TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Stanojković, Tatjana
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/325
AB  - Six gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate, general formula [AuCl2{(S,S)-R2eddch}]PF6, [(S,S)-eddch = (S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am, 1-6, respectively], were tested against cancer cell lines such as human melanoma Fem-x, human colon carcinoma LS174T and non-small cell lung carcinoma A549 as well as a non-cancerous human embryonic lung fibroblasts MRC-5 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with the aim of assessing in vitro antitumoral activity and selectivity. All investigated complexes showed lower cytotoxicity and better or similar selectivity in comparison to cisplatin, used as reference compound. Complex [AuCl2{(S,S)-(i-Am)2eddch}]PF6 (6) demonstrated the highest activity against Fem-x (IC50 = 14.98 ± 0.34 µM). Additionally, the same complex expressed 4.5 times higher selectivity than cisplatin. © 2017, University of Kragujevac, Faculty of Science. All rights reserved.
T2  - Serbian Journal of Experimental and Clinical Research (ranije: Medicus)
T1  - Antiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]
VL  - 18
IS  - 4
SP  - 289
EP  - 294
DO  - 10.1515/SJECR-2017-0067
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Stanojković, Tatjana and Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2017",
abstract = "Six gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate, general formula [AuCl2{(S,S)-R2eddch}]PF6, [(S,S)-eddch = (S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am, 1-6, respectively], were tested against cancer cell lines such as human melanoma Fem-x, human colon carcinoma LS174T and non-small cell lung carcinoma A549 as well as a non-cancerous human embryonic lung fibroblasts MRC-5 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with the aim of assessing in vitro antitumoral activity and selectivity. All investigated complexes showed lower cytotoxicity and better or similar selectivity in comparison to cisplatin, used as reference compound. Complex [AuCl2{(S,S)-(i-Am)2eddch}]PF6 (6) demonstrated the highest activity against Fem-x (IC50 = 14.98 ± 0.34 µM). Additionally, the same complex expressed 4.5 times higher selectivity than cisplatin. © 2017, University of Kragujevac, Faculty of Science. All rights reserved.",
journal = "Serbian Journal of Experimental and Clinical Research (ranije: Medicus)",
title = "Antiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]",
volume = "18",
number = "4",
pages = "289-294",
doi = "10.1515/SJECR-2017-0067"
}

Pantelić, N. Đ., Stanojković, T., Zmejkovski, B. B., Kaluđerović, G. N.,& Sabo, T.. (2017). Antiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]. in Serbian Journal of Experimental and Clinical Research (ranije: Medicus), 18(4), 289-294.
https://doi.org/10.1515/SJECR-2017-0067

Pantelić NĐ, Stanojković T, Zmejkovski BB, Kaluđerović GN, Sabo T. Antiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]. in Serbian Journal of Experimental and Clinical Research (ranije: Medicus). 2017;18(4):289-294.
doi:10.1515/SJECR-2017-0067 .

