Stanimirović, Bojana

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  • Stanimirović, Bojana (13)
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Author's Bibliography

Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study

Lješević, Marija; Gojgić-Cvijović, Gordana D.; Stanimirović, Bojana; Beškoski, Vladimir; Brčeski, Ilija

(Balkan Environmental Association, 2019)

TY  - JOUR
AU  - Lješević, Marija
AU  - Gojgić-Cvijović, Gordana D.
AU  - Stanimirović, Bojana
AU  - Beškoski, Vladimir
AU  - Brčeski, Ilija
PY  - 2019
UR  - http://www.jepe-journal.info/journal-content/vol-20-no-3
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4957
AB  - Microorganisms can grow on the surface of concrete and inside its pores and microcracks, producing different metabolites. Microbial metabolites, particularly acids, degrade concrete components and enhance its deterioration by abiotic factors. Deterioration of concrete is a serious problem worldwide since it affects construction functionality and requires high maintenance costs.This paper presents microbiological and chemical analyses of 12 concrete samples originating from6 hydroelectric power plants in Serbia, investigated in order to evaluate the key chemical factorsaffecting microbial growth on concrete. In most of the concrete samples, microorganisms from allexamined groups were present in high numbers (bacteria 8.64 × 103–3.4 × 108, fungi 9 × 102–2.08× 106, sulphur-oxidising bacteria 16.8–2.5×104 CFU/g). The high number and the presence of variousphysiological groups of microorganisms indicate the high intensity of deterioration caused bybiological sources. Values of pH of the concrete samples were in the range 8.46–11.23, Ca content5.43–19.93%, Fe 151–61100 ppm, sulphate 37.4–623.7 ppm and chloride 96.3–914.1 ppm. Correlation analysis between microbiological and chemical factors indicated a statistically significant strong negative correlation between sulphur-oxidising bacteria and pH (–0.759, p < 0.01).
PB  - Balkan Environmental Association
T2  - Journal of Environmental Protection and Ecology
T1  - Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study
VL  - 20
IS  - 3
SP  - 1180
EP  - 1188
UR  - https://hdl.handle.net/21.15107/rcub_cer_3947
ER  - 
@article{
author = "Lješević, Marija and Gojgić-Cvijović, Gordana D. and Stanimirović, Bojana and Beškoski, Vladimir and Brčeski, Ilija",
year = "2019",
abstract = "Microorganisms can grow on the surface of concrete and inside its pores and microcracks, producing different metabolites. Microbial metabolites, particularly acids, degrade concrete components and enhance its deterioration by abiotic factors. Deterioration of concrete is a serious problem worldwide since it affects construction functionality and requires high maintenance costs.This paper presents microbiological and chemical analyses of 12 concrete samples originating from6 hydroelectric power plants in Serbia, investigated in order to evaluate the key chemical factorsaffecting microbial growth on concrete. In most of the concrete samples, microorganisms from allexamined groups were present in high numbers (bacteria 8.64 × 103–3.4 × 108, fungi 9 × 102–2.08× 106, sulphur-oxidising bacteria 16.8–2.5×104 CFU/g). The high number and the presence of variousphysiological groups of microorganisms indicate the high intensity of deterioration caused bybiological sources. Values of pH of the concrete samples were in the range 8.46–11.23, Ca content5.43–19.93%, Fe 151–61100 ppm, sulphate 37.4–623.7 ppm and chloride 96.3–914.1 ppm. Correlation analysis between microbiological and chemical factors indicated a statistically significant strong negative correlation between sulphur-oxidising bacteria and pH (–0.759, p < 0.01).",
publisher = "Balkan Environmental Association",
journal = "Journal of Environmental Protection and Ecology",
title = "Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study",
volume = "20",
number = "3",
pages = "1180-1188",
url = "https://hdl.handle.net/21.15107/rcub_cer_3947"
}
Lješević, M., Gojgić-Cvijović, G. D., Stanimirović, B., Beškoski, V.,& Brčeski, I.. (2019). Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study. in Journal of Environmental Protection and Ecology
Balkan Environmental Association., 20(3), 1180-1188.
https://hdl.handle.net/21.15107/rcub_cer_3947
Lješević M, Gojgić-Cvijović GD, Stanimirović B, Beškoski V, Brčeski I. Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study. in Journal of Environmental Protection and Ecology. 2019;20(3):1180-1188.
https://hdl.handle.net/21.15107/rcub_cer_3947 .
Lješević, Marija, Gojgić-Cvijović, Gordana D., Stanimirović, Bojana, Beškoski, Vladimir, Brčeski, Ilija, "Microbially-induced deterioration of concrete from hydroelectric power plants – an initial study" in Journal of Environmental Protection and Ecology, 20, no. 3 (2019):1180-1188,
https://hdl.handle.net/21.15107/rcub_cer_3947 .

A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties

Stanimirović, Bojana; Vujović, Dragan; Pejin, Boris; Popović-Djordjević, Jelena; Maletić, Radojka; Raičević, Petar; Tešić, Živoslav Lj.

(2018)

TY  - JOUR
AU  - Stanimirović, Bojana
AU  - Vujović, Dragan
AU  - Pejin, Boris
AU  - Popović-Djordjević, Jelena
AU  - Maletić, Radojka
AU  - Raičević, Petar
AU  - Tešić, Živoslav Lj.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/329
AB  - The elemental profile of the leaf samples of three Cabernet Franc clone candidates recently developed in Serbia (Nos. 02, 010 and 012) obtained in the last phase of clonal selection was examined within this study by ICP-OES. Optimal content of Al, Fe, Cu and Zn, the metals well known for their links with a number of neurodegenerative disorders including Alzheimer’s disease, has actually highlighted the potential of the leaf sample No. 10 to afford a novel food supplement of natural origin possessing well balanced metal ingredients. Furthermore, lower content of some other elements (Cr, Mn, Ni and Pb) thoroughly supports such a claiming. Finally, the most favourable K/Na ratio observed for the aforementioned sample points out its likely cardioprotectivity. However, two other Cabernet Franc clone candidates might also be recommended for breeding in the same or similar viticultural conditions, since all obtained values were below toxic ones for human consumption. © 2018 Informa UK Limited, trading as Taylor & Francis Group
T2  - Natural Product Research
T1  - A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties
SP  - 1
EP  - 5
DO  - 10.1080/14786419.2018.1457671
ER  - 
@article{
author = "Stanimirović, Bojana and Vujović, Dragan and Pejin, Boris and Popović-Djordjević, Jelena and Maletić, Radojka and Raičević, Petar and Tešić, Živoslav Lj.",
year = "2018",
abstract = "The elemental profile of the leaf samples of three Cabernet Franc clone candidates recently developed in Serbia (Nos. 02, 010 and 012) obtained in the last phase of clonal selection was examined within this study by ICP-OES. Optimal content of Al, Fe, Cu and Zn, the metals well known for their links with a number of neurodegenerative disorders including Alzheimer’s disease, has actually highlighted the potential of the leaf sample No. 10 to afford a novel food supplement of natural origin possessing well balanced metal ingredients. Furthermore, lower content of some other elements (Cr, Mn, Ni and Pb) thoroughly supports such a claiming. Finally, the most favourable K/Na ratio observed for the aforementioned sample points out its likely cardioprotectivity. However, two other Cabernet Franc clone candidates might also be recommended for breeding in the same or similar viticultural conditions, since all obtained values were below toxic ones for human consumption. © 2018 Informa UK Limited, trading as Taylor & Francis Group",
journal = "Natural Product Research",
title = "A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties",
pages = "1-5",
doi = "10.1080/14786419.2018.1457671"
}
Stanimirović, B., Vujović, D., Pejin, B., Popović-Djordjević, J., Maletić, R., Raičević, P.,& Tešić, Ž. Lj.. (2018). A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties. in Natural Product Research, 1-5.
https://doi.org/10.1080/14786419.2018.1457671
Stanimirović B, Vujović D, Pejin B, Popović-Djordjević J, Maletić R, Raičević P, Tešić ŽL. A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties. in Natural Product Research. 2018;:1-5.
doi:10.1080/14786419.2018.1457671 .
Stanimirović, Bojana, Vujović, Dragan, Pejin, Boris, Popović-Djordjević, Jelena, Maletić, Radojka, Raičević, Petar, Tešić, Živoslav Lj., "A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties" in Natural Product Research (2018):1-5,
https://doi.org/10.1080/14786419.2018.1457671 . .
5
2
4
5

Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori

Lješević, Marija; Gojgić-Cvijović, Gordana D.; Stanimirović, Bojana; Beškoski, Vladimir; Brčeski, Ilija

(Beograd : Srpsko hemijsko društvo, 2018)

TY  - CONF
AU  - Lješević, Marija
AU  - Gojgić-Cvijović, Gordana D.
AU  - Stanimirović, Bojana
AU  - Beškoski, Vladimir
AU  - Brčeski, Ilija
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4964
AB  - Degradacija betona može da bude posledica različitih fizičkih promena kao što su korozija, pucanje, preopterećenje itd. Osim fizičkih promena, na izdržljivost betona mogu da utiču i mikroorganizmi u procesu biodeterioracije. Iako biodeterioracija retko može biti direktan uzrok degradacije, ona znatno ubrzava druge štetne procese kao što su prodor hlorida i karbonacija koji narušavaju strukturu betona [1]. U procesima biodeterioracije mogu da učestvuju različiti mikroorganizmi kao što su bakterije, gljive, alge, lišajevi [2]. Oni utiču na procese deterioracije betona na tri načina: narušavanjem izgleda, što je posledica formiranja biofilma, mehaničkim pucanjem usled rasta i kretanja mikroorganizama i hemijskim putem usled ekskrecije metabolita [3]. Na početku, pH betonske površine je veoma visoka, pa će, ukoliko je vlažnost i količina hranljivih supstanci dovoljna, doći do kolonizacije alkalifilnim i tionskim bakterijama. Produkcijom oksidovanih sumpornih jedinjenja snižava se pH vrednost što povećava kolonizaciju betonske površine neutrofilnim, a potom i acidofilnim mikroorganizmima. Osim promene pH vrednosti, kiseline koje se proizvode direktno utiču na strukturni integritet betona pošto razgrađuju cementni materijal [2]. Usled deterioracije, troškovi održavanja betonskih konstrukcija je povećavaju, što svake godine prouzrokuje znatnu ekonomsku štetu [1, 2, 3]. U okviru ove studije ispitivan je odnos između mikrobnog rasta i različitih hemijskih svojstava uzoraka poreklom iz tri hidroelektrane u Srbiji (HE Đerdap, HE Potpeć, HE Uvac). Uzorkovanje je radjeno na dva mesta na svakoj lokaciji. Ispitivan je broj ukupnih, gvožđevitih, sulfat-redukujućih i tionskih bakterija, kvasaca i plesni kao i pH vrednost i sadržaj sulfata, nitrata, hlorida, mangana, gvožđa, magnezijuma i kalcijuma. Vrednosti pH su bile u opsegu od 8,39- 9,09, koncentracije gvožđa su bile između 151,0- 61.100,0 mg/L, mangana 7,2- 4.900,0 mg/L, sulfata 37,4- 623,7 mg/L, nitrata 1,0- 11,3 mg/L, hlorida 88,2- 1.104,2 mg/L, kalcijuma 5,48- 19,93% i magnezijuma 0,11- 1,26%. Maksimalan broj ukupnih bakterija je bio 6,24x108 cfu/g, kvasaca i plesni 3,12x105 cfu/g, sulfat redukujućih bakterija 2,20x103 cfu/g , tionskih bakterija 2,50x104 cfu/g, a gvožđevitih bakterija 6.4 x 106 cfu/g. Broj mikroorganizama i njihova aktivnost se uobičajeno povezuje sa osnovnim fizičko-hemijskim i hemijskim karakteristikama ispitivanih uzoraka. Hemijski faktori se u ovim uzorcima znatno razlikuju u zavisnosti od mesta uzorkovanja, zbog čega nije moguće odrediti jedan faktor koji bi bio indikator biodeterioracije. Ipak, uzorci uzeti iz HE Đerdap imaju najveći broj tionskih i sulfat-redukujućih bakterija, kao i najveću koncentraciju hlorida. Jedan od uzoraka uzetih iz HE Potpeć imao je najniži broj svih određivanih mikroorganizama kao i ekstremno visoke koncentracije gvožđa i mangana.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 8. Simpozijum Hemija i zaštita životne sredine (sa međunarodnim učešćem) / 8th Symposium Chemistry and Environmental Protection (with international participation), 30.5-01.06.2018., Kruševac, Serbia
T1  - Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori
T1  - Deterioration of concrete in hydroelectric power plants- chemical and microbiological factors
SP  - 131
EP  - 132
UR  - https://hdl.handle.net/21.15107/rcub_cer_3561
ER  - 
@conference{
author = "Lješević, Marija and Gojgić-Cvijović, Gordana D. and Stanimirović, Bojana and Beškoski, Vladimir and Brčeski, Ilija",
year = "2018",
abstract = "Degradacija betona može da bude posledica različitih fizičkih promena kao što su korozija, pucanje, preopterećenje itd. Osim fizičkih promena, na izdržljivost betona mogu da utiču i mikroorganizmi u procesu biodeterioracije. Iako biodeterioracija retko može biti direktan uzrok degradacije, ona znatno ubrzava druge štetne procese kao što su prodor hlorida i karbonacija koji narušavaju strukturu betona [1]. U procesima biodeterioracije mogu da učestvuju različiti mikroorganizmi kao što su bakterije, gljive, alge, lišajevi [2]. Oni utiču na procese deterioracije betona na tri načina: narušavanjem izgleda, što je posledica formiranja biofilma, mehaničkim pucanjem usled rasta i kretanja mikroorganizama i hemijskim putem usled ekskrecije metabolita [3]. Na početku, pH betonske površine je veoma visoka, pa će, ukoliko je vlažnost i količina hranljivih supstanci dovoljna, doći do kolonizacije alkalifilnim i tionskim bakterijama. Produkcijom oksidovanih sumpornih jedinjenja snižava se pH vrednost što povećava kolonizaciju betonske površine neutrofilnim, a potom i acidofilnim mikroorganizmima. Osim promene pH vrednosti, kiseline koje se proizvode direktno utiču na strukturni integritet betona pošto razgrađuju cementni materijal [2]. Usled deterioracije, troškovi održavanja betonskih konstrukcija je povećavaju, što svake godine prouzrokuje znatnu ekonomsku štetu [1, 2, 3]. U okviru ove studije ispitivan je odnos između mikrobnog rasta i različitih hemijskih svojstava uzoraka poreklom iz tri hidroelektrane u Srbiji (HE Đerdap, HE Potpeć, HE Uvac). Uzorkovanje je radjeno na dva mesta na svakoj lokaciji. Ispitivan je broj ukupnih, gvožđevitih, sulfat-redukujućih i tionskih bakterija, kvasaca i plesni kao i pH vrednost i sadržaj sulfata, nitrata, hlorida, mangana, gvožđa, magnezijuma i kalcijuma. Vrednosti pH su bile u opsegu od 8,39- 9,09, koncentracije gvožđa su bile između 151,0- 61.100,0 mg/L, mangana 7,2- 4.900,0 mg/L, sulfata 37,4- 623,7 mg/L, nitrata 1,0- 11,3 mg/L, hlorida 88,2- 1.104,2 mg/L, kalcijuma 5,48- 19,93% i magnezijuma 0,11- 1,26%. Maksimalan broj ukupnih bakterija je bio 6,24x108 cfu/g, kvasaca i plesni 3,12x105 cfu/g, sulfat redukujućih bakterija 2,20x103 cfu/g , tionskih bakterija 2,50x104 cfu/g, a gvožđevitih bakterija 6.4 x 106 cfu/g. Broj mikroorganizama i njihova aktivnost se uobičajeno povezuje sa osnovnim fizičko-hemijskim i hemijskim karakteristikama ispitivanih uzoraka. Hemijski faktori se u ovim uzorcima znatno razlikuju u zavisnosti od mesta uzorkovanja, zbog čega nije moguće odrediti jedan faktor koji bi bio indikator biodeterioracije. Ipak, uzorci uzeti iz HE Đerdap imaju najveći broj tionskih i sulfat-redukujućih bakterija, kao i najveću koncentraciju hlorida. Jedan od uzoraka uzetih iz HE Potpeć imao je najniži broj svih određivanih mikroorganizama kao i ekstremno visoke koncentracije gvožđa i mangana.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "8. Simpozijum Hemija i zaštita životne sredine (sa međunarodnim učešćem) / 8th Symposium Chemistry and Environmental Protection (with international participation), 30.5-01.06.2018., Kruševac, Serbia",
title = "Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori, Deterioration of concrete in hydroelectric power plants- chemical and microbiological factors",
pages = "131-132",
url = "https://hdl.handle.net/21.15107/rcub_cer_3561"
}
Lješević, M., Gojgić-Cvijović, G. D., Stanimirović, B., Beškoski, V.,& Brčeski, I.. (2018). Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori. in 8. Simpozijum Hemija i zaštita životne sredine (sa međunarodnim učešćem) / 8th Symposium Chemistry and Environmental Protection (with international participation), 30.5-01.06.2018., Kruševac, Serbia
Beograd : Srpsko hemijsko društvo., 131-132.
https://hdl.handle.net/21.15107/rcub_cer_3561
Lješević M, Gojgić-Cvijović GD, Stanimirović B, Beškoski V, Brčeski I. Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori. in 8. Simpozijum Hemija i zaštita životne sredine (sa međunarodnim učešćem) / 8th Symposium Chemistry and Environmental Protection (with international participation), 30.5-01.06.2018., Kruševac, Serbia. 2018;:131-132.
https://hdl.handle.net/21.15107/rcub_cer_3561 .
Lješević, Marija, Gojgić-Cvijović, Gordana D., Stanimirović, Bojana, Beškoski, Vladimir, Brčeski, Ilija, "Deterioracija betona u hidroelektranama- hemijski i mikrobiološki faktori" in 8. Simpozijum Hemija i zaštita životne sredine (sa međunarodnim učešćem) / 8th Symposium Chemistry and Environmental Protection (with international participation), 30.5-01.06.2018., Kruševac, Serbia (2018):131-132,
https://hdl.handle.net/21.15107/rcub_cer_3561 .

Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043

Stanimirović, Bojana; Popović-Đorđevic, Jelena; Pejin, Boris; Maletić, Radojka; Vujović, Dragan; Raičević, Petar; Tešić, Živoslav Lj.

(Elsevier Science Bv, Amsterdam, 2018)

TY  - DATA
AU  - Stanimirović, Bojana
AU  - Popović-Đorđevic, Jelena
AU  - Pejin, Boris
AU  - Maletić, Radojka
AU  - Vujović, Dragan
AU  - Raičević, Petar
AU  - Tešić, Živoslav Lj.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3206
PB  - Elsevier Science Bv, Amsterdam
T2  - Scientia Horticulturae
T1  - Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3206
ER  - 
@misc{
author = "Stanimirović, Bojana and Popović-Đorđevic, Jelena and Pejin, Boris and Maletić, Radojka and Vujović, Dragan and Raičević, Petar and Tešić, Živoslav Lj.",
year = "2018",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Scientia Horticulturae",
title = "Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3206"
}
Stanimirović, B., Popović-Đorđevic, J., Pejin, B., Maletić, R., Vujović, D., Raičević, P.,& Tešić, Ž. Lj.. (2018). Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043. in Scientia Horticulturae
Elsevier Science Bv, Amsterdam..
https://hdl.handle.net/21.15107/rcub_cherry_3206
Stanimirović B, Popović-Đorđevic J, Pejin B, Maletić R, Vujović D, Raičević P, Tešić ŽL. Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043. in Scientia Horticulturae. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3206 .
Stanimirović, Bojana, Popović-Đorđevic, Jelena, Pejin, Boris, Maletić, Radojka, Vujović, Dragan, Raičević, Petar, Tešić, Živoslav Lj., "Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043" in Scientia Horticulturae (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3206 .

Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles

Stanimirović, Bojana; Popović-Đorđevic, Jelena; Pejin, Boris; Maletić, Radojka; Vujović, Dragan; Raičević, Petar; Tešić, Živoslav Lj.

