TY  - JOUR
AU  - Sarakhman, Olha
AU  - Pysarevska, Solomiya
AU  - Dubenska, Liliya
AU  - Stanković, Dalibor
AU  - Otrisal, Pavel
AU  - Planková, Alexandra
AU  - Kianicková, Kristína
AU  - Šovrc, Ľubomír
PY  - 2019
AB  - In present paper, a miniaturized boron-doped diamond electrode (BDDE) was for the first time used as a reliable electrochemical sensor within the novel voltammetric protocol for the rapid and simple determination of dipyridamole (DIP). Cyclic voltammetric studies uncovered that the electrochemical oxidation of DIP was shown to be irreversible and diffusion-controlled process with single and well-developed signal at a potential of +0.45 V in Britton-Robinson buffer at pH 3.0. Using the suitable experimental conditions, the linearity for DIP determination was observed in the concentration ranges of 0.1.5.0 μM and 0.1.6.0 μM with the corresponding limits of detection of 40 nM and 60 nM as well as the intra-day repeatability with relative standard deviation below 5% for differential pulse and square-wave voltammetry, respectively. This protocol was successfully applied to the determination of DIP in pharmaceutical tablets with result in good compliance with that declared by the producer. Biological pertinence of the developed procedure was presented by analysis of model human urine samples with adequate recoveries. The proposed protocol with a miniaturized BDDE could represent an effective and alternative analytical implement for DIP determination instead of commonly used toxic mercury and chemically-modified electrodes in previously published methods.
PB  - Electrochemical Society Inc.
T2  - Journal of the Electrochemical Society
T1  - Voltammetric protocol for reliable determination of a platelet aggregation inhibitor dipyridamole on a bare miniaturized boron-doped diamond electrochemical sensor
VL  - 166
IS  - 4
SP  - B219
EP  - B226
DO  - 10.1149/2.0381904jes
ER  - 

@article{
author = "Sarakhman, Olha and Pysarevska, Solomiya and Dubenska, Liliya and Stanković, Dalibor and Otrisal, Pavel and Planková, Alexandra and Kianicková, Kristína and Šovrc, Ľubomír",
year = "2019",
abstract = "In present paper, a miniaturized boron-doped diamond electrode (BDDE) was for the first time used as a reliable electrochemical sensor within the novel voltammetric protocol for the rapid and simple determination of dipyridamole (DIP). Cyclic voltammetric studies uncovered that the electrochemical oxidation of DIP was shown to be irreversible and diffusion-controlled process with single and well-developed signal at a potential of +0.45 V in Britton-Robinson buffer at pH 3.0. Using the suitable experimental conditions, the linearity for DIP determination was observed in the concentration ranges of 0.1.5.0 μM and 0.1.6.0 μM with the corresponding limits of detection of 40 nM and 60 nM as well as the intra-day repeatability with relative standard deviation below 5% for differential pulse and square-wave voltammetry, respectively. This protocol was successfully applied to the determination of DIP in pharmaceutical tablets with result in good compliance with that declared by the producer. Biological pertinence of the developed procedure was presented by analysis of model human urine samples with adequate recoveries. The proposed protocol with a miniaturized BDDE could represent an effective and alternative analytical implement for DIP determination instead of commonly used toxic mercury and chemically-modified electrodes in previously published methods.",
publisher = "Electrochemical Society Inc.",
journal = "Journal of the Electrochemical Society",
title = "Voltammetric protocol for reliable determination of a platelet aggregation inhibitor dipyridamole on a bare miniaturized boron-doped diamond electrochemical sensor",
volume = "166",
number = "4",
pages = "B219-B226",
doi = "10.1149/2.0381904jes"
}

Sarakhman, O., Pysarevska, S., Dubenska, L., Stanković, D., Otrisal, P., Planková, A., Kianicková, K.,& Šovrc, Ľ.. (2019). Voltammetric protocol for reliable determination of a platelet aggregation inhibitor dipyridamole on a bare miniaturized boron-doped diamond electrochemical sensor. in Journal of the Electrochemical Society
Electrochemical Society Inc.., 166(4), B219-B226.
https://doi.org/10.1149/2.0381904jes

Sarakhman O, Pysarevska S, Dubenska L, Stanković D, Otrisal P, Planková A, Kianicková K, Šovrc Ľ. Voltammetric protocol for reliable determination of a platelet aggregation inhibitor dipyridamole on a bare miniaturized boron-doped diamond electrochemical sensor. in Journal of the Electrochemical Society. 2019;166(4):B219-B226.
doi:10.1149/2.0381904jes .

Sarakhman, Olha, Pysarevska, Solomiya, Dubenska, Liliya, Stanković, Dalibor, Otrisal, Pavel, Planková, Alexandra, Kianicková, Kristína, Šovrc, Ľubomír, "Voltammetric protocol for reliable determination of a platelet aggregation inhibitor dipyridamole on a bare miniaturized boron-doped diamond electrochemical sensor" in Journal of the Electrochemical Society, 166, no. 4 (2019):B219-B226,
https://doi.org/10.1149/2.0381904jes . .