TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Tosti, Tomislav
AU  - Tešić, Živoslav Lj.
AU  - Milković, Borivoj
AU  - Dragičević, Dejan
AU  - Kozomara, Milutin
AU  - Čekerevac, Milica
AU  - Džamić, Zoran
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2479
AB  - BackgroundThere is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). MethodsTissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy. The criteria for biopsy were abnormal DRE and/or PSA gt 4ng/mL. Total prostate volume (TPV) was determined by transrectal ultrasound (TRUS). During TRUS- guided prostate biopsy, 10-12 samples were collected from the peripheral zone (PZ) and two additional samples were collected from the transition zone (TZ). The samples from the TZ were immediately frozen in liquid nitrogen at -70 degrees C, and transported for tissue androgen determination, using liquid chromatography mass spectrometry (LC-MS). ResultsPathological analysis revealed that prostate cancer (PCa) was present in 45 and absent in 48 patients. In the whole group, there were 42 men with small prostate (TPV lt 30mL) and 51 with enlarged prostate (TPV31mL). The overall average tT level was 0.790.66ng/g, while the average tDHT level was 10.27 +/- 7.15ng/g. There were no differences in tT and tDHT level in prostates with and without PCa. However, tT and tDHT levels were significantly higher in larger, than in smaller prostates (tT: 1.05 +/- 0.75 and 0.46 +/- 0.29ng/g, and tDHT: 15.0 +/- 6.09 and 4.51 +/- 2.75ng/g, respectively). There were strong correlations between tT and TPV (r=0.71), and tDHT and TPV (r=0.74). ConclusionsThe present study confirmed that both T and DHT accumulated in the stroma of enlarged prostates; the degree of accumulation correlated with prostate volume.
PB  - Wiley, Hoboken
T2  - Prostate
T1  - Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume
VL  - 77
IS  - 10
SP  - 1082
EP  - 1092
DO  - 10.1002/pros.23365
ER  - 

@article{
author = "Pejčić, Tomislav and Tosti, Tomislav and Tešić, Živoslav Lj. and Milković, Borivoj and Dragičević, Dejan and Kozomara, Milutin and Čekerevac, Milica and Džamić, Zoran",
year = "2017",
abstract = "BackgroundThere is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). MethodsTissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy. The criteria for biopsy were abnormal DRE and/or PSA gt 4ng/mL. Total prostate volume (TPV) was determined by transrectal ultrasound (TRUS). During TRUS- guided prostate biopsy, 10-12 samples were collected from the peripheral zone (PZ) and two additional samples were collected from the transition zone (TZ). The samples from the TZ were immediately frozen in liquid nitrogen at -70 degrees C, and transported for tissue androgen determination, using liquid chromatography mass spectrometry (LC-MS). ResultsPathological analysis revealed that prostate cancer (PCa) was present in 45 and absent in 48 patients. In the whole group, there were 42 men with small prostate (TPV lt 30mL) and 51 with enlarged prostate (TPV31mL). The overall average tT level was 0.790.66ng/g, while the average tDHT level was 10.27 +/- 7.15ng/g. There were no differences in tT and tDHT level in prostates with and without PCa. However, tT and tDHT levels were significantly higher in larger, than in smaller prostates (tT: 1.05 +/- 0.75 and 0.46 +/- 0.29ng/g, and tDHT: 15.0 +/- 6.09 and 4.51 +/- 2.75ng/g, respectively). There were strong correlations between tT and TPV (r=0.71), and tDHT and TPV (r=0.74). ConclusionsThe present study confirmed that both T and DHT accumulated in the stroma of enlarged prostates; the degree of accumulation correlated with prostate volume.",
publisher = "Wiley, Hoboken",
journal = "Prostate",
title = "Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume",
volume = "77",
number = "10",
pages = "1082-1092",
doi = "10.1002/pros.23365"
}

Pejčić, T., Tosti, T., Tešić, Ž. Lj., Milković, B., Dragičević, D., Kozomara, M., Čekerevac, M.,& Džamić, Z.. (2017). Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume. in Prostate
Wiley, Hoboken., 77(10), 1082-1092.
https://doi.org/10.1002/pros.23365

Pejčić T, Tosti T, Tešić ŽL, Milković B, Dragičević D, Kozomara M, Čekerevac M, Džamić Z. Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume. in Prostate. 2017;77(10):1082-1092.
doi:10.1002/pros.23365 .

Pejčić, Tomislav, Tosti, Tomislav, Tešić, Živoslav Lj., Milković, Borivoj, Dragičević, Dejan, Kozomara, Milutin, Čekerevac, Milica, Džamić, Zoran, "Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume" in Prostate, 77, no. 10 (2017):1082-1092,
https://doi.org/10.1002/pros.23365 . .