(Elsevier Science Bv, Amsterdam, 2018)

TY  - JOUR
AU  - Stanimirović, Bojana
AU  - Popović-Đorđevic, Jelena
AU  - Pejin, Boris
AU  - Maletić, Radojka
AU  - Vujović, Dragan
AU  - Raičević, Petar
AU  - Tešić, Živoslav Lj.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2141
AB  - Three Cabernet Franc (CF) clones (Nos. 02,010 and 012; not yet commercial) obtained in the last phase of clonal selection were examined within this study. Indeed, the content of 27 chemical elements in the vineyard soil along with CF grape and wine samples were determined by inductively coupled plasma - optical emission spectroscopy. The relative dependence of the selected elements in all samples were estimated using correlation matrices. While elemental profiles of both CF grape and wine samples were highly variable among the analysed clones, bioaccumulation factors (grape/soil) of Mg, Na and Sr were found to be specific for each single clone. Applying principal component analysis, the grape clones were differentiated among each other according to the content of 10 elements (Al, B, Ca, Cu, Fe, K, Mg, Mn, Na and Sr). Finally, hierarchical cluster analysis of CF grape and wine samples pointed out the similarity of the clones Nos. 010 and 012, since they were grouped within the same subcluster.
PB  - Elsevier Science Bv, Amsterdam
T2  - Scientia Horticulturae
T1  - Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles
VL  - 237
SP  - 74
EP  - 80
DO  - 10.1016/j.scienta.2018.03.043
ER  - 
@article{
author = "Stanimirović, Bojana and Popović-Đorđevic, Jelena and Pejin, Boris and Maletić, Radojka and Vujović, Dragan and Raičević, Petar and Tešić, Živoslav Lj.",
year = "2018",
abstract = "Three Cabernet Franc (CF) clones (Nos. 02,010 and 012; not yet commercial) obtained in the last phase of clonal selection were examined within this study. Indeed, the content of 27 chemical elements in the vineyard soil along with CF grape and wine samples were determined by inductively coupled plasma - optical emission spectroscopy. The relative dependence of the selected elements in all samples were estimated using correlation matrices. While elemental profiles of both CF grape and wine samples were highly variable among the analysed clones, bioaccumulation factors (grape/soil) of Mg, Na and Sr were found to be specific for each single clone. Applying principal component analysis, the grape clones were differentiated among each other according to the content of 10 elements (Al, B, Ca, Cu, Fe, K, Mg, Mn, Na and Sr). Finally, hierarchical cluster analysis of CF grape and wine samples pointed out the similarity of the clones Nos. 010 and 012, since they were grouped within the same subcluster.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Scientia Horticulturae",
title = "Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles",
volume = "237",
pages = "74-80",
doi = "10.1016/j.scienta.2018.03.043"
}
Stanimirović, B., Popović-Đorđevic, J., Pejin, B., Maletić, R., Vujović, D., Raičević, P.,& Tešić, Ž. Lj.. (2018). Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles. in Scientia Horticulturae
Elsevier Science Bv, Amsterdam., 237, 74-80.
https://doi.org/10.1016/j.scienta.2018.03.043
Stanimirović B, Popović-Đorđevic J, Pejin B, Maletić R, Vujović D, Raičević P, Tešić ŽL. Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles. in Scientia Horticulturae. 2018;237:74-80.
doi:10.1016/j.scienta.2018.03.043 .
Stanimirović, Bojana, Popović-Đorđevic, Jelena, Pejin, Boris, Maletić, Radojka, Vujović, Dragan, Raičević, Petar, Tešić, Živoslav Lj., "Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles" in Scientia Horticulturae, 237 (2018):74-80,
https://doi.org/10.1016/j.scienta.2018.03.043 . .
1
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7

Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148

Pejin, Boris; Stanimirović, Bojana; Vujović, Dragan; Popović-Đorđevic, Jelena; Veličković, Milovan; Tešević, Vele

(Taylor & Francis Ltd, Abingdon, 2016)

TY  - DATA
AU  - Pejin, Boris
AU  - Stanimirović, Bojana
AU  - Vujović, Dragan
AU  - Popović-Đorđevic, Jelena
AU  - Veličković, Milovan
AU  - Tešević, Vele
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3652
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3652
ER  - 
@misc{
author = "Pejin, Boris and Stanimirović, Bojana and Vujović, Dragan and Popović-Đorđevic, Jelena and Veličković, Milovan and Tešević, Vele",
year = "2016",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3652"
}
Pejin, B., Stanimirović, B., Vujović, D., Popović-Đorđevic, J., Veličković, M.,& Tešević, V.. (2016). Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
https://hdl.handle.net/21.15107/rcub_cherry_3652
Pejin B, Stanimirović B, Vujović D, Popović-Đorđevic J, Veličković M, Tešević V. Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148. in Natural Product Research. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3652 .
Pejin, Boris, Stanimirović, Bojana, Vujović, Dragan, Popović-Đorđevic, Jelena, Veličković, Milovan, Tešević, Vele, "Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148" in Natural Product Research (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3652 .

The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics

Pejin, Boris; Stanimirović, Bojana; Vujović, Dragan; Popović-Đorđevic, Jelena; Veličković, Milovan; Tešević, Vele

(Taylor & Francis Ltd, Abingdon, 2016)

TY  - JOUR
AU  - Pejin, Boris
AU  - Stanimirović, Bojana
AU  - Vujović, Dragan
AU  - Popović-Đorđevic, Jelena
AU  - Veličković, Milovan
AU  - Tešević, Vele
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2301
AB  - This work aimed to evaluate the content of selected phenolic natural products in the wine samples made of three new Serbian Cabernet Franc clones ( Nos. 02, 010 and 012, respectively) and mother vine ( used as the relevant standard) during the period 2008-2012. Compared with all other wine samples, the Cabernet Franc wine of the clone No. 010 was found to have the highest total content of polyphenolics ( 1.85 +/- 0.02 g/L) and anthocyanins ( 178.55 +/- 3.75 mg/L). In addition, its Folin-Ciocalteu index ( 36.86 +/- 0.12) stood out among the examined samples. Finally, the same wine was enriched with ellagic and gallic acids ( 3.44 +/- 0.29 and 27.46 +/- 0.21 mg/L, respectively), catechin ( 135.16 +/- 6.47 mg/L) and epicatechin ( 51.33 +/- 2.33 mg/L), the natural products known to exert significant lipid-lowering effects. Taken all together, the clone No. 010 developed in Serbia may offer new Cabernet Franc wine with geographical indication. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics
VL  - 30
IS  - 15
SP  - 1762
EP  - 1765
DO  - 10.1080/14786419.2015.1135148
ER  - 
@article{
author = "Pejin, Boris and Stanimirović, Bojana and Vujović, Dragan and Popović-Đorđevic, Jelena and Veličković, Milovan and Tešević, Vele",
year = "2016",
abstract = "This work aimed to evaluate the content of selected phenolic natural products in the wine samples made of three new Serbian Cabernet Franc clones ( Nos. 02, 010 and 012, respectively) and mother vine ( used as the relevant standard) during the period 2008-2012. Compared with all other wine samples, the Cabernet Franc wine of the clone No. 010 was found to have the highest total content of polyphenolics ( 1.85 +/- 0.02 g/L) and anthocyanins ( 178.55 +/- 3.75 mg/L). In addition, its Folin-Ciocalteu index ( 36.86 +/- 0.12) stood out among the examined samples. Finally, the same wine was enriched with ellagic and gallic acids ( 3.44 +/- 0.29 and 27.46 +/- 0.21 mg/L, respectively), catechin ( 135.16 +/- 6.47 mg/L) and epicatechin ( 51.33 +/- 2.33 mg/L), the natural products known to exert significant lipid-lowering effects. Taken all together, the clone No. 010 developed in Serbia may offer new Cabernet Franc wine with geographical indication. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics",
volume = "30",
number = "15",
pages = "1762-1765",
doi = "10.1080/14786419.2015.1135148"
}
Pejin, B., Stanimirović, B., Vujović, D., Popović-Đorđevic, J., Veličković, M.,& Tešević, V.. (2016). The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(15), 1762-1765.
https://doi.org/10.1080/14786419.2015.1135148
Pejin B, Stanimirović B, Vujović D, Popović-Đorđevic J, Veličković M, Tešević V. The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics. in Natural Product Research. 2016;30(15):1762-1765.
doi:10.1080/14786419.2015.1135148 .
Pejin, Boris, Stanimirović, Bojana, Vujović, Dragan, Popović-Đorđevic, Jelena, Veličković, Milovan, Tešević, Vele, "The natural product content of the selected Cabernet Franc wine samples originating from Serbia: a case study of phenolics" in Natural Product Research, 30, no. 15 (2016):1762-1765,
https://doi.org/10.1080/14786419.2015.1135148 . .
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14

