TY  - JOUR
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Kiewiet, Mensiena B. Gea
AU  - Peruško, Marija
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Paulie, Staffan
AU  - Hage, Marianne van
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6244
AB  - Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.
PB  - American Society for Clinical Investigation
T2  - The Journal of Clinical Investigation
T1  - Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome
VL  - 133
IS  - 6
DO  - 10.1172/JCI158357
ER  - 

@article{
author = "Apostolović, Danijela and Grundström, Jeanette and Kiewiet, Mensiena B. Gea and Peruško, Marija and Hamsten, Carl and Starkhammar, Maria and Paulie, Staffan and Hage, Marianne van",
year = "2023",
abstract = "Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.",
publisher = "American Society for Clinical Investigation",
journal = "The Journal of Clinical Investigation",
title = "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome",
volume = "133",
number = "6",
doi = "10.1172/JCI158357"
}

Apostolović, D., Grundström, J., Kiewiet, M. B. G., Peruško, M., Hamsten, C., Starkhammar, M., Paulie, S.,& Hage, M. v.. (2023). Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation
American Society for Clinical Investigation., 133(6).
https://doi.org/10.1172/JCI158357

Apostolović D, Grundström J, Kiewiet MBG, Peruško M, Hamsten C, Starkhammar M, Paulie S, Hage MV. Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation. 2023;133(6).
doi:10.1172/JCI158357 .

Apostolović, Danijela, Grundström, Jeanette, Kiewiet, Mensiena B. Gea, Peruško, Marija, Hamsten, Carl, Starkhammar, Maria, Paulie, Staffan, Hage, Marianne van, "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome" in The Journal of Clinical Investigation, 133, no. 6 (2023),
https://doi.org/10.1172/JCI158357 . .

TY  - DATA
AU  - Peruško, Marija
AU  - Apostolović, Danijela
AU  - Kiewiet, Mensiena Berentje Geertje
AU  - Grundström, Jeanette
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hage, Marianne van
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4447
PB  - Blackwell Publishing Ltd
T2  - Allergy
T2  - Allergy
T1  - Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4447
ER  - 

@misc{
author = "Peruško, Marija and Apostolović, Danijela and Kiewiet, Mensiena Berentje Geertje and Grundström, Jeanette and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hage, Marianne van",
year = "2021",
publisher = "Blackwell Publishing Ltd",
journal = "Allergy, Allergy",
title = "Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4447"
}

Peruško, M., Apostolović, D., Kiewiet, M. B. G., Grundström, J., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& Hage, M. v.. (2021). Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.. in Allergy
Blackwell Publishing Ltd..
https://hdl.handle.net/21.15107/rcub_cherry_4447

Peruško M, Apostolović D, Kiewiet MBG, Grundström J, Hamsten C, Starkhammar M, Ćirković-Veličković T, Hage MV. Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.. in Allergy. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4447 .

Peruško, Marija, Apostolović, Danijela, Kiewiet, Mensiena Berentje Geertje, Grundström, Jeanette, Hamsten, Carl, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hage, Marianne van, "Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889." in Allergy (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4447 .

TY  - JOUR
AU  - Peruško, Marija
AU  - Apostolović, Danijela
AU  - Kiewiet, Mensiena Berentje Geertje
AU  - Grundström, Jeanette
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hage, Marianne van
PY  - 2021
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/all.14889
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4446
AB  - Background Mammalian meat is the most common trigger of the allergic reactions in patients with α-Gal syndrome (AGS). Milk and dairy, although less often, also cause a significant number of allergic manifestations. The aim of this study was to identify α-Gal-containing bovine milk proteins with allergenic properties among AGS patients. Methods Thirty-eight AGS patients with IgE to milk were included in the study. Milk proteins were analyzed for the presence of α-Gal and for binding by patients’ IgE using immunoblot, ImmunoCAP, and inhibition ELISA. Allergenicity of milk and milk proteins was assessed by basophil activation test. Results More than half of the AGS patients reported allergic reactions to milk or dairy products. Bovine γ-globulin (BGG), lactoferrin (LF), and lactoperoxidase (LPO) were identified as α-Gal carrying proteins which were recognized by AGS patients’ IgE. Whey mirrored the anti-α-Gal and IgE reactivity of BGG, LF, and LPO. Eighty-nine percent of the patients displayed IgE to BGG, 91% to LF, and 57% to LPO. Inhibition of α-Gal-specific IgE binding was achieved by BGG, LF, LPO, and whey. These proteins also activated AGS patients’ basophils. Interestingly, at lower concentrations, LF was the most potent inhibitor of IgE binding, and the most potent activator of basophils. Conclusion BGG, LF, and LPO were all found to be relevant milk α-Gal-containing glycoproteins that bound AGS patients’ IgE antibodies and activated their basophils. These proteins are probably involved in the allergic reactions to milk in AGS patients. LPO was for the first time shown to be an allergen.
PB  - Wiley
T2  - Allergy
T2  - Allergy
T1  - Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome
VL  - 76
IS  - 12
SP  - 3766
EP  - 3775
DO  - 10.1111/all.14889
ER  - 

@article{
author = "Peruško, Marija and Apostolović, Danijela and Kiewiet, Mensiena Berentje Geertje and Grundström, Jeanette and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hage, Marianne van",
year = "2021",
abstract = "Background Mammalian meat is the most common trigger of the allergic reactions in patients with α-Gal syndrome (AGS). Milk and dairy, although less often, also cause a significant number of allergic manifestations. The aim of this study was to identify α-Gal-containing bovine milk proteins with allergenic properties among AGS patients. Methods Thirty-eight AGS patients with IgE to milk were included in the study. Milk proteins were analyzed for the presence of α-Gal and for binding by patients’ IgE using immunoblot, ImmunoCAP, and inhibition ELISA. Allergenicity of milk and milk proteins was assessed by basophil activation test. Results More than half of the AGS patients reported allergic reactions to milk or dairy products. Bovine γ-globulin (BGG), lactoferrin (LF), and lactoperoxidase (LPO) were identified as α-Gal carrying proteins which were recognized by AGS patients’ IgE. Whey mirrored the anti-α-Gal and IgE reactivity of BGG, LF, and LPO. Eighty-nine percent of the patients displayed IgE to BGG, 91% to LF, and 57% to LPO. Inhibition of α-Gal-specific IgE binding was achieved by BGG, LF, LPO, and whey. These proteins also activated AGS patients’ basophils. Interestingly, at lower concentrations, LF was the most potent inhibitor of IgE binding, and the most potent activator of basophils. Conclusion BGG, LF, and LPO were all found to be relevant milk α-Gal-containing glycoproteins that bound AGS patients’ IgE antibodies and activated their basophils. These proteins are probably involved in the allergic reactions to milk in AGS patients. LPO was for the first time shown to be an allergen.",
publisher = "Wiley",
journal = "Allergy, Allergy",
title = "Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome",
volume = "76",
number = "12",
pages = "3766-3775",
doi = "10.1111/all.14889"
}

