2012 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "European Journal of Pharmacology",
title = "The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside",
volume = "683",
number = "1-3",
pages = "93-100",
doi = "10.1016/j.ejphar.2012.03.011"
}

Ignjatović, Đ., Milutinovic, D. V., Nikolić-Kokić, A., Slavic, M., Andrić, D., Tomic, M.,& Kostić-Rajačić, S.. (2012). The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside. in European Journal of Pharmacology
Elsevier Science Bv, Amsterdam., 683(1-3), 93-100.
https://doi.org/10.1016/j.ejphar.2012.03.011

Ignjatović Đ, Milutinovic DV, Nikolić-Kokić A, Slavic M, Andrić D, Tomic M, Kostić-Rajačić S. The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside. in European Journal of Pharmacology. 2012;683(1-3):93-100.
doi:10.1016/j.ejphar.2012.03.011 .

Ignjatović, Đurđica, Milutinovic, Danijela Vojnovic, Nikolić-Kokić, Aleksandra, Slavic, Marija, Andrić, Deana, Tomic, Mirko, Kostić-Rajačić, Slađana, "The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside" in European Journal of Pharmacology, 683, no. 1-3 (2012):93-100,
https://doi.org/10.1016/j.ejphar.2012.03.011 . .

TY  - JOUR
AU  - Šukalović, Vladimir
AU  - Ignjatović, Đurđica
AU  - Tovilović, Gordana
AU  - Andrić, Deana
AU  - Shakib, Kaveh
AU  - Kostić-Rajačić, Slađana
AU  - Šoškić, Vukić
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1302
AB  - It is suggested that the ratio of dopamine D-2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D-2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT1A receptors. (C) 2012 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors
VL  - 22
IS  - 12
SP  - 3967
EP  - 3972
DO  - 10.1016/j.bmcl.2012.04.098
ER  - 

@article{
author = "Šukalović, Vladimir and Ignjatović, Đurđica and Tovilović, Gordana and Andrić, Deana and Shakib, Kaveh and Kostić-Rajačić, Slađana and Šoškić, Vukić",
year = "2012",
abstract = "It is suggested that the ratio of dopamine D-2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D-2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT1A receptors. (C) 2012 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors",
volume = "22",
number = "12",
pages = "3967-3972",
doi = "10.1016/j.bmcl.2012.04.098"
}

Šukalović, V., Ignjatović, Đ., Tovilović, G., Andrić, D., Shakib, K., Kostić-Rajačić, S.,& Šoškić, V.. (2012). Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 22(12), 3967-3972.
https://doi.org/10.1016/j.bmcl.2012.04.098

Šukalović V, Ignjatović Đ, Tovilović G, Andrić D, Shakib K, Kostić-Rajačić S, Šoškić V. Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors. in Bioorganic and Medicinal Chemistry Letters. 2012;22(12):3967-3972.
doi:10.1016/j.bmcl.2012.04.098 .

Šukalović, Vladimir, Ignjatović, Đurđica, Tovilović, Gordana, Andrić, Deana, Shakib, Kaveh, Kostić-Rajačić, Slađana, Šoškić, Vukić, "Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors" in Bioorganic and Medicinal Chemistry Letters, 22, no. 12 (2012):3967-3972,
https://doi.org/10.1016/j.bmcl.2012.04.098 . .

TY  - JOUR
AU  - Tomic, Mirko
AU  - Ignjatović, Đurđica
AU  - Tovijovic, Gordana
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Kostić-Rajačić, Slađana
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/886
AB  - Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Two new phenylpiperazines with atypical antipsychotic potential
VL  - 17
IS  - 21
SP  - 5749
EP  - 5753
DO  - 10.1016/j.bmcl.2007.08.066
ER  - 

@article{
author = "Tomic, Mirko and Ignjatović, Đurđica and Tovijovic, Gordana and Andrić, Deana and Roglić, Goran and Kostić-Rajačić, Slađana",
year = "2007",
abstract = "Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Two new phenylpiperazines with atypical antipsychotic potential",
volume = "17",
number = "21",
pages = "5749-5753",
doi = "10.1016/j.bmcl.2007.08.066"
}

Tomic, M., Ignjatović, Đ., Tovijovic, G., Andrić, D., Roglić, G.,& Kostić-Rajačić, S.. (2007). Two new phenylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 17(21), 5749-5753.
https://doi.org/10.1016/j.bmcl.2007.08.066

Tomic M, Ignjatović Đ, Tovijovic G, Andrić D, Roglić G, Kostić-Rajačić S. Two new phenylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2007;17(21):5749-5753.
doi:10.1016/j.bmcl.2007.08.066 .

