TY  - JOUR
AU  - Šmigić, Jelena
AU  - Sabo, Tibor
AU  - Vranić, Aleksandra
AU  - Živković, Vladimir
AU  - Srejović, Ivan
AU  - Turnić, Tamara N.
AU  - Milosavljević, Isidora
AU  - Poljarević, Jelena
AU  - Krivokapić, Miloš
AU  - Bolevich, Sergey
AU  - Jakovljević, Vladimir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3721
AB  - The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically significant differences between all experimental groups in maximum and minimum rate of pressure development as well as in systolic pressure of the left ventricle, whereas cisplatin, ligand and the platinum(IV) complex had effects on heart contractility without significant influences on coronary circulation. The findings of the present study could be important for a better understanding of anticancer drug cardiac side effects. Our results indicate that compared to cisplatin as a “gold standard”, novel platinum complexes and ligands do not possess fewer negative effects on the heart, indicating insufficient safety for their usage in terms of affecting cardiac function, a result that can be of great interest for further investigations.
PB  - Springer Science+Business Media, LLC
T2  - Molecular and Cellular Biochemistry
T1  - Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin
VL  - 458
IS  - 1-2
SP  - 89
EP  - 98
DO  - 10.1007/s11010-019-03533-8
ER  - 

@article{
author = "Šmigić, Jelena and Sabo, Tibor and Vranić, Aleksandra and Živković, Vladimir and Srejović, Ivan and Turnić, Tamara N. and Milosavljević, Isidora and Poljarević, Jelena and Krivokapić, Miloš and Bolevich, Sergey and Jakovljević, Vladimir",
year = "2019",
abstract = "The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically significant differences between all experimental groups in maximum and minimum rate of pressure development as well as in systolic pressure of the left ventricle, whereas cisplatin, ligand and the platinum(IV) complex had effects on heart contractility without significant influences on coronary circulation. The findings of the present study could be important for a better understanding of anticancer drug cardiac side effects. Our results indicate that compared to cisplatin as a “gold standard”, novel platinum complexes and ligands do not possess fewer negative effects on the heart, indicating insufficient safety for their usage in terms of affecting cardiac function, a result that can be of great interest for further investigations.",
publisher = "Springer Science+Business Media, LLC",
journal = "Molecular and Cellular Biochemistry",
title = "Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin",
volume = "458",
number = "1-2",
pages = "89-98",
doi = "10.1007/s11010-019-03533-8"
}

Šmigić, J., Sabo, T., Vranić, A., Živković, V., Srejović, I., Turnić, T. N., Milosavljević, I., Poljarević, J., Krivokapić, M., Bolevich, S.,& Jakovljević, V.. (2019). Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin. in Molecular and Cellular Biochemistry
Springer Science+Business Media, LLC., 458(1-2), 89-98.
https://doi.org/10.1007/s11010-019-03533-8

Šmigić J, Sabo T, Vranić A, Živković V, Srejović I, Turnić TN, Milosavljević I, Poljarević J, Krivokapić M, Bolevich S, Jakovljević V. Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin. in Molecular and Cellular Biochemistry. 2019;458(1-2):89-98.
doi:10.1007/s11010-019-03533-8 .

Šmigić, Jelena, Sabo, Tibor, Vranić, Aleksandra, Živković, Vladimir, Srejović, Ivan, Turnić, Tamara N., Milosavljević, Isidora, Poljarević, Jelena, Krivokapić, Miloš, Bolevich, Sergey, Jakovljević, Vladimir, "Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin" in Molecular and Cellular Biochemistry, 458, no. 1-2 (2019):89-98,
https://doi.org/10.1007/s11010-019-03533-8 . .

TY  - JOUR
AU  - Šmigić, Jelena
AU  - Stojić, I.
AU  - Živković, Vladimir
AU  - Srejović, Ivan
AU  - Nikolić, Tanja
AU  - Jeremić, J.
AU  - Sabo, Tibor
AU  - Jakovljević, Violeta D.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/330
AB  - Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. The hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH2O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H2O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H2O) and hyperoxia (higher than 80 cm H2O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity. © 2018, University of Kragujevac, Faculty of Science. All rights reserved.
T2  - Serbian Journal of Experimental and Clinical Research (ranije: Medicus)
T1  - The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart [Efekti hronične primene cisplatine na oksidacioni stres izolovanog srca pacova]
VL  - 19
IS  - 1
SP  - 11
EP  - 16
DO  - 10.1515/SJECR-2017-0003
ER  - 