Peruško, M., Apostolović, D., Kiewiet, M. B. G., Grundström, J., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& Hage, M. v.. (2021). Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome. in Allergy
Wiley., 76(12), 3766-3775.
https://doi.org/10.1111/all.14889

Peruško M, Apostolović D, Kiewiet MBG, Grundström J, Hamsten C, Starkhammar M, Ćirković-Veličković T, Hage MV. Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome. in Allergy. 2021;76(12):3766-3775.
doi:10.1111/all.14889 .

Peruško, Marija, Apostolović, Danijela, Kiewiet, Mensiena Berentje Geertje, Grundström, Jeanette, Hamsten, Carl, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hage, Marianne van, "Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome" in Allergy, 76, no. 12 (2021):3766-3775,
https://doi.org/10.1111/all.14889 . .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Peruško, Marija
AU  - Kiewiet, M. B. Gea
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - van Hage, Marianne
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4839
PB  - Wiley
T2  - Clinical and Translational Allergy
T2  - Clinical and Translational AllergyClin Transl Allergy
T1  - Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients
VL  - 11
IS  - 10
SP  - e12087
DO  - 10.1002/clt2.12087
ER  - 

@article{
author = "Apostolović, Danijela and Grundström, Jeanette and Peruško, Marija and Kiewiet, M. B. Gea and Hamsten, Carl and Starkhammar, Maria and van Hage, Marianne",
year = "2021",
publisher = "Wiley",
journal = "Clinical and Translational Allergy, Clinical and Translational AllergyClin Transl Allergy",
title = "Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients",
volume = "11",
number = "10",
pages = "e12087",
doi = "10.1002/clt2.12087"
}

Apostolović, D., Grundström, J., Peruško, M., Kiewiet, M. B. G., Hamsten, C., Starkhammar, M.,& van Hage, M.. (2021). Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients. in Clinical and Translational Allergy
Wiley., 11(10), e12087.
https://doi.org/10.1002/clt2.12087

Apostolović D, Grundström J, Peruško M, Kiewiet MBG, Hamsten C, Starkhammar M, van Hage M. Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients. in Clinical and Translational Allergy. 2021;11(10):e12087.
doi:10.1002/clt2.12087 .

Apostolović, Danijela, Grundström, Jeanette, Peruško, Marija, Kiewiet, M. B. Gea, Hamsten, Carl, Starkhammar, Maria, van Hage, Marianne, "Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients" in Clinical and Translational Allergy, 11, no. 10 (2021):e12087,
https://doi.org/10.1002/clt2.12087 . .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Mihailović, Jelena
AU  - Commins, Scott P.
AU  - Wijnveld, Michiel
AU  - Kazimirova, Maria
AU  - Starkhammar, Maria
AU  - Stockinger, Hannes
AU  - Platts-Mills, Thomas A. E.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3860
PB  - Wiley
T2  - Allergy: European Journal of Allergy and Clinical Immunology
T1  - Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy
VL  - 75
IS  - 1
SP  - 217
EP  - 220
DO  - 10.1111/ALL.13978
ER  - 

@article{
author = "Apostolović, Danijela and Mihailović, Jelena and Commins, Scott P. and Wijnveld, Michiel and Kazimirova, Maria and Starkhammar, Maria and Stockinger, Hannes and Platts-Mills, Thomas A. E. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2020",
publisher = "Wiley",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
title = "Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy",
volume = "75",
number = "1",
pages = "217-220",
doi = "10.1111/ALL.13978"
}

Apostolović, D., Mihailović, J., Commins, S. P., Wijnveld, M., Kazimirova, M., Starkhammar, M., Stockinger, H., Platts-Mills, T. A. E., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2020). Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy. in Allergy: European Journal of Allergy and Clinical Immunology
Wiley., 75(1), 217-220.
https://doi.org/10.1111/ALL.13978

Apostolović D, Mihailović J, Commins SP, Wijnveld M, Kazimirova M, Starkhammar M, Stockinger H, Platts-Mills TAE, Ćirković-Veličković T, Hamsten C, van Hage M. Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy. in Allergy: European Journal of Allergy and Clinical Immunology. 2020;75(1):217-220.
doi:10.1111/ALL.13978 .

Apostolović, Danijela, Mihailović, Jelena, Commins, Scott P., Wijnveld, Michiel, Kazimirova, Maria, Starkhammar, Maria, Stockinger, Hannes, Platts-Mills, Thomas A. E., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy" in Allergy: European Journal of Allergy and Clinical Immunology, 75, no. 1 (2020):217-220,
https://doi.org/10.1111/ALL.13978 . .

TY  - DATA
AU  - Apostolović, Danijela
AU  - Mihailović, Jelena
AU  - Commins, Scott P.
AU  - Wijnveld, Michiel
AU  - Kazimirova, Maria
AU  - Starkhammar, Maria
AU  - Stockinger, Hannes
AU  - Platts-Mills, Thomas A. E.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3864
PB  - Wiley
T2  - Allergy: European Journal of Allergy and Clinical Immunology
T1  - Supplementary data for the article: Apostolovic, D.; Mihailovic, J.; Commins, S. P.; Wijnveld, M.; Kazimirova, M.; Starkhammar, M.; Stockinger, H.; Platts-Mills, T. A. E.; Cirkovic Velickovic, T.; Hamsten, C.; et al. Allergenomics of the Tick Ixodes Ricinus Reveals Important α-Gal–Carrying IgE-Binding Proteins in Red Meat Allergy. Allergy: European Journal of Allergy and Clinical Immunology 2020, 75 (1), 217–220. https://doi.org/10.1111/all.13978
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3864
ER  - 

