TY  - JOUR
AU  - Vujovic, Katarina R. Savic
AU  - Vuckovic, Sonja
AU  - Srebro, Dragana
AU  - Ivanović, Milovan
AU  - Došen-Mićović, Ljiljana
AU  - Vucetic, Cedomir
AU  - Dzoljic, Eleonora
AU  - Prostran, Milica
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1633
AB  - In addition to producing antinociception, opioids exert profound effects on body temperature. This study aimed at comparing antinociceptive and hyperthermic responses between two groups of mu-opioid receptor agonists: fentanyl (4-anilinopiperidine-type) and morphine (phenanthrene-type) derivatives in rats. Analgesic activity was assessed by tail immersion test and the body temperature by insertion of a thermometer probe into the colon. Fentanyl (F), (+/-)-cis-3-methyl fentanyl (CM), (+/-)-cis-3-carbomethoxy fentanyl (C), (+/-)trans-3-carbomethoxy fentanyl (T) and (+/-)-cis-3 butyl fentanyl (B) produced dose-dependent increase in antinociception and hyperthermia. The relative order of analgesic potency was: CM(11.27) gt  F(1) gt  C(0.35)a parts per thousand yenT(0.11)a parts per thousand yenB(0.056). Similar to this, the relative order of hyperthermic potency was: CM(8.43) gt  F(1) gt  C(0.46)a parts per thousand yenT(0.11)a parts per thousand yenB(0.076). Morphine (M), oxycodone (O), thebacon (T) and 6,14-ethenomorphinan-7-methanol, 4,5-epoxy-6-fluoro-3-hydroxy-alpha,alpha,17-trimethyl-, (5 alpha,7 alpha) (E) also produced dose-dependent increase in antinociception and hyperthermia. Among morphine derivatives the relative order of analgesic potency was: E(56) gt  O(5)a parts per thousand yenT(2.6) gt  M(1), and similar to this, the relative order of hyperthermic potency was: E(37) gt  O(3)a parts per thousand yenT(2.3) gt  M(1). Morphine (phenanthrene-type) and fentanyl (4-anilinopiperidine-type) derivatives produced hyperthermia in rats at doses about 2 times lower, and 6-11 times higher, than their median antinociceptive doses, respectively. This study is first to identify difference between these two classes of opioid drugs in their potencies in producing hyperthermia. Further studies are needed to clarify the significance of these findings.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats
VL  - 36
IS  - 4
SP  - 501
EP  - 508
DO  - 10.1007/s12272-013-0072-z
ER  - 

@article{
author = "Vujovic, Katarina R. Savic and Vuckovic, Sonja and Srebro, Dragana and Ivanović, Milovan and Došen-Mićović, Ljiljana and Vucetic, Cedomir and Dzoljic, Eleonora and Prostran, Milica",
year = "2013",
abstract = "In addition to producing antinociception, opioids exert profound effects on body temperature. This study aimed at comparing antinociceptive and hyperthermic responses between two groups of mu-opioid receptor agonists: fentanyl (4-anilinopiperidine-type) and morphine (phenanthrene-type) derivatives in rats. Analgesic activity was assessed by tail immersion test and the body temperature by insertion of a thermometer probe into the colon. Fentanyl (F), (+/-)-cis-3-methyl fentanyl (CM), (+/-)-cis-3-carbomethoxy fentanyl (C), (+/-)trans-3-carbomethoxy fentanyl (T) and (+/-)-cis-3 butyl fentanyl (B) produced dose-dependent increase in antinociception and hyperthermia. The relative order of analgesic potency was: CM(11.27) gt  F(1) gt  C(0.35)a parts per thousand yenT(0.11)a parts per thousand yenB(0.056). Similar to this, the relative order of hyperthermic potency was: CM(8.43) gt  F(1) gt  C(0.46)a parts per thousand yenT(0.11)a parts per thousand yenB(0.076). Morphine (M), oxycodone (O), thebacon (T) and 6,14-ethenomorphinan-7-methanol, 4,5-epoxy-6-fluoro-3-hydroxy-alpha,alpha,17-trimethyl-, (5 alpha,7 alpha) (E) also produced dose-dependent increase in antinociception and hyperthermia. Among morphine derivatives the relative order of analgesic potency was: E(56) gt  O(5)a parts per thousand yenT(2.6) gt  M(1), and similar to this, the relative order of hyperthermic potency was: E(37) gt  O(3)a parts per thousand yenT(2.3) gt  M(1). Morphine (phenanthrene-type) and fentanyl (4-anilinopiperidine-type) derivatives produced hyperthermia in rats at doses about 2 times lower, and 6-11 times higher, than their median antinociceptive doses, respectively. This study is first to identify difference between these two classes of opioid drugs in their potencies in producing hyperthermia. Further studies are needed to clarify the significance of these findings.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats",
volume = "36",
number = "4",
pages = "501-508",
doi = "10.1007/s12272-013-0072-z"
}

Vujovic, K. R. S., Vuckovic, S., Srebro, D., Ivanović, M., Došen-Mićović, L., Vucetic, C., Dzoljic, E.,& Prostran, M.. (2013). A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 36(4), 501-508.
https://doi.org/10.1007/s12272-013-0072-z

Vujovic KRS, Vuckovic S, Srebro D, Ivanović M, Došen-Mićović L, Vucetic C, Dzoljic E, Prostran M. A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats. in Archives of Pharmacal Research. 2013;36(4):501-508.
doi:10.1007/s12272-013-0072-z .

