Mandić, Boris

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Authority KeyName Variants
orcid::0000-0001-6103-7657
  • Mandić, Boris (40)
Projects
Natural products of wild, cultivated and edible plants: structure and bioactivity determination Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM)
Coordenagdo de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Fundacdo de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Ontogenetic characterization of phylogenetic biodiversity Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry)
Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders Biomasa i metabolizam nekih mikroorganizama kao izvor široko upotrebljivih proizvoda i biohemijskih reakcija
Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost Organization for the Prohibition of Chemical Weapons (OPCW)
Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome Department of Chemistry, University of Houston, 112 Fleming Building, Houston TX 77204- 5003, USA.
Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research Holographic methods for generation of specific wave-fronts to better control quantum coherent effects in laser-atom interactions
Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors Studies of enzyme interactions with toxic and pharmacologically active molecules
Evaluation of ecophysiological and genetic plant diversity in forest ecosystems The effects of magnetic fields and other environmental stressors on the physiological responses and behavior of different species
Biological response modifiers in physiological and pathological conditions Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200051 (Institute of General and Physical Chemistry, Belgrade)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200135 (University of Belgrade, Faculty of Technology and Metallurgy) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200178 (University of Belgrade, Faculty of Biology)
Fabrication and characterization of nano-photonic functional structrues in biomedicine and informatics Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness
Funkcionalna analiza ontogenetske diverzifikacije faune i modifikacije evolutivnih odgovora tokom filogenije Ministry of Science and Technology of the People’s Republic of China (Grant ”Mimetics of Insects for Sensing and Security”, I-2)
Research Infrastructure for Campus-based Laboratories at University of Rijeka Research Infrastructure for Campus-based Laboratories at University of RijekaResearch Infrastructure for Campus-based Laboratories at University of Rijeka

Author's Bibliography

Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA

Milosavljević, Slobodan M.; Đorđević, Iris; Mandić, Boris; Tešević, Vele; Stanković, Miroslava; Todorović, Nina; Novaković, Miroslav M.

(SAGE Publications, 2021)

TY  - JOUR
AU  - Milosavljević, Slobodan M.
AU  - Đorđević, Iris
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Stanković, Miroslava
AU  - Todorović, Nina
AU  - Novaković, Miroslav M.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4838
AB  - In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.
PB  - SAGE Publications
T2  - Natural Product Communications
T1  - Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
VL  - 16
IS  - 12
SP  - 1
EP  - 8
DO  - 10.1177/1934578X211067289
ER  - 
@article{
author = "Milosavljević, Slobodan M. and Đorđević, Iris and Mandić, Boris and Tešević, Vele and Stanković, Miroslava and Todorović, Nina and Novaković, Miroslav M.",
year = "2021",
abstract = "In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.",
publisher = "SAGE Publications",
journal = "Natural Product Communications",
title = "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA",
volume = "16",
number = "12",
pages = "1-8",
doi = "10.1177/1934578X211067289"
}
Milosavljević, S. M., Đorđević, I., Mandić, B., Tešević, V., Stanković, M., Todorović, N.,& Novaković, M. M.. (2021). Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications
SAGE Publications., 16(12), 1-8.
https://doi.org/10.1177/1934578X211067289
Milosavljević SM, Đorđević I, Mandić B, Tešević V, Stanković M, Todorović N, Novaković MM. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications. 2021;16(12):1-8.
doi:10.1177/1934578X211067289 .
Milosavljević, Slobodan M., Đorđević, Iris, Mandić, Boris, Tešević, Vele, Stanković, Miroslava, Todorović, Nina, Novaković, Miroslav M., "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA" in Natural Product Communications, 16, no. 12 (2021):1-8,
https://doi.org/10.1177/1934578X211067289 . .
1

Inhibition potency of disulphides and trisulphides on various tumor cell lines growth

Mandić, Boris; Simić, K.; Trifunović, S.; Vujisić, Ljubodrag V.; Novaković, M.; Tešević, Vele; Miljanić, O. Š.

(2021)

TY  - JOUR
AU  - Mandić, Boris
AU  - Simić, K.
AU  - Trifunović, S.
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, M.
AU  - Tešević, Vele
AU  - Miljanić, O. Š.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4936
AB  - Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 μmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.
T2  - Digest Journal of Nanomaterials & Biostructures (DJNB)
T1  - Inhibition potency of disulphides and trisulphides on various tumor cell lines growth
VL  - 16
IS  - 2
SP  - 585
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4936
ER  - 
@article{
author = "Mandić, Boris and Simić, K. and Trifunović, S. and Vujisić, Ljubodrag V. and Novaković, M. and Tešević, Vele and Miljanić, O. Š.",
year = "2021",
abstract = "Tumor is one of the leading diseases of today. Chemotherapy and radiation therapy healing chances are limited, so some alternative methods are resorted to. Many papers indicated that garlic and organosulphur compounds diallyldisulphide (DADS) and diallyltrisulphide, which are main components of garlic decrease the cancer risk and inhibit the cell proliferation. In this paper inhibition potency of disulphides (DADS and its synthetic analogues) and trisulphides with different alkyl and phenyl substituents on growth of various tumor (Non-Small cell Lung Cancer, Colon cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, Breast Cancer, Leukemia) cell lines was investigated. Concentration of each compound (DADS, diethyl disulphide, dipropyl disulphide, diphenyl disulphide, tetraethylthiuram disulphide (TETUDS), dimetil trisulphide, dipropyl trisulphide and metilpropyl trisulphide (MPTS) was 10 μmol/L. It was found that DADS has an inhibitory effect on the growth of several cancer cell lines, but synthetic analogues TETUDS and MPTS exhibit stronger effect on certain cells lines. MPTS inhibits the growth of even 12 cell lines for more than 10%, especially leukemia cell line SR and NCI-H522 cell line of Non-Small cell Lung Cancer (reduction of growth for 24% and 47%, resp.). Trisulphide analogues exhibit little higher inhibitory effects in comparison to disulphide ones.",
journal = "Digest Journal of Nanomaterials & Biostructures (DJNB)",
title = "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth",
volume = "16",
number = "2",
pages = "585-592",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4936"
}
Mandić, B., Simić, K., Trifunović, S., Vujisić, L. V., Novaković, M., Tešević, V.,& Miljanić, O. Š.. (2021). Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials & Biostructures (DJNB), 16(2), 585-592.
https://hdl.handle.net/21.15107/rcub_cherry_4936
Mandić B, Simić K, Trifunović S, Vujisić LV, Novaković M, Tešević V, Miljanić OŠ. Inhibition potency of disulphides and trisulphides on various tumor cell lines growth. in Digest Journal of Nanomaterials & Biostructures (DJNB). 2021;16(2):585-592.
https://hdl.handle.net/21.15107/rcub_cherry_4936 .
Mandić, Boris, Simić, K., Trifunović, S., Vujisić, Ljubodrag V., Novaković, M., Tešević, Vele, Miljanić, O. Š., "Inhibition potency of disulphides and trisulphides on various tumor cell lines growth" in Digest Journal of Nanomaterials & Biostructures (DJNB), 16, no. 2 (2021):585-592,
https://hdl.handle.net/21.15107/rcub_cherry_4936 .

Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method

Kramar, Ana; Petrovic, Marija; Mihajlovski, Katarina; Mandić, Boris; Vukovic, Gorica; Blagojevic, Stevan; Kostić, Mirjana M.

(2021)

TY  - JOUR
AU  - Kramar, Ana
AU  - Petrovic, Marija
AU  - Mihajlovski, Katarina
AU  - Mandić, Boris
AU  - Vukovic, Gorica
AU  - Blagojevic, Stevan
AU  - Kostić, Mirjana M.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4939
AB  - Six ethanolic extracts, obtained from anise, fennel, lavender, sage, mint, white horehound and their mixture were directly applied onto cellulose (viscose) fabric to impart antimicrobial and antioxidant functionality for its potential use as a wound dressing. Antimicrobial activity of treated fabrics against gram-positive bacteria S. aureus and yeast C. albicans, as common skin pathogens, was determined by agar diffusion test. The most effective against both microorganisms was viscose with anise, fennel, and mint, whereby clear inhibition and suppression zones were detected. The oxidation of viscose, intended to improve sorption properties and consequently adsorption of extracts, increased the antimicrobial activity of viscose with a mixture of extracts. The antioxidant activity of fabric samples with extracts, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, was significantly higher when compared to the untreated viscose sample (2.38 %) and ranged from 11.82 % for viscose with fennel up to 87.71 % for viscose with sage. Oxidation of fabric before sorption of extracts mixture contributes to higher antioxidant activity (68.81 %). Direct impregnation of bioactive plants extracts onto the fabric represents low cost and simple method, which makes it suitable for obtaining eco-friendly, low-cost disposable medical textiles with the therapeutic and prophylactic role.
T2  - Fibers and Polymers
T1  - Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method
VL  - 22
IS  - 12
SP  - 3317
EP  - 3325
DO  - 10.1007/s12221-021-3007-1
ER  - 
@article{
author = "Kramar, Ana and Petrovic, Marija and Mihajlovski, Katarina and Mandić, Boris and Vukovic, Gorica and Blagojevic, Stevan and Kostić, Mirjana M.",
year = "2021",
abstract = "Six ethanolic extracts, obtained from anise, fennel, lavender, sage, mint, white horehound and their mixture were directly applied onto cellulose (viscose) fabric to impart antimicrobial and antioxidant functionality for its potential use as a wound dressing. Antimicrobial activity of treated fabrics against gram-positive bacteria S. aureus and yeast C. albicans, as common skin pathogens, was determined by agar diffusion test. The most effective against both microorganisms was viscose with anise, fennel, and mint, whereby clear inhibition and suppression zones were detected. The oxidation of viscose, intended to improve sorption properties and consequently adsorption of extracts, increased the antimicrobial activity of viscose with a mixture of extracts. The antioxidant activity of fabric samples with extracts, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, was significantly higher when compared to the untreated viscose sample (2.38 %) and ranged from 11.82 % for viscose with fennel up to 87.71 % for viscose with sage. Oxidation of fabric before sorption of extracts mixture contributes to higher antioxidant activity (68.81 %). Direct impregnation of bioactive plants extracts onto the fabric represents low cost and simple method, which makes it suitable for obtaining eco-friendly, low-cost disposable medical textiles with the therapeutic and prophylactic role.",
journal = "Fibers and Polymers",
title = "Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method",
volume = "22",
number = "12",
pages = "3317-3325",
doi = "10.1007/s12221-021-3007-1"
}
Kramar, A., Petrovic, M., Mihajlovski, K., Mandić, B., Vukovic, G., Blagojevic, S.,& Kostić, M. M.. (2021). Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method. in Fibers and Polymers, 22(12), 3317-3325.
https://doi.org/10.1007/s12221-021-3007-1
Kramar A, Petrovic M, Mihajlovski K, Mandić B, Vukovic G, Blagojevic S, Kostić MM. Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method. in Fibers and Polymers. 2021;22(12):3317-3325.
doi:10.1007/s12221-021-3007-1 .
Kramar, Ana, Petrovic, Marija, Mihajlovski, Katarina, Mandić, Boris, Vukovic, Gorica, Blagojevic, Stevan, Kostić, Mirjana M., "Selected Aromatic Plants Extracts as an Antimicrobial and Antioxidant Finish for Cellulose Fabric- Direct Impregnation Method" in Fibers and Polymers, 22, no. 12 (2021):3317-3325,
https://doi.org/10.1007/s12221-021-3007-1 . .
2