@misc{
author = "Apostolović, Danijela and Mihailović, Jelena and Commins, Scott P. and Wijnveld, Michiel and Kazimirova, Maria and Starkhammar, Maria and Stockinger, Hannes and Platts-Mills, Thomas A. E. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2020",
publisher = "Wiley",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
title = "Supplementary data for the article: Apostolovic, D.; Mihailovic, J.; Commins, S. P.; Wijnveld, M.; Kazimirova, M.; Starkhammar, M.; Stockinger, H.; Platts-Mills, T. A. E.; Cirkovic Velickovic, T.; Hamsten, C.; et al. Allergenomics of the Tick Ixodes Ricinus Reveals Important α-Gal–Carrying IgE-Binding Proteins in Red Meat Allergy. Allergy: European Journal of Allergy and Clinical Immunology 2020, 75 (1), 217–220. https://doi.org/10.1111/all.13978",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3864"
}

Apostolović, D., Mihailović, J., Commins, S. P., Wijnveld, M., Kazimirova, M., Starkhammar, M., Stockinger, H., Platts-Mills, T. A. E., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2020). Supplementary data for the article: Apostolovic, D.; Mihailovic, J.; Commins, S. P.; Wijnveld, M.; Kazimirova, M.; Starkhammar, M.; Stockinger, H.; Platts-Mills, T. A. E.; Cirkovic Velickovic, T.; Hamsten, C.; et al. Allergenomics of the Tick Ixodes Ricinus Reveals Important α-Gal–Carrying IgE-Binding Proteins in Red Meat Allergy. Allergy: European Journal of Allergy and Clinical Immunology 2020, 75 (1), 217–220. https://doi.org/10.1111/all.13978. in Allergy: European Journal of Allergy and Clinical Immunology
Wiley..
https://hdl.handle.net/21.15107/rcub_cherry_3864

Apostolović D, Mihailović J, Commins SP, Wijnveld M, Kazimirova M, Starkhammar M, Stockinger H, Platts-Mills TAE, Ćirković-Veličković T, Hamsten C, van Hage M. Supplementary data for the article: Apostolovic, D.; Mihailovic, J.; Commins, S. P.; Wijnveld, M.; Kazimirova, M.; Starkhammar, M.; Stockinger, H.; Platts-Mills, T. A. E.; Cirkovic Velickovic, T.; Hamsten, C.; et al. Allergenomics of the Tick Ixodes Ricinus Reveals Important α-Gal–Carrying IgE-Binding Proteins in Red Meat Allergy. Allergy: European Journal of Allergy and Clinical Immunology 2020, 75 (1), 217–220. https://doi.org/10.1111/all.13978. in Allergy: European Journal of Allergy and Clinical Immunology. 2020;.
https://hdl.handle.net/21.15107/rcub_cherry_3864 .

Apostolović, Danijela, Mihailović, Jelena, Commins, Scott P., Wijnveld, Michiel, Kazimirova, Maria, Starkhammar, Maria, Stockinger, Hannes, Platts-Mills, Thomas A. E., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Supplementary data for the article: Apostolovic, D.; Mihailovic, J.; Commins, S. P.; Wijnveld, M.; Kazimirova, M.; Starkhammar, M.; Stockinger, H.; Platts-Mills, T. A. E.; Cirkovic Velickovic, T.; Hamsten, C.; et al. Allergenomics of the Tick Ixodes Ricinus Reveals Important α-Gal–Carrying IgE-Binding Proteins in Red Meat Allergy. Allergy: European Journal of Allergy and Clinical Immunology 2020, 75 (1), 217–220. https://doi.org/10.1111/all.13978" in Allergy: European Journal of Allergy and Clinical Immunology (2020),
https://hdl.handle.net/21.15107/rcub_cherry_3864 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Mihailović, Jelena
AU  - Commins, Scott P.
AU  - Wijnveld, Michiel
AU  - Kazimirova, Maria
AU  - Starkhammar, Maria
AU  - Stockinger, Hannes
AU  - Platts-Mills, Thomas A. E.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3853
PB  - Wiley
T2  - Allergy: European Journal of Allergy and Clinical Immunology
T1  - Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy
VL  - 75
IS  - 1
SP  - 217
EP  - 220
DO  - 10.1111/all.13978
ER  - 

@article{
author = "Apostolović, Danijela and Mihailović, Jelena and Commins, Scott P. and Wijnveld, Michiel and Kazimirova, Maria and Starkhammar, Maria and Stockinger, Hannes and Platts-Mills, Thomas A. E. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2020",
publisher = "Wiley",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
title = "Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy",
volume = "75",
number = "1",
pages = "217-220",
doi = "10.1111/all.13978"
}

Apostolović, D., Mihailović, J., Commins, S. P., Wijnveld, M., Kazimirova, M., Starkhammar, M., Stockinger, H., Platts-Mills, T. A. E., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2020). Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy. in Allergy: European Journal of Allergy and Clinical Immunology
Wiley., 75(1), 217-220.
https://doi.org/10.1111/all.13978

Apostolović D, Mihailović J, Commins SP, Wijnveld M, Kazimirova M, Starkhammar M, Stockinger H, Platts-Mills TAE, Ćirković-Veličković T, Hamsten C, van Hage M. Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy. in Allergy: European Journal of Allergy and Clinical Immunology. 2020;75(1):217-220.
doi:10.1111/all.13978 .

Apostolović, Danijela, Mihailović, Jelena, Commins, Scott P., Wijnveld, Michiel, Kazimirova, Maria, Starkhammar, Maria, Stockinger, Hannes, Platts-Mills, Thomas A. E., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Allergenomics of the tick Ixodes ricinus reveal important α-Gal-carrying IgE-binding proteins in red meat allergy" in Allergy: European Journal of Allergy and Clinical Immunology, 75, no. 1 (2020):217-220,
https://doi.org/10.1111/all.13978 . .

TY  - DATA
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vesna
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3073
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3073
ER  - 

@misc{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vesna and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3073"
}

Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2018). Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8. in Scientific Reports
Nature Publishing Group, London..
https://hdl.handle.net/21.15107/rcub_cherry_3073

Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8. in Scientific Reports. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3073 .

