TY  - JOUR
AU  - Drazic, Branka
AU  - Grgurić-Šipka, Sanja
AU  - Ivanović, Ivanka
AU  - Tešić, Živoslav Lj.
AU  - Popović, Gordana V.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1244
AB  - Acid-base equilibria of the aqua adducts of Ru(II) arene complexes, general formulae [(eta(6)-p-cymene)Ru (L1-3)Cl-2] where L-1 = 3-acetylpyridine (1), L-2 = 4-acetylpyridine (2) and L-3 = 2-amino-5-chloropyridine (3), then [(eta(6)-p-cymene)Ru(HL4)Cl-2] with HL4 = isonicotinic acid (4); [(eta(6)-p-cymene)Ru(HL5-8)Cl] where H2L5 = 2,3-pyridine dicarboxylic acid (5), H2L6 = 2,4-pyridine dicarboxylic acid (6), H2L7 = 2,5-pyridine dicarboxylic acid (7) and H2L8 = 2,6-pyridine dicarboxylic acid (8) have been studied. pK (a) values were determined by potentiometry at 25 A degrees C and constant ionic strength of 0.1 M NaNO3. The assumed equilibria were confirmed by UV and H-1-NMR spectroscopy.
PB  - Springer, New York
T2  - Journal of the Iranian Chemical Society
T1  - Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines
VL  - 9
IS  - 1
SP  - 7
EP  - 12
DO  - 10.1007/s13738-011-0001-3
ER  - 

@article{
author = "Drazic, Branka and Grgurić-Šipka, Sanja and Ivanović, Ivanka and Tešić, Živoslav Lj. and Popović, Gordana V.",
year = "2012",
abstract = "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes, general formulae [(eta(6)-p-cymene)Ru (L1-3)Cl-2] where L-1 = 3-acetylpyridine (1), L-2 = 4-acetylpyridine (2) and L-3 = 2-amino-5-chloropyridine (3), then [(eta(6)-p-cymene)Ru(HL4)Cl-2] with HL4 = isonicotinic acid (4); [(eta(6)-p-cymene)Ru(HL5-8)Cl] where H2L5 = 2,3-pyridine dicarboxylic acid (5), H2L6 = 2,4-pyridine dicarboxylic acid (6), H2L7 = 2,5-pyridine dicarboxylic acid (7) and H2L8 = 2,6-pyridine dicarboxylic acid (8) have been studied. pK (a) values were determined by potentiometry at 25 A degrees C and constant ionic strength of 0.1 M NaNO3. The assumed equilibria were confirmed by UV and H-1-NMR spectroscopy.",
publisher = "Springer, New York",
journal = "Journal of the Iranian Chemical Society",
title = "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines",
volume = "9",
number = "1",
pages = "7-12",
doi = "10.1007/s13738-011-0001-3"
}

Drazic, B., Grgurić-Šipka, S., Ivanović, I., Tešić, Ž. Lj.,& Popović, G. V.. (2012). Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines. in Journal of the Iranian Chemical Society
Springer, New York., 9(1), 7-12.
https://doi.org/10.1007/s13738-011-0001-3

Drazic B, Grgurić-Šipka S, Ivanović I, Tešić ŽL, Popović GV. Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines. in Journal of the Iranian Chemical Society. 2012;9(1):7-12.
doi:10.1007/s13738-011-0001-3 .

Drazic, Branka, Grgurić-Šipka, Sanja, Ivanović, Ivanka, Tešić, Živoslav Lj., Popović, Gordana V., "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines" in Journal of the Iranian Chemical Society, 9, no. 1 (2012):7-12,
https://doi.org/10.1007/s13738-011-0001-3 . .

