TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Bukvicki, Danka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2150
AB  - A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger
VL  - 13
IS  - 4
SP  - 479
EP  - 482
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2150
ER  - 

@article{
author = "Novaković, Miroslav M. and Bukvicki, Danka and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan M. and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger",
volume = "13",
number = "4",
pages = "479-482",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2150"
}

Novaković, M. M., Bukvicki, D., Vajs, V., Tešević, V., Milosavljević, S. M., Marin, P. D.,& Asakawa, Y.. (2018). Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications
Natural Products Inc, Westerville., 13(4), 479-482.
https://hdl.handle.net/21.15107/rcub_cherry_2150

Novaković MM, Bukvicki D, Vajs V, Tešević V, Milosavljević SM, Marin PD, Asakawa Y. Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications. 2018;13(4):479-482.
https://hdl.handle.net/21.15107/rcub_cherry_2150 .

Novaković, Miroslav M., Bukvicki, Danka, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan M., Marin, Petar D., Asakawa, Yoshinori, "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger" in Natural Product Communications, 13, no. 4 (2018):479-482,
https://hdl.handle.net/21.15107/rcub_cherry_2150 .

TY  - CHAP
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Vujisić, Ljubodrag V.
AU  - Milosavljević, Slobodan M.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2841
AB  - The detection of illegal drugs in various samples has been among the most fascinating objects for the practicing analytical chemist involved in forensic analysis. For centuries (until the end of the nineteenth century), drugs were almost entirely of natural origin, mostly herbal, and in some cases slightly chemically modified (e.g., through acetylation of morphine to heroin). By the development of synthetic organic chemistry (commencing at the beginning of the twentieth century), quite a few synthetic drugs designed to mimic the pharmacological effects of drugs originating from natural sources have been designed (e.g., cannabimimetic indazole derivatives or amphetamines, etc.). Detection of such synthetic drugs, named “designer drugs,” due to a large number of new substances continuously emerging on the market, is crucial. The efficacy of this analysis has become a tremendous challenge in the analytical forensic field. A development of fast identification and structural characterization is greatly facilitated by the advent of modern spectroscopic techniques, namely nuclear magnetic resonance spectroscopy (NMR) and modern mass spectrometry (MS) as well as separation techniques, such as gas and liquid chromatography (GC and LC). Nowadays, rapid strategies for chemical characterizations of illicit drugs are available.
T2  - Chromatographic Techniques in the Forensic Analysis of Designer Drugs
T1  - NMR Spectroscopy in the Analysis of Illegal Drugs
SP  - 177
EP  - 197
DO  - 10.1201/9781315313177
ER  - 

@inbook{
author = "Vajs, Vlatka and Đorđević, Iris and Vujisić, Ljubodrag V. and Milosavljević, Slobodan M.",
year = "2018",
abstract = "The detection of illegal drugs in various samples has been among the most fascinating objects for the practicing analytical chemist involved in forensic analysis. For centuries (until the end of the nineteenth century), drugs were almost entirely of natural origin, mostly herbal, and in some cases slightly chemically modified (e.g., through acetylation of morphine to heroin). By the development of synthetic organic chemistry (commencing at the beginning of the twentieth century), quite a few synthetic drugs designed to mimic the pharmacological effects of drugs originating from natural sources have been designed (e.g., cannabimimetic indazole derivatives or amphetamines, etc.). Detection of such synthetic drugs, named “designer drugs,” due to a large number of new substances continuously emerging on the market, is crucial. The efficacy of this analysis has become a tremendous challenge in the analytical forensic field. A development of fast identification and structural characterization is greatly facilitated by the advent of modern spectroscopic techniques, namely nuclear magnetic resonance spectroscopy (NMR) and modern mass spectrometry (MS) as well as separation techniques, such as gas and liquid chromatography (GC and LC). Nowadays, rapid strategies for chemical characterizations of illicit drugs are available.",
journal = "Chromatographic Techniques in the Forensic Analysis of Designer Drugs",
booktitle = "NMR Spectroscopy in the Analysis of Illegal Drugs",
pages = "177-197",
doi = "10.1201/9781315313177"
}

Vajs, V., Đorđević, I., Vujisić, L. V.,& Milosavljević, S. M.. (2018). NMR Spectroscopy in the Analysis of Illegal Drugs. in Chromatographic Techniques in the Forensic Analysis of Designer Drugs, 177-197.
https://doi.org/10.1201/9781315313177

Vajs V, Đorđević I, Vujisić LV, Milosavljević SM. NMR Spectroscopy in the Analysis of Illegal Drugs. in Chromatographic Techniques in the Forensic Analysis of Designer Drugs. 2018;:177-197.
doi:10.1201/9781315313177 .

Vajs, Vlatka, Đorđević, Iris, Vujisić, Ljubodrag V., Milosavljević, Slobodan M., "NMR Spectroscopy in the Analysis of Illegal Drugs" in Chromatographic Techniques in the Forensic Analysis of Designer Drugs (2018):177-197,
https://doi.org/10.1201/9781315313177 . .

TY  - JOUR
AU  - Vajs, Vlatka
AU  - Jokić, Aleksandar
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2511
AB  - The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Artemisinin Story from the Balkans
VL  - 12
IS  - 8
SP  - 1157
EP  - 1160
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2511
ER  - 

@article{
author = "Vajs, Vlatka and Jokić, Aleksandar and Milosavljević, Slobodan M.",
year = "2017",
abstract = "The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Artemisinin Story from the Balkans",
volume = "12",
number = "8",
pages = "1157-1160",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2511"
}

Vajs, V., Jokić, A.,& Milosavljević, S. M.. (2017). Artemisinin Story from the Balkans. in Natural Product Communications
Natural Products Inc, Westerville., 12(8), 1157-1160.
https://hdl.handle.net/21.15107/rcub_cherry_2511

Vajs V, Jokić A, Milosavljević SM. Artemisinin Story from the Balkans. in Natural Product Communications. 2017;12(8):1157-1160.
https://hdl.handle.net/21.15107/rcub_cherry_2511 .

Vajs, Vlatka, Jokić, Aleksandar, Milosavljević, Slobodan M., "Artemisinin Story from the Balkans" in Natural Product Communications, 12, no. 8 (2017):1157-1160,
https://hdl.handle.net/21.15107/rcub_cherry_2511 .