Krstić-Ristivojević, Maja, Grundström, Jeanette, Tran, Thi Anh Thu, Apostolović, Danijela, Radoi, Vlad, Starkhammar, Maria, Vukojević, Vesna, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8" in Scientific Reports (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3073 .

TY  - JOUR
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vladana
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2207
AB  - Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells
VL  - 8
DO  - 10.1038/s41598-018-30887-8
ER  - 

@article{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vladana and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
abstract = "Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells",
volume = "8",
doi = "10.1038/s41598-018-30887-8"
}

Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2018). alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells. in Scientific Reports
Nature Publishing Group, London., 8.
https://doi.org/10.1038/s41598-018-30887-8

Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells. in Scientific Reports. 2018;8.
doi:10.1038/s41598-018-30887-8 .

Krstić-Ristivojević, Maja, Grundström, Jeanette, Tran, Thi Anh Thu, Apostolović, Danijela, Radoi, Vlad, Starkhammar, Maria, Vukojević, Vladana, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells" in Scientific Reports, 8 (2018),
https://doi.org/10.1038/s41598-018-30887-8 . .

TY  - DATA
AU  - Apostolović, Danijela
AU  - Krstić-Ristivojević, Maja
AU  - Mihailović-Vesić, Jelena
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3020
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Supplementary data for article: Apostolovic, D.; Krstic, M.; Mihailovic, J.; Starkhammar, M.; Cirkovic Velickovic, T.; Hamsten, C.; Van Hage, M. Peptidomics of an in Vitro Digested α-Gal Carrying Protein Revealed IgE-Reactive Peptides. Scientific Reports 2017, 7 (1). https://doi.org/10.1038/s41598-017-05355-4
VL  - 7
IS  - 1
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3020
ER  - 

@misc{
author = "Apostolović, Danijela and Krstić-Ristivojević, Maja and Mihailović-Vesić, Jelena and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2017",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Supplementary data for article: Apostolovic, D.; Krstic, M.; Mihailovic, J.; Starkhammar, M.; Cirkovic Velickovic, T.; Hamsten, C.; Van Hage, M. Peptidomics of an in Vitro Digested α-Gal Carrying Protein Revealed IgE-Reactive Peptides. Scientific Reports 2017, 7 (1). https://doi.org/10.1038/s41598-017-05355-4",
volume = "7",
number = "1",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3020"
}

Apostolović, D., Krstić-Ristivojević, M., Mihailović-Vesić, J., Starkhammar, M., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2017). Supplementary data for article: Apostolovic, D.; Krstic, M.; Mihailovic, J.; Starkhammar, M.; Cirkovic Velickovic, T.; Hamsten, C.; Van Hage, M. Peptidomics of an in Vitro Digested α-Gal Carrying Protein Revealed IgE-Reactive Peptides. Scientific Reports 2017, 7 (1). https://doi.org/10.1038/s41598-017-05355-4. in Scientific Reports
Nature Publishing Group, London., 7(1).
https://hdl.handle.net/21.15107/rcub_cherry_3020

Apostolović D, Krstić-Ristivojević M, Mihailović-Vesić J, Starkhammar M, Ćirković-Veličković T, Hamsten C, van Hage M. Supplementary data for article: Apostolovic, D.; Krstic, M.; Mihailovic, J.; Starkhammar, M.; Cirkovic Velickovic, T.; Hamsten, C.; Van Hage, M. Peptidomics of an in Vitro Digested α-Gal Carrying Protein Revealed IgE-Reactive Peptides. Scientific Reports 2017, 7 (1). https://doi.org/10.1038/s41598-017-05355-4. in Scientific Reports. 2017;7(1).
https://hdl.handle.net/21.15107/rcub_cherry_3020 .

Apostolović, Danijela, Krstić-Ristivojević, Maja, Mihailović-Vesić, Jelena, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Supplementary data for article: Apostolovic, D.; Krstic, M.; Mihailovic, J.; Starkhammar, M.; Cirkovic Velickovic, T.; Hamsten, C.; Van Hage, M. Peptidomics of an in Vitro Digested α-Gal Carrying Protein Revealed IgE-Reactive Peptides. Scientific Reports 2017, 7 (1). https://doi.org/10.1038/s41598-017-05355-4" in Scientific Reports, 7, no. 1 (2017),
https://hdl.handle.net/21.15107/rcub_cherry_3020 .

TY  - CONF
AU  - Krstić-Ristivojević, Maja
AU  - Apostolović, Danijela
AU  - Tran, T.
AU  - Grundström, Jeanette
AU  - Radoi, Vlad
AU  - Vukojević, Vladana
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2516
PB  - Wiley, Hoboken
C3  - Allergy
T1  - Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells
VL  - 72
SP  - 796
EP  - 796
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2516
ER  - 

@conference{
author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Tran, T. and Grundström, Jeanette and Radoi, Vlad and Vukojević, Vladana and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2017",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells",
volume = "72",
pages = "796-796",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2516"
}

Krstić-Ristivojević, M., Apostolović, D., Tran, T., Grundström, J., Radoi, V., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2017). Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells. in Allergy
Wiley, Hoboken., 72, 796-796.
https://hdl.handle.net/21.15107/rcub_cherry_2516

Krstić-Ristivojević M, Apostolović D, Tran T, Grundström J, Radoi V, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells. in Allergy. 2017;72:796-796.
https://hdl.handle.net/21.15107/rcub_cherry_2516 .

