TY  - JOUR
AU  - Mićović, Ivan V.
AU  - Ivanović, Milovan
AU  - Vuckovic, SM
AU  - Prostran, MS
AU  - Došen-Mićović, Ljiljana
AU  - Kiricojevic, VD
PY  - 2000
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/442
AB  - The synthesis of 4-methyl fentanyl, a prototype of a novel class of fentanyl analogues has been effected in 5 steps, starting from N-ethoxycarbonyl-4-piperidone (similar to 20% overall yield). In the key step, N-phenylation of secondary aliphatic amide intermediate was achieved by a novel reaction, using diphenyliodonium chloride for the phenyl group transfer. Preliminary pharmacological results indicate that 4-methyl fentanyl is a super potent narcotic analgesic, about four times more potent than fentanyl. (C) 2000 Elsevier Science Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl
VL  - 10
IS  - 17
SP  - 2011
EP  - 2014
DO  - 10.1016/S0960-894X(00)00394-2
ER  - 

@article{
author = "Mićović, Ivan V. and Ivanović, Milovan and Vuckovic, SM and Prostran, MS and Došen-Mićović, Ljiljana and Kiricojevic, VD",
year = "2000",
abstract = "The synthesis of 4-methyl fentanyl, a prototype of a novel class of fentanyl analogues has been effected in 5 steps, starting from N-ethoxycarbonyl-4-piperidone (similar to 20% overall yield). In the key step, N-phenylation of secondary aliphatic amide intermediate was achieved by a novel reaction, using diphenyliodonium chloride for the phenyl group transfer. Preliminary pharmacological results indicate that 4-methyl fentanyl is a super potent narcotic analgesic, about four times more potent than fentanyl. (C) 2000 Elsevier Science Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl",
volume = "10",
number = "17",
pages = "2011-2014",
doi = "10.1016/S0960-894X(00)00394-2"
}

Mićović, I. V., Ivanović, M., Vuckovic, S., Prostran, M., Došen-Mićović, L.,& Kiricojevic, V.. (2000). The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 10(17), 2011-2014.
https://doi.org/10.1016/S0960-894X(00)00394-2

Mićović IV, Ivanović M, Vuckovic S, Prostran M, Došen-Mićović L, Kiricojevic V. The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl. in Bioorganic and Medicinal Chemistry Letters. 2000;10(17):2011-2014.
doi:10.1016/S0960-894X(00)00394-2 .

Mićović, Ivan V., Ivanović, Milovan, Vuckovic, SM, Prostran, MS, Došen-Mićović, Ljiljana, Kiricojevic, VD, "The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl" in Bioorganic and Medicinal Chemistry Letters, 10, no. 17 (2000):2011-2014,
https://doi.org/10.1016/S0960-894X(00)00394-2 . .