TY  - JOUR
AU  - Kulaš, Jelena
AU  - Ninkov, Marina
AU  - Tucović, Dina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Ukropina, Mirela
AU  - Cakić-Milošević, Maja
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Mikrov, Ivana
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3455
AB  - Objective The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.
T2  - Biomedical and environmental sciences : BES
T1  - Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats
VL  - 32
IS  - 7
SP  - 508
EP  - 519
DO  - 10.3967/bes2019.068
ER  - 

@article{
author = "Kulaš, Jelena and Ninkov, Marina and Tucović, Dina and Popov-Aleksandrov, Aleksandra and Ukropina, Mirela and Cakić-Milošević, Maja and Mutić, Jelena and Kataranovski, Milena and Mikrov, Ivana",
year = "2019",
abstract = "Objective The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.",
journal = "Biomedical and environmental sciences : BES",
title = "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats",
volume = "32",
number = "7",
pages = "508-519",
doi = "10.3967/bes2019.068"
}

Kulaš, J., Ninkov, M., Tucović, D., Popov-Aleksandrov, A., Ukropina, M., Cakić-Milošević, M., Mutić, J., Kataranovski, M.,& Mikrov, I.. (2019). Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats. in Biomedical and environmental sciences : BES, 32(7), 508-519.
https://doi.org/10.3967/bes2019.068

Kulaš J, Ninkov M, Tucović D, Popov-Aleksandrov A, Ukropina M, Cakić-Milošević M, Mutić J, Kataranovski M, Mikrov I. Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats. in Biomedical and environmental sciences : BES. 2019;32(7):508-519.
doi:10.3967/bes2019.068 .

Kulaš, Jelena, Ninkov, Marina, Tucović, Dina, Popov-Aleksandrov, Aleksandra, Ukropina, Mirela, Cakić-Milošević, Maja, Mutić, Jelena, Kataranovski, Milena, Mikrov, Ivana, "Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats" in Biomedical and environmental sciences : BES, 32, no. 7 (2019):508-519,
https://doi.org/10.3967/bes2019.068 . .

TY  - JOUR
AU  - Tucović, Dina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Kulaš, Jelena
AU  - Zolotarevski, Lidija
AU  - Vukojević, Vesna
AU  - Mutić, Jelena
AU  - Tatalović, Nikola
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/339
AB  - Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30–day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies. © 2018 Elsevier Inc.
T2  - Ecotoxicology and Environmental Safety
T1  - Oral cadmium exposure affects skin immune reactivity in rats
VL  - 164
SP  - 12
EP  - 20
DO  - 10.1016/j.ecoenv.2018.07.117
ER  - 

@article{
author = "Tucović, Dina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Kulaš, Jelena and Zolotarevski, Lidija and Vukojević, Vesna and Mutić, Jelena and Tatalović, Nikola and Kataranovski, Milena",
year = "2018",
abstract = "Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30–day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies. © 2018 Elsevier Inc.",
journal = "Ecotoxicology and Environmental Safety",
title = "Oral cadmium exposure affects skin immune reactivity in rats",
volume = "164",
pages = "12-20",
doi = "10.1016/j.ecoenv.2018.07.117"
}

Tucović, D., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Kulaš, J., Zolotarevski, L., Vukojević, V., Mutić, J., Tatalović, N.,& Kataranovski, M.. (2018). Oral cadmium exposure affects skin immune reactivity in rats. in Ecotoxicology and Environmental Safety, 164, 12-20.
https://doi.org/10.1016/j.ecoenv.2018.07.117

Tucović D, Popov-Aleksandrov A, Mirkov I, Ninkov M, Kulaš J, Zolotarevski L, Vukojević V, Mutić J, Tatalović N, Kataranovski M. Oral cadmium exposure affects skin immune reactivity in rats. in Ecotoxicology and Environmental Safety. 2018;164:12-20.
doi:10.1016/j.ecoenv.2018.07.117 .

