TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Prashar, Sanjiv
AU  - Polo-Ceron, Dorian
AU  - Fajardo, Mariano
AU  - Žižak, Željko S.
AU  - Sabo, Tibor
AU  - Juranić, Zorica D.
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/959
AB  - A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(eta(5)-C5Me4) (eta(5)-C5H3{CMe2CH2CH2CH=CH2})}Cl-2] (8), [Ti{Me(CH2=CH)Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (9) and [Ti(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (12) showed higher cytotoxic activities (IC50 values from 24 +/- 3 to 151 +/- 10 mu M) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (10) and [Ti{Me{(CH2=CH)(3)SiCH2CH2} Si(eta(5)-C5Me4)(eta(5) -C5H4)}Cl-2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 +/- 9 to  gt  200 mu M). In addition, the synthesis of the analogous niobocene complex [Nb(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported. (c) 2008 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs
VL  - 102
IS  - 8
SP  - 1558
EP  - 1570
DO  - 10.1016/j.jinorgbio.2008.02.001
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Prashar, Sanjiv and Polo-Ceron, Dorian and Fajardo, Mariano and Žižak, Željko S. and Sabo, Tibor and Juranić, Zorica D.",
year = "2008",
abstract = "A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(eta(5)-C5Me4) (eta(5)-C5H3{CMe2CH2CH2CH=CH2})}Cl-2] (8), [Ti{Me(CH2=CH)Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (9) and [Ti(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (12) showed higher cytotoxic activities (IC50 values from 24 +/- 3 to 151 +/- 10 mu M) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (10) and [Ti{Me{(CH2=CH)(3)SiCH2CH2} Si(eta(5)-C5Me4)(eta(5) -C5H4)}Cl-2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 +/- 9 to  gt  200 mu M). In addition, the synthesis of the analogous niobocene complex [Nb(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported. (c) 2008 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs",
volume = "102",
number = "8",
pages = "1558-1570",
doi = "10.1016/j.jinorgbio.2008.02.001"
}

Gomez-Ruiz, S., Kaluđerović, G. N., Prashar, S., Polo-Ceron, D., Fajardo, M., Žižak, Ž. S., Sabo, T.,& Juranić, Z. D.. (2008). Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 102(8), 1558-1570.
https://doi.org/10.1016/j.jinorgbio.2008.02.001

Gomez-Ruiz S, Kaluđerović GN, Prashar S, Polo-Ceron D, Fajardo M, Žižak ŽS, Sabo T, Juranić ZD. Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry. 2008;102(8):1558-1570.
doi:10.1016/j.jinorgbio.2008.02.001 .

Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Prashar, Sanjiv, Polo-Ceron, Dorian, Fajardo, Mariano, Žižak, Željko S., Sabo, Tibor, Juranić, Zorica D., "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs" in Journal of Inorganic Biochemistry, 102, no. 8 (2008):1558-1570,
https://doi.org/10.1016/j.jinorgbio.2008.02.001 . .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Polo-Ceron, Dorian
AU  - Prashar, Sanjiv
AU  - Fajardo, Mariano
AU  - Žižak, Žejko S.
AU  - Juranić, Zorica D.
AU  - Sabo, Tibor
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/847
AB  - The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Inorganic Chemistry Communications
T1  - Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes
VL  - 10
IS  - 7
SP  - 748
EP  - 752
DO  - 10.1016/j.inoche.2007.03.016
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Polo-Ceron, Dorian and Prashar, Sanjiv and Fajardo, Mariano and Žižak, Žejko S. and Juranić, Zorica D. and Sabo, Tibor",
year = "2007",
abstract = "The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Inorganic Chemistry Communications",
title = "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes",
volume = "10",
number = "7",
pages = "748-752",
doi = "10.1016/j.inoche.2007.03.016"
}

Gomez-Ruiz, S., Kaluđerović, G. N., Polo-Ceron, D., Prashar, S., Fajardo, M., Žižak, Ž. S., Juranić, Z. D.,& Sabo, T.. (2007). Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications
Elsevier Science Bv, Amsterdam., 10(7), 748-752.
https://doi.org/10.1016/j.inoche.2007.03.016

Gomez-Ruiz S, Kaluđerović GN, Polo-Ceron D, Prashar S, Fajardo M, Žižak ŽS, Juranić ZD, Sabo T. Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications. 2007;10(7):748-752.
doi:10.1016/j.inoche.2007.03.016 .

Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Polo-Ceron, Dorian, Prashar, Sanjiv, Fajardo, Mariano, Žižak, Žejko S., Juranić, Zorica D., Sabo, Tibor, "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes" in Inorganic Chemistry Communications, 10, no. 7 (2007):748-752,
https://doi.org/10.1016/j.inoche.2007.03.016 . .