@conference{
author = "Filipović, Nenad and Bjelogrlić, Snežana and Kojić, Milan and Senćanski, Milan and Nikolić, Milan and Višnjevac, Aleksandar and Araškov, Jovana and Marija, Miljković and Muller, Christian and Todorović, Tamara",
year = "2018",
abstract = "Anticancer activity of five Pd(II) pyridine-based hydrazone complexes (1‒5, Figure 1) was investigated against a human monocytic leukemia THP-1 (2D) cell line and a breast cancer MCF-7 (2D and 3D) cell line. For complexes with apoptosis as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce ROS and in vitro inhibit topoisomerase I in a low micromolar range. In silico studies corroborate experimental findings and indicate binding to DNA's minor groove. The most active compounds are suitable to be transported via blood stream by human serum albumin, as results of CD and fluorescence spectroscopy showed.",
publisher = "Università “Magna Græcia” di Catanzaro, Italy",
journal = "MuTaLig COST ACTION CA15135, Annual meeting,Valletta, Malta, October 18-19, 2018",
title = "Pd(II) complexes with N-heteroaromatic hydrazones as dual targeting DNA/Topoisomerase 1 agents: experimental and in silico study",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6010"
}