A novel β-orcinol depsidone of lichen lobaria pulmonaria

Pejin, Boris; Iodice, Carmine; Stanimirović, Bojana; Vajs, Vlatka; Tešević, Vele

(2014)

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Stanimirović, Bojana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/285
AB  - In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.
T2  - Asian Journal of Chemistry
T1  - A novel β-orcinol depsidone of lichen lobaria pulmonaria
VL  - 26
IS  - 23
SP  - 8257
EP  - 8258
DO  - 10.14233/ajchem.2014.17834
ER  - 
@article{
author = "Pejin, Boris and Iodice, Carmine and Stanimirović, Bojana and Vajs, Vlatka and Tešević, Vele",
year = "2014",
abstract = "In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.",
journal = "Asian Journal of Chemistry",
title = "A novel β-orcinol depsidone of lichen lobaria pulmonaria",
volume = "26",
number = "23",
pages = "8257-8258",
doi = "10.14233/ajchem.2014.17834"
}
Pejin, B., Iodice, C., Stanimirović, B., Vajs, V.,& Tešević, V.. (2014). A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry, 26(23), 8257-8258.
https://doi.org/10.14233/ajchem.2014.17834
Pejin B, Iodice C, Stanimirović B, Vajs V, Tešević V. A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry. 2014;26(23):8257-8258.
doi:10.14233/ajchem.2014.17834 .
Pejin, Boris, Iodice, Carmine, Stanimirović, Bojana, Vajs, Vlatka, Tešević, Vele, "A novel β-orcinol depsidone of lichen lobaria pulmonaria" in Asian Journal of Chemistry, 26, no. 23 (2014):8257-8258,
https://doi.org/10.14233/ajchem.2014.17834 . .
1

Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples

Lolić, Aleksandar; Tripkovic, Tatjana; Baošić, Rada; Nikolić-Mandić, Snežana D.; Stanimirović, Bojana

(Serbian Chemical Soc, Belgrade, 2012)