Krstić-Ristivojević, Maja, Apostolović, Danijela, Tran, T., Grundström, Jeanette, Radoi, Vlad, Vukojević, Vladana, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells" in Allergy, 72 (2017):796-796,
https://hdl.handle.net/21.15107/rcub_cherry_2516 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Krstić-Ristivojević, Maja
AU  - Mihailović-Vesić, Jelena
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2486
AB  - The mammalian carbohydrate galactose-alpha 1,3-galactose (alpha-Gal) causes a novel form of food allergy, red meat allergy, where patients experience severe allergic reactions several hours after red meat consumption. Here we explored gastric digestion of alpha-Gal glycoproteins using an in vitro model. Bovine thyroglobulin (BTG), a typical alpha-Gal carrying glycoprotein, was digested with pepsin. The resulting peptides were characterised by SDS PAGE, immunoblot and ImmunoCAP using sera from 20 red meat allergic patients. During pepsinolysis of BTG, a wide range of peptide bands was observed of which 14 to 17 kDa peptides remained stable throughout the gastric phase. The presence of the alpha-Gal epitope on the obtained peptides was demonstrated by an anti-alpha-Gal antibody and IgE from red meat allergic patients. The alpha-Gal digests were able to inhibit up to 86% of IgE reactivity to BTG. Importantly, basophil activation test demonstrated that the allergenic activity of BTG was retained after digestion in all four tested patients. Mass spectrometry-based peptidomics revealed that these peptides represent mostly internal and C-terminal parts of the protein, where the most potent IgE-binding alpha-Gal residues were identified at Asn(1756), Asn(1850) and Asn(2231). Thus allergenic a-Gal epitopes are stable to pepsinolysis, reinforcing their role as clinically relevant food allergens.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Peptidomics of an in vitro digested alpha-Gal carrying protein revealed IgE-reactive peptides
VL  - 7
DO  - 10.1038/s41598-017-05355-4
ER  - 

@article{
author = "Apostolović, Danijela and Krstić-Ristivojević, Maja and Mihailović-Vesić, Jelena and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2017",
abstract = "The mammalian carbohydrate galactose-alpha 1,3-galactose (alpha-Gal) causes a novel form of food allergy, red meat allergy, where patients experience severe allergic reactions several hours after red meat consumption. Here we explored gastric digestion of alpha-Gal glycoproteins using an in vitro model. Bovine thyroglobulin (BTG), a typical alpha-Gal carrying glycoprotein, was digested with pepsin. The resulting peptides were characterised by SDS PAGE, immunoblot and ImmunoCAP using sera from 20 red meat allergic patients. During pepsinolysis of BTG, a wide range of peptide bands was observed of which 14 to 17 kDa peptides remained stable throughout the gastric phase. The presence of the alpha-Gal epitope on the obtained peptides was demonstrated by an anti-alpha-Gal antibody and IgE from red meat allergic patients. The alpha-Gal digests were able to inhibit up to 86% of IgE reactivity to BTG. Importantly, basophil activation test demonstrated that the allergenic activity of BTG was retained after digestion in all four tested patients. Mass spectrometry-based peptidomics revealed that these peptides represent mostly internal and C-terminal parts of the protein, where the most potent IgE-binding alpha-Gal residues were identified at Asn(1756), Asn(1850) and Asn(2231). Thus allergenic a-Gal epitopes are stable to pepsinolysis, reinforcing their role as clinically relevant food allergens.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Peptidomics of an in vitro digested alpha-Gal carrying protein revealed IgE-reactive peptides",
volume = "7",
doi = "10.1038/s41598-017-05355-4"
}

Apostolović, D., Krstić-Ristivojević, M., Mihailović-Vesić, J., Starkhammar, M., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2017). Peptidomics of an in vitro digested alpha-Gal carrying protein revealed IgE-reactive peptides. in Scientific Reports
Nature Publishing Group, London., 7.
https://doi.org/10.1038/s41598-017-05355-4

Apostolović D, Krstić-Ristivojević M, Mihailović-Vesić J, Starkhammar M, Ćirković-Veličković T, Hamsten C, van Hage M. Peptidomics of an in vitro digested alpha-Gal carrying protein revealed IgE-reactive peptides. in Scientific Reports. 2017;7.
doi:10.1038/s41598-017-05355-4 .

Apostolović, Danijela, Krstić-Ristivojević, Maja, Mihailović-Vesić, Jelena, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Peptidomics of an in vitro digested alpha-Gal carrying protein revealed IgE-reactive peptides" in Scientific Reports, 7 (2017),
https://doi.org/10.1038/s41598-017-05355-4 . .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3650
AB  - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
VL  - 71
IS  - 10
SP  - 1490
EP  - 1495
DO  - 10.1111/all.12955
ER  - 

@article{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1",
volume = "71",
number = "10",
pages = "1490-1495",
doi = "10.1111/all.12955"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy
Wiley-Blackwell, Hoboken., 71(10), 1490-1495.
https://doi.org/10.1111/all.12955

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495.
doi:10.1111/all.12955 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495,
https://doi.org/10.1111/all.12955 . .

TY  - DATA
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3651
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3651
ER  - 

@misc{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3651"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955. in Allergy
Wiley-Blackwell, Hoboken..
https://hdl.handle.net/21.15107/rcub_cherry_3651

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955. in Allergy. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3651 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955" in Allergy (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3651 .

TY  - CONF
AU  - Tran, Thi Anh Thu
AU  - Grundström, Jeanette
AU  - Krstić-Ristivojević, Maja
AU  - Vukojević, Vladana
AU  - Apostolović, Danijela
AU  - Hamsten, Carl
AU  - Gafvelin, Guro
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2309
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells
VL  - 71
SP  - 284
EP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2309
ER  - 

@conference{
author = "Tran, Thi Anh Thu and Grundström, Jeanette and Krstić-Ristivojević, Maja and Vukojević, Vladana and Apostolović, Danijela and Hamsten, Carl and Gafvelin, Guro and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells",
volume = "71",
pages = "284-284",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2309"
}

Tran, T. A. T., Grundström, J., Krstić-Ristivojević, M., Vukojević, V., Apostolović, D., Hamsten, C., Gafvelin, G.,& van Hage, M.. (2016). In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells. in Allergy
Wiley-Blackwell, Hoboken., 71, 284-284.
https://hdl.handle.net/21.15107/rcub_cherry_2309

Tran TAT, Grundström J, Krstić-Ristivojević M, Vukojević V, Apostolović D, Hamsten C, Gafvelin G, van Hage M. In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells. in Allergy. 2016;71:284-284.
https://hdl.handle.net/21.15107/rcub_cherry_2309 .

Tran, Thi Anh Thu, Grundström, Jeanette, Krstić-Ristivojević, Maja, Vukojević, Vladana, Apostolović, Danijela, Hamsten, Carl, Gafvelin, Guro, van Hage, Marianne, "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells" in Allergy, 71 (2016):284-284,
https://hdl.handle.net/21.15107/rcub_cherry_2309 .