Pantelić, Nebojša Đ., Stanojković, Tatjana, Zmejkovski, Bojana B., Kaluđerović, Goran N., Sabo, Tibor, "Antiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]" in Serbian Journal of Experimental and Clinical Research (ranije: Medicus), 18, no. 4 (2017):289-294,
https://doi.org/10.1515/SJECR-2017-0067 . .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Kolundžija, Branka
AU  - Crnogorac, Marija Đorđić
AU  - Vujić, Jelena M.
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Srećko R.
AU  - Stanojković, Tatjana
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2478
AB  - Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R(2)eddl}]PF6 (R(2)eddl = O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoate, R= n-Pr, n-Bu, n-Pe, i-Bu; 1-4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N'-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24 h, and for the reaction with ascorbic acid in which was reduced immediately. Additionally, 3 interacts with bovine serum albumin (BSA) as proven by UV/Vis spectroscopy. In vitro antitumor activity was determined against human cervix adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human melanoma (Fem-x) cancer cell lines, as well as against non-cancerous human embryonic lung fibroblast cells MRC-5. The highest activity was observed against K562 cells (IC50: 5.04-6.51 mu M). Selectivity indices showed that these complexes are less toxic than cisplatin. 3 had a similar viability kinetics on HeLa cells as cisplatin. Drug accumulation studies in HeLa cells showed that the total gold uptake increased much faster than that of cisplatin pointing out that 3 more efficiently enters the cells than cisplatin. Furthermore, morphological and cell cycle analysis reveal that gold(III) complexes induced apoptosis in time- and dose-dependent manner.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N '-ethylenediamine bidentate ester ligands
VL  - 172
SP  - 55
EP  - 66
DO  - 10.1016/j.jinorgbio.2017.04.001
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Kolundžija, Branka and Crnogorac, Marija Đorđić and Vujić, Jelena M. and Dojčinović, Biljana P. and Trifunović, Srećko R. and Stanojković, Tatjana and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2017",
abstract = "Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R(2)eddl}]PF6 (R(2)eddl = O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoate, R= n-Pr, n-Bu, n-Pe, i-Bu; 1-4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N'-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24 h, and for the reaction with ascorbic acid in which was reduced immediately. Additionally, 3 interacts with bovine serum albumin (BSA) as proven by UV/Vis spectroscopy. In vitro antitumor activity was determined against human cervix adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human melanoma (Fem-x) cancer cell lines, as well as against non-cancerous human embryonic lung fibroblast cells MRC-5. The highest activity was observed against K562 cells (IC50: 5.04-6.51 mu M). Selectivity indices showed that these complexes are less toxic than cisplatin. 3 had a similar viability kinetics on HeLa cells as cisplatin. Drug accumulation studies in HeLa cells showed that the total gold uptake increased much faster than that of cisplatin pointing out that 3 more efficiently enters the cells than cisplatin. Furthermore, morphological and cell cycle analysis reveal that gold(III) complexes induced apoptosis in time- and dose-dependent manner.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N '-ethylenediamine bidentate ester ligands",
volume = "172",
pages = "55-66",
doi = "10.1016/j.jinorgbio.2017.04.001"
}

Pantelić, N. Đ., Zmejkovski, B. B., Kolundžija, B., Crnogorac, M. Đ., Vujić, J. M., Dojčinović, B. P., Trifunović, S. R., Stanojković, T., Sabo, T.,& Kaluđerović, G. N.. (2017). In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N '-ethylenediamine bidentate ester ligands. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 172, 55-66.
https://doi.org/10.1016/j.jinorgbio.2017.04.001

Pantelić NĐ, Zmejkovski BB, Kolundžija B, Crnogorac MĐ, Vujić JM, Dojčinović BP, Trifunović SR, Stanojković T, Sabo T, Kaluđerović GN. In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N '-ethylenediamine bidentate ester ligands. in Journal of Inorganic Biochemistry. 2017;172:55-66.
doi:10.1016/j.jinorgbio.2017.04.001 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Kolundžija, Branka, Crnogorac, Marija Đorđić, Vujić, Jelena M., Dojčinović, Biljana P., Trifunović, Srećko R., Stanojković, Tatjana, Sabo, Tibor, Kaluđerović, Goran N., "In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N '-ethylenediamine bidentate ester ligands" in Journal of Inorganic Biochemistry, 172 (2017):55-66,
https://doi.org/10.1016/j.jinorgbio.2017.04.001 . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Pantelić, Nebojša Đ.
AU  - Filipović, Lana
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2501
AB  - Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid
VL  - 17
IS  - 8
SP  - 1136
EP  - 1143
DO  - 10.2174/1871520616666161207155634
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Pantelić, Nebojša Đ. and Filipović, Lana and Aranđelović, Sandra and Radulović, Siniša and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2017",
abstract = "Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid",
volume = "17",
number = "8",
pages = "1136-1143",
doi = "10.2174/1871520616666161207155634"
}

Zmejkovski, B. B., Pantelić, N. Đ., Filipović, L., Aranđelović, S., Radulović, S., Sabo, T.,& Kaluđerović, G. N.. (2017). In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 17(8), 1136-1143.
https://doi.org/10.2174/1871520616666161207155634

Zmejkovski BB, Pantelić NĐ, Filipović L, Aranđelović S, Radulović S, Sabo T, Kaluđerović GN. In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid. in Anti-Cancer Agents in Medicinal Chemistry. 2017;17(8):1136-1143.
doi:10.2174/1871520616666161207155634 .