TY  - JOUR
AU  - Makarov, Slobodan E.
AU  - Bodner, Michaela
AU  - Reineke, Doris
AU  - Vujisić, Ljubodrag V.
AU  - Todosijević, Marina
AU  - Antić, Dragan Ž.
AU  - Vagalinski, Boyan
AU  - Lučić, Luka
AU  - Mitić, Bojan M.
AU  - Mitov, Plamen
AU  - Anđelković, Boban D.
AU  - Lucić, Sofija Pavković
AU  - Vajs, Vlatka
AU  - Tomić, Vladimir T.
AU  - Raspotnig, Guenther
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2450
AB  - Cave animals live under highly constant ecological conditions and in permanent darkness, and many evolutionary adaptations of cave-dwellers have been triggered by their specific environment. A similar "cave effect" leading to pronounced chemical interactions under such conditions may be assumed, but the chemoecology of troglobionts is mostly unknown. We investigated the defensive chemistry of a largely cave-dwelling julid group, the controversial tribe "Typhloiulini", and we included some cave-dwelling and some endogean representatives. While chemical defense in juliform diplopods is known to be highly uniform, and mainly based on methyl- and methoxy-substituted benzoquinones, the defensive secretions of typhloiulines contained ethyl-benzoquinones and related compounds. Interestingly, ethyl-benzoquinones were found in some, but not all cave-dwelling typhloiulines, and some non-cave dwellers also contained these compounds. On the other hand, ethyl-benzoquinones were not detected in troglobiont nor in endogean typhloiuline outgroups. In order to explain the taxonomic pattern of ethyl-benzoquinone occurrence, and to unravel whether a cave-effect triggered ethyl-benzoquinone evolution, we classed the "Typhloiulini" investigated here within a phylogenetic framework of julid taxa, and traced the evolutionary history of ethyl-benzoquinones in typhloiulines in relation to cave-dwelling. The results indicated a cave-independent evolution of ethyl-substituted benzoquinones, indicating the absence of a "cave effect" on the secretions of troglobiont Typhloiulini. Ethyl-benzoquinones probably evolved early in an epi- or endogean ancestor of a clade including several, but not all Typhloiulus (basically comprising a taxonomic entity known as "Typhloiulus sensu stricto") and Serboiulus. Ethyl-benzoquinones are proposed as novel and valuable chemical characters for julid systematics.
PB  - Springer, Dordrecht
T2  - Journal of Chemical Ecology
T1  - Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae)
VL  - 43
IS  - 4
SP  - 317
EP  - 326
DO  - 10.1007/s10886-017-0832-1
ER  - 

@article{
author = "Makarov, Slobodan E. and Bodner, Michaela and Reineke, Doris and Vujisić, Ljubodrag V. and Todosijević, Marina and Antić, Dragan Ž. and Vagalinski, Boyan and Lučić, Luka and Mitić, Bojan M. and Mitov, Plamen and Anđelković, Boban D. and Lucić, Sofija Pavković and Vajs, Vlatka and Tomić, Vladimir T. and Raspotnig, Guenther",
year = "2017",
abstract = "Cave animals live under highly constant ecological conditions and in permanent darkness, and many evolutionary adaptations of cave-dwellers have been triggered by their specific environment. A similar "cave effect" leading to pronounced chemical interactions under such conditions may be assumed, but the chemoecology of troglobionts is mostly unknown. We investigated the defensive chemistry of a largely cave-dwelling julid group, the controversial tribe "Typhloiulini", and we included some cave-dwelling and some endogean representatives. While chemical defense in juliform diplopods is known to be highly uniform, and mainly based on methyl- and methoxy-substituted benzoquinones, the defensive secretions of typhloiulines contained ethyl-benzoquinones and related compounds. Interestingly, ethyl-benzoquinones were found in some, but not all cave-dwelling typhloiulines, and some non-cave dwellers also contained these compounds. On the other hand, ethyl-benzoquinones were not detected in troglobiont nor in endogean typhloiuline outgroups. In order to explain the taxonomic pattern of ethyl-benzoquinone occurrence, and to unravel whether a cave-effect triggered ethyl-benzoquinone evolution, we classed the "Typhloiulini" investigated here within a phylogenetic framework of julid taxa, and traced the evolutionary history of ethyl-benzoquinones in typhloiulines in relation to cave-dwelling. The results indicated a cave-independent evolution of ethyl-substituted benzoquinones, indicating the absence of a "cave effect" on the secretions of troglobiont Typhloiulini. Ethyl-benzoquinones probably evolved early in an epi- or endogean ancestor of a clade including several, but not all Typhloiulus (basically comprising a taxonomic entity known as "Typhloiulus sensu stricto") and Serboiulus. Ethyl-benzoquinones are proposed as novel and valuable chemical characters for julid systematics.",
publisher = "Springer, Dordrecht",
journal = "Journal of Chemical Ecology",
title = "Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae)",
volume = "43",
number = "4",
pages = "317-326",
doi = "10.1007/s10886-017-0832-1"
}

Makarov, S. E., Bodner, M., Reineke, D., Vujisić, L. V., Todosijević, M., Antić, D. Ž., Vagalinski, B., Lučić, L., Mitić, B. M., Mitov, P., Anđelković, B. D., Lucić, S. P., Vajs, V., Tomić, V. T.,& Raspotnig, G.. (2017). Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae). in Journal of Chemical Ecology
Springer, Dordrecht., 43(4), 317-326.
https://doi.org/10.1007/s10886-017-0832-1

Makarov SE, Bodner M, Reineke D, Vujisić LV, Todosijević M, Antić DŽ, Vagalinski B, Lučić L, Mitić BM, Mitov P, Anđelković BD, Lucić SP, Vajs V, Tomić VT, Raspotnig G. Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae). in Journal of Chemical Ecology. 2017;43(4):317-326.
doi:10.1007/s10886-017-0832-1 .

Makarov, Slobodan E., Bodner, Michaela, Reineke, Doris, Vujisić, Ljubodrag V., Todosijević, Marina, Antić, Dragan Ž., Vagalinski, Boyan, Lučić, Luka, Mitić, Bojan M., Mitov, Plamen, Anđelković, Boban D., Lucić, Sofija Pavković, Vajs, Vlatka, Tomić, Vladimir T., Raspotnig, Guenther, "Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae)" in Journal of Chemical Ecology, 43, no. 4 (2017):317-326,
https://doi.org/10.1007/s10886-017-0832-1 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Mutić, Jelena
AU  - Vajs, Vlatka
AU  - Pajović, Snezana B.
AU  - Tešević, Vele
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2481
AB  - Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Comparative analytical study of the selected wine varieties grown in Montenegro
VL  - 31
IS  - 15
SP  - 1825
EP  - 1830
DO  - 10.1080/14786419.2017.1289209
ER  - 

@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Mutić, Jelena and Vajs, Vlatka and Pajović, Snezana B. and Tešević, Vele",
year = "2017",
abstract = "Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Comparative analytical study of the selected wine varieties grown in Montenegro",
volume = "31",
number = "15",
pages = "1825-1830",
doi = "10.1080/14786419.2017.1289209"
}

Đorđević, N. O., Novaković, M. M., Pejin, B., Mutić, J., Vajs, V., Pajović, S. B.,& Tešević, V.. (2017). Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(15), 1825-1830.
https://doi.org/10.1080/14786419.2017.1289209

Đorđević NO, Novaković MM, Pejin B, Mutić J, Vajs V, Pajović SB, Tešević V. Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research. 2017;31(15):1825-1830.
doi:10.1080/14786419.2017.1289209 .

Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Mutić, Jelena, Vajs, Vlatka, Pajović, Snezana B., Tešević, Vele, "Comparative analytical study of the selected wine varieties grown in Montenegro" in Natural Product Research, 31, no. 15 (2017):1825-1830,
https://doi.org/10.1080/14786419.2017.1289209 . .

TY  - JOUR
AU  - Anđelković, Boban D.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Gođevac, Dejan
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2386
AB  - Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Metabolomics study of Populus type propolis
VL  - 135
SP  - 217
EP  - 226
DO  - 10.1016/j.jpba.2016.12.003
ER  - 

@article{
author = "Anđelković, Boban D. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Tešević, Vele and Vajs, Vlatka and Gođevac, Dejan",
year = "2017",
abstract = "Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Metabolomics study of Populus type propolis",
volume = "135",
pages = "217-226",
doi = "10.1016/j.jpba.2016.12.003"
}

Anđelković, B. D., Vujisić, L. V., Vučković, I. M., Tešević, V., Vajs, V.,& Gođevac, D.. (2017). Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam., 135, 217-226.
https://doi.org/10.1016/j.jpba.2016.12.003

Anđelković BD, Vujisić LV, Vučković IM, Tešević V, Vajs V, Gođevac D. Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis. 2017;135:217-226.
doi:10.1016/j.jpba.2016.12.003 .

Anđelković, Boban D., Vujisić, Ljubodrag V., Vučković, Ivan M., Tešević, Vele, Vajs, Vlatka, Gođevac, Dejan, "Metabolomics study of Populus type propolis" in Journal of Pharmaceutical and Biomedical Analysis, 135 (2017):217-226,
https://doi.org/10.1016/j.jpba.2016.12.003 . .

TY  - JOUR
AU  - Pavković-Lučić, Sofija
AU  - Todosijević, Marina
AU  - Savic, Tatjana
AU  - Vajs, Vlatka
AU  - Trajković, Jelena
AU  - Anđelković, Boban D.
AU  - Lučić, Luka
AU  - Krstić, Gordana B.
AU  - Makarov, Slobodan E.
AU  - Tomić, Vladimir T.
AU  - Miličić, Dragana
AU  - Vujisić, Ljubodrag V.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2057
AB  - Cuticular hydrocarbons (CHCs) in Drosophila melanogaster represent the basis of chemical communication being involved in many important biological functions. The aim of this study was to characterize chemical composition and variation of cuticular profiles in five D. melanogaster strains. These strains were reared for approximately 300 generations on five diets: standard cornmeal medium and substrates prepared with apple, banana, tomato, and carrot. Differences in quantity and/or quality in CHCs were assumed as a result of activation of different metabolic pathways involved in food digestion and adaptations to the particular diet type. In total, independently of sex and strain, 66 chemical compounds were identified. In females of all strains, 60 compounds were identified, while, in males, 47 compounds were extracted. Certain new chemical compounds for D. melanogaster were found. MANOVA confirmed that CHC amounts significantly depend on sex and substrates, as well as on their interactions. Discriminant analysis revealed that flies belonging to apple' and carrot' strains exhibited the most noticeable differences in CHC repertoires. A non-hydrocarbon pheromone, cis-vaccenyl acetate (cVA) also contributed to the variation in the pheromone bouquet among the strains. Variability detected in CHCs and cVA may be used in the explanation of differences in mating behaviour previously determined in analyzed fly strains.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - "Does my Diet Affect my Perfume?' Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets
VL  - 13
IS  - 2
SP  - 224
EP  - 232
DO  - 10.1002/cbdv.201500064
ER  - 

@article{
author = "Pavković-Lučić, Sofija and Todosijević, Marina and Savic, Tatjana and Vajs, Vlatka and Trajković, Jelena and Anđelković, Boban D. and Lučić, Luka and Krstić, Gordana B. and Makarov, Slobodan E. and Tomić, Vladimir T. and Miličić, Dragana and Vujisić, Ljubodrag V.",
year = "2016",
abstract = "Cuticular hydrocarbons (CHCs) in Drosophila melanogaster represent the basis of chemical communication being involved in many important biological functions. The aim of this study was to characterize chemical composition and variation of cuticular profiles in five D. melanogaster strains. These strains were reared for approximately 300 generations on five diets: standard cornmeal medium and substrates prepared with apple, banana, tomato, and carrot. Differences in quantity and/or quality in CHCs were assumed as a result of activation of different metabolic pathways involved in food digestion and adaptations to the particular diet type. In total, independently of sex and strain, 66 chemical compounds were identified. In females of all strains, 60 compounds were identified, while, in males, 47 compounds were extracted. Certain new chemical compounds for D. melanogaster were found. MANOVA confirmed that CHC amounts significantly depend on sex and substrates, as well as on their interactions. Discriminant analysis revealed that flies belonging to apple' and carrot' strains exhibited the most noticeable differences in CHC repertoires. A non-hydrocarbon pheromone, cis-vaccenyl acetate (cVA) also contributed to the variation in the pheromone bouquet among the strains. Variability detected in CHCs and cVA may be used in the explanation of differences in mating behaviour previously determined in analyzed fly strains.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = ""Does my Diet Affect my Perfume?' Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets",
volume = "13",
number = "2",
pages = "224-232",
doi = "10.1002/cbdv.201500064"
}

Pavković-Lučić, S., Todosijević, M., Savic, T., Vajs, V., Trajković, J., Anđelković, B. D., Lučić, L., Krstić, G. B., Makarov, S. E., Tomić, V. T., Miličić, D.,& Vujisić, L. V.. (2016). "Does my Diet Affect my Perfume?' Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 13(2), 224-232.
https://doi.org/10.1002/cbdv.201500064

Pavković-Lučić S, Todosijević M, Savic T, Vajs V, Trajković J, Anđelković BD, Lučić L, Krstić GB, Makarov SE, Tomić VT, Miličić D, Vujisić LV. "Does my Diet Affect my Perfume?' Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets. in Chemistry and Biodiversity. 2016;13(2):224-232.
doi:10.1002/cbdv.201500064 .

Pavković-Lučić, Sofija, Todosijević, Marina, Savic, Tatjana, Vajs, Vlatka, Trajković, Jelena, Anđelković, Boban D., Lučić, Luka, Krstić, Gordana B., Makarov, Slobodan E., Tomić, Vladimir T., Miličić, Dragana, Vujisić, Ljubodrag V., ""Does my Diet Affect my Perfume?' Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets" in Chemistry and Biodiversity, 13, no. 2 (2016):224-232,
https://doi.org/10.1002/cbdv.201500064 . .