Tomic, Mirko, Ignjatović, Đurđica, Tovijovic, Gordana, Andrić, Deana, Roglić, Goran, Kostić-Rajačić, Slađana, "Two new phenylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 17, no. 21 (2007):5749-5753,
https://doi.org/10.1016/j.bmcl.2007.08.066 . .

TY  - JOUR
AU  - Tomic, M
AU  - Kundakovic, M
AU  - Butorovi, B
AU  - Janac, B
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Ignjatović, Đurđica
AU  - Kostić-Rajačić, Slađana
PY  - 2004
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/652
AB  - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics ( gt 1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. (C) 2004 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
VL  - 14
IS  - 16
SP  - 4263
EP  - 4266
DO  - 10.1016/j.bmcl.2004.06.005
ER  - 

@article{
author = "Tomic, M and Kundakovic, M and Butorovi, B and Janac, B and Andrić, Deana and Roglić, Goran and Ignjatović, Đurđica and Kostić-Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics ( gt 1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. (C) 2004 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
volume = "14",
number = "16",
pages = "4263-4266",
doi = "10.1016/j.bmcl.2004.06.005"
}

Tomic, M., Kundakovic, M., Butorovi, B., Janac, B., Andrić, D., Roglić, G., Ignjatović, Đ.,& Kostić-Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 14(16), 4263-4266.
https://doi.org/10.1016/j.bmcl.2004.06.005

Tomic M, Kundakovic M, Butorovi B, Janac B, Andrić D, Roglić G, Ignjatović Đ, Kostić-Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266.
doi:10.1016/j.bmcl.2004.06.005 .

Tomic, M, Kundakovic, M, Butorovi, B, Janac, B, Andrić, Deana, Roglić, Goran, Ignjatović, Đurđica, Kostić-Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266,
https://doi.org/10.1016/j.bmcl.2004.06.005 . .

TY  - JOUR
AU  - Tomic, M
AU  - Kundakovic, M
AU  - Butorovic, B
AU  - Vasilev, V
AU  - Dragovic, D
AU  - Roglić, Goran
AU  - Ignjatović, Đurđica
AU  - Šoškić, Vukić
AU  - Kostić-Rajačić, Slađana
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/149
PB  - Govi-Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Pharmacological evaluation of 5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydro-benz-imidazole-2-thione as a potential atypical antipsychotic agent
VL  - 58
IS  - 9
SP  - 677
EP  - 678
UR  - https://hdl.handle.net/21.15107/rcub_cherry_149
ER  - 

@article{
author = "Tomic, M and Kundakovic, M and Butorovic, B and Vasilev, V and Dragovic, D and Roglić, Goran and Ignjatović, Đurđica and Šoškić, Vukić and Kostić-Rajačić, Slađana",
year = "2003",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Pharmacological evaluation of 5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydro-benz-imidazole-2-thione as a potential atypical antipsychotic agent",
volume = "58",
number = "9",
pages = "677-678",
url = "https://hdl.handle.net/21.15107/rcub_cherry_149"
}

Tomic, M., Kundakovic, M., Butorovic, B., Vasilev, V., Dragovic, D., Roglić, G., Ignjatović, Đ., Šoškić, V.,& Kostić-Rajačić, S.. (2003). Pharmacological evaluation of 5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydro-benz-imidazole-2-thione as a potential atypical antipsychotic agent. in Pharmazie
Govi-Verlag Gmbh, Eschborn., 58(9), 677-678.
https://hdl.handle.net/21.15107/rcub_cherry_149

Tomic M, Kundakovic M, Butorovic B, Vasilev V, Dragovic D, Roglić G, Ignjatović Đ, Šoškić V, Kostić-Rajačić S. Pharmacological evaluation of 5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydro-benz-imidazole-2-thione as a potential atypical antipsychotic agent. in Pharmazie. 2003;58(9):677-678.
https://hdl.handle.net/21.15107/rcub_cherry_149 .

Tomic, M, Kundakovic, M, Butorovic, B, Vasilev, V, Dragovic, D, Roglić, Goran, Ignjatović, Đurđica, Šoškić, Vukić, Kostić-Rajačić, Slađana, "Pharmacological evaluation of 5-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydro-benz-imidazole-2-thione as a potential atypical antipsychotic agent" in Pharmazie, 58, no. 9 (2003):677-678,
https://hdl.handle.net/21.15107/rcub_cherry_149 .