Zmejkovski, Bojana B., Pantelić, Nebojša Đ., Filipović, Lana, Aranđelović, Sandra, Radulović, Siniša, Sabo, Tibor, Kaluđerović, Goran N., "In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid" in Anti-Cancer Agents in Medicinal Chemistry, 17, no. 8 (2017):1136-1143,
https://doi.org/10.2174/1871520616666161207155634 . .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Kolundžija, Branka
AU  - Crnogorac, Marija Đorđić
AU  - Vujić, Jelena M.
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Srećko R.
AU  - Stanojković, Tatjana
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3070
AB  - Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R(2)eddl}]PF6 (R(2)eddl = O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoate, R= n-Pr, n-Bu, n-Pe, i-Bu; 1-4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N'-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24 h, and for the reaction with ascorbic acid in which was reduced immediately. Additionally, 3 interacts with bovine serum albumin (BSA) as proven by UV/Vis spectroscopy. In vitro antitumor activity was determined against human cervix adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human melanoma (Fem-x) cancer cell lines, as well as against non-cancerous human embryonic lung fibroblast cells MRC-5. The highest activity was observed against K562 cells (IC50: 5.04-6.51 mu M). Selectivity indices showed that these complexes are less toxic than cisplatin. 3 had a similar viability kinetics on HeLa cells as cisplatin. Drug accumulation studies in HeLa cells showed that the total gold uptake increased much faster than that of cisplatin pointing out that 3 more efficiently enters the cells than cisplatin. Furthermore, morphological and cell cycle analysis reveal that gold(III) complexes induced apoptosis in time- and dose-dependent manner.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands
VL  - 172
SP  - 55
EP  - 66
DO  - 10.1016/j.jinorgbio.2017.04.001
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Kolundžija, Branka and Crnogorac, Marija Đorđić and Vujić, Jelena M. and Dojčinović, Biljana P. and Trifunović, Srećko R. and Stanojković, Tatjana and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2017",
abstract = "Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R(2)eddl}]PF6 (R(2)eddl = O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoate, R= n-Pr, n-Bu, n-Pe, i-Bu; 1-4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N'-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24 h, and for the reaction with ascorbic acid in which was reduced immediately. Additionally, 3 interacts with bovine serum albumin (BSA) as proven by UV/Vis spectroscopy. In vitro antitumor activity was determined against human cervix adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human melanoma (Fem-x) cancer cell lines, as well as against non-cancerous human embryonic lung fibroblast cells MRC-5. The highest activity was observed against K562 cells (IC50: 5.04-6.51 mu M). Selectivity indices showed that these complexes are less toxic than cisplatin. 3 had a similar viability kinetics on HeLa cells as cisplatin. Drug accumulation studies in HeLa cells showed that the total gold uptake increased much faster than that of cisplatin pointing out that 3 more efficiently enters the cells than cisplatin. Furthermore, morphological and cell cycle analysis reveal that gold(III) complexes induced apoptosis in time- and dose-dependent manner.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands",
volume = "172",
pages = "55-66",
doi = "10.1016/j.jinorgbio.2017.04.001"
}

Pantelić, N. Đ., Zmejkovski, B. B., Kolundžija, B., Crnogorac, M. Đ., Vujić, J. M., Dojčinović, B. P., Trifunović, S. R., Stanojković, T., Sabo, T.,& Kaluđerović, G. N.. (2017). In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 172, 55-66.
https://doi.org/10.1016/j.jinorgbio.2017.04.001

Pantelić NĐ, Zmejkovski BB, Kolundžija B, Crnogorac MĐ, Vujić JM, Dojčinović BP, Trifunović SR, Stanojković T, Sabo T, Kaluđerović GN. In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands. in Journal of Inorganic Biochemistry. 2017;172:55-66.
doi:10.1016/j.jinorgbio.2017.04.001 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Kolundžija, Branka, Crnogorac, Marija Đorđić, Vujić, Jelena M., Dojčinović, Biljana P., Trifunović, Srećko R., Stanojković, Tatjana, Sabo, Tibor, Kaluđerović, Goran N., "In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands" in Journal of Inorganic Biochemistry, 172 (2017):55-66,
https://doi.org/10.1016/j.jinorgbio.2017.04.001 . .

