TY  - JOUR
AU  - Milić Komić, Sonja
AU  - Živanović, Bojana
AU  - Dumanović, Jelena
AU  - Kolarž, Predrag
AU  - Sedlarević Zorić, Ana
AU  - Morina, Filis
AU  - Vidović, Marija
AU  - Veljović Jovanović, Sonja
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6386
AB  - Three basil plant varieties (Ocimum basilicum var. Genovese, Ocimum × citriodorum, and Ocimum basilicum var. purpurascens) were grown under moderate light (about 300 µmol photons m−2 s−1) in a glasshouse or growth chamber and then either transferred to an open field (average daily dose: 29.2 kJ m−2 d−1) or additionally exposed to UV-B irradiation in a growth chamber (29.16 kJ m−2 d−1), to reveal the variety-specific and light-specific acclimation responses. Total antioxidant capacity (TAC), phenolic profile, ascorbate content, and class III peroxidase (POD) activity were used to determine the antioxidant status of leaves under all four light regimes. Exposure to high solar irradiation at the open field resulted in an increase in TAC, total hydroxycinnamic acids (HCAs, especially caffeic acid), flavonoids, and epidermal UV-absorbing substances in all three varieties, as well as a two-fold increase in the leaf dry/fresh weight ratio. The supplemental UV-B irradiation induced preferential accumulation of HCAs (rosmarinic acid) over flavonoids, increased TAC and POD activity, but decreased the ascorbate content in the leaves, and inhibited the accumulation of epidermal flavonoids in all basil varieties. Furthermore, characteristic leaf curling and UV-B-induced inhibition of plant growth were observed in all basil varieties, while a pro-oxidant effect of UV-B was indicated with H2O2 accumulation in the leaves and spotty leaf browning. The extent of these morphological changes, and oxidative damage depended on the basil cultivar, implies a genotype-specific tolerance mechanism to high doses of UV-B irradiation.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Differential Antioxidant Response to Supplemental UV-B Irradiation and Sunlight in Three Basil Varieties
VL  - 24
IS  - 20
SP  - 15350
DO  - 10.3390/ijms242015350
ER  - 

@article{
author = "Milić Komić, Sonja and Živanović, Bojana and Dumanović, Jelena and Kolarž, Predrag and Sedlarević Zorić, Ana and Morina, Filis and Vidović, Marija and Veljović Jovanović, Sonja",
year = "2023",
abstract = "Three basil plant varieties (Ocimum basilicum var. Genovese, Ocimum × citriodorum, and Ocimum basilicum var. purpurascens) were grown under moderate light (about 300 µmol photons m−2 s−1) in a glasshouse or growth chamber and then either transferred to an open field (average daily dose: 29.2 kJ m−2 d−1) or additionally exposed to UV-B irradiation in a growth chamber (29.16 kJ m−2 d−1), to reveal the variety-specific and light-specific acclimation responses. Total antioxidant capacity (TAC), phenolic profile, ascorbate content, and class III peroxidase (POD) activity were used to determine the antioxidant status of leaves under all four light regimes. Exposure to high solar irradiation at the open field resulted in an increase in TAC, total hydroxycinnamic acids (HCAs, especially caffeic acid), flavonoids, and epidermal UV-absorbing substances in all three varieties, as well as a two-fold increase in the leaf dry/fresh weight ratio. The supplemental UV-B irradiation induced preferential accumulation of HCAs (rosmarinic acid) over flavonoids, increased TAC and POD activity, but decreased the ascorbate content in the leaves, and inhibited the accumulation of epidermal flavonoids in all basil varieties. Furthermore, characteristic leaf curling and UV-B-induced inhibition of plant growth were observed in all basil varieties, while a pro-oxidant effect of UV-B was indicated with H2O2 accumulation in the leaves and spotty leaf browning. The extent of these morphological changes, and oxidative damage depended on the basil cultivar, implies a genotype-specific tolerance mechanism to high doses of UV-B irradiation.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Differential Antioxidant Response to Supplemental UV-B Irradiation and Sunlight in Three Basil Varieties",
volume = "24",
number = "20",
pages = "15350",
doi = "10.3390/ijms242015350"
}