TY  - JOUR
AU  - Lolić, Aleksandar
AU  - Tripkovic, Tatjana
AU  - Baošić, Rada
AU  - Nikolić-Mandić, Snežana D.
AU  - Stanimirović, Bojana
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1569
AB  - A gas-diffusion flow injection method with amperometric detection for the indirect determination of copper on a silver electrode was developed. The flow through system was equipped with two injection valves and a gas-diffusion unit. In the first step, a signal of a cyanide solution was recorded. In the subsequent step, the signal of cyanide in the presence of copper was measured. Interferences (Cd(II), Co(II), Ag(I), Ni(II), Fe(III), Hg(II) and Zn(II)) were investigated and successfully removed. The calibration graph was linear in the range 1-90 mu mol dm(-3) of copper with a correlation coefficient of 0.993. The regression equation is I = (0.0455 +/- 0.0015)c + (0.4611 +/- 0.0671), where I is the relative signal decrease in mu A and c is concentration in mu mol dm(-3). Relative standard deviation for six consecutive injections of 30 mu mol dm(-3) copper(II) was 1.47 % and for 1 mu mol dm(-3) copper(II), it was 3.40 %. The detection limit, calculated as 3 s/m (where s is a standard deviation of nine measurement of a reagent blank and m is the slope of the calibration curve), was 0.32 mu mol dm(-3), which corresponds to 2.44 ng of copper(II) (the loop volume was 0.12 cm(3)). The method enables 60 analyses per hour and it was successfully applied for the determination of copper in drinking water samples.
AB  - Cilj ovog rada bio je razvoj gasno-difuzione protočno injekcione metode sa amperometrijskom detekcijom za indirektno određivanje bakra na srebrnoj elektrodi. Protočni sistem je opremljen sa dva injekciona ventila i gasno-difuzionom jedinicom. U prvom koraku snima se signal rastvora cijanida, a u drugom snima se signal pri istovremenom ubrizgavanju rastvora cijanida i rastvora bakra. Smetnje od Cd(II), Co(II), Ag(I), Ni(II), Fe(III), Hg(II) i Zn(II) su ispitane i uspešno uklonjene. Kalibraciona kriva je linearna u opsegu 1-90 μmol dm-3 bakra, koeficijent korelacije je 0,993, a jednačina prave I = (0,0455±0,0015)c + (0,4611±0,0671), gde je I razlika visine signala u μA, a c je koncentracija u μmol dm-3. Relativna standardna devijacija za šest uzastopnih ubrizgavanja rastvora bakra koncentracije 30 μmol dm-3 je 1,47 %, a za 1 μmol dm-3 rastvor Cu(II) je 3,40 %. Limit detekcije, izračunat kao 3s/m (gde je s standardna devijacija devet merenja slepe probe i m je nagib kalibracione prave), je 0,32 μmol dm-3, što odgovara 2,44 ng Cu(II) (zapremina petlje za uzorak je 0,12 cm3). Metoda omogućava 60 analiza po jednom satu i uspešno je primenjena za određivanje bakra u pijaćoj vodi.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples
T1  - Razvoj protočne injekcione metode za indirektno određivanje bakra sa amperometrijskom detekcijom u pijaćoj vodi
VL  - 77
IS  - 11
SP  - 1641
EP  - 1647
DO  - 10.2298/JSC120616090L
ER  - 
@article{
author = "Lolić, Aleksandar and Tripkovic, Tatjana and Baošić, Rada and Nikolić-Mandić, Snežana D. and Stanimirović, Bojana",
year = "2012",
abstract = "A gas-diffusion flow injection method with amperometric detection for the indirect determination of copper on a silver electrode was developed. The flow through system was equipped with two injection valves and a gas-diffusion unit. In the first step, a signal of a cyanide solution was recorded. In the subsequent step, the signal of cyanide in the presence of copper was measured. Interferences (Cd(II), Co(II), Ag(I), Ni(II), Fe(III), Hg(II) and Zn(II)) were investigated and successfully removed. The calibration graph was linear in the range 1-90 mu mol dm(-3) of copper with a correlation coefficient of 0.993. The regression equation is I = (0.0455 +/- 0.0015)c + (0.4611 +/- 0.0671), where I is the relative signal decrease in mu A and c is concentration in mu mol dm(-3). Relative standard deviation for six consecutive injections of 30 mu mol dm(-3) copper(II) was 1.47 % and for 1 mu mol dm(-3) copper(II), it was 3.40 %. The detection limit, calculated as 3 s/m (where s is a standard deviation of nine measurement of a reagent blank and m is the slope of the calibration curve), was 0.32 mu mol dm(-3), which corresponds to 2.44 ng of copper(II) (the loop volume was 0.12 cm(3)). The method enables 60 analyses per hour and it was successfully applied for the determination of copper in drinking water samples., Cilj ovog rada bio je razvoj gasno-difuzione protočno injekcione metode sa amperometrijskom detekcijom za indirektno određivanje bakra na srebrnoj elektrodi. Protočni sistem je opremljen sa dva injekciona ventila i gasno-difuzionom jedinicom. U prvom koraku snima se signal rastvora cijanida, a u drugom snima se signal pri istovremenom ubrizgavanju rastvora cijanida i rastvora bakra. Smetnje od Cd(II), Co(II), Ag(I), Ni(II), Fe(III), Hg(II) i Zn(II) su ispitane i uspešno uklonjene. Kalibraciona kriva je linearna u opsegu 1-90 μmol dm-3 bakra, koeficijent korelacije je 0,993, a jednačina prave I = (0,0455±0,0015)c + (0,4611±0,0671), gde je I razlika visine signala u μA, a c je koncentracija u μmol dm-3. Relativna standardna devijacija za šest uzastopnih ubrizgavanja rastvora bakra koncentracije 30 μmol dm-3 je 1,47 %, a za 1 μmol dm-3 rastvor Cu(II) je 3,40 %. Limit detekcije, izračunat kao 3s/m (gde je s standardna devijacija devet merenja slepe probe i m je nagib kalibracione prave), je 0,32 μmol dm-3, što odgovara 2,44 ng Cu(II) (zapremina petlje za uzorak je 0,12 cm3). Metoda omogućava 60 analiza po jednom satu i uspešno je primenjena za određivanje bakra u pijaćoj vodi.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples, Razvoj protočne injekcione metode za indirektno određivanje bakra sa amperometrijskom detekcijom u pijaćoj vodi",
volume = "77",
number = "11",
pages = "1641-1647",
doi = "10.2298/JSC120616090L"
}
Lolić, A., Tripkovic, T., Baošić, R., Nikolić-Mandić, S. D.,& Stanimirović, B.. (2012). Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 77(11), 1641-1647.
https://doi.org/10.2298/JSC120616090L
Lolić A, Tripkovic T, Baošić R, Nikolić-Mandić SD, Stanimirović B. Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples. in Journal of the Serbian Chemical Society. 2012;77(11):1641-1647.
doi:10.2298/JSC120616090L .
Lolić, Aleksandar, Tripkovic, Tatjana, Baošić, Rada, Nikolić-Mandić, Snežana D., Stanimirović, Bojana, "Development of a flow injection method with amperometric detection for the indirect determination of copper in drinking water samples" in Journal of the Serbian Chemical Society, 77, no. 11 (2012):1641-1647,
https://doi.org/10.2298/JSC120616090L . .
1
2
2
1

Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal

Aćimović, Jelena M.; Stanimirović, Bojana; Todorović, Nina; Jovanović, Vesna B.; Mandić, Ljuba M.

(Elsevier Ireland Ltd, Clare, 2010)

TY  - JOUR
AU  - Aćimović, Jelena M.
AU  - Stanimirović, Bojana
AU  - Todorović, Nina
AU  - Jovanović, Vesna B.
AU  - Mandić, Ljuba M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1122
AB  - Methylglyoxal (MG), a reactive alpha-oxoaldehyde that is produced in higher quantities in diabetes, uremia, oxidative stress, aging and inflammation, reacts with the thiol groups (in addition to the amino and guanidino groups) of proteins. This causes protein modification, formation of advanced glycated end products (AGEs) and cross-linking. Low molecular mass thiols can be used as competitive targets for MG, preventing the reactions mentioned above. Therefore, this paper investigated how the microenvironment of the thiol group in low molecular mass thiols (cysteine, N-acetylcysteine (NAcCys), carboxymethylcysteine (CMC) and glutathione (GSH)) and human serum albumin (HSA) affected the thiol reaction with MG. The SH group reaction course was monitored by (1)H-NMR spectroscopy and spectrophotometric quantification. Changes in the HSA molecules were monitored by SDS-PAGE. The microenvironment of the SH group had a major effect on its reactivity and on the product yield. The reactivity of SH groups decreased in the order Cys  gt  GSH  gt  NAcCys. CMC did not react. The percentages of the reacted SH groups in the equilibrium state were almost equal, regardless of the ratio of thiol compound/MG (1:1, 1:2, 1:5): 38.1 +/- 0.9%; 38.2 +/- 0.7% and 39.0 +/- 0.8% for Cys; 26.5 +/- 0.6%; 26.6 +/- 2.6% and 27.4 +/- 2.5% for GSH; 10.8 +/- 0.9%; and 11.2 +/- 0.7% and 12.2 +/- 0.9% for NAcCys, respectively. Our results explain why substances containing alpha-amino-beta-mercapto-ethane as a pharmacophore are successful scavengers of MG. In equilibrium, HSA SH reacted in high percentages both with an insufficient amount and with an excess of MG (55% and 65%, respectively). An analysis of the hydrophobicity of the microenvironment of the SH group on the HSA surface showed that it could contribute to high levels of SH modification, leading to an increase in the scavenging activity of the albumin thiol. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-biological Interactions
T1  - Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal
VL  - 188
IS  - 1
SP  - 21
EP  - 30
DO  - 10.1016/j.cbi.2010.07.013
ER  - 
@article{
author = "Aćimović, Jelena M. and Stanimirović, Bojana and Todorović, Nina and Jovanović, Vesna B. and Mandić, Ljuba M.",
year = "2010",
abstract = "Methylglyoxal (MG), a reactive alpha-oxoaldehyde that is produced in higher quantities in diabetes, uremia, oxidative stress, aging and inflammation, reacts with the thiol groups (in addition to the amino and guanidino groups) of proteins. This causes protein modification, formation of advanced glycated end products (AGEs) and cross-linking. Low molecular mass thiols can be used as competitive targets for MG, preventing the reactions mentioned above. Therefore, this paper investigated how the microenvironment of the thiol group in low molecular mass thiols (cysteine, N-acetylcysteine (NAcCys), carboxymethylcysteine (CMC) and glutathione (GSH)) and human serum albumin (HSA) affected the thiol reaction with MG. The SH group reaction course was monitored by (1)H-NMR spectroscopy and spectrophotometric quantification. Changes in the HSA molecules were monitored by SDS-PAGE. The microenvironment of the SH group had a major effect on its reactivity and on the product yield. The reactivity of SH groups decreased in the order Cys  gt  GSH  gt  NAcCys. CMC did not react. The percentages of the reacted SH groups in the equilibrium state were almost equal, regardless of the ratio of thiol compound/MG (1:1, 1:2, 1:5): 38.1 +/- 0.9%; 38.2 +/- 0.7% and 39.0 +/- 0.8% for Cys; 26.5 +/- 0.6%; 26.6 +/- 2.6% and 27.4 +/- 2.5% for GSH; 10.8 +/- 0.9%; and 11.2 +/- 0.7% and 12.2 +/- 0.9% for NAcCys, respectively. Our results explain why substances containing alpha-amino-beta-mercapto-ethane as a pharmacophore are successful scavengers of MG. In equilibrium, HSA SH reacted in high percentages both with an insufficient amount and with an excess of MG (55% and 65%, respectively). An analysis of the hydrophobicity of the microenvironment of the SH group on the HSA surface showed that it could contribute to high levels of SH modification, leading to an increase in the scavenging activity of the albumin thiol. (C) 2010 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-biological Interactions",
title = "Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal",
volume = "188",
number = "1",
pages = "21-30",
doi = "10.1016/j.cbi.2010.07.013"
}
Aćimović, J. M., Stanimirović, B., Todorović, N., Jovanović, V. B.,& Mandić, L. M.. (2010). Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal. in Chemico-biological Interactions
Elsevier Ireland Ltd, Clare., 188(1), 21-30.
https://doi.org/10.1016/j.cbi.2010.07.013
Aćimović JM, Stanimirović B, Todorović N, Jovanović VB, Mandić LM. Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal. in Chemico-biological Interactions. 2010;188(1):21-30.
doi:10.1016/j.cbi.2010.07.013 .
Aćimović, Jelena M., Stanimirović, Bojana, Todorović, Nina, Jovanović, Vesna B., Mandić, Ljuba M., "Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal" in Chemico-biological Interactions, 188, no. 1 (2010):21-30,
https://doi.org/10.1016/j.cbi.2010.07.013 . .
20
15
19
18