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Anđelković, Boban D.
AU  - Choi, Young Hae
AU  - Vajs, Vlatka
AU  - Stević, Tatjana
AU  - Tešević, Vele
AU  - Gođevac, Dejan
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2335
AB  - The variations of metabolic profile of the latex of wild-growing Euphorbia palustris was carried out using multivariate analysis of NMR spectral data. One population was infected with fungi Fusarium sporotrichioides, Fusarium proliferatum and Alternaria alternata, while the other consisted of healthy plant species. The non-polar metabolites of latex extracts such as benzoyl ingenol-laurate, amyrin decadienoate esters, cis-1,4-polyisoprene, and 24-methylenecycloartanol were identified using H-1 and 2D NMR spectra. Principal component analysis of H-1 NMR data provided a clear discrimination between the latex of infected and healthy plants. Minimum inhibitory concentration and minimum fungicidal concentration values of the latex extracts of healthy and infected plants were determined. The latex of infected plants was found to contain higher levels of benzoyl ingenol-laurate and 24-methylenecycloartanol, of which concentrations were strongly correlated with the antifungal activities of the latex. (C) 2016 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Metabolic changes in Euphorbia palusrtis latex after fungal infection
VL  - 131
SP  - 17
EP  - 25
DO  - 10.1016/j.phytochem.2016.08.005
ER  - 

@article{
author = "Krstić, Gordana B. and Anđelković, Boban D. and Choi, Young Hae and Vajs, Vlatka and Stević, Tatjana and Tešević, Vele and Gođevac, Dejan",
year = "2016",
abstract = "The variations of metabolic profile of the latex of wild-growing Euphorbia palustris was carried out using multivariate analysis of NMR spectral data. One population was infected with fungi Fusarium sporotrichioides, Fusarium proliferatum and Alternaria alternata, while the other consisted of healthy plant species. The non-polar metabolites of latex extracts such as benzoyl ingenol-laurate, amyrin decadienoate esters, cis-1,4-polyisoprene, and 24-methylenecycloartanol were identified using H-1 and 2D NMR spectra. Principal component analysis of H-1 NMR data provided a clear discrimination between the latex of infected and healthy plants. Minimum inhibitory concentration and minimum fungicidal concentration values of the latex extracts of healthy and infected plants were determined. The latex of infected plants was found to contain higher levels of benzoyl ingenol-laurate and 24-methylenecycloartanol, of which concentrations were strongly correlated with the antifungal activities of the latex. (C) 2016 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Metabolic changes in Euphorbia palusrtis latex after fungal infection",
volume = "131",
pages = "17-25",
doi = "10.1016/j.phytochem.2016.08.005"
}

Krstić, G. B., Anđelković, B. D., Choi, Y. H., Vajs, V., Stević, T., Tešević, V.,& Gođevac, D.. (2016). Metabolic changes in Euphorbia palusrtis latex after fungal infection. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 131, 17-25.
https://doi.org/10.1016/j.phytochem.2016.08.005

Krstić GB, Anđelković BD, Choi YH, Vajs V, Stević T, Tešević V, Gođevac D. Metabolic changes in Euphorbia palusrtis latex after fungal infection. in Phytochemistry. 2016;131:17-25.
doi:10.1016/j.phytochem.2016.08.005 .

Krstić, Gordana B., Anđelković, Boban D., Choi, Young Hae, Vajs, Vlatka, Stević, Tatjana, Tešević, Vele, Gođevac, Dejan, "Metabolic changes in Euphorbia palusrtis latex after fungal infection" in Phytochemistry, 131 (2016):17-25,
https://doi.org/10.1016/j.phytochem.2016.08.005 . .

TY  - JOUR
AU  - Dinić, Jelena
AU  - Novaković, Miroslav M.
AU  - Podolski-Renić, Ana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Isaković, Aleksandra J.
AU  - Pešić, Milica
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2066
AB  - Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 30 and 300-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 30 and 300-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-biological Interactions
T1  - Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells
VL  - 249
SP  - 36
EP  - 45
DO  - 10.1016/j.cbi.2016.02.019
ER  - 

@article{
author = "Dinić, Jelena and Novaković, Miroslav M. and Podolski-Renić, Ana and Vajs, Vlatka and Tešević, Vele and Isaković, Aleksandra J. and Pešić, Milica",
year = "2016",
abstract = "Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 30 and 300-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 30 and 300-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-biological Interactions",
title = "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells",
volume = "249",
pages = "36-45",
doi = "10.1016/j.cbi.2016.02.019"
}

Dinić, J., Novaković, M. M., Podolski-Renić, A., Vajs, V., Tešević, V., Isaković, A. J.,& Pešić, M.. (2016). Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells. in Chemico-biological Interactions
Elsevier Ireland Ltd, Clare., 249, 36-45.
https://doi.org/10.1016/j.cbi.2016.02.019

Dinić J, Novaković MM, Podolski-Renić A, Vajs V, Tešević V, Isaković AJ, Pešić M. Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells. in Chemico-biological Interactions. 2016;249:36-45.
doi:10.1016/j.cbi.2016.02.019 .

Dinić, Jelena, Novaković, Miroslav M., Podolski-Renić, Ana, Vajs, Vlatka, Tešević, Vele, Isaković, Aleksandra J., Pešić, Milica, "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells" in Chemico-biological Interactions, 249 (2016):36-45,
https://doi.org/10.1016/j.cbi.2016.02.019 . .

TY  - JOUR
AU  - Rajčević, Nemanja
AU  - Marin, Petar D.
AU  - Vujisić, Ljubodrag V.
AU  - Krivosej, Zoran
AU  - Vajs, Vlatka
AU  - Janaćković, Peđa T.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1962
AB  - The composition of essential oil isolated from the areal parts of Aster albanicus Deg, an endemic species of the central Balkans, was analyzed. In total, 111 compounds were identified, representing 98% of the essential oil. The essential oil was dominated by sesquiterpene (69.3%) and monoterpene hydrocarbons (15.9%), with germacrene D as the most abundant compound (34.7%). Several multivariant statistical methods (HCA, NJ, PCoA) were deployed to infer the relation between A. albanicus and other species belonging to this genus. Taxonomical implications are discussed.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of biological sciences
T1  - Chemical Composition of Aster Albanicus Deg. (Asteraceae) Essential Oil: Taxonomical Implications
VL  - 67
IS  - 3
SP  - 1055
EP  - 1061
DO  - 10.2298/ABS150223068R
ER  - 