TY  - JOUR
AU  - Verbić, Tatjana
AU  - Drakulić, Branko J.
AU  - Zloh, Mire
AU  - Pecelj, Jovana R.
AU  - Popović, Gordana V.
AU  - Juranić, Ivan O.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/902
AB  - The protolytic equilibria of 13 4-aryl-2,4-dioxobutanoic acids (ADKs) were spectrophotometrically studied in aqueous solutions in the pH range 1-9 at 25 +/- 1 degrees C and an ionic strength of 0.1 mol 1(-1) (NaCl), with the exception of the 4-OH-derivative which was also potentiometrically studied in the pH range 7-10 at 25 +/- 1 degrees C and an ionic strength of 0.1 mol 1(-1) (NaCl). In solution, the compounds simultaneously exist in one diketo and two enolic forms; therefore, the determined acidity constants (pK(al) 1.87-2.29. pK(a2) 6.63-8.13 and pK(a3)(4-OH-) 9.52) represent system macro constants. The H-1-NMR spectrum of the parent compound (4-phenyl-2,4-dioxobutanoic acid) (25 degrees C, pD 5.0) proved the existence of all tautomeric forms. Using the extended Hammett relation, the determined pK(a) values were correlated with literature sigma values. The predicted pK(a) values were in fair accordance with the experimentally observed ones. Molecular, monoanionic and dianionic forms of the parent compound were optimized by the semi-empirical molecular orbital PM6 method using the implicit water solvation model (COSMO). The obtained geometries were used to explain the quality of the LEER models.
AB  - Protolitičke ravnoteže 13 jedinjenja iz klase 4-aril-2,4-dioksobutanskih kiselina (ADK) spektrofotometrijski su proučavane u vodenim rastvorima u pH intervalu 1-9 pri temperaturi 25±1 °C i jonskoj jačini rastvora 0.1 mol l-1 (NaCl), sa izuzetkom 4-OH-derivata koji je proučavan i potenciometrijski u pH intervalu 7-10 pri istim uslovima. Kako ADK u vodenom rastvoru podležu keto-enolnoj tautomeriji i istovremeno postoje u diketo i dva enolna oblika, to određene kiselinske konstante (pKa1 1.87-2.29, pKa2 6.63-8.13 i pKa3(4-OH-) 9.52) predstavljaju makro konstante za dati sistem. 1H-NMR spektar osnovne supstance (4-fenil-2,4-dioksobutanska kiselina) (25 °C, pD 5.0) potvrđuje prisustvo svih tautomernih oblika. Upotrebom proširene Hametove korelacije, određene pKa vrednosti korelisane su sa literaturnim σ vrednostima. Predviđene pKa vrednosti dobro se slažu sa eksperimentalno dobijenim. Molekulski, monoanjonski i dianjonski oblici osnovne supstance su optimizovani semiempirijskom molekulsko-orbitalnom PM6 metodom sa implicitnim modelom solvatacije u vodi (COSMO). Dobijene geometrije su upotrebljene za objašnjenje kvaliteta LFER modela.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - An LFER study of the protolytic equililbria of 4-aryl-2,4-dioxolbutanoic acids in aqueous solutions
T1  - Linearne korelacije slobodne energije (LFER) protolitičkih ravnoteža 4-aril-2,4-dioksobutanskih kiselina u vodenim rastvorima
VL  - 72
IS  - 12
SP  - 1201
EP  - 1216
DO  - 10.2298/JSC0712201V
ER  - 