GC–MS-based metabolomics for the detection of adulteration in oregano samples

Ivanović, Stefan; Mandrone, Manuela; Simić, Katarina; Ristić, Mirjana; Todosijević, Marina; Mandić, Boris; Gođevac, Dejan

(Belgrade : Serbian Chemical Society, 2021)

TY  - JOUR
AU  - Ivanović, Stefan
AU  - Mandrone, Manuela
AU  - Simić, Katarina
AU  - Ristić, Mirjana
AU  - Todosijević, Marina
AU  - Mandić, Boris
AU  - Gođevac, Dejan
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5035
AB  - Oregano is one of the most used culinary herb and it is often adulterated with cheaper plants. In this study, GC–MS was used for identification
and quantification of metabolites from 104 samples of oregano (Origanum vulgare and O. onites) adulterated with olive (Olea europaea), venetian sumac
(Cotinus coggygria) and myrtle (Myrtus communis) leaves, at five different
concentration levels. The metabolomics profiles obtained after the two-step
derivatization, involving methoxyamination and silanization, were subjected to
multivariate data analysis to reveal markers of adulteration and to build the regression models on the basis of the oregano-to-adulterants mixing ratio. Orthogonal partial least squares enabled detection of oregano adulterations with
olive, Venetian sumac and myrtle leaves. Sorbitol levels distinguished oregano
samples adulterated with olive leaves, while shikimic and quinic acids were
recognized as discrimination factor for adulteration of oregano with venetian
sumac. Fructose and quinic acid levels correlated with oregano adulteration
with myrtle. Orthogonal partial least squares discriminant analysis enabled discrimination of O. vulgare and O. onites samples, where catechollactate was
found to be discriminating metabolite.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - GC–MS-based metabolomics for the detection of adulteration in oregano samples
VL  - 86
IS  - 12
SP  - 1195
EP  - 1203
DO  - 10.2298/JSC210809089I
ER  - 
@article{
author = "Ivanović, Stefan and Mandrone, Manuela and Simić, Katarina and Ristić, Mirjana and Todosijević, Marina and Mandić, Boris and Gođevac, Dejan",
year = "2021",
abstract = "Oregano is one of the most used culinary herb and it is often adulterated with cheaper plants. In this study, GC–MS was used for identification
and quantification of metabolites from 104 samples of oregano (Origanum vulgare and O. onites) adulterated with olive (Olea europaea), venetian sumac
(Cotinus coggygria) and myrtle (Myrtus communis) leaves, at five different
concentration levels. The metabolomics profiles obtained after the two-step
derivatization, involving methoxyamination and silanization, were subjected to
multivariate data analysis to reveal markers of adulteration and to build the regression models on the basis of the oregano-to-adulterants mixing ratio. Orthogonal partial least squares enabled detection of oregano adulterations with
olive, Venetian sumac and myrtle leaves. Sorbitol levels distinguished oregano
samples adulterated with olive leaves, while shikimic and quinic acids were
recognized as discrimination factor for adulteration of oregano with venetian
sumac. Fructose and quinic acid levels correlated with oregano adulteration
with myrtle. Orthogonal partial least squares discriminant analysis enabled discrimination of O. vulgare and O. onites samples, where catechollactate was
found to be discriminating metabolite.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "GC–MS-based metabolomics for the detection of adulteration in oregano samples",
volume = "86",
number = "12",
pages = "1195-1203",
doi = "10.2298/JSC210809089I"
}
Ivanović, S., Mandrone, M., Simić, K., Ristić, M., Todosijević, M., Mandić, B.,& Gođevac, D.. (2021). GC–MS-based metabolomics for the detection of adulteration in oregano samples. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(12), 1195-1203.
https://doi.org/10.2298/JSC210809089I
Ivanović S, Mandrone M, Simić K, Ristić M, Todosijević M, Mandić B, Gođevac D. GC–MS-based metabolomics for the detection of adulteration in oregano samples. in Journal of the Serbian Chemical Society. 2021;86(12):1195-1203.
doi:10.2298/JSC210809089I .
Ivanović, Stefan, Mandrone, Manuela, Simić, Katarina, Ristić, Mirjana, Todosijević, Marina, Mandić, Boris, Gođevac, Dejan, "GC–MS-based metabolomics for the detection of adulteration in oregano samples" in Journal of the Serbian Chemical Society, 86, no. 12 (2021):1195-1203,
https://doi.org/10.2298/JSC210809089I . .

Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I.

Ivanović, Stefan; Mandrone, Manuela; Simić, Katarina; Ristić, Mirjana; Todosijević, Marina; Mandić, Boris; Gođevac, Dejan

(Belgrade : Serbian Chemical Society, 2021)

TY  - DATA
AU  - Ivanović, Stefan
AU  - Mandrone, Manuela
AU  - Simić, Katarina
AU  - Ristić, Mirjana
AU  - Todosijević, Marina
AU  - Mandić, Boris
AU  - Gođevac, Dejan
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5118
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5118
ER  - 
@misc{
author = "Ivanović, Stefan and Mandrone, Manuela and Simić, Katarina and Ristić, Mirjana and Todosijević, Marina and Mandić, Boris and Gođevac, Dejan",
year = "2021",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5118"
}
Ivanović, S., Mandrone, M., Simić, K., Ristić, M., Todosijević, M., Mandić, B.,& Gođevac, D.. (2021). Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I.. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_5118
Ivanović S, Mandrone M, Simić K, Ristić M, Todosijević M, Mandić B, Gođevac D. Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I.. in Journal of the Serbian Chemical Society. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_5118 .
Ivanović, Stefan, Mandrone, Manuela, Simić, Katarina, Ristić, Mirjana, Todosijević, Marina, Mandić, Boris, Gođevac, Dejan, "Supplementary data for the article: Ivanović, S.; Mandrone, M.; Simić, K.; Ristić, M.; Todosijević, M.; Mandić, B.; Gođevac, D. GC-MS-Based Metabolomics for the Detection of Adulteration in Oregano Samples. Journal of the Serbian Chemical Society 2021, 86 (12), 1195–1203. https://doi.org/10.2298/JSC210809089I." in Journal of the Serbian Chemical Society (2021),
https://hdl.handle.net/21.15107/rcub_cherry_5118 .