Tucović, Dina, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Kulaš, Jelena, Zolotarevski, Lidija, Vukojević, Vesna, Mutić, Jelena, Tatalović, Nikola, Kataranovski, Milena, "Oral cadmium exposure affects skin immune reactivity in rats" in Ecotoxicology and Environmental Safety, 164 (2018):12-20,
https://doi.org/10.1016/j.ecoenv.2018.07.117 . .

TY  - JOUR
AU  - Demenesku, Jelena
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2266
AB  - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
VL  - 256
SP  - 33
EP  - 43
DO  - 10.1016/j.toxlet.2016.05.022
ER  - 

@article{
author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses",
volume = "256",
pages = "33-43",
doi = "10.1016/j.toxlet.2016.05.022"
}

Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 256, 33-43.
https://doi.org/10.1016/j.toxlet.2016.05.022

Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters. 2016;256:33-43.
doi:10.1016/j.toxlet.2016.05.022 .

Demenesku, Jelena, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" in Toxicology Letters, 256 (2016):33-43,
https://doi.org/10.1016/j.toxlet.2016.05.022 . .

TY  - JOUR
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Demenesku, Jelena
AU  - Mileusnić, Dina
AU  - Jovanović-Stojanov, Sofija
AU  - Golić, Nataša
AU  - Tolinački, Maja
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2312
AB  - Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Strain differences in toxicity of oral cadmium intake in rats
VL  - 96
SP  - 11
EP  - 23
DO  - 10.1016/j.fct.2016.07.021
ER  - 

@article{
author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Demenesku, Jelena and Mileusnić, Dina and Jovanović-Stojanov, Sofija and Golić, Nataša and Tolinački, Maja and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
abstract = "Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Strain differences in toxicity of oral cadmium intake in rats",
volume = "96",
pages = "11-23",
doi = "10.1016/j.fct.2016.07.021"
}

Ninkov, M., Popov-Aleksandrov, A., Mirkov, I., Demenesku, J., Mileusnić, D., Jovanović-Stojanov, S., Golić, N., Tolinački, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences in toxicity of oral cadmium intake in rats. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 96, 11-23.
https://doi.org/10.1016/j.fct.2016.07.021

Ninkov M, Popov-Aleksandrov A, Mirkov I, Demenesku J, Mileusnić D, Jovanović-Stojanov S, Golić N, Tolinački M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences in toxicity of oral cadmium intake in rats. in Food and Chemical Toxicology. 2016;96:11-23.
doi:10.1016/j.fct.2016.07.021 .

Ninkov, Marina, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Demenesku, Jelena, Mileusnić, Dina, Jovanović-Stojanov, Sofija, Golić, Nataša, Tolinački, Maja, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences in toxicity of oral cadmium intake in rats" in Food and Chemical Toxicology, 96 (2016):11-23,
https://doi.org/10.1016/j.fct.2016.07.021 . .

TY  - JOUR
AU  - Demenesku, Jelena
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3615
AB  - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
VL  - 256
SP  - 33
EP  - 43
DO  - 10.1016/j.toxlet.2016.05.022
ER  - 

@article{
author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses",
volume = "256",
pages = "33-43",
doi = "10.1016/j.toxlet.2016.05.022"
}

Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 256, 33-43.
https://doi.org/10.1016/j.toxlet.2016.05.022

Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters. 2016;256:33-43.
doi:10.1016/j.toxlet.2016.05.022 .

Demenesku, Jelena, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" in Toxicology Letters, 256 (2016):33-43,
https://doi.org/10.1016/j.toxlet.2016.05.022 . .