Milić Komić, S., Živanović, B., Dumanović, J., Kolarž, P., Sedlarević Zorić, A., Morina, F., Vidović, M.,& Veljović Jovanović, S.. (2023). Differential Antioxidant Response to Supplemental UV-B Irradiation and Sunlight in Three Basil Varieties. in International Journal of Molecular Sciences
MDPI., 24(20), 15350.
https://doi.org/10.3390/ijms242015350

Milić Komić S, Živanović B, Dumanović J, Kolarž P, Sedlarević Zorić A, Morina F, Vidović M, Veljović Jovanović S. Differential Antioxidant Response to Supplemental UV-B Irradiation and Sunlight in Three Basil Varieties. in International Journal of Molecular Sciences. 2023;24(20):15350.
doi:10.3390/ijms242015350 .

Milić Komić, Sonja, Živanović, Bojana, Dumanović, Jelena, Kolarž, Predrag, Sedlarević Zorić, Ana, Morina, Filis, Vidović, Marija, Veljović Jovanović, Sonja, "Differential Antioxidant Response to Supplemental UV-B Irradiation and Sunlight in Three Basil Varieties" in International Journal of Molecular Sciences, 24, no. 20 (2023):15350,
https://doi.org/10.3390/ijms242015350 . .

TY  - JOUR
AU  - Chrienova, Zofia
AU  - Rysanek, David
AU  - Novak, Josef
AU  - Vasicova, Pavla
AU  - Oleksak, Patrik
AU  - Andrys, Rudolf
AU  - Skarka, Adam
AU  - Dumanović, Jelena
AU  - Milovanović, Zoran
AU  - Jaćević, Vesna
AU  - Chvojkova, Marketa
AU  - Holubova, Kristina
AU  - Vales, Karel
AU  - Skoupilova, Veronika
AU  - Valko, Marian
AU  - Jomova, Klaudia
AU  - Alomar, Suliman Y.
AU  - Botelho, Fernanda D.
AU  - Franca, Tanos C. C.
AU  - Kuca, Kamil
AU  - Hodny, Zdenek
AU  - Nepovimova, Eugenie
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6376
AB  - Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed. Another broadly studied drug with anti-aging and immunosuppressive properties is an mTOR inhibitor – rapamycin. Since we do not yet precisely know what is behind the lifespan-prolonging effect of rapamycin and frentizole, whether it is the ability to inhibit the mTOR signaling pathway, reduction in mitochondrial toxicity, immunosuppressive effect, or a combination of all of them, we have decided within our previous work to dock the entire in-house library of almost 240 Aβ-ABAD modulators into the FKBP-rapamycin-binding (FRB) domain of mTOR in order to interlink mTOR-centric and mitochondrial free radical-centric theories of aging and thus to increase the chances of success. Based on the results of the docking study, molecular dynamic simulation and MM-PBSA calculations, we have selected nine frentizole-like compounds (1 – 9). Subsequently, we have determined their real physical-chemical properties (logP, logD, pKa and solubility in water and buffer), cytotoxic/cytostatic, mTOR inhibitory, and in vitro anti-senescence (senolytic and senomorphic) effects. Finally, the three best candidates (4, 8, and 9) have been forwarded for in vivo safety studies to assess their acute toxicity and pharmacokinetic properties. Based on obtained results, only compound 4 demonstrated the best results within in vitro testing, the ability to cross the blood-brain barrier and the lowest acute toxicity (LD50 in male mice 559 mg/kg; LD50 in female mice 575 mg/kg).
PB  - Elsevier
T2  - Biomedicine & Pharmacotherapy
T1  - Frentizole derivatives with mTOR inhibiting and senomorphic properties
VL  - 167
SP  - 115600
DO  - 10.1016/j.biopha.2023.115600
ER  - 