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić, Bojan; Vidaković, Vera; Jadranin, Milka; Novaković, Irena T.; Trifunović, Snežana S.; Tešević, Vele; Mandić, Boris

(MDPI, 2020)

TY  - JOUR
AU  - Vujić, Bojan
AU  - Vidaković, Vera
AU  - Jadranin, Milka
AU  - Novaković, Irena T.
AU  - Trifunović, Snežana S.
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3962
AB  - Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.
PB  - MDPI
T2  - Plants
T1  - Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts
VL  - 9
IS  - 3
SP  - 337
DO  - 10.3390/plants9030337
ER  - 
@article{
author = "Vujić, Bojan and Vidaković, Vera and Jadranin, Milka and Novaković, Irena T. and Trifunović, Snežana S. and Tešević, Vele and Mandić, Boris",
year = "2020",
abstract = "Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.",
publisher = "MDPI",
journal = "Plants",
title = "Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts",
volume = "9",
number = "3",
pages = "337",
doi = "10.3390/plants9030337"
}
Vujić, B., Vidaković, V., Jadranin, M., Novaković, I. T., Trifunović, S. S., Tešević, V.,& Mandić, B.. (2020). Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts. in Plants
MDPI., 9(3), 337.
https://doi.org/10.3390/plants9030337
Vujić B, Vidaković V, Jadranin M, Novaković IT, Trifunović SS, Tešević V, Mandić B. Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts. in Plants. 2020;9(3):337.
doi:10.3390/plants9030337 .
Vujić, Bojan, Vidaković, Vera, Jadranin, Milka, Novaković, Irena T., Trifunović, Snežana S., Tešević, Vele, Mandić, Boris, "Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts" in Plants, 9, no. 3 (2020):337,
https://doi.org/10.3390/plants9030337 . .
7
2
4

Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)

Ivanović, Stefan; Avramović, Nataša; Dojčinović, Biljana P.; Trifunović, Snežana S.; Novaković, Miroslav M.; Tešević, Vele; Mandić, Boris

(Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI), 2020)

TY  - JOUR
AU  - Ivanović, Stefan
AU  - Avramović, Nataša
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Snežana S.
AU  - Novaković, Miroslav M.
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3992
AB  - The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.
PB  - Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Foods
T1  - Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)
VL  - 9
IS  - 4
SP  - 430
DO  - 10.3390/foods9040430
ER  - 
@article{
author = "Ivanović, Stefan and Avramović, Nataša and Dojčinović, Biljana P. and Trifunović, Snežana S. and Novaković, Miroslav M. and Tešević, Vele and Mandić, Boris",
year = "2020",
abstract = "The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.",
publisher = "Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Foods",
title = "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)",
volume = "9",
number = "4",
pages = "430",
doi = "10.3390/foods9040430"
}
Ivanović, S., Avramović, N., Dojčinović, B. P., Trifunović, S. S., Novaković, M. M., Tešević, V.,& Mandić, B.. (2020). Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods
Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)., 9(4), 430.
https://doi.org/10.3390/foods9040430
Ivanović S, Avramović N, Dojčinović BP, Trifunović SS, Novaković MM, Tešević V, Mandić B. Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods. 2020;9(4):430.
doi:10.3390/foods9040430 .
Ivanović, Stefan, Avramović, Nataša, Dojčinović, Biljana P., Trifunović, Snežana S., Novaković, Miroslav M., Tešević, Vele, Mandić, Boris, "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)" in Foods, 9, no. 4 (2020):430,
https://doi.org/10.3390/foods9040430 . .
8
7
9

Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

Avramović, Nataša; Mandić, Boris; Savić-Radojević, Ana; Simić, Tatjana

(2020)

TY  - JOUR
AU  - Avramović, Nataša
AU  - Mandić, Boris
AU  - Savić-Radojević, Ana
AU  - Simić, Tatjana
PY  - 2020
UR  - https://www.mdpi.com/1999-4923/12/4/298
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4021
AB  - Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
T2  - Pharmaceutics
T2  - Pharmaceutics
T1  - Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
VL  - 12
IS  - 4
SP  - 298
DO  - 10.3390/pharmaceutics12040298
ER  - 
@article{
author = "Avramović, Nataša and Mandić, Boris and Savić-Radojević, Ana and Simić, Tatjana",
year = "2020",
abstract = "Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.",
journal = "Pharmaceutics, Pharmaceutics",
title = "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy",
volume = "12",
number = "4",
pages = "298",
doi = "10.3390/pharmaceutics12040298"
}
Avramović, N., Mandić, B., Savić-Radojević, A.,& Simić, T.. (2020). Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics, 12(4), 298.
https://doi.org/10.3390/pharmaceutics12040298
Avramović N, Mandić B, Savić-Radojević A, Simić T. Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics. 2020;12(4):298.
doi:10.3390/pharmaceutics12040298 .
Avramović, Nataša, Mandić, Boris, Savić-Radojević, Ana, Simić, Tatjana, "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy" in Pharmaceutics, 12, no. 4 (2020):298,
https://doi.org/10.3390/pharmaceutics12040298 . .
1
67
42
54

Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae)

Vranić, Sofija; Ćurčić, Srećko; Vesović, Nikola; Mandić, Boris; Pantelić, Dejan; Vasović, Marija; Lazović, Vladimir; Zhang, Wang; Vujisić, Ljubodrag V.

(Elsevier, 2020)

TY  - JOUR
AU  - Vranić, Sofija
AU  - Ćurčić, Srećko
AU  - Vesović, Nikola
AU  - Mandić, Boris
AU  - Pantelić, Dejan
AU  - Vasović, Marija
AU  - Lazović, Vladimir
AU  - Zhang, Wang
AU  - Vujisić, Ljubodrag V.
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4240
AB  - Morphology of the pygidial glands and chemical composition of their secretions in adults of four ground beetle representatives of the Pterostichini tribe (Coleoptera: Carabidae) were analysed. Molops (Stenochoromus) montenegrinus, Pterostichus (Cophosus) cylindricus, P. (Feronidius) melas and P. (Pseudomaseus) nigrita were chemically tested, while the latter three species were morphologically investigated. Pterostichus (C.) cylindricus, P. (P.) nigrita and M. (S.) montenegrinus were chemically studied for the first time. Altogether, 23 chemical compounds were isolated using gas chromatography-mass spectrometry (GC-MS), of which some are new for Pterostichini or even Carabidae. Methacrylic acid was present in all species analysed. It was predominant in the secretion extract of P. (C.) cylindricus and P. (F.) melas. Isobutyric and 2-methylbutyric acids were the major components in the secretion of M. (S.) montenegrinus. Undecane, methacrylic and tiglic acids were the main components in the secretion of P. (P.) nigrita. The simplest chemical mixture was found in P. (C.) cylindricus (two compounds), while the most complex one was detected in P. (P.) nigrita (15 compounds). No significant differences in the chemical composition of the pygidial gland secretions were evidenced in P. (C.) cylindricus sampled from the same area and in the same season in two different years. Morphology of the pygidial glands of the studied species was analysed for the first time. Morphological features of the pygidial glands were observed using bright-field microscopy and nonlinear microscopy and described in details.
PB  - Elsevier
T2  - Zoology
T1  - Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae)
VL  - 142
SP  - 125772
DO  - 10.1016/j.zool.2020.125772
ER  - 
@article{
author = "Vranić, Sofija and Ćurčić, Srećko and Vesović, Nikola and Mandić, Boris and Pantelić, Dejan and Vasović, Marija and Lazović, Vladimir and Zhang, Wang and Vujisić, Ljubodrag V.",
year = "2020",
abstract = "Morphology of the pygidial glands and chemical composition of their secretions in adults of four ground beetle representatives of the Pterostichini tribe (Coleoptera: Carabidae) were analysed. Molops (Stenochoromus) montenegrinus, Pterostichus (Cophosus) cylindricus, P. (Feronidius) melas and P. (Pseudomaseus) nigrita were chemically tested, while the latter three species were morphologically investigated. Pterostichus (C.) cylindricus, P. (P.) nigrita and M. (S.) montenegrinus were chemically studied for the first time. Altogether, 23 chemical compounds were isolated using gas chromatography-mass spectrometry (GC-MS), of which some are new for Pterostichini or even Carabidae. Methacrylic acid was present in all species analysed. It was predominant in the secretion extract of P. (C.) cylindricus and P. (F.) melas. Isobutyric and 2-methylbutyric acids were the major components in the secretion of M. (S.) montenegrinus. Undecane, methacrylic and tiglic acids were the main components in the secretion of P. (P.) nigrita. The simplest chemical mixture was found in P. (C.) cylindricus (two compounds), while the most complex one was detected in P. (P.) nigrita (15 compounds). No significant differences in the chemical composition of the pygidial gland secretions were evidenced in P. (C.) cylindricus sampled from the same area and in the same season in two different years. Morphology of the pygidial glands of the studied species was analysed for the first time. Morphological features of the pygidial glands were observed using bright-field microscopy and nonlinear microscopy and described in details.",
publisher = "Elsevier",
journal = "Zoology",
title = "Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae)",
volume = "142",
pages = "125772",
doi = "10.1016/j.zool.2020.125772"
}
Vranić, S., Ćurčić, S., Vesović, N., Mandić, B., Pantelić, D., Vasović, M., Lazović, V., Zhang, W.,& Vujisić, L. V.. (2020). Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae). in Zoology
Elsevier., 142, 125772.
https://doi.org/10.1016/j.zool.2020.125772
Vranić S, Ćurčić S, Vesović N, Mandić B, Pantelić D, Vasović M, Lazović V, Zhang W, Vujisić LV. Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae). in Zoology. 2020;142:125772.
doi:10.1016/j.zool.2020.125772 .
Vranić, Sofija, Ćurčić, Srećko, Vesović, Nikola, Mandić, Boris, Pantelić, Dejan, Vasović, Marija, Lazović, Vladimir, Zhang, Wang, Vujisić, Ljubodrag V., "Chemistry and morphology of the pygidial glands in four Pterostichini ground beetle taxa (Coleoptera: Carabidae: Pterostichinae)" in Zoology, 142 (2020):125772,
https://doi.org/10.1016/j.zool.2020.125772 . .
5
3
4

Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA

Krstić, Gordana B.; Jadranin, Milka; Stanković, Miroslava; Aljančić, Ivana; Vujisić, Ljubodrag V.; Mandić, Boris; Tešević, Vele

(SAGE Journals, 2019)

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Aljančić, Ivana
AU  - Vujisić, Ljubodrag V.
AU  - Mandić, Boris
AU  - Tešević, Vele
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3143
AB  - Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).
PB  - SAGE Journals
T2  - Natural Product Communications
T1  - Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
VL  - 14
IS  - 5
DO  - 10.1177/1934578X19848168
ER  - 
@article{
author = "Krstić, Gordana B. and Jadranin, Milka and Stanković, Miroslava and Aljančić, Ivana and Vujisić, Ljubodrag V. and Mandić, Boris and Tešević, Vele",
year = "2019",
abstract = "Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).",
publisher = "SAGE Journals",
journal = "Natural Product Communications",
title = "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA",
volume = "14",
number = "5",
doi = "10.1177/1934578X19848168"
}
Krstić, G. B., Jadranin, M., Stanković, M., Aljančić, I., Vujisić, L. V., Mandić, B.,& Tešević, V.. (2019). Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications
SAGE Journals., 14(5).
https://doi.org/10.1177/1934578X19848168
Krstić GB, Jadranin M, Stanković M, Aljančić I, Vujisić LV, Mandić B, Tešević V. Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications. 2019;14(5).
doi:10.1177/1934578X19848168 .
Krstić, Gordana B., Jadranin, Milka, Stanković, Miroslava, Aljančić, Ivana, Vujisić, Ljubodrag V., Mandić, Boris, Tešević, Vele, "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA" in Natural Product Communications, 14, no. 5 (2019),
https://doi.org/10.1177/1934578X19848168 . .
4
4
5

Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA

Cvetković, Mirjana; Đorđević, Iris; Jadranin, Milka; Stanković, Miroslava; Mandić, Boris; Milosavljević, Slobodan M.; Vujisić, Ljubodrag V.