@article{
author = "Šmigić, Jelena and Stojić, I. and Živković, Vladimir and Srejović, Ivan and Nikolić, Tanja and Jeremić, J. and Sabo, Tibor and Jakovljević, Violeta D.",
year = "2018",
abstract = "Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. The hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH2O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H2O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H2O) and hyperoxia (higher than 80 cm H2O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity. © 2018, University of Kragujevac, Faculty of Science. All rights reserved.",
journal = "Serbian Journal of Experimental and Clinical Research (ranije: Medicus)",
title = "The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart [Efekti hronične primene cisplatine na oksidacioni stres izolovanog srca pacova]",
volume = "19",
number = "1",
pages = "11-16",
doi = "10.1515/SJECR-2017-0003"
}

Šmigić, J., Stojić, I., Živković, V., Srejović, I., Nikolić, T., Jeremić, J., Sabo, T.,& Jakovljević, V. D.. (2018). The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart [Efekti hronične primene cisplatine na oksidacioni stres izolovanog srca pacova]. in Serbian Journal of Experimental and Clinical Research (ranije: Medicus), 19(1), 11-16.
https://doi.org/10.1515/SJECR-2017-0003

Šmigić J, Stojić I, Živković V, Srejović I, Nikolić T, Jeremić J, Sabo T, Jakovljević VD. The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart [Efekti hronične primene cisplatine na oksidacioni stres izolovanog srca pacova]. in Serbian Journal of Experimental and Clinical Research (ranije: Medicus). 2018;19(1):11-16.
doi:10.1515/SJECR-2017-0003 .

Šmigić, Jelena, Stojić, I., Živković, Vladimir, Srejović, Ivan, Nikolić, Tanja, Jeremić, J., Sabo, Tibor, Jakovljević, Violeta D., "The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart [Efekti hronične primene cisplatine na oksidacioni stres izolovanog srca pacova]" in Serbian Journal of Experimental and Clinical Research (ranije: Medicus), 19, no. 1 (2018):11-16,
https://doi.org/10.1515/SJECR-2017-0003 . .

TY  - CONF
AU  - Jeremić, J.
AU  - Stojić, I.
AU  - Nikolic, T.
AU  - Šmigić, Jelena
AU  - Živković, Vladimir
AU  - Srejović, Ivan
AU  - Sabo, Tibor
AU  - Jakovljević, Vladimir
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2519
PB  - Wiley, Hoboken
C3  - Acta Physiologica
T1  - The Effects of Chronic Administration of Cisplatin on Oxidative Stress in Isolated Rat Heart
VL  - 221
SP  - 166
EP  - 166
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2519
ER  - 

@conference{
author = "Jeremić, J. and Stojić, I. and Nikolic, T. and Šmigić, Jelena and Živković, Vladimir and Srejović, Ivan and Sabo, Tibor and Jakovljević, Vladimir",
year = "2017",
publisher = "Wiley, Hoboken",
journal = "Acta Physiologica",
title = "The Effects of Chronic Administration of Cisplatin on Oxidative Stress in Isolated Rat Heart",
volume = "221",
pages = "166-166",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2519"
}

Jeremić, J., Stojić, I., Nikolic, T., Šmigić, J., Živković, V., Srejović, I., Sabo, T.,& Jakovljević, V.. (2017). The Effects of Chronic Administration of Cisplatin on Oxidative Stress in Isolated Rat Heart. in Acta Physiologica
Wiley, Hoboken., 221, 166-166.
https://hdl.handle.net/21.15107/rcub_cherry_2519

Jeremić J, Stojić I, Nikolic T, Šmigić J, Živković V, Srejović I, Sabo T, Jakovljević V. The Effects of Chronic Administration of Cisplatin on Oxidative Stress in Isolated Rat Heart. in Acta Physiologica. 2017;221:166-166.
https://hdl.handle.net/21.15107/rcub_cherry_2519 .

Jeremić, J., Stojić, I., Nikolic, T., Šmigić, Jelena, Živković, Vladimir, Srejović, Ivan, Sabo, Tibor, Jakovljević, Vladimir, "The Effects of Chronic Administration of Cisplatin on Oxidative Stress in Isolated Rat Heart" in Acta Physiologica, 221 (2017):166-166,
https://hdl.handle.net/21.15107/rcub_cherry_2519 .