@article{
author = "Chrienova, Zofia and Rysanek, David and Novak, Josef and Vasicova, Pavla and Oleksak, Patrik and Andrys, Rudolf and Skarka, Adam and Dumanović, Jelena and Milovanović, Zoran and Jaćević, Vesna and Chvojkova, Marketa and Holubova, Kristina and Vales, Karel and Skoupilova, Veronika and Valko, Marian and Jomova, Klaudia and Alomar, Suliman Y. and Botelho, Fernanda D. and Franca, Tanos C. C. and Kuca, Kamil and Hodny, Zdenek and Nepovimova, Eugenie",
year = "2023",
abstract = "Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed. Another broadly studied drug with anti-aging and immunosuppressive properties is an mTOR inhibitor – rapamycin. Since we do not yet precisely know what is behind the lifespan-prolonging effect of rapamycin and frentizole, whether it is the ability to inhibit the mTOR signaling pathway, reduction in mitochondrial toxicity, immunosuppressive effect, or a combination of all of them, we have decided within our previous work to dock the entire in-house library of almost 240 Aβ-ABAD modulators into the FKBP-rapamycin-binding (FRB) domain of mTOR in order to interlink mTOR-centric and mitochondrial free radical-centric theories of aging and thus to increase the chances of success. Based on the results of the docking study, molecular dynamic simulation and MM-PBSA calculations, we have selected nine frentizole-like compounds (1 – 9). Subsequently, we have determined their real physical-chemical properties (logP, logD, pKa and solubility in water and buffer), cytotoxic/cytostatic, mTOR inhibitory, and in vitro anti-senescence (senolytic and senomorphic) effects. Finally, the three best candidates (4, 8, and 9) have been forwarded for in vivo safety studies to assess their acute toxicity and pharmacokinetic properties. Based on obtained results, only compound 4 demonstrated the best results within in vitro testing, the ability to cross the blood-brain barrier and the lowest acute toxicity (LD50 in male mice 559 mg/kg; LD50 in female mice 575 mg/kg).",
publisher = "Elsevier",
journal = "Biomedicine & Pharmacotherapy",
title = "Frentizole derivatives with mTOR inhibiting and senomorphic properties",
volume = "167",
pages = "115600",
doi = "10.1016/j.biopha.2023.115600"
}

Chrienova, Z., Rysanek, D., Novak, J., Vasicova, P., Oleksak, P., Andrys, R., Skarka, A., Dumanović, J., Milovanović, Z., Jaćević, V., Chvojkova, M., Holubova, K., Vales, K., Skoupilova, V., Valko, M., Jomova, K., Alomar, S. Y., Botelho, F. D., Franca, T. C. C., Kuca, K., Hodny, Z.,& Nepovimova, E.. (2023). Frentizole derivatives with mTOR inhibiting and senomorphic properties. in Biomedicine & Pharmacotherapy
Elsevier., 167, 115600.
https://doi.org/10.1016/j.biopha.2023.115600

Chrienova Z, Rysanek D, Novak J, Vasicova P, Oleksak P, Andrys R, Skarka A, Dumanović J, Milovanović Z, Jaćević V, Chvojkova M, Holubova K, Vales K, Skoupilova V, Valko M, Jomova K, Alomar SY, Botelho FD, Franca TCC, Kuca K, Hodny Z, Nepovimova E. Frentizole derivatives with mTOR inhibiting and senomorphic properties. in Biomedicine & Pharmacotherapy. 2023;167:115600.
doi:10.1016/j.biopha.2023.115600 .

Chrienova, Zofia, Rysanek, David, Novak, Josef, Vasicova, Pavla, Oleksak, Patrik, Andrys, Rudolf, Skarka, Adam, Dumanović, Jelena, Milovanović, Zoran, Jaćević, Vesna, Chvojkova, Marketa, Holubova, Kristina, Vales, Karel, Skoupilova, Veronika, Valko, Marian, Jomova, Klaudia, Alomar, Suliman Y., Botelho, Fernanda D., Franca, Tanos C. C., Kuca, Kamil, Hodny, Zdenek, Nepovimova, Eugenie, "Frentizole derivatives with mTOR inhibiting and senomorphic properties" in Biomedicine & Pharmacotherapy, 167 (2023):115600,
https://doi.org/10.1016/j.biopha.2023.115600 . .