@article{
author = "Rajčević, Nemanja and Marin, Petar D. and Vujisić, Ljubodrag V. and Krivosej, Zoran and Vajs, Vlatka and Janaćković, Peđa T.",
year = "2015",
abstract = "The composition of essential oil isolated from the areal parts of Aster albanicus Deg, an endemic species of the central Balkans, was analyzed. In total, 111 compounds were identified, representing 98% of the essential oil. The essential oil was dominated by sesquiterpene (69.3%) and monoterpene hydrocarbons (15.9%), with germacrene D as the most abundant compound (34.7%). Several multivariant statistical methods (HCA, NJ, PCoA) were deployed to infer the relation between A. albanicus and other species belonging to this genus. Taxonomical implications are discussed.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of biological sciences",
title = "Chemical Composition of Aster Albanicus Deg. (Asteraceae) Essential Oil: Taxonomical Implications",
volume = "67",
number = "3",
pages = "1055-1061",
doi = "10.2298/ABS150223068R"
}

Rajčević, N., Marin, P. D., Vujisić, L. V., Krivosej, Z., Vajs, V.,& Janaćković, P. T.. (2015). Chemical Composition of Aster Albanicus Deg. (Asteraceae) Essential Oil: Taxonomical Implications. in Archives of biological sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 67(3), 1055-1061.
https://doi.org/10.2298/ABS150223068R

Rajčević N, Marin PD, Vujisić LV, Krivosej Z, Vajs V, Janaćković PT. Chemical Composition of Aster Albanicus Deg. (Asteraceae) Essential Oil: Taxonomical Implications. in Archives of biological sciences. 2015;67(3):1055-1061.
doi:10.2298/ABS150223068R .

Rajčević, Nemanja, Marin, Petar D., Vujisić, Ljubodrag V., Krivosej, Zoran, Vajs, Vlatka, Janaćković, Peđa T., "Chemical Composition of Aster Albanicus Deg. (Asteraceae) Essential Oil: Taxonomical Implications" in Archives of biological sciences, 67, no. 3 (2015):1055-1061,
https://doi.org/10.2298/ABS150223068R . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vučković, Ivan M.
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Menkovic, Nebojsa
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1500
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
ER  - 

@article{
author = "Aljančić, Ivana and Vučković, Ivan M. and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menkovic, Nebojsa and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025"
}

Aljančić, I., Vučković, I. M., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menkovic, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025

Aljančić I, Vučković IM, Jadranin M, Pešić M, Đorđević I, Podolski-Renić A, Stojković S, Menkovic N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025 .

Aljančić, Ivana, Vučković, Ivan M., Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menkovic, Nebojsa, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 . .

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra J.
AU  - Vučković, Ivan M.
AU  - Mandić, Boris
AU  - Novaković, Miroslav M.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1511
AB  - Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 297
EP  - 305
DO  - 10.1055/s-0033-1360312
ER  - 

@article{
author = "Trifunović, Snežana S. and Isaković, Anđelka M. and Isaković, Aleksandra J. and Vučković, Ivan M. and Mandić, Boris and Novaković, Miroslav M. and Vajs, Vlatka and Milosavljević, Slobodan M. and Trajković, Vladimir S.",
year = "2014",
abstract = "Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "297-305",
doi = "10.1055/s-0033-1360312"
}

Trifunović, S. S., Isaković, A. M., Isaković, A. J., Vučković, I. M., Mandić, B., Novaković, M. M., Vajs, V., Milosavljević, S. M.,& Trajković, V. S.. (2014). Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 80(4), 297-305.
https://doi.org/10.1055/s-0033-1360312

Trifunović SS, Isaković AM, Isaković AJ, Vučković IM, Mandić B, Novaković MM, Vajs V, Milosavljević SM, Trajković VS. Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica. 2014;80(4):297-305.
doi:10.1055/s-0033-1360312 .

Trifunović, Snežana S., Isaković, Anđelka M., Isaković, Aleksandra J., Vučković, Ivan M., Mandić, Boris, Novaković, Miroslav M., Vajs, Vlatka, Milosavljević, Slobodan M., Trajković, Vladimir S., "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae" in Planta Medica, 80, no. 4 (2014):297-305,
https://doi.org/10.1055/s-0033-1360312 . .

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Apostolović, Danijela
AU  - Mandić, Boris
AU  - Veljić, Milan
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1793
AB  - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL  - 11
IS  - 6
SP  - 872
EP  - 885
DO  - 10.1002/cbdv.201300277
ER  - 

@article{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Apostolović, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277"
}

Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Apostolović, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277

Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Apostolović D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277 .

Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Apostolović, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry and Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Vučković, Ivan M.
AU  - Menkovic, Nebojsa
AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1855
AB  - Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro
VL  - 11
IS  - 9
SP  - 1428
EP  - 1437
DO  - 10.1002/cbdv.201400101
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Vajs, Vlatka and Vučković, Ivan M. and Menkovic, Nebojsa and Milosavljević, Slobodan M. and Tešević, Vele",
year = "2014",
abstract = "Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro",
volume = "11",
number = "9",
pages = "1428-1437",
doi = "10.1002/cbdv.201400101"
}

Cvetković, M., Đorđević, I., Jadranin, M., Vajs, V., Vučković, I. M., Menkovic, N., Milosavljević, S. M.,& Tešević, V.. (2014). Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(9), 1428-1437.
https://doi.org/10.1002/cbdv.201400101

Cvetković M, Đorđević I, Jadranin M, Vajs V, Vučković IM, Menkovic N, Milosavljević SM, Tešević V. Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry and Biodiversity. 2014;11(9):1428-1437.
doi:10.1002/cbdv.201400101 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Vajs, Vlatka, Vučković, Ivan M., Menkovic, Nebojsa, Milosavljević, Slobodan M., Tešević, Vele, "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro" in Chemistry and Biodiversity, 11, no. 9 (2014):1428-1437,
https://doi.org/10.1002/cbdv.201400101 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Menkovic, Nebojsa
AU  - Matevski, Vlado
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1890
AB  - The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of three endemic Centaurea L. species
VL  - 79
IS  - 11
SP  - 1355
EP  - 1362
DO  - 10.2298/JSC140318048T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Milosavljević, Slobodan M. and Vajs, Vlatka and Đorđević, Iris and Jadranin, Milka and Menkovic, Nebojsa and Matevski, Vlado",
year = "2014",
abstract = "The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of three endemic Centaurea L. species",
volume = "79",
number = "11",
pages = "1355-1362",
doi = "10.2298/JSC140318048T"
}

Tešević, V., Aljančić, I., Milosavljević, S. M., Vajs, V., Đorđević, I., Jadranin, M., Menkovic, N.,& Matevski, V.. (2014). Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(11), 1355-1362.
https://doi.org/10.2298/JSC140318048T

Tešević V, Aljančić I, Milosavljević SM, Vajs V, Đorđević I, Jadranin M, Menkovic N, Matevski V. Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society. 2014;79(11):1355-1362.
doi:10.2298/JSC140318048T .

Tešević, Vele, Aljančić, Ivana, Milosavljević, Slobodan M., Vajs, Vlatka, Đorđević, Iris, Jadranin, Milka, Menkovic, Nebojsa, Matevski, Vlado, "Secondary metabolites of three endemic Centaurea L. species" in Journal of the Serbian Chemical Society, 79, no. 11 (2014):1355-1362,
https://doi.org/10.2298/JSC140318048T . .