(Informa UK Limited, 2019)

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Milosavljević, Slobodan M.
AU  - Vujisić, Ljubodrag V.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4938
AB  - Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB  - Informa UK Limited
T2  - Natural Product Research
T1  - Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA
SP  - 1
EP  - 9
DO  - 10.1080/14786419.2019.1687470
ER  - 
@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Stanković, Miroslava and Mandić, Boris and Milosavljević, Slobodan M. and Vujisić, Ljubodrag V.",
year = "2019",
abstract = "Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Informa UK Limited",
journal = "Natural Product Research",
title = "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA",
pages = "1-9",
doi = "10.1080/14786419.2019.1687470"
}
Cvetković, M., Đorđević, I., Jadranin, M., Stanković, M., Mandić, B., Milosavljević, S. M.,& Vujisić, L. V.. (2019). Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research
Informa UK Limited., 1-9.
https://doi.org/10.1080/14786419.2019.1687470
Cvetković M, Đorđević I, Jadranin M, Stanković M, Mandić B, Milosavljević SM, Vujisić LV. Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research. 2019;:1-9.
doi:10.1080/14786419.2019.1687470 .
Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Stanković, Miroslava, Mandić, Boris, Milosavljević, Slobodan M., Vujisić, Ljubodrag V., "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA" in Natural Product Research (2019):1-9,
https://doi.org/10.1080/14786419.2019.1687470 . .
1
3

Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone

Glamočlija, Una; Padhye, Subhash; Špirtović-Halilović, Selma; Osmanović, Amar; Veljović, Elma; Roca, Sunčica; Novaković, Irena T.; Mandić, Boris; Turel, Iztok; Kljun, Jakob; Trifunović, Snežana S.; Kahrović, Emira; Pavelić-Kraljević, Sandra; Harej, Anja; Klobučar, Marko; Završnik, Davorka

(MDPI, 2018)

TY  - JOUR
AU  - Glamočlija, Una
AU  - Padhye, Subhash
AU  - Špirtović-Halilović, Selma
AU  - Osmanović, Amar
AU  - Veljović, Elma
AU  - Roca, Sunčica
AU  - Novaković, Irena T.
AU  - Mandić, Boris
AU  - Turel, Iztok
AU  - Kljun, Jakob
AU  - Trifunović, Snežana S.
AU  - Kahrović, Emira
AU  - Pavelić-Kraljević, Sandra
AU  - Harej, Anja
AU  - Klobučar, Marko
AU  - Završnik, Davorka
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2807
AB  - Thymoquinone (TQ), a natural compound with antimicrobial and antitumor activity, was used as the starting molecule for the preparation of 3-aminothymoquinone (ATQ) from which ten novel benzoxazole derivatives were prepared and characterized by elemental analysis, IR spectroscopy, mass spectrometry and NMR (1H,13C) spectroscopy in solution. The crystal structure of 4-methyl-2-phenyl-7-isopropyl-1,3-benzoxazole-5-ol (1a) has been determined by X-ray diffraction. All compounds were tested for their antibacterial, antifungal and antitumor activities. TQ and ATQ showed better antibacterial activity against tested Gram-positive and Gram-negative bacterial strains than benzoxazoles. ATQ had the most potent antifungal effect against Candida albicans, Saccharomyces cerevisiae and Aspergillus brasiliensis. Three benzoxazole derivatives and ATQ showed the highest antitumor activities. The most potent was 2-(4-fluorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1f). Western blot analyses have shown that this compound inhibited phosphorylation of protein kinase B (Akt) and Insulin-like Growth Factor-1 Receptor (IGF1R β) in HeLa and HepG2 cells. The least toxic compound against normal fibroblast cells, which maintains similar antitumor activities as TQ, was 2-(4-chlorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1e). Docking studies indicated that 1e and 1f have significant effects against selected receptors playing important roles in tumour survival.
PB  - MDPI
T2  - Molecules
T1  - Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone
VL  - 23
IS  - 12
DO  - 10.3390/molecules23123297
ER  - 
@article{
author = "Glamočlija, Una and Padhye, Subhash and Špirtović-Halilović, Selma and Osmanović, Amar and Veljović, Elma and Roca, Sunčica and Novaković, Irena T. and Mandić, Boris and Turel, Iztok and Kljun, Jakob and Trifunović, Snežana S. and Kahrović, Emira and Pavelić-Kraljević, Sandra and Harej, Anja and Klobučar, Marko and Završnik, Davorka",
year = "2018",
abstract = "Thymoquinone (TQ), a natural compound with antimicrobial and antitumor activity, was used as the starting molecule for the preparation of 3-aminothymoquinone (ATQ) from which ten novel benzoxazole derivatives were prepared and characterized by elemental analysis, IR spectroscopy, mass spectrometry and NMR (1H,13C) spectroscopy in solution. The crystal structure of 4-methyl-2-phenyl-7-isopropyl-1,3-benzoxazole-5-ol (1a) has been determined by X-ray diffraction. All compounds were tested for their antibacterial, antifungal and antitumor activities. TQ and ATQ showed better antibacterial activity against tested Gram-positive and Gram-negative bacterial strains than benzoxazoles. ATQ had the most potent antifungal effect against Candida albicans, Saccharomyces cerevisiae and Aspergillus brasiliensis. Three benzoxazole derivatives and ATQ showed the highest antitumor activities. The most potent was 2-(4-fluorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1f). Western blot analyses have shown that this compound inhibited phosphorylation of protein kinase B (Akt) and Insulin-like Growth Factor-1 Receptor (IGF1R β) in HeLa and HepG2 cells. The least toxic compound against normal fibroblast cells, which maintains similar antitumor activities as TQ, was 2-(4-chlorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1e). Docking studies indicated that 1e and 1f have significant effects against selected receptors playing important roles in tumour survival.",
publisher = "MDPI",
journal = "Molecules",
title = "Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone",
volume = "23",
number = "12",
doi = "10.3390/molecules23123297"
}
Glamočlija, U., Padhye, S., Špirtović-Halilović, S., Osmanović, A., Veljović, E., Roca, S., Novaković, I. T., Mandić, B., Turel, I., Kljun, J., Trifunović, S. S., Kahrović, E., Pavelić-Kraljević, S., Harej, A., Klobučar, M.,& Završnik, D.. (2018). Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone. in Molecules
MDPI., 23(12).
https://doi.org/10.3390/molecules23123297
Glamočlija U, Padhye S, Špirtović-Halilović S, Osmanović A, Veljović E, Roca S, Novaković IT, Mandić B, Turel I, Kljun J, Trifunović SS, Kahrović E, Pavelić-Kraljević S, Harej A, Klobučar M, Završnik D. Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone. in Molecules. 2018;23(12).
doi:10.3390/molecules23123297 .
Glamočlija, Una, Padhye, Subhash, Špirtović-Halilović, Selma, Osmanović, Amar, Veljović, Elma, Roca, Sunčica, Novaković, Irena T., Mandić, Boris, Turel, Iztok, Kljun, Jakob, Trifunović, Snežana S., Kahrović, Emira, Pavelić-Kraljević, Sandra, Harej, Anja, Klobučar, Marko, Završnik, Davorka, "Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinone" in Molecules, 23, no. 12 (2018),
https://doi.org/10.3390/molecules23123297 . .
1
12
10
8

Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.; Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12). https://doi.org/10.3390/molecules23123297

Glamočlija, Una; Padhye, Subhash; Špirtović-Halilović, Selma; Osmanović, Amar; Veljović, Elma; Roca, Sunčica; Novaković, Irena T.; Mandić, Boris; Turel, Iztok; Kljun, Jakob; Trifunović, Snežana S.; Kahrović, Emira; Pavelić-Kraljević, Sandra; Harej, Anja; Klobučar, Marko; Završnik, Davorka

(MDPI, 2018)