@article{
author = "Verbić, Tatjana and Drakulić, Branko J. and Zloh, Mire and Pecelj, Jovana R. and Popović, Gordana V. and Juranić, Ivan O.",
year = "2007",
abstract = "The protolytic equilibria of 13 4-aryl-2,4-dioxobutanoic acids (ADKs) were spectrophotometrically studied in aqueous solutions in the pH range 1-9 at 25 +/- 1 degrees C and an ionic strength of 0.1 mol 1(-1) (NaCl), with the exception of the 4-OH-derivative which was also potentiometrically studied in the pH range 7-10 at 25 +/- 1 degrees C and an ionic strength of 0.1 mol 1(-1) (NaCl). In solution, the compounds simultaneously exist in one diketo and two enolic forms; therefore, the determined acidity constants (pK(al) 1.87-2.29. pK(a2) 6.63-8.13 and pK(a3)(4-OH-) 9.52) represent system macro constants. The H-1-NMR spectrum of the parent compound (4-phenyl-2,4-dioxobutanoic acid) (25 degrees C, pD 5.0) proved the existence of all tautomeric forms. Using the extended Hammett relation, the determined pK(a) values were correlated with literature sigma values. The predicted pK(a) values were in fair accordance with the experimentally observed ones. Molecular, monoanionic and dianionic forms of the parent compound were optimized by the semi-empirical molecular orbital PM6 method using the implicit water solvation model (COSMO). The obtained geometries were used to explain the quality of the LEER models., Protolitičke ravnoteže 13 jedinjenja iz klase 4-aril-2,4-dioksobutanskih kiselina (ADK) spektrofotometrijski su proučavane u vodenim rastvorima u pH intervalu 1-9 pri temperaturi 25±1 °C i jonskoj jačini rastvora 0.1 mol l-1 (NaCl), sa izuzetkom 4-OH-derivata koji je proučavan i potenciometrijski u pH intervalu 7-10 pri istim uslovima. Kako ADK u vodenom rastvoru podležu keto-enolnoj tautomeriji i istovremeno postoje u diketo i dva enolna oblika, to određene kiselinske konstante (pKa1 1.87-2.29, pKa2 6.63-8.13 i pKa3(4-OH-) 9.52) predstavljaju makro konstante za dati sistem. 1H-NMR spektar osnovne supstance (4-fenil-2,4-dioksobutanska kiselina) (25 °C, pD 5.0) potvrđuje prisustvo svih tautomernih oblika. Upotrebom proširene Hametove korelacije, određene pKa vrednosti korelisane su sa literaturnim σ vrednostima. Predviđene pKa vrednosti dobro se slažu sa eksperimentalno dobijenim. Molekulski, monoanjonski i dianjonski oblici osnovne supstance su optimizovani semiempirijskom molekulsko-orbitalnom PM6 metodom sa implicitnim modelom solvatacije u vodi (COSMO). Dobijene geometrije su upotrebljene za objašnjenje kvaliteta LFER modela.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "An LFER study of the protolytic equililbria of 4-aryl-2,4-dioxolbutanoic acids in aqueous solutions, Linearne korelacije slobodne energije (LFER) protolitičkih ravnoteža 4-aril-2,4-dioksobutanskih kiselina u vodenim rastvorima",
volume = "72",
number = "12",
pages = "1201-1216",
doi = "10.2298/JSC0712201V"
}

Verbić, T., Drakulić, B. J., Zloh, M., Pecelj, J. R., Popović, G. V.,& Juranić, I. O.. (2007). An LFER study of the protolytic equililbria of 4-aryl-2,4-dioxolbutanoic acids in aqueous solutions. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 72(12), 1201-1216.
https://doi.org/10.2298/JSC0712201V

Verbić T, Drakulić BJ, Zloh M, Pecelj JR, Popović GV, Juranić IO. An LFER study of the protolytic equililbria of 4-aryl-2,4-dioxolbutanoic acids in aqueous solutions. in Journal of the Serbian Chemical Society. 2007;72(12):1201-1216.
doi:10.2298/JSC0712201V .

Verbić, Tatjana, Drakulić, Branko J., Zloh, Mire, Pecelj, Jovana R., Popović, Gordana V., Juranić, Ivan O., "An LFER study of the protolytic equililbria of 4-aryl-2,4-dioxolbutanoic acids in aqueous solutions" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1201-1216,
https://doi.org/10.2298/JSC0712201V . .