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra J.
AU  - Vučković, Ivan M.
AU  - Mandić, Boris
AU  - Novaković, Miroslav M.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2816
AB  - Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 
the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 
compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 
oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 
elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 
While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 
seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 
apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag
T2  - Planta medica
T1  - Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 275
EP  - 305
DO  - 10.1055/s-0033-1360312
ER  - 

@article{
author = "Trifunović, Snežana S. and Isaković, Anđelka M. and Isaković, Aleksandra J. and Vučković, Ivan M. and Mandić, Boris and Novaković, Miroslav M. and Vajs, Vlatka and Milosavljević, Slobodan M. and Trajković, Vladimir S.",
year = "2014",
abstract = "Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 
the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 
compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 
oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 
elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 
While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 
seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 
apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag",
journal = "Planta medica",
title = "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "275-305",
doi = "10.1055/s-0033-1360312"
}

Trifunović, S. S., Isaković, A. M., Isaković, A. J., Vučković, I. M., Mandić, B., Novaković, M. M., Vajs, V., Milosavljević, S. M.,& Trajković, V. S.. (2014). Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica
Georg Thieme Verlag., 80(4), 275-305.
https://doi.org/10.1055/s-0033-1360312

Trifunović SS, Isaković AM, Isaković AJ, Vučković IM, Mandić B, Novaković MM, Vajs V, Milosavljević SM, Trajković VS. Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica. 2014;80(4):275-305.
doi:10.1055/s-0033-1360312 .

Trifunović, Snežana S., Isaković, Anđelka M., Isaković, Aleksandra J., Vučković, Ivan M., Mandić, Boris, Novaković, Miroslav M., Vajs, Vlatka, Milosavljević, Slobodan M., Trajković, Vladimir S., "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae" in Planta medica, 80, no. 4 (2014):275-305,
https://doi.org/10.1055/s-0033-1360312 . .

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Pešić, Milica
AU  - Trifunović, Snežana S.
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Dinić, Jelena
AU  - Stojković, Sonja
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1492
AB  - An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
VL  - 97
SP  - 46
EP  - 54
DO  - 10.1016/j.phytochem.2013.11.001
ER  - 

@article{
author = "Novaković, Miroslav M. and Pešić, Milica and Trifunović, Snežana S. and Vučković, Ivan M. and Todorović, Nina and Podolski-Renić, Ana and Dinić, Jelena and Stojković, Sonja and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells",
volume = "97",
pages = "46-54",
doi = "10.1016/j.phytochem.2013.11.001"
}

Novaković, M. M., Pešić, M., Trifunović, S. S., Vučković, I. M., Todorović, N., Podolski-Renić, A., Dinić, J., Stojković, S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 97, 46-54.
https://doi.org/10.1016/j.phytochem.2013.11.001

Novaković MM, Pešić M, Trifunović SS, Vučković IM, Todorović N, Podolski-Renić A, Dinić J, Stojković S, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry. 2014;97:46-54.
doi:10.1016/j.phytochem.2013.11.001 .

Novaković, Miroslav M., Pešić, Milica, Trifunović, Snežana S., Vučković, Ivan M., Todorović, Nina, Podolski-Renić, Ana, Dinić, Jelena, Stojković, Sonja, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells" in Phytochemistry, 97 (2014):46-54,
https://doi.org/10.1016/j.phytochem.2013.11.001 . .

TY  - JOUR
AU  - Sekulić, Tatjana Lj.
AU  - Vujisić, Ljubodrag V.
AU  - Curcic, B. P. M.
AU  - Mandić, Boris
AU  - Antic, D. Z.
AU  - Trifunović, Snežana S.
AU  - Gođevac, Dejan
AU  - Vajs, Vlatka
AU  - Tomić, Vladimir T.
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1496
AB  - A complex mixture of compounds was identified from the secretion of specimens of Unciger transsilvanicus. Phenol and p-cresol were detected for the first time in the family Julidae, and for the second time in the order Julida. Thirteen quinones were identified, with a great relative abundance of toloquinone and 2-methoxy-3-methyl- 1,4-benzoquinone. Hydroquinone was detected for the first time in the order Julida. Besides these compounds, isopentyl hexacosatetraenoate and isopentyl esters of saturated and unsaturated fatty acids with chain lengths from C-14 to C(20)were identified. The most abundant non-quinone compound was isopentyl eicosenoate. The relative abundance of quinone and non-quinone in the defensive fluid of U transsilvanicus was 77% and 23%, respectively. The phylogenetic importance of the registered compounds is briefly discussed.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of biological sciences
T1  - Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia
VL  - 66
IS  - 1
SP  - 385
EP  - 391
DO  - 10.2298/ABS1401385S
ER  - 

@article{
author = "Sekulić, Tatjana Lj. and Vujisić, Ljubodrag V. and Curcic, B. P. M. and Mandić, Boris and Antic, D. Z. and Trifunović, Snežana S. and Gođevac, Dejan and Vajs, Vlatka and Tomić, Vladimir T. and Makarov, Slobodan E.",
year = "2014",
abstract = "A complex mixture of compounds was identified from the secretion of specimens of Unciger transsilvanicus. Phenol and p-cresol were detected for the first time in the family Julidae, and for the second time in the order Julida. Thirteen quinones were identified, with a great relative abundance of toloquinone and 2-methoxy-3-methyl- 1,4-benzoquinone. Hydroquinone was detected for the first time in the order Julida. Besides these compounds, isopentyl hexacosatetraenoate and isopentyl esters of saturated and unsaturated fatty acids with chain lengths from C-14 to C(20)were identified. The most abundant non-quinone compound was isopentyl eicosenoate. The relative abundance of quinone and non-quinone in the defensive fluid of U transsilvanicus was 77% and 23%, respectively. The phylogenetic importance of the registered compounds is briefly discussed.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of biological sciences",
title = "Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia",
volume = "66",
number = "1",
pages = "385-391",
doi = "10.2298/ABS1401385S"
}

Sekulić, T. Lj., Vujisić, L. V., Curcic, B. P. M., Mandić, B., Antic, D. Z., Trifunović, S. S., Gođevac, D., Vajs, V., Tomić, V. T.,& Makarov, S. E.. (2014). Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia. in Archives of biological sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 66(1), 385-391.
https://doi.org/10.2298/ABS1401385S

Sekulić TL, Vujisić LV, Curcic BPM, Mandić B, Antic DZ, Trifunović SS, Gođevac D, Vajs V, Tomić VT, Makarov SE. Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia. in Archives of biological sciences. 2014;66(1):385-391.
doi:10.2298/ABS1401385S .