TY  - JOUR
AU  - Mandić, Danijela
AU  - Nežić, Lana
AU  - Amdžić, Ljiljana
AU  - Vojinović, Nataša
AU  - Gajanin, Radoslav
AU  - Popović, Miroslav
AU  - Đeri, Jugoslav
AU  - Balint, Milena Todorović
AU  - Dumanović, Jelena
AU  - Milovanović, Zoran
AU  - Grujić-Milanović, Jelica
AU  - Škrbić, Ranko
AU  - Jaćević, Vesna
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6327
AB  - Background: Approximately 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience treatment resistance to the first-line R-CHOP regimen. ATP binding cassette (ABC) transporters and survivin might play a role in multidrug resistance (MDR) in various tumors. The aim was to investigate if the coexpression of ABC transporters and survivin was associated with R-CHOP treatment response. Methods: The expression of Bcl-2, survivin, P-glycoprotein/ABCB1, MRP1/ABCC1, and BCRP/ABCC2 was analyzed using immunohistochemistry in tumor specimens obtained from patients with DLBCL, and classified according to the treatment response as Remission, Relapsed, and (primary) Refractory groups. All patients received R-CHOP or equivalent treatment. Results: Bcl-2 was in strong positive correlation with clinical parameters and all biomarkers except P-gp/ABCB1. The overexpression of MRP1/ABCC1, survivin, and BCRP/ABCC2 presented as high immunoreactive scores (IRSs) was detected in the Refractory and Relapsed groups (p < 0.05 vs. Remission), respectively, whereas the IRS of P-gp/ABCB1 was low. Significant correlations were found among either MRP1/ABCC1 and survivin or BCRP/ABCC2 in the Refractory and Relapsed groups, respectively. In multiple linear regression analysis, ECOG status along with MRP1/ABCC1 or survivin and BRCP/ABCG2 was significantly associated with the prediction of the R-CHOP treatment response. Conclusions: DLBCL might harbor certain molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.
PB  - MDPI
T2  - Cancers
T1  - Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment
VL  - 15
IS  - 16
SP  - 4106
DO  - 10.3390/cancers15164106
ER  - 

@article{
author = "Mandić, Danijela and Nežić, Lana and Amdžić, Ljiljana and Vojinović, Nataša and Gajanin, Radoslav and Popović, Miroslav and Đeri, Jugoslav and Balint, Milena Todorović and Dumanović, Jelena and Milovanović, Zoran and Grujić-Milanović, Jelica and Škrbić, Ranko and Jaćević, Vesna",
year = "2023",
abstract = "Background: Approximately 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience treatment resistance to the first-line R-CHOP regimen. ATP binding cassette (ABC) transporters and survivin might play a role in multidrug resistance (MDR) in various tumors. The aim was to investigate if the coexpression of ABC transporters and survivin was associated with R-CHOP treatment response. Methods: The expression of Bcl-2, survivin, P-glycoprotein/ABCB1, MRP1/ABCC1, and BCRP/ABCC2 was analyzed using immunohistochemistry in tumor specimens obtained from patients with DLBCL, and classified according to the treatment response as Remission, Relapsed, and (primary) Refractory groups. All patients received R-CHOP or equivalent treatment. Results: Bcl-2 was in strong positive correlation with clinical parameters and all biomarkers except P-gp/ABCB1. The overexpression of MRP1/ABCC1, survivin, and BCRP/ABCC2 presented as high immunoreactive scores (IRSs) was detected in the Refractory and Relapsed groups (p < 0.05 vs. Remission), respectively, whereas the IRS of P-gp/ABCB1 was low. Significant correlations were found among either MRP1/ABCC1 and survivin or BCRP/ABCC2 in the Refractory and Relapsed groups, respectively. In multiple linear regression analysis, ECOG status along with MRP1/ABCC1 or survivin and BRCP/ABCG2 was significantly associated with the prediction of the R-CHOP treatment response. Conclusions: DLBCL might harbor certain molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.",
publisher = "MDPI",
journal = "Cancers",
title = "Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment",
volume = "15",
number = "16",
pages = "4106",
doi = "10.3390/cancers15164106"
}

Mandić, D., Nežić, L., Amdžić, L., Vojinović, N., Gajanin, R., Popović, M., Đeri, J., Balint, M. T., Dumanović, J., Milovanović, Z., Grujić-Milanović, J., Škrbić, R.,& Jaćević, V.. (2023). Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment. in Cancers
MDPI., 15(16), 4106.
https://doi.org/10.3390/cancers15164106

Mandić D, Nežić L, Amdžić L, Vojinović N, Gajanin R, Popović M, Đeri J, Balint MT, Dumanović J, Milovanović Z, Grujić-Milanović J, Škrbić R, Jaćević V. Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment. in Cancers. 2023;15(16):4106.
doi:10.3390/cancers15164106 .