TY  - CONF
AU  - Krstić-Ristivojević, Maja
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Tran, Thu T. A.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2310
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer
VL  - 71
SP  - 402
EP  - 402
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2310
ER  - 

@conference{
author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Grundström, Jeanette and Tran, Thu T. A. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer",
volume = "71",
pages = "402-402",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2310"
}

Krstić-Ristivojević, M., Apostolović, D., Grundström, J., Tran, T. T. A., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2016). alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer. in Allergy
Wiley-Blackwell, Hoboken., 71, 402-402.
https://hdl.handle.net/21.15107/rcub_cherry_2310

Krstić-Ristivojević M, Apostolović D, Grundström J, Tran TTA, Ćirković-Veličković T, Hamsten C, van Hage M. alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer. in Allergy. 2016;71:402-402.
https://hdl.handle.net/21.15107/rcub_cherry_2310 .

Krstić-Ristivojević, Maja, Apostolović, Danijela, Grundström, Jeanette, Tran, Thu T. A., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer" in Allergy, 71 (2016):402-402,
https://hdl.handle.net/21.15107/rcub_cherry_2310 .

TY  - CONF
AU  - Apostolović, Danijela
AU  - Commins, S.
AU  - Starkhammar, Maria
AU  - Grunstrom, J.
AU  - Bigdeli, N.
AU  - Ćirković-Veličković, Tanja
AU  - Platts-Mills, T.
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2308
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Immunoproteomics of ticks from two geographical regions reveal IgE reactivity to the same alpha-Gal containing proteins
VL  - 71
SP  - 91
EP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2308
ER  - 

@conference{
author = "Apostolović, Danijela and Commins, S. and Starkhammar, Maria and Grunstrom, J. and Bigdeli, N. and Ćirković-Veličković, Tanja and Platts-Mills, T. and Hamsten, Carl and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Immunoproteomics of ticks from two geographical regions reveal IgE reactivity to the same alpha-Gal containing proteins",
volume = "71",
pages = "91-91",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2308"
}

Apostolović, D., Commins, S., Starkhammar, M., Grunstrom, J., Bigdeli, N., Ćirković-Veličković, T., Platts-Mills, T., Hamsten, C.,& van Hage, M.. (2016). Immunoproteomics of ticks from two geographical regions reveal IgE reactivity to the same alpha-Gal containing proteins. in Allergy
Wiley-Blackwell, Hoboken., 71, 91-91.
https://hdl.handle.net/21.15107/rcub_cherry_2308

Apostolović D, Commins S, Starkhammar M, Grunstrom J, Bigdeli N, Ćirković-Veličković T, Platts-Mills T, Hamsten C, van Hage M. Immunoproteomics of ticks from two geographical regions reveal IgE reactivity to the same alpha-Gal containing proteins. in Allergy. 2016;71:91-91.
https://hdl.handle.net/21.15107/rcub_cherry_2308 .

Apostolović, Danijela, Commins, S., Starkhammar, Maria, Grunstrom, J., Bigdeli, N., Ćirković-Veličković, Tanja, Platts-Mills, T., Hamsten, Carl, van Hage, Marianne, "Immunoproteomics of ticks from two geographical regions reveal IgE reactivity to the same alpha-Gal containing proteins" in Allergy, 71 (2016):91-91,
https://hdl.handle.net/21.15107/rcub_cherry_2308 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2337
AB  - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
VL  - 71
IS  - 10
SP  - 1490
EP  - 1495
DO  - 10.1111/all.12955
ER  - 

@article{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1",
volume = "71",
number = "10",
pages = "1490-1495",
doi = "10.1111/all.12955"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy
Wiley-Blackwell, Hoboken., 71(10), 1490-1495.
https://doi.org/10.1111/all.12955

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495.
doi:10.1111/all.12955 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495,
https://doi.org/10.1111/all.12955 . .

TY  - DATA
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Ćirković-Veličković, Tanja
AU  - Starkhammar, Maria
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3407
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3407
ER  - 

@misc{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Ćirković-Veličković, Tanja and Starkhammar, Maria and Hamsten, Carl and van Hage, Marianne",
year = "2015",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3407"
}

Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Ćirković-Veličković, T., Starkhammar, M., Hamsten, C.,& van Hage, M.. (2015). Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695. in Allergy
Wiley, Hoboken..
https://hdl.handle.net/21.15107/rcub_cherry_3407

Apostolović D, Tran TAT, Sanchez-Vidaurre S, Ćirković-Veličković T, Starkhammar M, Hamsten C, van Hage M. Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695. in Allergy. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3407 .

Apostolović, Danijela, Tran, Thi Anh Thu, Sanchez-Vidaurre, Sara, Ćirković-Veličković, Tanja, Starkhammar, Maria, Hamsten, Carl, van Hage, Marianne, "Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695" in Allergy (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3407 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Ćirković-Veličković, Tanja
AU  - Starkhammar, Maria
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1982
AB  - Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Red meat allergic patients have a selective IgE response to the alpha-Gal glycan
VL  - 70
IS  - 11
SP  - 1497
EP  - 1500
DO  - 10.1111/all.12695
ER  - 

@article{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Ćirković-Veličković, Tanja and Starkhammar, Maria and Hamsten, Carl and van Hage, Marianne",
year = "2015",
abstract = "Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan",
volume = "70",
number = "11",
pages = "1497-1500",
doi = "10.1111/all.12695"
}

Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Ćirković-Veličković, T., Starkhammar, M., Hamsten, C.,& van Hage, M.. (2015). Red meat allergic patients have a selective IgE response to the alpha-Gal glycan. in Allergy
Wiley, Hoboken., 70(11), 1497-1500.
https://doi.org/10.1111/all.12695

Apostolović D, Tran TAT, Sanchez-Vidaurre S, Ćirković-Veličković T, Starkhammar M, Hamsten C, van Hage M. Red meat allergic patients have a selective IgE response to the alpha-Gal glycan. in Allergy. 2015;70(11):1497-1500.
doi:10.1111/all.12695 .

Apostolović, Danijela, Tran, Thi Anh Thu, Sanchez-Vidaurre, Sara, Ćirković-Veličković, Tanja, Starkhammar, Maria, Hamsten, Carl, van Hage, Marianne, "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan" in Allergy, 70, no. 11 (2015):1497-1500,
https://doi.org/10.1111/all.12695 . .