Sekulić, Tatjana Lj., Vujisić, Ljubodrag V., Curcic, B. P. M., Mandić, Boris, Antic, D. Z., Trifunović, Snežana S., Gođevac, Dejan, Vajs, Vlatka, Tomić, Vladimir T., Makarov, Slobodan E., "Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia" in Archives of biological sciences, 66, no. 1 (2014):385-391,
https://doi.org/10.2298/ABS1401385S . .

TY  - JOUR
AU  - Vujisić, Ljubodrag V.
AU  - Antić, Dragan Ž.
AU  - Vučković, Ivan M.
AU  - Sekulić, Tatjana Lj.
AU  - Tomić, Vladimir T.
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Curčić, Božidar P. M.
AU  - Vajs, Vlatka
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1515
AB  - The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?
VL  - 11
IS  - 3
SP  - 483
EP  - 490
DO  - 10.1002/cbdv.201300355
ER  - 

@article{
author = "Vujisić, Ljubodrag V. and Antić, Dragan Ž. and Vučković, Ivan M. and Sekulić, Tatjana Lj. and Tomić, Vladimir T. and Mandić, Boris and Tešević, Vele and Curčić, Božidar P. M. and Vajs, Vlatka and Makarov, Slobodan E.",
year = "2014",
abstract = "The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?",
volume = "11",
number = "3",
pages = "483-490",
doi = "10.1002/cbdv.201300355"
}

Vujisić, L. V., Antić, D. Ž., Vučković, I. M., Sekulić, T. Lj., Tomić, V. T., Mandić, B., Tešević, V., Curčić, B. P. M., Vajs, V.,& Makarov, S. E.. (2014). Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(3), 483-490.
https://doi.org/10.1002/cbdv.201300355

Vujisić LV, Antić DŽ, Vučković IM, Sekulić TL, Tomić VT, Mandić B, Tešević V, Curčić BPM, Vajs V, Makarov SE. Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity. 2014;11(3):483-490.
doi:10.1002/cbdv.201300355 .

Vujisić, Ljubodrag V., Antić, Dragan Ž., Vučković, Ivan M., Sekulić, Tatjana Lj., Tomić, Vladimir T., Mandić, Boris, Tešević, Vele, Curčić, Božidar P. M., Vajs, Vlatka, Makarov, Slobodan E., "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?" in Chemistry and Biodiversity, 11, no. 3 (2014):483-490,
https://doi.org/10.1002/cbdv.201300355 . .

TY  - JOUR
AU  - Dinić, Jelena
AU  - Novaković, Miroslav M.
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Isaković, Aleksandra J.
AU  - Pešić, Milica
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1845
AB  - Diarylheptanoids belong to polyphenols, a group of plant secondary metabolites with multiple biological properties. Many of them display antioxidative, cytotoxic, or anticancer actions and are increasingly recognized as potential therapeutic agents. The aim of this study was to evaluate antioxidant and cytoprotective activity of two diarylheptanoids: platyphylloside 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-beta-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-beta-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2), both isolated from the bark of black alder (Alnus glutinosa). To that end, we have employed a cancer cell line (NCI-H460), normal human keratinocytes (HaCaT), and peripheral blood mononuclear cells. The effects on cell growth were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Cell death was examined by annexin V/propidium iodide staining on a flow cytometer. Reactive oxygen species production was examined by dihydroethidium staining. Mitochondrial structure and doxorubicin localization were visualized by fluorescent microscopy. Gene expression of manganese superoxide dismutase and hypoxia-inducible factor-1 alpha was determined by reverse transcription polymerase chain reaction. Diarylheptanoids antagonized the effects of either doxorubicin or cisplatin, significantly increasing their IC50 values in normal cells. Diarylheptanoid 1 induced the retention of doxorubicin in cytoplasm and reduced mitochondrial fragmentation associated with doxorubicin application. Diarylheptanoid 2 reduced the reactive oxygen species production induced by cisplatin. Both compounds increased the messenger ribonucleic acid expression of enzymes involved in reactive oxygen species elimination (manganese superoxide dismutase and hypoxia-inducible factor-1 alpha). These results indicate that neutralization of reactive oxygen species is an important mechanism of diarylheptanoid action, although these compounds exert a considerable anticancer effect. Therefore, these compounds may serve as protectors of normal cells during chemotherapy without significantly diminishing the effect of the applied chemotherapeutic.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs
VL  - 80
IS  - 13
SP  - 1088
EP  - 1096
DO  - 10.1055/s-0034-1382993
ER  - 

@article{
author = "Dinić, Jelena and Novaković, Miroslav M. and Podolski-Renić, Ana and Stojković, Sonja and Mandić, Boris and Tešević, Vele and Vajs, Vlatka and Isaković, Aleksandra J. and Pešić, Milica",
year = "2014",
abstract = "Diarylheptanoids belong to polyphenols, a group of plant secondary metabolites with multiple biological properties. Many of them display antioxidative, cytotoxic, or anticancer actions and are increasingly recognized as potential therapeutic agents. The aim of this study was to evaluate antioxidant and cytoprotective activity of two diarylheptanoids: platyphylloside 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-beta-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-beta-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2), both isolated from the bark of black alder (Alnus glutinosa). To that end, we have employed a cancer cell line (NCI-H460), normal human keratinocytes (HaCaT), and peripheral blood mononuclear cells. The effects on cell growth were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Cell death was examined by annexin V/propidium iodide staining on a flow cytometer. Reactive oxygen species production was examined by dihydroethidium staining. Mitochondrial structure and doxorubicin localization were visualized by fluorescent microscopy. Gene expression of manganese superoxide dismutase and hypoxia-inducible factor-1 alpha was determined by reverse transcription polymerase chain reaction. Diarylheptanoids antagonized the effects of either doxorubicin or cisplatin, significantly increasing their IC50 values in normal cells. Diarylheptanoid 1 induced the retention of doxorubicin in cytoplasm and reduced mitochondrial fragmentation associated with doxorubicin application. Diarylheptanoid 2 reduced the reactive oxygen species production induced by cisplatin. Both compounds increased the messenger ribonucleic acid expression of enzymes involved in reactive oxygen species elimination (manganese superoxide dismutase and hypoxia-inducible factor-1 alpha). These results indicate that neutralization of reactive oxygen species is an important mechanism of diarylheptanoid action, although these compounds exert a considerable anticancer effect. Therefore, these compounds may serve as protectors of normal cells during chemotherapy without significantly diminishing the effect of the applied chemotherapeutic.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs",
volume = "80",
number = "13",
pages = "1088-1096",
doi = "10.1055/s-0034-1382993"
}

Dinić, J., Novaković, M. M., Podolski-Renić, A., Stojković, S., Mandić, B., Tešević, V., Vajs, V., Isaković, A. J.,& Pešić, M.. (2014). Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 80(13), 1088-1096.
https://doi.org/10.1055/s-0034-1382993

Dinić J, Novaković MM, Podolski-Renić A, Stojković S, Mandić B, Tešević V, Vajs V, Isaković AJ, Pešić M. Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs. in Planta Medica. 2014;80(13):1088-1096.
doi:10.1055/s-0034-1382993 .