Mandić, Danijela, Nežić, Lana, Amdžić, Ljiljana, Vojinović, Nataša, Gajanin, Radoslav, Popović, Miroslav, Đeri, Jugoslav, Balint, Milena Todorović, Dumanović, Jelena, Milovanović, Zoran, Grujić-Milanović, Jelica, Škrbić, Ranko, Jaćević, Vesna, "Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment" in Cancers, 15, no. 16 (2023):4106,
https://doi.org/10.3390/cancers15164106 . .

TY  - JOUR
AU  - Nežić, Lana
AU  - Amidžić, Ljiljana
AU  - Škrbić, Ranko
AU  - Gajanin, Radoslav
AU  - Mandić, Danijela
AU  - Dumanović, Jelena
AU  - Milovanović, Zoran
AU  - Jaćević, Vesna
PY  - 2022
UR  - https://www.mdpi.com/1422-0067/23/5/2596
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5208
AB  - Disruption of the alveolar–endothelial barrier caused by inflammation leads to the progression of septic acute lung injury (ALI). In the present study, we investigated the beneficial effects of simvastatin on the endotoxin lipopolysaccharide (LPS)-induced ALI and its related mechanisms. A model of ALI was induced within experimental sepsis developed by intraperitoneal injection of a single non-lethal LPS dose after short-term simvastatin pretreatment (10–40 mg/kg orally). The severity of the lung tissue inflammatory injury was expressed as pulmonary damage scores (PDS). Alveolar epithelial cell apoptosis was confirmed by TUNEL assay (DNA fragmentation) and expressed as an apoptotic index (AI), and immunohistochemically for cleaved caspase-3, cytochrome C, and anti-apoptotic Bcl-xL, an inhibitor of apoptosis, survivin, and transcriptional factor, NF-kB/p65. Severe inflammatory injury of pulmonary parenchyma (PDS 3.33 ± 0.48) was developed after the LPS challenge, whereas simvastatin significantly and dose-dependently protected lung histology after LPS (p < 0.01). Simvastatin in a dose of 40 mg/kg showed the most significant effects in amelioration alveolar epithelial cells apoptosis, demonstrating this as a marked decrease of AI (p < 0.01 vs. LPS), cytochrome C, and cleaved caspase-3 expression. Furthermore, simvastatin significantly enhanced the expression of Bcl-xL and survivin. Finally, the expression of survivin and its regulator NF-kB/p65 in the alveolar epithelium was in strong positive correlation across the groups. Simvastatin could play a protective role against LPS-induced ALI and apoptosis of the alveolar–endothelial barrier. Taken together, these effects were seemingly mediated by inhibition of caspase 3 and cytochrome C, a finding that might be associated with the up-regulation of cell-survival survivin/NF-kB/p65 pathway and Bcl-xL.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Amelioration of Endotoxin-Induced Acute Lung Injury and
Alveolar Epithelial Cells Apoptosis by Simvastatin Is
Associated with Up-Regulation of Survivin/NF-KB/p65 Pathway
VL  - 23
IS  - 5
SP  - 2596
DO  - 10.3390/ijms23052596
ER  - 