TY  - CONF
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Bigdeli, N.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2046
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Red meat allergy and IgE antibody responses against glycans
VL  - 70
SP  - 2
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2046
ER  - 

@conference{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Bigdeli, N. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2015",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Red meat allergy and IgE antibody responses against glycans",
volume = "70",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2046"
}

Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Bigdeli, N., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2015). Red meat allergy and IgE antibody responses against glycans. in Allergy
Wiley-Blackwell, Hoboken., 70, 2-2.
https://hdl.handle.net/21.15107/rcub_cherry_2046

Apostolović D, Tran TAT, Sanchez-Vidaurre S, Bigdeli N, Ćirković-Veličković T, Hamsten C, van Hage M. Red meat allergy and IgE antibody responses against glycans. in Allergy. 2015;70:2-2.
https://hdl.handle.net/21.15107/rcub_cherry_2046 .

Apostolović, Danijela, Tran, Thi Anh Thu, Sanchez-Vidaurre, Sara, Bigdeli, N., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Red meat allergy and IgE antibody responses against glycans" in Allergy, 70 (2015):2-2,
https://hdl.handle.net/21.15107/rcub_cherry_2046 .

TY  - CONF
AU  - Waden, Konrad
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2047
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity
VL  - 70
SP  - 517
EP  - 517
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2047
ER  - 

@conference{
author = "Waden, Konrad and Apostolović, Danijela and Sanchez-Vidaurre, Sara and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2015",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity",
volume = "70",
pages = "517-517",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2047"
}

Waden, K., Apostolović, D., Sanchez-Vidaurre, S., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2015). The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity. in Allergy
Wiley-Blackwell, Hoboken., 70, 517-517.
https://hdl.handle.net/21.15107/rcub_cherry_2047

Waden K, Apostolović D, Sanchez-Vidaurre S, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity. in Allergy. 2015;70:517-517.
https://hdl.handle.net/21.15107/rcub_cherry_2047 .

Waden, Konrad, Apostolović, Danijela, Sanchez-Vidaurre, Sara, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity" in Allergy, 70 (2015):517-517,
https://hdl.handle.net/21.15107/rcub_cherry_2047 .

TY  - CONF
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Smiljanić, Katarina
AU  - Bigdeli, N.
AU  - Ćirković-Veličković, Tanja
AU  - van Hage, Marianne
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1836
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins
VL  - 69
SP  - 209
EP  - 210
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1836
ER  - 

@conference{
author = "Tran, Thi Anh Thu and Apostolović, Danijela and Hamsten, Carl and Starkhammar, Maria and Smiljanić, Katarina and Bigdeli, N. and Ćirković-Veličković, Tanja and van Hage, Marianne",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins",
volume = "69",
pages = "209-210",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1836"
}

Tran, T. A. T., Apostolović, D., Hamsten, C., Starkhammar, M., Smiljanić, K., Bigdeli, N., Ćirković-Veličković, T.,& van Hage, M.. (2014). Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins. in Allergy
Wiley-Blackwell, Hoboken., 69, 209-210.
https://hdl.handle.net/21.15107/rcub_cherry_1836

Tran TAT, Apostolović D, Hamsten C, Starkhammar M, Smiljanić K, Bigdeli N, Ćirković-Veličković T, van Hage M. Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins. in Allergy. 2014;69:209-210.
https://hdl.handle.net/21.15107/rcub_cherry_1836 .

Tran, Thi Anh Thu, Apostolović, Danijela, Hamsten, Carl, Starkhammar, Maria, Smiljanić, Katarina, Bigdeli, N., Ćirković-Veličković, Tanja, van Hage, Marianne, "Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins" in Allergy, 69 (2014):209-210,
https://hdl.handle.net/21.15107/rcub_cherry_1836 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - van Hage, Marianne
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1858
AB  - BackgroundRed meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate -Gal epitope. Food preparation and processing can influence the allergenicity of proteins. The aim of this study was to characterize the proteomic profile of different beef preparations and to investigate their -Gal reactivity and potential allergenicity. MethodsExtracts from raw, boiled, fried, and medium rare prepared beef were assessed by 2D PAGE for the comparison of protein profiles. IgE-binding proteins were identified using immunoblot-coupled proteomic analysis using sera from red meat-allergic patients. Presence of the -Gal epitope was verified using anti--Gal antibody and IgE inhibition immunoblot with -Gal. ResultsMultiple IgE-binding proteins were detected in the different beef preparations, many of which were also recognized by the anti--Gal antibody. Protein spots reacting with IgE in patient sera were analyzed by MS/MS, resulting in identification of 18 proteins with high identification scores. Seven of the 18 beef allergens identified using meat-allergic patient sera were also recognized by the anti--Gal monoclonal antibody, and four of them were stabile to thermal treatment. Furthermore, a dose-dependent inhibition of red meat-allergic patients' IgE to beef by -Gal was demonstrated. ConclusionsWe show that the -Gal epitope is commonly present in IgE-reactive beef proteins recognized by meat-allergic patients. Seven novel -Gal-containing IgE-binding proteins were identified, of which four were stable to heat treatment. Thus, the allergenicity of red meat proteins is preserved even upon different thermal cooking.
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens
VL  - 69
IS  - 10
SP  - 1308
EP  - 1315
DO  - 10.1111/all.12462
ER  - 

@article{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and van Hage, Marianne",
year = "2014",
abstract = "BackgroundRed meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate -Gal epitope. Food preparation and processing can influence the allergenicity of proteins. The aim of this study was to characterize the proteomic profile of different beef preparations and to investigate their -Gal reactivity and potential allergenicity. MethodsExtracts from raw, boiled, fried, and medium rare prepared beef were assessed by 2D PAGE for the comparison of protein profiles. IgE-binding proteins were identified using immunoblot-coupled proteomic analysis using sera from red meat-allergic patients. Presence of the -Gal epitope was verified using anti--Gal antibody and IgE inhibition immunoblot with -Gal. ResultsMultiple IgE-binding proteins were detected in the different beef preparations, many of which were also recognized by the anti--Gal antibody. Protein spots reacting with IgE in patient sera were analyzed by MS/MS, resulting in identification of 18 proteins with high identification scores. Seven of the 18 beef allergens identified using meat-allergic patient sera were also recognized by the anti--Gal monoclonal antibody, and four of them were stabile to thermal treatment. Furthermore, a dose-dependent inhibition of red meat-allergic patients' IgE to beef by -Gal was demonstrated. ConclusionsWe show that the -Gal epitope is commonly present in IgE-reactive beef proteins recognized by meat-allergic patients. Seven novel -Gal-containing IgE-binding proteins were identified, of which four were stable to heat treatment. Thus, the allergenicity of red meat proteins is preserved even upon different thermal cooking.",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens",
volume = "69",
number = "10",
pages = "1308-1315",
doi = "10.1111/all.12462"
}