TY  - JOUR
AU  - Vojic, MP
AU  - Popović, Gordana V.
AU  - Sladić, Dušan
AU  - Pfendt, Lidija B.
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/687
AB  - The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25 degreesC at a constant ionic strength of 0.1 M (NaCl). The acidity constant K,,, was determined by potentiometric (pK(a1) 3.20) and spectrophotometric (pK(al) 3.26) methods. A pK(a2) constant of 6.10 was obtained based on the equilibrium constants pK(s0) 4.84 and pK(s1) -1.26, determined in a heterogeneous ketoconazole system. The obtained values of the constants served to calculate the solubility and the distribution of the equilibrium forms of ketoconazole as a function of pH. On the basis of the distribution of the equilibrium forms of ketoconazole, a spectrophotometric method for the determination of its content in commercial tablets was developed. The determinations were performed at 225 nm in 0.1 M HCl. The method is simple and rapid and enables the direct spectrophotometric determination of the content of ketoconazole without previous isolation.
AB  - Proučene su kiselinsko-bazne ravnoteže u homogenom i heterogenom vodenom sistemu ketokonazola, diprotične teško rastvorne baze. Određivanja su vršena na temperaturi 25ºC i pri konstantnoj jonskoj sili 0,1M(NaCl). Kiselinska konstantaKa1 određena je potenciometrijski (pKa1 3,20) i spektrofotometrijski (pKa1 3,26). Konstanta pKa2 6,10 izračunata je iz ravnotežnih konstanti određenih u heterogenom sistemu: pKs0 4,84 i pKs1 -1,26. Na osnovu dobijenih vrednosti za konstante izračunata je rastvorljivost i raspodela ravnotežnih oblika ketokonazola u funkciji pH. Na bazi raspodele ravnotežnih oblika ketokonazola predložena je spektrofotometrijska metoda za njegovo određivanje u komercijalnim tabletama. Određivanja su vršena na talasnoj dužini 225 nm u 0,1M HCl.Metoda je jednostavna i brza, i omogućava direktno spektrofotometrijsko određivanje ketokonazola, bez prethodnog izolovanja.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets
T1  - Protolitičke ravnoteže u homogenom i heterogenom sistemu ketokonazola i njegovo direktno spektrofotometrijsko određivanje u tabletama
VL  - 70
IS  - 1
SP  - 67
EP  - 78
DO  - 10.2298/JSC0501067V
ER  - 

@article{
author = "Vojic, MP and Popović, Gordana V. and Sladić, Dušan and Pfendt, Lidija B.",
year = "2005",
abstract = "The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25 degreesC at a constant ionic strength of 0.1 M (NaCl). The acidity constant K,,, was determined by potentiometric (pK(a1) 3.20) and spectrophotometric (pK(al) 3.26) methods. A pK(a2) constant of 6.10 was obtained based on the equilibrium constants pK(s0) 4.84 and pK(s1) -1.26, determined in a heterogeneous ketoconazole system. The obtained values of the constants served to calculate the solubility and the distribution of the equilibrium forms of ketoconazole as a function of pH. On the basis of the distribution of the equilibrium forms of ketoconazole, a spectrophotometric method for the determination of its content in commercial tablets was developed. The determinations were performed at 225 nm in 0.1 M HCl. The method is simple and rapid and enables the direct spectrophotometric determination of the content of ketoconazole without previous isolation., Proučene su kiselinsko-bazne ravnoteže u homogenom i heterogenom vodenom sistemu ketokonazola, diprotične teško rastvorne baze. Određivanja su vršena na temperaturi 25ºC i pri konstantnoj jonskoj sili 0,1M(NaCl). Kiselinska konstantaKa1 određena je potenciometrijski (pKa1 3,20) i spektrofotometrijski (pKa1 3,26). Konstanta pKa2 6,10 izračunata je iz ravnotežnih konstanti određenih u heterogenom sistemu: pKs0 4,84 i pKs1 -1,26. Na osnovu dobijenih vrednosti za konstante izračunata je rastvorljivost i raspodela ravnotežnih oblika ketokonazola u funkciji pH. Na bazi raspodele ravnotežnih oblika ketokonazola predložena je spektrofotometrijska metoda za njegovo određivanje u komercijalnim tabletama. Određivanja su vršena na talasnoj dužini 225 nm u 0,1M HCl.Metoda je jednostavna i brza, i omogućava direktno spektrofotometrijsko određivanje ketokonazola, bez prethodnog izolovanja.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets, Protolitičke ravnoteže u homogenom i heterogenom sistemu ketokonazola i njegovo direktno spektrofotometrijsko određivanje u tabletama",
volume = "70",
number = "1",
pages = "67-78",
doi = "10.2298/JSC0501067V"
}

Vojic, M., Popović, G. V., Sladić, D.,& Pfendt, L. B.. (2005). Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 70(1), 67-78.
https://doi.org/10.2298/JSC0501067V

Vojic M, Popović GV, Sladić D, Pfendt LB. Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets. in Journal of the Serbian Chemical Society. 2005;70(1):67-78.
doi:10.2298/JSC0501067V .

Vojic, MP, Popović, Gordana V., Sladić, Dušan, Pfendt, Lidija B., "Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets" in Journal of the Serbian Chemical Society, 70, no. 1 (2005):67-78,
https://doi.org/10.2298/JSC0501067V . .