@article{
author = "Nežić, Lana and Amidžić, Ljiljana and Škrbić, Ranko and Gajanin, Radoslav and Mandić, Danijela and Dumanović, Jelena and Milovanović, Zoran and Jaćević, Vesna",
year = "2022",
abstract = "Disruption of the alveolar–endothelial barrier caused by inflammation leads to the progression of septic acute lung injury (ALI). In the present study, we investigated the beneficial effects of simvastatin on the endotoxin lipopolysaccharide (LPS)-induced ALI and its related mechanisms. A model of ALI was induced within experimental sepsis developed by intraperitoneal injection of a single non-lethal LPS dose after short-term simvastatin pretreatment (10–40 mg/kg orally). The severity of the lung tissue inflammatory injury was expressed as pulmonary damage scores (PDS). Alveolar epithelial cell apoptosis was confirmed by TUNEL assay (DNA fragmentation) and expressed as an apoptotic index (AI), and immunohistochemically for cleaved caspase-3, cytochrome C, and anti-apoptotic Bcl-xL, an inhibitor of apoptosis, survivin, and transcriptional factor, NF-kB/p65. Severe inflammatory injury of pulmonary parenchyma (PDS 3.33 ± 0.48) was developed after the LPS challenge, whereas simvastatin significantly and dose-dependently protected lung histology after LPS (p < 0.01). Simvastatin in a dose of 40 mg/kg showed the most significant effects in amelioration alveolar epithelial cells apoptosis, demonstrating this as a marked decrease of AI (p < 0.01 vs. LPS), cytochrome C, and cleaved caspase-3 expression. Furthermore, simvastatin significantly enhanced the expression of Bcl-xL and survivin. Finally, the expression of survivin and its regulator NF-kB/p65 in the alveolar epithelium was in strong positive correlation across the groups. Simvastatin could play a protective role against LPS-induced ALI and apoptosis of the alveolar–endothelial barrier. Taken together, these effects were seemingly mediated by inhibition of caspase 3 and cytochrome C, a finding that might be associated with the up-regulation of cell-survival survivin/NF-kB/p65 pathway and Bcl-xL.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Amelioration of Endotoxin-Induced Acute Lung Injury and
Alveolar Epithelial Cells Apoptosis by Simvastatin Is
Associated with Up-Regulation of Survivin/NF-KB/p65 Pathway",
volume = "23",
number = "5",
pages = "2596",
doi = "10.3390/ijms23052596"
}

Nežić, L., Amidžić, L., Škrbić, R., Gajanin, R., Mandić, D., Dumanović, J., Milovanović, Z.,& Jaćević, V.. (2022). Amelioration of Endotoxin-Induced Acute Lung Injury and
Alveolar Epithelial Cells Apoptosis by Simvastatin Is
Associated with Up-Regulation of Survivin/NF-KB/p65 Pathway. in International Journal of Molecular Sciences
MDPI., 23(5), 2596.
https://doi.org/10.3390/ijms23052596

Nežić L, Amidžić L, Škrbić R, Gajanin R, Mandić D, Dumanović J, Milovanović Z, Jaćević V. Amelioration of Endotoxin-Induced Acute Lung Injury and
Alveolar Epithelial Cells Apoptosis by Simvastatin Is
Associated with Up-Regulation of Survivin/NF-KB/p65 Pathway. in International Journal of Molecular Sciences. 2022;23(5):2596.
doi:10.3390/ijms23052596 .

Nežić, Lana, Amidžić, Ljiljana, Škrbić, Ranko, Gajanin, Radoslav, Mandić, Danijela, Dumanović, Jelena, Milovanović, Zoran, Jaćević, Vesna, "Amelioration of Endotoxin-Induced Acute Lung Injury and
Alveolar Epithelial Cells Apoptosis by Simvastatin Is
Associated with Up-Regulation of Survivin/NF-KB/p65 Pathway" in International Journal of Molecular Sciences, 23, no. 5 (2022):2596,
https://doi.org/10.3390/ijms23052596 . .

TY  - JOUR
AU  - Dumanović, Jelena
AU  - Nepovimova, Eugenie
AU  - Natić, Maja
AU  - Kuča, Kamil
AU  - Jaćević, Vesna
PY  - 2021
UR  - https://www.frontiersin.org/articles/10.3389/fpls.2020.552969/full
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4452
AB  - In plants, there's a complex and multilevel network of the antioxidative system (AOS) operating to counteract harmful reactive species (RS), the foremost important of which are reactive oxygen species (ROS), and maintain homeostasis within the cell. Specific AOSs for plant cells are, first and foremost, enzymes of the glutathione-ascorbate cycle (Asc-GSH), followed by phenolic compounds and lipophilic antioxidants like carotenoids and tocopherols. Evidence that plant cells have excellent antioxidative defence systems is their ability to survive at H2O2 concentrations incompatible with animal cell life. For the survival of stressed plants, it's of particular importance that AOS cooperate and participate in redox reactions, therefore providing better protection and regeneration of the active reduced forms. Considering that plants abound in antioxidant compounds, and humans are not predisposed to synthesize the majority of them, new fields of research have emerged. Antioxidant potential of plant compounds has been exploited for antiaging formulations preparation, food fortification and preservation, but also in designing new therapies for diseases with oxidative stress implicated in aetiology.
PB  - Frontiers
T2  - Frontiers in Plant Science
T1  - The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview
VL  - 11
SP  - 552969
DO  - 10.3389/fpls.2020.552969
ER  - 