Apostolović, D., Tran, T. A. T., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& van Hage, M.. (2014). Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens. in Allergy
Wiley, Hoboken., 69(10), 1308-1315.
https://doi.org/10.1111/all.12462

Apostolović D, Tran TAT, Hamsten C, Starkhammar M, Ćirković-Veličković T, van Hage M. Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens. in Allergy. 2014;69(10):1308-1315.
doi:10.1111/all.12462 .

Apostolović, Danijela, Tran, Thi Anh Thu, Hamsten, Carl, Starkhammar, Maria, Ćirković-Veličković, Tanja, van Hage, Marianne, "Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens" in Allergy, 69, no. 10 (2014):1308-1315,
https://doi.org/10.1111/all.12462 . .

TY  - CONF
AU  - Waden, Konrad
AU  - Polović, Natalija
AU  - Binnmyr, J.
AU  - Hamsten, Carl
AU  - Gronneberg, R.
AU  - Palmberg, C.
AU  - Milčić-Matić, Natalija
AU  - Bergman, T.
AU  - Gronlund, Hans
AU  - van Hage, Marianne
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1409
AB  - Background Allergy to dog (Canis familiaris) is a worldwide common cause of asthma and allergic rhinitis. However, dander extract in routine diagnostics is not an optimal predictor of IgE-mediated dog allergy. Our objective was to evaluate saliva as an allergen source for improved diagnostics of allergy to dog. Methods IgE-binding proteins in dog saliva and dander extract were analysed by immunoblot and mass spectrometry (LC-MS/MS) using pooled or individual sera from dog-allergic patients (n = 13). Sera from 59 patients IgE positive to dander and 55 patients IgE negative to dander but with symptoms to dog were analysed for IgE against saliva and dander by ELISA. Basophil stimulation with dog saliva and dander extract was measured by flow cytometry among three dog-allergic patients. Additionally, IgE-binding protein profiles of saliva from different breeds were investigated by immunoblot. Results Greater number and diversity of IgE-binding proteins was found in saliva compared to dander extract and varied among dog breeds. In saliva, Can f 1, 2, 3 and 6 were identified but also four new saliva allergen candidates. The majority of the 59 dog dander-positive sera (n = 44) were IgE positive to dog saliva. Among patients IgE negative to dander, but with symptoms to dog, 20% were IgE positive to saliva. The biological activity of saliva was confirmed by basophil degranulation. Conclusions Dog saliva is an allergen source for improved diagnostics of dog allergy. The IgE-binding protein profile of saliva from different dogs varies. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Dog saliva - an important source of dog allergens
VL  - 68
SP  - 35
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1409
ER  - 

@conference{
author = "Waden, Konrad and Polović, Natalija and Binnmyr, J. and Hamsten, Carl and Gronneberg, R. and Palmberg, C. and Milčić-Matić, Natalija and Bergman, T. and Gronlund, Hans and van Hage, Marianne",
year = "2013",
abstract = "Background Allergy to dog (Canis familiaris) is a worldwide common cause of asthma and allergic rhinitis. However, dander extract in routine diagnostics is not an optimal predictor of IgE-mediated dog allergy. Our objective was to evaluate saliva as an allergen source for improved diagnostics of allergy to dog. Methods IgE-binding proteins in dog saliva and dander extract were analysed by immunoblot and mass spectrometry (LC-MS/MS) using pooled or individual sera from dog-allergic patients (n = 13). Sera from 59 patients IgE positive to dander and 55 patients IgE negative to dander but with symptoms to dog were analysed for IgE against saliva and dander by ELISA. Basophil stimulation with dog saliva and dander extract was measured by flow cytometry among three dog-allergic patients. Additionally, IgE-binding protein profiles of saliva from different breeds were investigated by immunoblot. Results Greater number and diversity of IgE-binding proteins was found in saliva compared to dander extract and varied among dog breeds. In saliva, Can f 1, 2, 3 and 6 were identified but also four new saliva allergen candidates. The majority of the 59 dog dander-positive sera (n = 44) were IgE positive to dog saliva. Among patients IgE negative to dander, but with symptoms to dog, 20% were IgE positive to saliva. The biological activity of saliva was confirmed by basophil degranulation. Conclusions Dog saliva is an allergen source for improved diagnostics of dog allergy. The IgE-binding protein profile of saliva from different dogs varies. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Dog saliva - an important source of dog allergens",
volume = "68",
pages = "35-35",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1409"
}

Waden, K., Polović, N., Binnmyr, J., Hamsten, C., Gronneberg, R., Palmberg, C., Milčić-Matić, N., Bergman, T., Gronlund, H.,& van Hage, M.. (2013). Dog saliva - an important source of dog allergens. in Allergy
Wiley-Blackwell, Hoboken., 68, 35-35.
https://hdl.handle.net/21.15107/rcub_cherry_1409

Waden K, Polović N, Binnmyr J, Hamsten C, Gronneberg R, Palmberg C, Milčić-Matić N, Bergman T, Gronlund H, van Hage M. Dog saliva - an important source of dog allergens. in Allergy. 2013;68:35-35.
https://hdl.handle.net/21.15107/rcub_cherry_1409 .

Waden, Konrad, Polović, Natalija, Binnmyr, J., Hamsten, Carl, Gronneberg, R., Palmberg, C., Milčić-Matić, Natalija, Bergman, T., Gronlund, Hans, van Hage, Marianne, "Dog saliva - an important source of dog allergens" in Allergy, 68 (2013):35-35,
https://hdl.handle.net/21.15107/rcub_cherry_1409 .