TY  - JOUR
AU  - Aničić, Neda
AU  - Gašić, Uroš M.
AU  - Lu, Feng
AU  - Ćirić, Ana
AU  - Ivanov, Marija
AU  - Jevtić, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban D.
AU  - Skorić, Marijana
AU  - Nestorović Živković, Jasmina
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Mišić, Danijela
PY  - 2021
UR  - https://www.mdpi.com/1424-8247/14/5/414
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4444
AB  - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
PB  - MDPI
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
VL  - 14
IS  - 5
SP  - 414
DO  - 10.3390/ph14050414
ER  - 

@article{
author = "Aničić, Neda and Gašić, Uroš M. and Lu, Feng and Ćirić, Ana and Ivanov, Marija and Jevtić, Bojan and Dimitrijević, Milena and Anđelković, Boban D. and Skorić, Marijana and Nestorović Živković, Jasmina and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Mišić, Danijela",
year = "2021",
abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.",
publisher = "MDPI",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources",
volume = "14",
number = "5",
pages = "414",
doi = "10.3390/ph14050414"
}

Aničić, N., Gašić, U. M., Lu, F., Ćirić, A., Ivanov, M., Jevtić, B., Dimitrijević, M., Anđelković, B. D., Skorić, M., Nestorović Živković, J., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Mišić, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals
MDPI., 14(5), 414.
https://doi.org/10.3390/ph14050414

Aničić N, Gašić UM, Lu F, Ćirić A, Ivanov M, Jevtić B, Dimitrijević M, Anđelković BD, Skorić M, Nestorović Živković J, Mao Y, Liu J, Tang C, Soković M, Ye Y, Mišić D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5):414.
doi:10.3390/ph14050414 .

Aničić, Neda, Gašić, Uroš M., Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban D., Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021):414,
https://doi.org/10.3390/ph14050414 . .

TY  - DATA
AU  - Aničić, Neda
AU  - Gašić, Uroš M.
AU  - Lu, Feng
AU  - Ćirić, Ana
AU  - Ivanov, Marija
AU  - Jevtić, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban D.
AU  - Skorić, Marijana
AU  - Nestorović Živković, Jasmina
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Mišić, Danijela
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4445
PB  - MDPI
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.
VL  - 14
IS  - 5
SP  - 414
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4445
ER  - 

@misc{
author = "Aničić, Neda and Gašić, Uroš M. and Lu, Feng and Ćirić, Ana and Ivanov, Marija and Jevtić, Bojan and Dimitrijević, Milena and Anđelković, Boban D. and Skorić, Marijana and Nestorović Živković, Jasmina and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Mišić, Danijela",
year = "2021",
publisher = "MDPI",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.",
volume = "14",
number = "5",
pages = "414",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4445"
}

Aničić, N., Gašić, U. M., Lu, F., Ćirić, A., Ivanov, M., Jevtić, B., Dimitrijević, M., Anđelković, B. D., Skorić, M., Nestorović Živković, J., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Mišić, D.. (2021). Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.. in Pharmaceuticals
MDPI., 14(5), 414.
https://hdl.handle.net/21.15107/rcub_cherry_4445

Aničić N, Gašić UM, Lu F, Ćirić A, Ivanov M, Jevtić B, Dimitrijević M, Anđelković BD, Skorić M, Nestorović Živković J, Mao Y, Liu J, Tang C, Soković M, Ye Y, Mišić D. Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.. in Pharmaceuticals. 2021;14(5):414.
https://hdl.handle.net/21.15107/rcub_cherry_4445 .

Aničić, Neda, Gašić, Uroš M., Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban D., Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela, "Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414." in Pharmaceuticals, 14, no. 5 (2021):414,
https://hdl.handle.net/21.15107/rcub_cherry_4445 .