@article{
author = "Dumanović, Jelena and Nepovimova, Eugenie and Natić, Maja and Kuča, Kamil and Jaćević, Vesna",
year = "2021",
abstract = "In plants, there's a complex and multilevel network of the antioxidative system (AOS) operating to counteract harmful reactive species (RS), the foremost important of which are reactive oxygen species (ROS), and maintain homeostasis within the cell. Specific AOSs for plant cells are, first and foremost, enzymes of the glutathione-ascorbate cycle (Asc-GSH), followed by phenolic compounds and lipophilic antioxidants like carotenoids and tocopherols. Evidence that plant cells have excellent antioxidative defence systems is their ability to survive at H2O2 concentrations incompatible with animal cell life. For the survival of stressed plants, it's of particular importance that AOS cooperate and participate in redox reactions, therefore providing better protection and regeneration of the active reduced forms. Considering that plants abound in antioxidant compounds, and humans are not predisposed to synthesize the majority of them, new fields of research have emerged. Antioxidant potential of plant compounds has been exploited for antiaging formulations preparation, food fortification and preservation, but also in designing new therapies for diseases with oxidative stress implicated in aetiology.",
publisher = "Frontiers",
journal = "Frontiers in Plant Science",
title = "The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview",
volume = "11",
pages = "552969",
doi = "10.3389/fpls.2020.552969"
}

Dumanović, J., Nepovimova, E., Natić, M., Kuča, K.,& Jaćević, V.. (2021). The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview. in Frontiers in Plant Science
Frontiers., 11, 552969.
https://doi.org/10.3389/fpls.2020.552969

Dumanović J, Nepovimova E, Natić M, Kuča K, Jaćević V. The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview. in Frontiers in Plant Science. 2021;11:552969.
doi:10.3389/fpls.2020.552969 .

Dumanović, Jelena, Nepovimova, Eugenie, Natić, Maja, Kuča, Kamil, Jaćević, Vesna, "The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview" in Frontiers in Plant Science, 11 (2021):552969,
https://doi.org/10.3389/fpls.2020.552969 . .

TY  - JOUR
AU  - Jaćević, Vesna
AU  - Dumanović, Jelena
AU  - Lazarević, Miodrag
AU  - Nepovimova, Eugenie
AU  - Resanović, Radmila
AU  - Milovanović, Zoran
AU  - Wu, Qinghua
AU  - Kuča, Kamil
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4258
AB  - In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.
PB  - MDPI
T2  - Toxins
T1  - Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin
VL  - 12
IS  - 10
SP  - 643
DO  - 10.3390/toxins12100643
ER  - 

@article{
author = "Jaćević, Vesna and Dumanović, Jelena and Lazarević, Miodrag and Nepovimova, Eugenie and Resanović, Radmila and Milovanović, Zoran and Wu, Qinghua and Kuča, Kamil",
year = "2020",
abstract = "In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.",
publisher = "MDPI",
journal = "Toxins",
title = "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin",
volume = "12",
number = "10",
pages = "643",
doi = "10.3390/toxins12100643"
}

Jaćević, V., Dumanović, J., Lazarević, M., Nepovimova, E., Resanović, R., Milovanović, Z., Wu, Q.,& Kuča, K.. (2020). Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins
MDPI., 12(10), 643.
https://doi.org/10.3390/toxins12100643

Jaćević V, Dumanović J, Lazarević M, Nepovimova E, Resanović R, Milovanović Z, Wu Q, Kuča K. Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins. 2020;12(10):643.
doi:10.3390/toxins12100643 .

Jaćević, Vesna, Dumanović, Jelena, Lazarević, Miodrag, Nepovimova, Eugenie, Resanović, Radmila, Milovanović, Zoran, Wu, Qinghua, Kuča, Kamil, "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin" in Toxins, 12, no. 10 (2020):643,
https://doi.org/10.3390/toxins12100643 . .