TY  - JOUR
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Demenesku, Jelena
AU  - Mirkov, Ivana
AU  - Mileusnić, Dina
AU  - Petrović, Anja
AU  - Grigorov, Ilijana
AU  - Zolotarevski, Lidija
AU  - Tolinački, Maja
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1730
AB  - Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Toxicity of oral cadmium intake: Impact on gut immunity
VL  - 237
IS  - 2
SP  - 89
EP  - 99
DO  - 10.1016/j.toxlet.2015.06.002
ER  - 

@article{
author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Demenesku, Jelena and Mirkov, Ivana and Mileusnić, Dina and Petrović, Anja and Grigorov, Ilijana and Zolotarevski, Lidija and Tolinački, Maja and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2015",
abstract = "Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Toxicity of oral cadmium intake: Impact on gut immunity",
volume = "237",
number = "2",
pages = "89-99",
doi = "10.1016/j.toxlet.2015.06.002"
}

Ninkov, M., Popov-Aleksandrov, A., Demenesku, J., Mirkov, I., Mileusnić, D., Petrović, A., Grigorov, I., Zolotarevski, L., Tolinački, M., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2015). Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 237(2), 89-99.
https://doi.org/10.1016/j.toxlet.2015.06.002

Ninkov M, Popov-Aleksandrov A, Demenesku J, Mirkov I, Mileusnić D, Petrović A, Grigorov I, Zolotarevski L, Tolinački M, Kataranovski D, Brčeski I, Kataranovski M. Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters. 2015;237(2):89-99.
doi:10.1016/j.toxlet.2015.06.002 .

Ninkov, Marina, Popov-Aleksandrov, Aleksandra, Demenesku, Jelena, Mirkov, Ivana, Mileusnić, Dina, Petrović, Anja, Grigorov, Ilijana, Zolotarevski, Lidija, Tolinački, Maja, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Toxicity of oral cadmium intake: Impact on gut immunity" in Toxicology Letters, 237, no. 2 (2015):89-99,
https://doi.org/10.1016/j.toxlet.2015.06.002 . .

TY  - JOUR
AU  - Đokić, Jelena
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Subota, Vesna
AU  - Mihajlovic, Luka
AU  - Stojadinović, Marija M.
AU  - Stanić-Vučinić, Dragana
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1624
AB  - Warfarin (3-(alpha-acetonylbenzy1)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-gamma production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy.
AB  - Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Strain differences in the toxicity of the vitamin K antagonist warfarin in rats
T1  - Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova
VL  - 78
IS  - 3
SP  - 381
EP  - 394
DO  - 10.2298/JSC121114010D
ER  - 

@article{
author = "Đokić, Jelena and Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Subota, Vesna and Mihajlovic, Luka and Stojadinović, Marija M. and Stanić-Vučinić, Dragana and Kataranovski, Dragan and Kataranovski, Milena",
year = "2013",
abstract = "Warfarin (3-(alpha-acetonylbenzy1)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-gamma production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy., Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Strain differences in the toxicity of the vitamin K antagonist warfarin in rats, Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova",
volume = "78",
number = "3",
pages = "381-394",
doi = "10.2298/JSC121114010D"
}

Đokić, J., Ninkov, M., Popov-Aleksandrov, A., Mirkov, I., Subota, V., Mihajlovic, L., Stojadinović, M. M., Stanić-Vučinić, D., Kataranovski, D.,& Kataranovski, M.. (2013). Strain differences in the toxicity of the vitamin K antagonist warfarin in rats. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 78(3), 381-394.
https://doi.org/10.2298/JSC121114010D

Đokić J, Ninkov M, Popov-Aleksandrov A, Mirkov I, Subota V, Mihajlovic L, Stojadinović MM, Stanić-Vučinić D, Kataranovski D, Kataranovski M. Strain differences in the toxicity of the vitamin K antagonist warfarin in rats. in Journal of the Serbian Chemical Society. 2013;78(3):381-394.
doi:10.2298/JSC121114010D .

Đokić, Jelena, Ninkov, Marina, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Subota, Vesna, Mihajlovic, Luka, Stojadinović, Marija M., Stanić-Vučinić, Dragana, Kataranovski, Dragan, Kataranovski, Milena, "Strain differences in the toxicity of the vitamin K antagonist warfarin in rats" in Journal of the Serbian Chemical Society, 78, no. 3 (2013):381-394,
https://doi.org/10.2298/JSC121114010D . .