Vujovic, Katarina R. Savic, Vuckovic, Sonja, Srebro, Dragana, Ivanović, Milovan, Došen-Mićović, Ljiljana, Vucetic, Cedomir, Dzoljic, Eleonora, Prostran, Milica, "A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats" in Archives of Pharmacal Research, 36, no. 4 (2013):501-508,
https://doi.org/10.1007/s12272-013-0072-z . .

TY  - JOUR
AU  - Senćanski, Milan
AU  - Ivanović, Milovan
AU  - Vuckovic, Sonja
AU  - Došen-Mićović, Ljiljana
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1207
AB  - An automated docking procedure was applied to study the binding of a series of mu- and delta-selective ligands to ligand-specific mu- and delta-opioid receptor models. Short-time molecular dynamic simulations were used to obtain ligand-specific mu- and delta-opioid receptors from arbitrarily chosen models of the active form of these receptors. The quality of receptor model depended on the molecular volume of the ligand in the receptor-ligand complex used in the molecular dynamic simulations. Within a series of ligands of similar size (volume), the results of ligand docking to the obtained ligand-specific receptor conformation were in agreement with point mutation studies. The correlation of the calculated and the experimentally determined binding energies was improved in relation to the initial receptor conformation.
AB  - Računska metoda automatizovanog dokiranja primenjena je na vezivanje serije liganada, specifičnih za µ- i δ-receptore, za modele ovih receptora. Kratkotrajna molekulsko dinamička simulacija je korišćena za dobijanje konformacija ovih receptora koje su specifične za pojedine ligande, polazeći od slučajno izabranog modela aktiviranog receptora. Kvalitet ovako dobijenog modela receptora zavisi od molekulske zapremine liganda u ligand-receptor kompleksu korišćenog u molekulsko-dinamičkoj simulaciji. Za seriju liganda slične zapremine rezultati dokiranja su u skladu sa eksperimentalnim rezltatima mutacija aminokiselina u receptoru. Korelacija izračunatih i merenih energija vezivanja je poboljšana u odnosu na rezultate dobijene sa polaznom konformacijom receptora.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Modeling the ligand specific mu- and delta-opioid receptor conformations
T1  - Modelovanje konformacija µ- i δ-opioidnih receptora specifičnih za pojedine ligande
VL  - 76
IS  - 9
SP  - 1247
EP  - 1262
DO  - 10.2298/JSC110120110S
ER  - 

@article{
author = "Senćanski, Milan and Ivanović, Milovan and Vuckovic, Sonja and Došen-Mićović, Ljiljana",
year = "2011",
abstract = "An automated docking procedure was applied to study the binding of a series of mu- and delta-selective ligands to ligand-specific mu- and delta-opioid receptor models. Short-time molecular dynamic simulations were used to obtain ligand-specific mu- and delta-opioid receptors from arbitrarily chosen models of the active form of these receptors. The quality of receptor model depended on the molecular volume of the ligand in the receptor-ligand complex used in the molecular dynamic simulations. Within a series of ligands of similar size (volume), the results of ligand docking to the obtained ligand-specific receptor conformation were in agreement with point mutation studies. The correlation of the calculated and the experimentally determined binding energies was improved in relation to the initial receptor conformation., Računska metoda automatizovanog dokiranja primenjena je na vezivanje serije liganada, specifičnih za µ- i δ-receptore, za modele ovih receptora. Kratkotrajna molekulsko dinamička simulacija je korišćena za dobijanje konformacija ovih receptora koje su specifične za pojedine ligande, polazeći od slučajno izabranog modela aktiviranog receptora. Kvalitet ovako dobijenog modela receptora zavisi od molekulske zapremine liganda u ligand-receptor kompleksu korišćenog u molekulsko-dinamičkoj simulaciji. Za seriju liganda slične zapremine rezultati dokiranja su u skladu sa eksperimentalnim rezltatima mutacija aminokiselina u receptoru. Korelacija izračunatih i merenih energija vezivanja je poboljšana u odnosu na rezultate dobijene sa polaznom konformacijom receptora.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Modeling the ligand specific mu- and delta-opioid receptor conformations, Modelovanje konformacija µ- i δ-opioidnih receptora specifičnih za pojedine ligande",
volume = "76",
number = "9",
pages = "1247-1262",
doi = "10.2298/JSC110120110S"
}

Senćanski, M., Ivanović, M., Vuckovic, S.,& Došen-Mićović, L.. (2011). Modeling the ligand specific mu- and delta-opioid receptor conformations. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 76(9), 1247-1262.
https://doi.org/10.2298/JSC110120110S

Senćanski M, Ivanović M, Vuckovic S, Došen-Mićović L. Modeling the ligand specific mu- and delta-opioid receptor conformations. in Journal of the Serbian Chemical Society. 2011;76(9):1247-1262.
doi:10.2298/JSC110120110S .

Senćanski, Milan, Ivanović, Milovan, Vuckovic, Sonja, Došen-Mićović, Ljiljana, "Modeling the ligand specific mu- and delta-opioid receptor conformations" in Journal of the Serbian Chemical Society, 76, no. 9 (2011):1247-1262,
https://doi.org/10.2298/JSC110120110S . .