The role of the thiol group in protein modification with methylglyoxal

Aćimović, Jelena M.; Stanimirović, Bojana; Mandić, Ljuba M.

(Serbian Chemical Soc, Belgrade, 2009)

TY  - JOUR
AU  - Aćimović, Jelena M.
AU  - Stanimirović, Bojana
AU  - Mandić, Ljuba M.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1015
AB  - Methylglyoxal is a highly reactive a-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction of the Cys thiol group with methylglyoxal in protein modification, the competitiveness of this reaction with those of amino and guanidine groups, the time course of these reactions and their role and contribution to protein cross-linking were investigated. Human and bovine serum albumins were used as model systems. It was found that despite the very low levels of thiol groups on the surface of the examined protein molecules (approx. 80 times lower than those of amino and guanidino groups), a very high percentage of it reacts (25-85%). The amount of reacted thiol groups and the rate of the reaction, the time for the reaction to reach equilibrium, the formation of a stable product and the contribution of thiol groups to protein cross-linking depend on the methylglyoxal concentration. The product formed in the reaction of thiol and an insufficient quantity of methylglyoxal (compared to the concentrations of the groups accessible for modification) participates to a significant extent (4%) to protein cross-linking. Metformin applied in equimolar concentration with methylglyoxal prevents its reaction with amino and guanidino groups but, however, not with thiol groups.
AB  - Metilglioksal je veoma reaktivni α-oksoaldehid koji se povećano stvara u hiperglikemiji. Reaguje sa nukleofilnim grupama bočnih ostataka Lys, Arg i N-terminalnom amino-grupom, što dovodi do modifikacije proteina. U ovom radu ispitivani su značaj reakcije SH grupe sa metilglioksalom u modifikaciji proteina, konkurentnost ove reakcije u odnosu na reakcije sa amino- i gvanidino-grupom, tok ovih reakcija i njihova uloga i doprinos u umrežavanju proteina. Kao model-sistemi upotrebljeni su humani i goveđi serum-albumin. Utvrđeno je da i pored veoma male zastupljenosti SH grupe na površini ispitivanih molekula proteina (oko 80 puta manja u odnosu na ukupan broj amino- i gvanidino-grupa), ona reaguje u velikom procentu (od 25-85 %). Količina izreagovanih SH grupa i brzina reakcije, vreme uspostavljanja ravnoteže reakcije, stvaranja stabilnog proizvoda i doprinos SH grupa umrežavanju proteina zavise od koncentracije metilglioksala. Proizvod stvoren u reakciji SH grupa i nedovoljne količine metilglioksala (u odnosu na koncentraciju grupa dostupnih za modifikaciju) učestvuje u umrežavanju proteina sa značajnim udelom (4 %). U ekvimolarnoj koncentraciji sa metilglioksalom metformin sprečava njegovu reakciju sa amino i guanidino grupama albumina, ali ne i sa tiol grupom.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - The role of the thiol group in protein modification with methylglyoxal
T1  - Uloga tiolne grupe u modifikaciji proteina sa metilglioksalom
VL  - 74
IS  - 8-9
SP  - 867
EP  - 883
DO  - 10.2298/JSC0909867A
ER  - 
@article{
author = "Aćimović, Jelena M. and Stanimirović, Bojana and Mandić, Ljuba M.",
year = "2009",
abstract = "Methylglyoxal is a highly reactive a-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction of the Cys thiol group with methylglyoxal in protein modification, the competitiveness of this reaction with those of amino and guanidine groups, the time course of these reactions and their role and contribution to protein cross-linking were investigated. Human and bovine serum albumins were used as model systems. It was found that despite the very low levels of thiol groups on the surface of the examined protein molecules (approx. 80 times lower than those of amino and guanidino groups), a very high percentage of it reacts (25-85%). The amount of reacted thiol groups and the rate of the reaction, the time for the reaction to reach equilibrium, the formation of a stable product and the contribution of thiol groups to protein cross-linking depend on the methylglyoxal concentration. The product formed in the reaction of thiol and an insufficient quantity of methylglyoxal (compared to the concentrations of the groups accessible for modification) participates to a significant extent (4%) to protein cross-linking. Metformin applied in equimolar concentration with methylglyoxal prevents its reaction with amino and guanidino groups but, however, not with thiol groups., Metilglioksal je veoma reaktivni α-oksoaldehid koji se povećano stvara u hiperglikemiji. Reaguje sa nukleofilnim grupama bočnih ostataka Lys, Arg i N-terminalnom amino-grupom, što dovodi do modifikacije proteina. U ovom radu ispitivani su značaj reakcije SH grupe sa metilglioksalom u modifikaciji proteina, konkurentnost ove reakcije u odnosu na reakcije sa amino- i gvanidino-grupom, tok ovih reakcija i njihova uloga i doprinos u umrežavanju proteina. Kao model-sistemi upotrebljeni su humani i goveđi serum-albumin. Utvrđeno je da i pored veoma male zastupljenosti SH grupe na površini ispitivanih molekula proteina (oko 80 puta manja u odnosu na ukupan broj amino- i gvanidino-grupa), ona reaguje u velikom procentu (od 25-85 %). Količina izreagovanih SH grupa i brzina reakcije, vreme uspostavljanja ravnoteže reakcije, stvaranja stabilnog proizvoda i doprinos SH grupa umrežavanju proteina zavise od koncentracije metilglioksala. Proizvod stvoren u reakciji SH grupa i nedovoljne količine metilglioksala (u odnosu na koncentraciju grupa dostupnih za modifikaciju) učestvuje u umrežavanju proteina sa značajnim udelom (4 %). U ekvimolarnoj koncentraciji sa metilglioksalom metformin sprečava njegovu reakciju sa amino i guanidino grupama albumina, ali ne i sa tiol grupom.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "The role of the thiol group in protein modification with methylglyoxal, Uloga tiolne grupe u modifikaciji proteina sa metilglioksalom",
volume = "74",
number = "8-9",
pages = "867-883",
doi = "10.2298/JSC0909867A"
}
Aćimović, J. M., Stanimirović, B.,& Mandić, L. M.. (2009). The role of the thiol group in protein modification with methylglyoxal. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(8-9), 867-883.
https://doi.org/10.2298/JSC0909867A
Aćimović JM, Stanimirović B, Mandić LM. The role of the thiol group in protein modification with methylglyoxal. in Journal of the Serbian Chemical Society. 2009;74(8-9):867-883.
doi:10.2298/JSC0909867A .
Aćimović, Jelena M., Stanimirović, Bojana, Mandić, Ljuba M., "The role of the thiol group in protein modification with methylglyoxal" in Journal of the Serbian Chemical Society, 74, no. 8-9 (2009):867-883,
https://doi.org/10.2298/JSC0909867A . .
28
26
27
27

Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue

Jankovic, J.; Aćimović, Jelena M.; Stanimirović, Bojana; Ivanovska, J.; Mandić, Ljuba M.

(Blackwell Publishing, Oxford, 2007)

TY  - CONF
AU  - Jankovic, J.
AU  - Aćimović, Jelena M.
AU  - Stanimirović, Bojana
AU  - Ivanovska, J.
AU  - Mandić, Ljuba M.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/916
PB  - Blackwell Publishing, Oxford
C3  - FEBS Journal / Federation of European of Biochemical Societies
T1  - Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue
VL  - 274
SP  - 241
EP  - 241
UR  - https://hdl.handle.net/21.15107/rcub_cherry_916
ER  - 
@conference{
author = "Jankovic, J. and Aćimović, Jelena M. and Stanimirović, Bojana and Ivanovska, J. and Mandić, Ljuba M.",
year = "2007",
publisher = "Blackwell Publishing, Oxford",
journal = "FEBS Journal / Federation of European of Biochemical Societies",
title = "Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue",
volume = "274",
pages = "241-241",
url = "https://hdl.handle.net/21.15107/rcub_cherry_916"
}
Jankovic, J., Aćimović, J. M., Stanimirović, B., Ivanovska, J.,& Mandić, L. M.. (2007). Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue. in FEBS Journal / Federation of European of Biochemical Societies
Blackwell Publishing, Oxford., 274, 241-241.
https://hdl.handle.net/21.15107/rcub_cherry_916
Jankovic J, Aćimović JM, Stanimirović B, Ivanovska J, Mandić LM. Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue. in FEBS Journal / Federation of European of Biochemical Societies. 2007;274:241-241.
https://hdl.handle.net/21.15107/rcub_cherry_916 .
Jankovic, J., Aćimović, Jelena M., Stanimirović, Bojana, Ivanovska, J., Mandić, Ljuba M., "Biochemical characterization of advanced glycation end products: Modifications of thiol amino-acid residue" in FEBS Journal / Federation of European of Biochemical Societies, 274 (2007):241-241,
https://hdl.handle.net/21.15107/rcub_cherry_916 .

Kinetics of reaction of human serum albumine with methyl-glyoxal

Ivanovska, J.; Jankovic, J.; Aćimović, Jelena M.; Stanimirović, Bojana; Mandić, Ljuba M.

(Blackwell Publishing, Oxford, 2007)

TY  - CONF
AU  - Ivanovska, J.
AU  - Jankovic, J.
AU  - Aćimović, Jelena M.
AU  - Stanimirović, Bojana
AU  - Mandić, Ljuba M.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/917
PB  - Blackwell Publishing, Oxford
C3  - FEBS Journal / Federation of European of Biochemical Societies
T1  - Kinetics of reaction of human serum albumine with methyl-glyoxal
VL  - 274
SP  - 241
EP  - 241
UR  - https://hdl.handle.net/21.15107/rcub_cherry_917
ER  - 
@conference{
author = "Ivanovska, J. and Jankovic, J. and Aćimović, Jelena M. and Stanimirović, Bojana and Mandić, Ljuba M.",
year = "2007",
publisher = "Blackwell Publishing, Oxford",
journal = "FEBS Journal / Federation of European of Biochemical Societies",
title = "Kinetics of reaction of human serum albumine with methyl-glyoxal",
volume = "274",
pages = "241-241",
url = "https://hdl.handle.net/21.15107/rcub_cherry_917"
}
Ivanovska, J., Jankovic, J., Aćimović, J. M., Stanimirović, B.,& Mandić, L. M.. (2007). Kinetics of reaction of human serum albumine with methyl-glyoxal. in FEBS Journal / Federation of European of Biochemical Societies
Blackwell Publishing, Oxford., 274, 241-241.
https://hdl.handle.net/21.15107/rcub_cherry_917
Ivanovska J, Jankovic J, Aćimović JM, Stanimirović B, Mandić LM. Kinetics of reaction of human serum albumine with methyl-glyoxal. in FEBS Journal / Federation of European of Biochemical Societies. 2007;274:241-241.
https://hdl.handle.net/21.15107/rcub_cherry_917 .
Ivanovska, J., Jankovic, J., Aćimović, Jelena M., Stanimirović, Bojana, Mandić, Ljuba M., "Kinetics of reaction of human serum albumine with methyl-glyoxal" in FEBS Journal / Federation of European of Biochemical Societies, 274 (2007):241-241,
https://hdl.handle.net/21.15107/rcub_cherry_917 .