TY  - JOUR
AU  - Popović, Gordana V.
AU  - Sladić, Dušan
AU  - Stefanovic, VM
AU  - Pfendt, Lidija B.
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/549
AB  - Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. (C) 2003 Elsevier Science B.V. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
VL  - 31
IS  - 4
SP  - 693
EP  - 699
DO  - 10.1016/S0731-7085(02)00686-6
ER  - 

@article{
author = "Popović, Gordana V. and Sladić, Dušan and Stefanovic, VM and Pfendt, Lidija B.",
year = "2003",
abstract = "Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. (C) 2003 Elsevier Science B.V. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy",
volume = "31",
number = "4",
pages = "693-699",
doi = "10.1016/S0731-7085(02)00686-6"
}

Popović, G. V., Sladić, D., Stefanovic, V.,& Pfendt, L. B.. (2003). Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 31(4), 693-699.
https://doi.org/10.1016/S0731-7085(02)00686-6

Popović GV, Sladić D, Stefanovic V, Pfendt LB. Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis. 2003;31(4):693-699.
doi:10.1016/S0731-7085(02)00686-6 .

Popović, Gordana V., Sladić, Dušan, Stefanovic, VM, Pfendt, Lidija B., "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy" in Journal of Pharmaceutical and Biomedical Analysis, 31, no. 4 (2003):693-699,
https://doi.org/10.1016/S0731-7085(02)00686-6 . .

TY  - JOUR
AU  - Pfendt, Lidija B.
AU  - Popović, Gordana V.
AU  - Damjanović, Tatjana Ž.
AU  - Sladić, Dušan
PY  - 2002
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/484
AB  - The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0-14 at 25 degreesC and at ionic strength of 0.1 mol/dm(3) (NaCl). On the basis of C-13-NMR spectra, the protonation site was predicted - in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pK(a1) 2.83 and pK(a2) 11.60) and potentiometrically (pk(a1) 2.99). In the heterogeneous system the following equilibrium constants were determined: K-s0 = [HA] (pK(s0) 3.44), K-s1 = [H(2)A(+)]/[H3O+] (pK(s1) 0.61), and K-s2 = [A(-)][H3O+] (pK(s2) 15.04).
AB  - Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equilibria of bromazepam
T1  - Protolitičke ravnoteže bromazepama
VL  - 67
IS  - 3
SP  - 187
EP  - 195
DO  - 10.2298/JSC0203187P
ER  - 

@article{
author = "Pfendt, Lidija B. and Popović, Gordana V. and Damjanović, Tatjana Ž. and Sladić, Dušan",
year = "2002",
abstract = "The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0-14 at 25 degreesC and at ionic strength of 0.1 mol/dm(3) (NaCl). On the basis of C-13-NMR spectra, the protonation site was predicted - in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pK(a1) 2.83 and pK(a2) 11.60) and potentiometrically (pk(a1) 2.99). In the heterogeneous system the following equilibrium constants were determined: K-s0 = [HA] (pK(s0) 3.44), K-s1 = [H(2)A(+)]/[H3O+] (pK(s1) 0.61), and K-s2 = [A(-)][H3O+] (pK(s2) 15.04)., Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equilibria of bromazepam, Protolitičke ravnoteže bromazepama",
volume = "67",
number = "3",
pages = "187-195",
doi = "10.2298/JSC0203187P"
}

Pfendt, L. B., Popović, G. V., Damjanović, T. Ž.,& Sladić, D.. (2002). Protolytic equilibria of bromazepam. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 67(3), 187-195.
https://doi.org/10.2298/JSC0203187P

Pfendt LB, Popović GV, Damjanović TŽ, Sladić D. Protolytic equilibria of bromazepam. in Journal of the Serbian Chemical Society. 2002;67(3):187-195.
doi:10.2298/JSC0203187P .

Pfendt, Lidija B., Popović, Gordana V., Damjanović, Tatjana Ž., Sladić, Dušan, "Protolytic equilibria of bromazepam" in Journal of the Serbian Chemical Society, 67, no. 3 (2002):187-195,
https://doi.org/10.2298/JSC0203187P . .