TY  - JOUR
AU  - Muellers, Tobias
AU  - Petrovic, Predrag V.
AU  - Zimmerman, Julie
AU  - Anastas, Paul
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6314
AB  - An expanding web of adverse impacts on people and the environment has been steadily linked to anthropogenic chemicals and their proliferation. Central to this web are the regulatory structures intended to protect human and environmental health through the control of new molecules. Through chronically insufficient and inefficient action, the current chemical-by-chemical regulatory approach, which considers regulation at the level of chemical identity, has enabled many adverse impacts to develop and persist. Recognizing the link between fundamental physicochemical properties and hazards, we describe a new paradigm─property-based regulation. By regulating physicochemical properties, we show how governments can delineate and enforce safe chemical spaces, increasing the scalability of chemical assessments, reducing the time and resources to regulate a substance, and providing transparency for chemical designers. We highlight sparse existing property-based approaches and demonstrate their applicability using bioaccumulation as an example. Finally, we present a path to implementation in the United States, prescribing roles and steps for government, nongovernmental organizations, and industry to accelerate this transition, to the benefit of all.
PB  - American Chemical Society
T2  - Environ. Sci. Technol.
T1  - Toward Property-Based Regulation
VL  - 57
IS  - 32
SP  - 11718
EP  - 11730
DO  - 10.1021/acs.est.3c00643
ER  - 

@article{
author = "Muellers, Tobias and Petrovic, Predrag V. and Zimmerman, Julie and Anastas, Paul",
year = "2023",
abstract = "An expanding web of adverse impacts on people and the environment has been steadily linked to anthropogenic chemicals and their proliferation. Central to this web are the regulatory structures intended to protect human and environmental health through the control of new molecules. Through chronically insufficient and inefficient action, the current chemical-by-chemical regulatory approach, which considers regulation at the level of chemical identity, has enabled many adverse impacts to develop and persist. Recognizing the link between fundamental physicochemical properties and hazards, we describe a new paradigm─property-based regulation. By regulating physicochemical properties, we show how governments can delineate and enforce safe chemical spaces, increasing the scalability of chemical assessments, reducing the time and resources to regulate a substance, and providing transparency for chemical designers. We highlight sparse existing property-based approaches and demonstrate their applicability using bioaccumulation as an example. Finally, we present a path to implementation in the United States, prescribing roles and steps for government, nongovernmental organizations, and industry to accelerate this transition, to the benefit of all.",
publisher = "American Chemical Society",
journal = "Environ. Sci. Technol.",
title = "Toward Property-Based Regulation",
volume = "57",
number = "32",
pages = "11718-11730",
doi = "10.1021/acs.est.3c00643"
}

Muellers, T., Petrovic, P. V., Zimmerman, J.,& Anastas, P.. (2023). Toward Property-Based Regulation. in Environ. Sci. Technol.
American Chemical Society., 57(32), 11718-11730.
https://doi.org/10.1021/acs.est.3c00643

Muellers T, Petrovic PV, Zimmerman J, Anastas P. Toward Property-Based Regulation. in Environ. Sci. Technol.. 2023;57(32):11718-11730.
doi:10.1021/acs.est.3c00643 .

Muellers, Tobias, Petrovic, Predrag V., Zimmerman, Julie, Anastas, Paul, "Toward Property-Based Regulation" in Environ. Sci. Technol., 57, no. 32 (2023):11718-11730,
https://doi.org/10.1021/acs.est.3c00643 . .