Dinić, Jelena, Novaković, Miroslav M., Podolski-Renić, Ana, Stojković, Sonja, Mandić, Boris, Tešević, Vele, Vajs, Vlatka, Isaković, Aleksandra J., Pešić, Milica, "Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs" in Planta Medica, 80, no. 13 (2014):1088-1096,
https://doi.org/10.1055/s-0034-1382993 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Živković, Marijana B.
AU  - Nikićević, Ninoslav
AU  - Urosevic, Ivan
AU  - Vujisić, Ljubodrag V.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1648
AB  - An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies
VL  - 79
IS  - 12
SP  - 1537
EP  - 1543
DO  - 10.2298/JSC140225079T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Vajs, Vlatka and Živković, Marijana B. and Nikićević, Ninoslav and Urosevic, Ivan and Vujisić, Ljubodrag V.",
year = "2014",
abstract = "An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies",
volume = "79",
number = "12",
pages = "1537-1543",
doi = "10.2298/JSC140225079T"
}

Tešević, V., Aljančić, I., Vajs, V., Živković, M. B., Nikićević, N., Urosevic, I.,& Vujisić, L. V.. (2014). Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(12), 1537-1543.
https://doi.org/10.2298/JSC140225079T

Tešević V, Aljančić I, Vajs V, Živković MB, Nikićević N, Urosevic I, Vujisić LV. Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society. 2014;79(12):1537-1543.
doi:10.2298/JSC140225079T .

Tešević, Vele, Aljančić, Ivana, Vajs, Vlatka, Živković, Marijana B., Nikićević, Ninoslav, Urosevic, Ivan, Vujisić, Ljubodrag V., "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies" in Journal of the Serbian Chemical Society, 79, no. 12 (2014):1537-1543,
https://doi.org/10.2298/JSC140225079T . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Stanimirović, Bojana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/285
AB  - In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.
T2  - Asian Journal of Chemistry
T1  - A novel β-orcinol depsidone of lichen lobaria pulmonaria
VL  - 26
IS  - 23
SP  - 8257
EP  - 8258
DO  - 10.14233/ajchem.2014.17834
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Stanimirović, Bojana and Vajs, Vlatka and Tešević, Vele",
year = "2014",
abstract = "In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.",
journal = "Asian Journal of Chemistry",
title = "A novel β-orcinol depsidone of lichen lobaria pulmonaria",
volume = "26",
number = "23",
pages = "8257-8258",
doi = "10.14233/ajchem.2014.17834"
}

Pejin, B., Iodice, C., Stanimirović, B., Vajs, V.,& Tešević, V.. (2014). A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry, 26(23), 8257-8258.
https://doi.org/10.14233/ajchem.2014.17834

Pejin B, Iodice C, Stanimirović B, Vajs V, Tešević V. A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry. 2014;26(23):8257-8258.
doi:10.14233/ajchem.2014.17834 .

Pejin, Boris, Iodice, Carmine, Stanimirović, Bojana, Vajs, Vlatka, Tešević, Vele, "A novel β-orcinol depsidone of lichen lobaria pulmonaria" in Asian Journal of Chemistry, 26, no. 23 (2014):8257-8258,
https://doi.org/10.14233/ajchem.2014.17834 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Banković, Jasna
AU  - Tanić, Nikola
AU  - Marković, Ivanka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1585
AB  - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
VL  - 86
SP  - 208
EP  - 217
DO  - 10.1016/j.phytochem.2012.09.003
ER  - 

@article{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan M. and Todorović, Nina and Podolski-Renić, Ana and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines",
volume = "86",
pages = "208-217",
doi = "10.1016/j.phytochem.2012.09.003"
}

Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S. M., Todorović, N., Podolski-Renić, A., Banković, J., Tanić, N., Marković, I., Vajs, V.,& Tešević, V.. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 86, 208-217.
https://doi.org/10.1016/j.phytochem.2012.09.003

Jadranin M, Pešić M, Aljančić I, Milosavljević SM, Todorović N, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry. 2013;86:208-217.
doi:10.1016/j.phytochem.2012.09.003 .

Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan M., Todorović, Nina, Podolski-Renić, Ana, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Vajs, Vlatka, Tešević, Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" in Phytochemistry, 86 (2013):208-217,
https://doi.org/10.1016/j.phytochem.2012.09.003 . .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Žižak, Željko S.
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
AU  - Juranić, Zorica D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1608
AB  - Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.
PB  - Biomed Central Ltd, London
T2  - BMC Complementary and Alternative Medicine
T1  - In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii
VL  - 13
DO  - 10.1186/1472-6882-13-36
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Žižak, Željko S. and Vajs, Vlatka and Jadranin, Milka and Milosavljević, Slobodan M. and Juranić, Zorica D.",
year = "2013",
abstract = "Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.",
publisher = "Biomed Central Ltd, London",
journal = "BMC Complementary and Alternative Medicine",
title = "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii",
volume = "13",
doi = "10.1186/1472-6882-13-36"
}

Matić, I. Z., Aljančić, I., Žižak, Ž. S., Vajs, V., Jadranin, M., Milosavljević, S. M.,& Juranić, Z. D.. (2013). In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine
Biomed Central Ltd, London., 13.
https://doi.org/10.1186/1472-6882-13-36

Matić IZ, Aljančić I, Žižak ŽS, Vajs V, Jadranin M, Milosavljević SM, Juranić ZD. In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine. 2013;13.
doi:10.1186/1472-6882-13-36 .

Matić, Ivana Z., Aljančić, Ivana, Žižak, Željko S., Vajs, Vlatka, Jadranin, Milka, Milosavljević, Slobodan M., Juranić, Zorica D., "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii" in BMC Complementary and Alternative Medicine, 13 (2013),
https://doi.org/10.1186/1472-6882-13-36 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Stanković, Miroslava
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1626
AB  - This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Mini Reviews in Medicinal Chemistry
T1  - Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
VL  - 13
IS  - 3
SP  - 431
EP  - 438
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1626
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Stanković, Miroslava",
year = "2013",
abstract = "This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Mini Reviews in Medicinal Chemistry",
title = "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay",
volume = "13",
number = "3",
pages = "431-438",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1626"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M.,& Stanković, M.. (2013). Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(3), 431-438.
https://hdl.handle.net/21.15107/rcub_cherry_1626

Gođevac D, Tešević V, Vajs V, Milosavljević SM, Stanković M. Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry. 2013;13(3):431-438.
https://hdl.handle.net/21.15107/rcub_cherry_1626 .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Stanković, Miroslava, "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay" in Mini Reviews in Medicinal Chemistry, 13, no. 3 (2013):431-438,
https://hdl.handle.net/21.15107/rcub_cherry_1626 .