TY  - DATA
AU  - Glamočlija, Una
AU  - Padhye, Subhash
AU  - Špirtović-Halilović, Selma
AU  - Osmanović, Amar
AU  - Veljović, Elma
AU  - Roca, Sunčica
AU  - Novaković, Irena T.
AU  - Mandić, Boris
AU  - Turel, Iztok
AU  - Kljun, Jakob
AU  - Trifunović, Snežana S.
AU  - Kahrović, Emira
AU  - Pavelić-Kraljević, Sandra
AU  - Harej, Anja
AU  - Klobučar, Marko
AU  - Završnik, Davorka
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3004
PB  - MDPI
T2  - Molecules
T1  - Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.;  Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and  Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12).  https://doi.org/10.3390/molecules23123297
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3004
ER  - 
@misc{
author = "Glamočlija, Una and Padhye, Subhash and Špirtović-Halilović, Selma and Osmanović, Amar and Veljović, Elma and Roca, Sunčica and Novaković, Irena T. and Mandić, Boris and Turel, Iztok and Kljun, Jakob and Trifunović, Snežana S. and Kahrović, Emira and Pavelić-Kraljević, Sandra and Harej, Anja and Klobučar, Marko and Završnik, Davorka",
year = "2018",
publisher = "MDPI",
journal = "Molecules",
title = "Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.;  Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and  Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12).  https://doi.org/10.3390/molecules23123297",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3004"
}
Glamočlija, U., Padhye, S., Špirtović-Halilović, S., Osmanović, A., Veljović, E., Roca, S., Novaković, I. T., Mandić, B., Turel, I., Kljun, J., Trifunović, S. S., Kahrović, E., Pavelić-Kraljević, S., Harej, A., Klobučar, M.,& Završnik, D.. (2018). Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.;  Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and  Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12).  https://doi.org/10.3390/molecules23123297. in Molecules
MDPI..
https://hdl.handle.net/21.15107/rcub_cherry_3004
Glamočlija U, Padhye S, Špirtović-Halilović S, Osmanović A, Veljović E, Roca S, Novaković IT, Mandić B, Turel I, Kljun J, Trifunović SS, Kahrović E, Pavelić-Kraljević S, Harej A, Klobučar M, Završnik D. Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.;  Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and  Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12).  https://doi.org/10.3390/molecules23123297. in Molecules. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3004 .
Glamočlija, Una, Padhye, Subhash, Špirtović-Halilović, Selma, Osmanović, Amar, Veljović, Elma, Roca, Sunčica, Novaković, Irena T., Mandić, Boris, Turel, Iztok, Kljun, Jakob, Trifunović, Snežana S., Kahrović, Emira, Pavelić-Kraljević, Sandra, Harej, Anja, Klobučar, Marko, Završnik, Davorka, "Supplementary material for the article: Glamočlija, U.; Padhye, S.; Špirtović-Halilović, S.; Osmanović, A.; Veljović, E.; Roca, S.;  Novaković, I.; Mandić, B.; Turel, I.; Kljun, J.; et al. Synthesis, Biological Evaluation and  Docking Studies of Benzoxazoles Derived from Thymoquinone. Molecules 2018, 23 (12).  https://doi.org/10.3390/molecules23123297" in Molecules (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3004 .

Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests

Villalta-Romero, Fabian; Borro, Luiz; Mandić, Boris; Escalante, Teresa; Rucavado, Alexandra; Gutierrez, Jose Maria; Nešić, Goran; Tasić, Ljubica

(Pergamon-Elsevier Science Ltd, Oxford, 2017)

TY  - JOUR
AU  - Villalta-Romero, Fabian
AU  - Borro, Luiz
AU  - Mandić, Boris
AU  - Escalante, Teresa
AU  - Rucavado, Alexandra
AU  - Gutierrez, Jose Maria
AU  - Nešić, Goran
AU  - Tasić, Ljubica
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2449
AB  - Snakebites represent an important public health problem, with a great number of victims with permanent sequelae or fatal outcomes, particularly in rural, agriculturally active areas. The snake venom metalloproteases (SVMPs) are the principal proteins responsible for some clinically-relevant effects, such as local and systemic hemorrhage, dermonecrosis, and myonecrosis. Because of the difficulties in neutralizing them rapidly and locally by antivenoms, the search and design of small molecules as inhibitors of SVMPs are proposed. The Bothrops asper metalloprotease P1 (BaP1) is hereby used as a target protein and by High Throughput Virtual Screening (HTVS) approach, the free access virtual libraries: ZINC, PubChem and ChEMBL, were searched for potent small molecule inhibitors. Results from the aforementioned approaches provided strong evidences on the structural requirements for the efficient BaP1 inhibition such as the presence of the pyrimidine-2,4,6-trione moiety. The two proposed compounds have also shown excellent results in performed in vitro interaction studies against BaPl. (C) 2017 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests
VL  - 27
IS  - 9
SP  - 2018
EP  - 2022
DO  - 10.1016/j.bmcl.2017.03.007
UR  - Kon_3265
ER  - 
@article{
author = "Villalta-Romero, Fabian and Borro, Luiz and Mandić, Boris and Escalante, Teresa and Rucavado, Alexandra and Gutierrez, Jose Maria and Nešić, Goran and Tasić, Ljubica",
year = "2017",
abstract = "Snakebites represent an important public health problem, with a great number of victims with permanent sequelae or fatal outcomes, particularly in rural, agriculturally active areas. The snake venom metalloproteases (SVMPs) are the principal proteins responsible for some clinically-relevant effects, such as local and systemic hemorrhage, dermonecrosis, and myonecrosis. Because of the difficulties in neutralizing them rapidly and locally by antivenoms, the search and design of small molecules as inhibitors of SVMPs are proposed. The Bothrops asper metalloprotease P1 (BaP1) is hereby used as a target protein and by High Throughput Virtual Screening (HTVS) approach, the free access virtual libraries: ZINC, PubChem and ChEMBL, were searched for potent small molecule inhibitors. Results from the aforementioned approaches provided strong evidences on the structural requirements for the efficient BaP1 inhibition such as the presence of the pyrimidine-2,4,6-trione moiety. The two proposed compounds have also shown excellent results in performed in vitro interaction studies against BaPl. (C) 2017 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests",
volume = "27",
number = "9",
pages = "2018-2022",
doi = "10.1016/j.bmcl.2017.03.007",
url = "Kon_3265"
}
Villalta-Romero, F., Borro, L., Mandić, B., Escalante, T., Rucavado, A., Gutierrez, J. M., Nešić, G.,& Tasić, L.. (2017). Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 27(9), 2018-2022.
https://doi.org/10.1016/j.bmcl.2017.03.007
Kon_3265
Villalta-Romero F, Borro L, Mandić B, Escalante T, Rucavado A, Gutierrez JM, Nešić G, Tasić L. Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests. in Bioorganic and Medicinal Chemistry Letters. 2017;27(9):2018-2022.
doi:10.1016/j.bmcl.2017.03.007
Kon_3265 .
Villalta-Romero, Fabian, Borro, Luiz, Mandić, Boris, Escalante, Teresa, Rucavado, Alexandra, Gutierrez, Jose Maria, Nešić, Goran, Tasić, Ljubica, "Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests" in Bioorganic and Medicinal Chemistry Letters, 27, no. 9 (2017):2018-2022,
https://doi.org/10.1016/j.bmcl.2017.03.007 .,
Kon_3265 .
4
5
5

Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests

Villalta-Romero, Fabian; Borro, Luiz; Mandić, Boris; Escalante, Teresa; Rucavado, Alexandra; Gutierrez, Jose Maria; Nešić, Goran; Tasić, Ljubica

(Pergamon-Elsevier Science Ltd, Oxford, 2017)

TY  - JOUR
AU  - Villalta-Romero, Fabian
AU  - Borro, Luiz
AU  - Mandić, Boris
AU  - Escalante, Teresa
AU  - Rucavado, Alexandra
AU  - Gutierrez, Jose Maria
AU  - Nešić, Goran
AU  - Tasić, Ljubica
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3001
AB  - Snakebites represent an important public health problem, with a great number of victims with permanent sequelae or fatal outcomes, particularly in rural, agriculturally active areas. The snake venom metalloproteases (SVMPs) are the principal proteins responsible for some clinically-relevant effects, such as local and systemic hemorrhage, dermonecrosis, and myonecrosis. Because of the difficulties in neutralizing them rapidly and locally by antivenoms, the search and design of small molecules as inhibitors of SVMPs are proposed. The Bothrops asper metalloprotease P1 (BaP1) is hereby used as a target protein and by High Throughput Virtual Screening (HTVS) approach, the free access virtual libraries: ZINC, PubChem and ChEMBL, were searched for potent small molecule inhibitors. Results from the aforementioned approaches provided strong evidences on the structural requirements for the efficient BaP1 inhibition such as the presence of the pyrimidine-2,4,6-trione moiety. The two proposed compounds have also shown excellent results in performed in vitro interaction studies against BaPl.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests
VL  - 27
IS  - 9
SP  - 2018
EP  - 2022
DO  - 10.1016/j.bmcl.2017.03.007
ER  - 
@article{
author = "Villalta-Romero, Fabian and Borro, Luiz and Mandić, Boris and Escalante, Teresa and Rucavado, Alexandra and Gutierrez, Jose Maria and Nešić, Goran and Tasić, Ljubica",
year = "2017",
abstract = "Snakebites represent an important public health problem, with a great number of victims with permanent sequelae or fatal outcomes, particularly in rural, agriculturally active areas. The snake venom metalloproteases (SVMPs) are the principal proteins responsible for some clinically-relevant effects, such as local and systemic hemorrhage, dermonecrosis, and myonecrosis. Because of the difficulties in neutralizing them rapidly and locally by antivenoms, the search and design of small molecules as inhibitors of SVMPs are proposed. The Bothrops asper metalloprotease P1 (BaP1) is hereby used as a target protein and by High Throughput Virtual Screening (HTVS) approach, the free access virtual libraries: ZINC, PubChem and ChEMBL, were searched for potent small molecule inhibitors. Results from the aforementioned approaches provided strong evidences on the structural requirements for the efficient BaP1 inhibition such as the presence of the pyrimidine-2,4,6-trione moiety. The two proposed compounds have also shown excellent results in performed in vitro interaction studies against BaPl.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests",
volume = "27",
number = "9",
pages = "2018-2022",
doi = "10.1016/j.bmcl.2017.03.007"
}
Villalta-Romero, F., Borro, L., Mandić, B., Escalante, T., Rucavado, A., Gutierrez, J. M., Nešić, G.,& Tasić, L.. (2017). Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 27(9), 2018-2022.
https://doi.org/10.1016/j.bmcl.2017.03.007
Villalta-Romero F, Borro L, Mandić B, Escalante T, Rucavado A, Gutierrez JM, Nešić G, Tasić L. Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests. in Bioorganic and Medicinal Chemistry Letters. 2017;27(9):2018-2022.
doi:10.1016/j.bmcl.2017.03.007 .
Villalta-Romero, Fabian, Borro, Luiz, Mandić, Boris, Escalante, Teresa, Rucavado, Alexandra, Gutierrez, Jose Maria, Nešić, Goran, Tasić, Ljubica, "Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests" in Bioorganic and Medicinal Chemistry Letters, 27, no. 9 (2017):2018-2022,
https://doi.org/10.1016/j.bmcl.2017.03.007 . .
4
5
5

Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022. https://doi.org/10.1016/j.bmcl.2017.03.007

Villalta-Romero, Fabian; Borro, Luiz; Mandić, Boris; Escalante, Teresa; Rucavado, Alexandra; Gutierrez, Jose Maria; Nešić, Goran; Tasić, Ljubica

(Pergamon-Elsevier Science Ltd, Oxford, 2017)

TY  - DATA
AU  - Villalta-Romero, Fabian
AU  - Borro, Luiz
AU  - Mandić, Boris
AU  - Escalante, Teresa
AU  - Rucavado, Alexandra
AU  - Gutierrez, Jose Maria
AU  - Nešić, Goran
AU  - Tasić, Ljubica
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3002
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022.  https://doi.org/10.1016/j.bmcl.2017.03.007
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3002
ER  - 
@misc{
author = "Villalta-Romero, Fabian and Borro, Luiz and Mandić, Boris and Escalante, Teresa and Rucavado, Alexandra and Gutierrez, Jose Maria and Nešić, Goran and Tasić, Ljubica",
year = "2017",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022.  https://doi.org/10.1016/j.bmcl.2017.03.007",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3002"
}
Villalta-Romero, F., Borro, L., Mandić, B., Escalante, T., Rucavado, A., Gutierrez, J. M., Nešić, G.,& Tasić, L.. (2017). Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022.  https://doi.org/10.1016/j.bmcl.2017.03.007. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford..
https://hdl.handle.net/21.15107/rcub_cherry_3002
Villalta-Romero F, Borro L, Mandić B, Escalante T, Rucavado A, Gutierrez JM, Nešić G, Tasić L. Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022.  https://doi.org/10.1016/j.bmcl.2017.03.007. in Bioorganic and Medicinal Chemistry Letters. 2017;.
https://hdl.handle.net/21.15107/rcub_cherry_3002 .
Villalta-Romero, Fabian, Borro, Luiz, Mandić, Boris, Escalante, Teresa, Rucavado, Alexandra, Gutierrez, Jose Maria, Nešić, Goran, Tasić, Ljubica, "Supplementary data for article: Villalta-Romero, F.; Borro, L.; Mandić, B.; Escalante, T.; Rucavado, A.; Gutierrez, J. M.; Neshich, G.; Tasic, L. Discovery of Small Molecule Inhibitors for the Snake Venom Metalloprotease BaP1 Using in Silico and in Vitro Tests. Bioorganic and Medicinal Chemistry Letters 2017, 27 (9), 2018–2022.  https://doi.org/10.1016/j.bmcl.2017.03.007" in Bioorganic and Medicinal Chemistry Letters (2017),
https://hdl.handle.net/21.15107/rcub_cherry_3002 .

Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis

Damjanović, Ana; Zdunić, Gordana; Šavikin, Katarina; Mandić, Boris; Jadranin, Milka; Matić, Ivana Z.; Stanojković, Tatjana

(Bangladesh Pharmacological Soc, Shahbah, 2016)

TY  - JOUR
AU  - Damjanović, Ana
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2366
AB  - The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.
PB  - Bangladesh Pharmacological Soc, Shahbah
T2  - Bangladesh Journal of Pharmacology
T1  - Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis
VL  - 11
IS  - 3
SP  - 741
EP  - 749
DO  - 10.3329/bjp.v11i3.27103
UR  - Kon_3182
ER  - 
@article{
author = "Damjanović, Ana and Zdunić, Gordana and Šavikin, Katarina and Mandić, Boris and Jadranin, Milka and Matić, Ivana Z. and Stanojković, Tatjana",
year = "2016",
abstract = "The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.",
publisher = "Bangladesh Pharmacological Soc, Shahbah",
journal = "Bangladesh Journal of Pharmacology",
title = "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis",
volume = "11",
number = "3",
pages = "741-749",
doi = "10.3329/bjp.v11i3.27103",
url = "Kon_3182"
}
Damjanović, A., Zdunić, G., Šavikin, K., Mandić, B., Jadranin, M., Matić, I. Z.,& Stanojković, T.. (2016). Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology
Bangladesh Pharmacological Soc, Shahbah., 11(3), 741-749.
https://doi.org/10.3329/bjp.v11i3.27103
Kon_3182
Damjanović A, Zdunić G, Šavikin K, Mandić B, Jadranin M, Matić IZ, Stanojković T. Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology. 2016;11(3):741-749.
doi:10.3329/bjp.v11i3.27103
Kon_3182 .
Damjanović, Ana, Zdunić, Gordana, Šavikin, Katarina, Mandić, Boris, Jadranin, Milka, Matić, Ivana Z., Stanojković, Tatjana, "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis" in Bangladesh Journal of Pharmacology, 11, no. 3 (2016):741-749,
https://doi.org/10.3329/bjp.v11i3.27103 .,
Kon_3182 .
1
5
7
7

Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence

Vesović, Nikola; Ćurčić, Srećko; Vujisić, Ljubodrag V.; Nenadic, Marija; Krstić, Gordana B.; Peric-Mataruga, Vesna; Milosavljević, Slobodan M.; Antic, Dragan; Mandić, Boris; Petkovic, Matija; Vučković, Ivan M.; Marković, Đorđe; Vrbica, Maja; Ćurčić, Božidar P. M.; Makarov, Slobodan E.

(Springer, Dordrecht, 2015)

TY  - JOUR
AU  - Vesović, Nikola
AU  - Ćurčić, Srećko
AU  - Vujisić, Ljubodrag V.
AU  - Nenadic, Marija
AU  - Krstić, Gordana B.
AU  - Peric-Mataruga, Vesna
AU  - Milosavljević, Slobodan M.
AU  - Antic, Dragan
AU  - Mandić, Boris
AU  - Petkovic, Matija
AU  - Vučković, Ivan M.
AU  - Marković, Đorđe
AU  - Vrbica, Maja
AU  - Ćurčić, Božidar P. M.
AU  - Makarov, Slobodan E.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1482
AB  - Three adult cave-dwelling ground beetle species were induced to discharge secretions of their pygidial glands into vials. Dichloromethane extraction was used to obtain the secretions. In total, 42 compounds were identified by GC/MS analysis. Pheggomisetes ninae contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus 13, whereas Duvalius (Paraduvalius) milutini had nine compounds. Caproic, oleic, palmitic, and stearic acids were present in the samples of all analyzed species. Undecane was predominant in the extract of L. punctatus. Palmitic acid was the major component in the secretion of D. milutini. Finally, the most abundant compounds in P. ninae secretion were heptacosene and nonacosadienes. Herein, we present the first data on the identification of pygidial gland secretion components in both troglophilous and troglobite cave-dwelling ground beetles. Some compounds are reported for the first time in the secretions of ground beetles and other higher or lower taxa. The adaptation to underground life has not led to a reduction or changes in the chemical defense mechanism in the analyzed troglophilous and troglobitic Platyninae and Trechinae taxa.
PB  - Springer, Dordrecht
T2  - Journal of Chemical Ecology
T1  - Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence
VL  - 41
IS  - 6
SP  - 533
EP  - 539
DO  - 10.1007/s10886-015-0593-7
UR  - Kon_2602
ER  - 
@article{
author = "Vesović, Nikola and Ćurčić, Srećko and Vujisić, Ljubodrag V. and Nenadic, Marija and Krstić, Gordana B. and Peric-Mataruga, Vesna and Milosavljević, Slobodan M. and Antic, Dragan and Mandić, Boris and Petkovic, Matija and Vučković, Ivan M. and Marković, Đorđe and Vrbica, Maja and Ćurčić, Božidar P. M. and Makarov, Slobodan E.",
year = "2015",
abstract = "Three adult cave-dwelling ground beetle species were induced to discharge secretions of their pygidial glands into vials. Dichloromethane extraction was used to obtain the secretions. In total, 42 compounds were identified by GC/MS analysis. Pheggomisetes ninae contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus 13, whereas Duvalius (Paraduvalius) milutini had nine compounds. Caproic, oleic, palmitic, and stearic acids were present in the samples of all analyzed species. Undecane was predominant in the extract of L. punctatus. Palmitic acid was the major component in the secretion of D. milutini. Finally, the most abundant compounds in P. ninae secretion were heptacosene and nonacosadienes. Herein, we present the first data on the identification of pygidial gland secretion components in both troglophilous and troglobite cave-dwelling ground beetles. Some compounds are reported for the first time in the secretions of ground beetles and other higher or lower taxa. The adaptation to underground life has not led to a reduction or changes in the chemical defense mechanism in the analyzed troglophilous and troglobitic Platyninae and Trechinae taxa.",
publisher = "Springer, Dordrecht",
journal = "Journal of Chemical Ecology",
title = "Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence",
volume = "41",
number = "6",
pages = "533-539",
doi = "10.1007/s10886-015-0593-7",
url = "Kon_2602"
}
Vesović, N., Ćurčić, S., Vujisić, L. V., Nenadic, M., Krstić, G. B., Peric-Mataruga, V., Milosavljević, S. M., Antic, D., Mandić, B., Petkovic, M., Vučković, I. M., Marković, Đ., Vrbica, M., Ćurčić, B. P. M.,& Makarov, S. E.. (2015). Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology
Springer, Dordrecht., 41(6), 533-539.
https://doi.org/10.1007/s10886-015-0593-7
Kon_2602
Vesović N, Ćurčić S, Vujisić LV, Nenadic M, Krstić GB, Peric-Mataruga V, Milosavljević SM, Antic D, Mandić B, Petkovic M, Vučković IM, Marković Đ, Vrbica M, Ćurčić BPM, Makarov SE. Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology. 2015;41(6):533-539.
doi:10.1007/s10886-015-0593-7
Kon_2602 .
Vesović, Nikola, Ćurčić, Srećko, Vujisić, Ljubodrag V., Nenadic, Marija, Krstić, Gordana B., Peric-Mataruga, Vesna, Milosavljević, Slobodan M., Antic, Dragan, Mandić, Boris, Petkovic, Matija, Vučković, Ivan M., Marković, Đorđe, Vrbica, Maja, Ćurčić, Božidar P. M., Makarov, Slobodan E., "Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence" in Journal of Chemical Ecology, 41, no. 6 (2015):533-539,
https://doi.org/10.1007/s10886-015-0593-7 .,
Kon_2602 .
3
12
11
10

Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes

Simić, Milena R.; Stanković, Miroslava; Mandić, Boris; Tešević, Vele; Savić, Vladimir

(Wiley-V C H Verlag Gmbh, Weinheim, 2015)

TY  - JOUR
AU  - Simić, Milena R.
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Savić, Vladimir
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1660
AB  - Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Archiv der Pharmazie
T1  - Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes
VL  - 348
IS  - 2
SP  - 100
EP  - 112
DO  - 10.1002/ardp.201400350
UR  - Kon_2806
ER  - 
@article{
author = "Simić, Milena R. and Stanković, Miroslava and Mandić, Boris and Tešević, Vele and Savić, Vladimir",
year = "2015",
abstract = "Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Archiv der Pharmazie",
title = "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes",
volume = "348",
number = "2",
pages = "100-112",
doi = "10.1002/ardp.201400350",
url = "Kon_2806"
}
Simić, M. R., Stanković, M., Mandić, B., Tešević, V.,& Savić, V.. (2015). Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie
Wiley-V C H Verlag Gmbh, Weinheim., 348(2), 100-112.
https://doi.org/10.1002/ardp.201400350
Kon_2806
Simić MR, Stanković M, Mandić B, Tešević V, Savić V. Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie. 2015;348(2):100-112.
doi:10.1002/ardp.201400350
Kon_2806 .
Simić, Milena R., Stanković, Miroslava, Mandić, Boris, Tešević, Vele, Savić, Vladimir, "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes" in Archiv der Pharmazie, 348, no. 2 (2015):100-112,
https://doi.org/10.1002/ardp.201400350 .,
Kon_2806 .
2
2
2

Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge

Mandić, Boris; Vlajić, Marina D.; Trifunović, Snežana S.; Simić, Milena R.; Vujisić, Ljubodrag V.; Vučković, Ivan M.; Novaković, Miroslav M.; Nikolić-Mandić, Snežana D.; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Taylor & Francis Ltd, Abingdon, 2015)

TY  - JOUR
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1692
AB  - Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge
VL  - 29
IS  - 9
SP  - 887
EP  - 890
DO  - 10.1080/14786419.2014.991929
UR  - Kon_2838
ER  - 
@article{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
abstract = "Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge",
volume = "29",
number = "9",
pages = "887-890",
doi = "10.1080/14786419.2014.991929",
url = "Kon_2838"
}
Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(9), 887-890.
https://doi.org/10.1080/14786419.2014.991929
Kon_2838
Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research. 2015;29(9):887-890.
doi:10.1080/14786419.2014.991929
Kon_2838 .
Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge" in Natural Product Research, 29, no. 9 (2015):887-890,
https://doi.org/10.1080/14786419.2014.991929 .,
Kon_2838 .
10
6
9

Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu

Mandić, Boris

(Универзитет у Београду, Хемијски факултет, 2015)

TY  - THES
AU  - Mandić, Boris
PY  - 2015
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2788
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:10956/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47593231
UR  - http://nardus.mpn.gov.rs/123456789/5192
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2661
AB  - rasprostranjenih u biljnom svetu. Više stotina PA i njihovih derivata N-oksidaidentifikovano je u preko 6000 biljaka, koje pripadaju različitim biljnim familijama.Mnoge biljke bogate PA koriste se u tradicionalnoj medicini u Aziji i Africi, što ih činiinteresantnim za fitohemijska istraživanja. Sa druge strane, neki PA su veoma toksičniza ljude i životinje. Akutno trovanje PA dovodi do oštećenja jetre, dok dugotrajnaizloženost subletalnim dozama dovodi do kumulativnih oštećenja, ispoljavanjaneurotoksičnih, mutagenih i karcinogenih efekata. Zbog svega ovog je naučnoistraživanje PA značajno, pa je neophodan razvoj analitičkih metoda za određivanjepojedinačnih i ukupnih pirolizidinskih alkaloida u biljnom materijalu. Uprkos brojnimpredloženim postupcima za izolovanje i prečišćavanje pirolizidinskih alkaloida, zbograznolikosti njihovih struktura i hemijskih svojstava, ni jedan od njih nije našao širokuprimenu u praksi. Stoga je cilj ove doktorske teze optimizacija svih faza postupka zaizolovanje pirolizidinskih alkaloida iz biljnog materijala, tako da se ova strukturnorazličita jedinjenja mogu izolovati sa maksimalnim prinosima. Kao model-sistemupotrebljena je biljna vrsta Rindera umbellata Bunge. Pored toga, cilj teze je iizolovanje pojedinačnih alkaloida iz pomenute biljne vrste, njihova karakterizacija,odnosno određivanje struktura.Izolovano je i strukturno okarakterisano šest PA (7-angeloilheliotridan, 7-angeloilheliotridin, lindelofin, 7-angeloilrinderin, punktanecin i heliosupin, PA1 – PA6,redom).
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu
T1  - Optimization of Procedure for Isolation and Determination of Pyrrolizidine Alkaloids from Plant Material
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5192
ER  - 
@phdthesis{
author = "Mandić, Boris",
year = "2015",
abstract = "rasprostranjenih u biljnom svetu. Više stotina PA i njihovih derivata N-oksidaidentifikovano je u preko 6000 biljaka, koje pripadaju različitim biljnim familijama.Mnoge biljke bogate PA koriste se u tradicionalnoj medicini u Aziji i Africi, što ih činiinteresantnim za fitohemijska istraživanja. Sa druge strane, neki PA su veoma toksičniza ljude i životinje. Akutno trovanje PA dovodi do oštećenja jetre, dok dugotrajnaizloženost subletalnim dozama dovodi do kumulativnih oštećenja, ispoljavanjaneurotoksičnih, mutagenih i karcinogenih efekata. Zbog svega ovog je naučnoistraživanje PA značajno, pa je neophodan razvoj analitičkih metoda za određivanjepojedinačnih i ukupnih pirolizidinskih alkaloida u biljnom materijalu. Uprkos brojnimpredloženim postupcima za izolovanje i prečišćavanje pirolizidinskih alkaloida, zbograznolikosti njihovih struktura i hemijskih svojstava, ni jedan od njih nije našao širokuprimenu u praksi. Stoga je cilj ove doktorske teze optimizacija svih faza postupka zaizolovanje pirolizidinskih alkaloida iz biljnog materijala, tako da se ova strukturnorazličita jedinjenja mogu izolovati sa maksimalnim prinosima. Kao model-sistemupotrebljena je biljna vrsta Rindera umbellata Bunge. Pored toga, cilj teze je iizolovanje pojedinačnih alkaloida iz pomenute biljne vrste, njihova karakterizacija,odnosno određivanje struktura.Izolovano je i strukturno okarakterisano šest PA (7-angeloilheliotridan, 7-angeloilheliotridin, lindelofin, 7-angeloilrinderin, punktanecin i heliosupin, PA1 – PA6,redom).",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu, Optimization of Procedure for Isolation and Determination of Pyrrolizidine Alkaloids from Plant Material",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5192"
}
Mandić, B.. (2015). Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_5192
Mandić B. Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu. in Универзитет у Београду. 2015;.
https://hdl.handle.net/21.15107/rcub_nardus_5192 .
Mandić, Boris, "Optimizacija postupka za izolovanje i određivanje pirolizidinskih alkaloida u biljnom materijalu" in Универзитет у Београду (2015),
https://hdl.handle.net/21.15107/rcub_nardus_5192 .

Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929

Mandić, Boris; Vlajić, Marina D.; Trifunović, Snežana S.; Simić, Milena R.; Vujisić, Ljubodrag V.; Vučković, Ivan M.; Novaković, Miroslav M.; Nikolić-Mandić, Snežana D.; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Taylor & Francis Ltd, Abingdon, 2015)

TY  - DATA
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3388
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3388
ER  - 
@misc{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3388"
}
Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
https://hdl.handle.net/21.15107/rcub_cherry_3388
Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3388 .
Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929" in Natural Product Research (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3388 .

Quinones and Non-Quinones from the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from Serbia

Sekulić, Tatjana Lj.; Vujisić, Ljubodrag V.; Curcic, B. P. M.; Mandić, Boris; Antic, D. Z.; Trifunović, Snežana S.; Gođevac, Dejan; Vajs, Vlatka; Tomić, Vladimir T.; Makarov, Slobodan E.

(Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd, 2014)

TY  - JOUR
AU  - Sekulić, Tatjana Lj.
AU  - Vujisić, Ljubodrag V.
AU  - Curcic, B. P. M.
AU  - Mandić, Boris
AU  - Antic, D. Z.
AU  - Trifunović, Snežana S.
AU  - Gođevac, Dejan
AU  - Vajs, Vlatka
AU  - Tomić, Vladimir T.
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1496
AB  - A complex mixture of compounds was identified from the secretion of specimens of Unciger transsilvanicus. Phenol and p-cresol were detected for the first time in the family Julidae, and for the second time in the order Julida. Thirteen quinones were identified, with a great relative abundance of toloquinone and 2-methoxy-3-methyl- 1,4-benzoquinone. Hydroquinone was detected for the first time in the order Julida. Besides these compounds, isopentyl hexacosatetraenoate and isopentyl esters of saturated and unsaturated fatty acids with chain lengths from C-14 to C(20)were identified. The most abundant non-quinone compound was isopentyl eicosenoate. The relative abundance of quinone and non-quinone in the defensive fluid of U transsilvanicus was 77% and 23%, respectively. The phylogenetic importance of the registered compounds is briefly discussed.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of biological sciences
T1  - Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia
VL  - 66
IS  - 1
SP  - 385
EP  - 391
DO  - 10.2298/ABS1401385S
UR  - Kon_2616
ER  - 
@article{
author = "Sekulić, Tatjana Lj. and Vujisić, Ljubodrag V. and Curcic, B. P. M. and Mandić, Boris and Antic, D. Z. and Trifunović, Snežana S. and Gođevac, Dejan and Vajs, Vlatka and Tomić, Vladimir T. and Makarov, Slobodan E.",
year = "2014",
abstract = "A complex mixture of compounds was identified from the secretion of specimens of Unciger transsilvanicus. Phenol and p-cresol were detected for the first time in the family Julidae, and for the second time in the order Julida. Thirteen quinones were identified, with a great relative abundance of toloquinone and 2-methoxy-3-methyl- 1,4-benzoquinone. Hydroquinone was detected for the first time in the order Julida. Besides these compounds, isopentyl hexacosatetraenoate and isopentyl esters of saturated and unsaturated fatty acids with chain lengths from C-14 to C(20)were identified. The most abundant non-quinone compound was isopentyl eicosenoate. The relative abundance of quinone and non-quinone in the defensive fluid of U transsilvanicus was 77% and 23%, respectively. The phylogenetic importance of the registered compounds is briefly discussed.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of biological sciences",
title = "Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia",
volume = "66",
number = "1",
pages = "385-391",
doi = "10.2298/ABS1401385S",
url = "Kon_2616"
}
Sekulić, T. Lj., Vujisić, L. V., Curcic, B. P. M., Mandić, B., Antic, D. Z., Trifunović, S. S., Gođevac, D., Vajs, V., Tomić, V. T.,& Makarov, S. E.. (2014). Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia. in Archives of biological sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 66(1), 385-391.
https://doi.org/10.2298/ABS1401385S
Kon_2616
Sekulić TL, Vujisić LV, Curcic BPM, Mandić B, Antic DZ, Trifunović SS, Gođevac D, Vajs V, Tomić VT, Makarov SE. Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia. in Archives of biological sciences. 2014;66(1):385-391.
doi:10.2298/ABS1401385S
Kon_2616 .
Sekulić, Tatjana Lj., Vujisić, Ljubodrag V., Curcic, B. P. M., Mandić, Boris, Antic, D. Z., Trifunović, Snežana S., Gođevac, Dejan, Vajs, Vlatka, Tomić, Vladimir T., Makarov, Slobodan E., "Quinones and Non-Quinones from  the Defensive Secretion of Unciger Transsilvanicus (Verhoeff, 1899) (Diplopoda, Julida, Julidae), from  Serbia" in Archives of biological sciences, 66, no. 1 (2014):385-391,
https://doi.org/10.2298/ABS1401385S .,
Kon_2616 .
9
8
8

Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae

Trifunović, Snežana S.; Isaković, Anđelka M.; Isaković, Aleksandra J.; Vučković, Ivan M.; Mandić, Boris; Novaković, Miroslav M.; Vajs, Vlatka; Milosavljević, Slobodan M.; Trajković, Vladimir S.

(Georg Thieme Verlag Kg, Stuttgart, 2014)

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra J.
AU  - Vučković, Ivan M.
AU  - Mandić, Boris
AU  - Novaković, Miroslav M.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1511
AB  - Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 297
EP  - 305
DO  - 10.1055/s-0033-1360312
UR  - Kon_2631
ER  - 
@article{
author = "Trifunović, Snežana S. and Isaković, Anđelka M. and Isaković, Aleksandra J. and Vučković, Ivan M. and Mandić, Boris and Novaković, Miroslav M. and Vajs, Vlatka and Milosavljević, Slobodan M. and Trajković, Vladimir S.",
year = "2014",
abstract = "Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "297-305",
doi = "10.1055/s-0033-1360312",
url = "Kon_2631"
}
Trifunović, S. S., Isaković, A. M., Isaković, A. J., Vučković, I. M., Mandić, B., Novaković, M. M., Vajs, V., Milosavljević, S. M.,& Trajković, V. S.. (2014). Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 80(4), 297-305.
https://doi.org/10.1055/s-0033-1360312
Kon_2631
Trifunović SS, Isaković AM, Isaković AJ, Vučković IM, Mandić B, Novaković MM, Vajs V, Milosavljević SM, Trajković VS. Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica. 2014;80(4):297-305.
doi:10.1055/s-0033-1360312
Kon_2631 .
Trifunović, Snežana S., Isaković, Anđelka M., Isaković, Aleksandra J., Vučković, Ivan M., Mandić, Boris, Novaković, Miroslav M., Vajs, Vlatka, Milosavljević, Slobodan M., Trajković, Vladimir S., "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae" in Planta Medica, 80, no. 4 (2014):297-305,
https://doi.org/10.1055/s-0033-1360312 .,
Kon_2631 .
9
5
7

Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?

Vujisić, Ljubodrag V.; Antić, Dragan Ž.; Vučković, Ivan M.; Sekulić, Tatjana Lj.; Tomić, Vladimir T.; Mandić, Boris; Tešević, Vele; Curčić, Božidar P. M.; Vajs, Vlatka; Makarov, Slobodan E.

(Wiley-V C H Verlag Gmbh, Weinheim, 2014)

TY  - JOUR
AU  - Vujisić, Ljubodrag V.
AU  - Antić, Dragan Ž.
AU  - Vučković, Ivan M.
AU  - Sekulić, Tatjana Lj.
AU  - Tomić, Vladimir T.
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Curčić, Božidar P. M.
AU  - Vajs, Vlatka
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1515
AB  - The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?
VL  - 11
IS  - 3
SP  - 483
EP  - 490
DO  - 10.1002/cbdv.201300355
UR  - Kon_2635
ER  - 
@article{
author = "Vujisić, Ljubodrag V. and Antić, Dragan Ž. and Vučković, Ivan M. and Sekulić, Tatjana Lj. and Tomić, Vladimir T. and Mandić, Boris and Tešević, Vele and Curčić, Božidar P. M. and Vajs, Vlatka and Makarov, Slobodan E.",
year = "2014",
abstract = "The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?",
volume = "11",
number = "3",
pages = "483-490",
doi = "10.1002/cbdv.201300355",
url = "Kon_2635"
}
Vujisić, L. V., Antić, D. Ž., Vučković, I. M., Sekulić, T. Lj., Tomić, V. T., Mandić, B., Tešević, V., Curčić, B. P. M., Vajs, V.,& Makarov, S. E.. (2014). Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(3), 483-490.
https://doi.org/10.1002/cbdv.201300355
Kon_2635
Vujisić LV, Antić DŽ, Vučković IM, Sekulić TL, Tomić VT, Mandić B, Tešević V, Curčić BPM, Vajs V, Makarov SE. Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity. 2014;11(3):483-490.
doi:10.1002/cbdv.201300355
Kon_2635 .
Vujisić, Ljubodrag V., Antić, Dragan Ž., Vučković, Ivan M., Sekulić, Tatjana Lj., Tomić, Vladimir T., Mandić, Boris, Tešević, Vele, Curčić, Božidar P. M., Vajs, Vlatka, Makarov, Slobodan E., "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?" in Chemistry and Biodiversity, 11, no. 3 (2014):483-490,
https://doi.org/10.1002/cbdv.201300355 .,
Kon_2635 .
8
7
8