TY  - DATA
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Kolundžija, Branka
AU  - Crnogorac, Marija Đorđić
AU  - Vujić, Jelena M.
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Srećko R.
AU  - Stanojković, Tatjana
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3071
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Supplementary data for article:          Pantelić, N.; Zmejkovski, B. B.; Kolundžija, B.; Crnogorac, M. Đ.; Vujić, J. M.; Dojčinović, B.; Trifunović, S. R.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N. In Vitro Antitumor Activity, Metal Uptake and Reactivity with Ascorbic Acid and BSA of Some Gold(III) Complexes with N,N′-Ethylenediamine Bidentate Ester Ligands. Journal of Inorganic Biochemistry 2017, 172, 55–66. https://doi.org/10.1016/j.jinorgbio.2017.04.001
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3071
ER  - 

@misc{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Kolundžija, Branka and Crnogorac, Marija Đorđić and Vujić, Jelena M. and Dojčinović, Biljana P. and Trifunović, Srećko R. and Stanojković, Tatjana and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2017",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Supplementary data for article:          Pantelić, N.; Zmejkovski, B. B.; Kolundžija, B.; Crnogorac, M. Đ.; Vujić, J. M.; Dojčinović, B.; Trifunović, S. R.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N. In Vitro Antitumor Activity, Metal Uptake and Reactivity with Ascorbic Acid and BSA of Some Gold(III) Complexes with N,N′-Ethylenediamine Bidentate Ester Ligands. Journal of Inorganic Biochemistry 2017, 172, 55–66. https://doi.org/10.1016/j.jinorgbio.2017.04.001",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3071"
}

Pantelić, N. Đ., Zmejkovski, B. B., Kolundžija, B., Crnogorac, M. Đ., Vujić, J. M., Dojčinović, B. P., Trifunović, S. R., Stanojković, T., Sabo, T.,& Kaluđerović, G. N.. (2017). Supplementary data for article:          Pantelić, N.; Zmejkovski, B. B.; Kolundžija, B.; Crnogorac, M. Đ.; Vujić, J. M.; Dojčinović, B.; Trifunović, S. R.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N. In Vitro Antitumor Activity, Metal Uptake and Reactivity with Ascorbic Acid and BSA of Some Gold(III) Complexes with N,N′-Ethylenediamine Bidentate Ester Ligands. Journal of Inorganic Biochemistry 2017, 172, 55–66. https://doi.org/10.1016/j.jinorgbio.2017.04.001. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York..
https://hdl.handle.net/21.15107/rcub_cherry_3071

Pantelić NĐ, Zmejkovski BB, Kolundžija B, Crnogorac MĐ, Vujić JM, Dojčinović BP, Trifunović SR, Stanojković T, Sabo T, Kaluđerović GN. Supplementary data for article:          Pantelić, N.; Zmejkovski, B. B.; Kolundžija, B.; Crnogorac, M. Đ.; Vujić, J. M.; Dojčinović, B.; Trifunović, S. R.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N. In Vitro Antitumor Activity, Metal Uptake and Reactivity with Ascorbic Acid and BSA of Some Gold(III) Complexes with N,N′-Ethylenediamine Bidentate Ester Ligands. Journal of Inorganic Biochemistry 2017, 172, 55–66. https://doi.org/10.1016/j.jinorgbio.2017.04.001. in Journal of Inorganic Biochemistry. 2017;.
https://hdl.handle.net/21.15107/rcub_cherry_3071 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Kolundžija, Branka, Crnogorac, Marija Đorđić, Vujić, Jelena M., Dojčinović, Biljana P., Trifunović, Srećko R., Stanojković, Tatjana, Sabo, Tibor, Kaluđerović, Goran N., "Supplementary data for article:          Pantelić, N.; Zmejkovski, B. B.; Kolundžija, B.; Crnogorac, M. Đ.; Vujić, J. M.; Dojčinović, B.; Trifunović, S. R.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N. In Vitro Antitumor Activity, Metal Uptake and Reactivity with Ascorbic Acid and BSA of Some Gold(III) Complexes with N,N′-Ethylenediamine Bidentate Ester Ligands. Journal of Inorganic Biochemistry 2017, 172, 55–66. https://doi.org/10.1016/j.jinorgbio.2017.04.001" in Journal of Inorganic Biochemistry (2017),
https://hdl.handle.net/21.15107/rcub_cherry_3071 .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Stanković, Dalibor
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2060
AB  - Oxidation-reduction properties of eleven gold(III) complexes with (S,S)-R(2)edda-type ligands was studied by cyclic and differential pulse voltammetry in DMSO. Series I: [AuCl2{(S,S)-R(2)eddip}]PF6, (S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-butyl, n-pentyl, isobutyl, isoamyl, cyclopentyl, 1-5; II: [AuCl2{(S,S)-R(2)eddch}]PF6, (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = methyl, ethyl, n-propyl, n-butyl, isobutyl, isoamyl, 6-11. Voltammograms in DMSO showed two successive irreversible reduction steps, where Au-I species were the final reduction product. Reduction potential values are in range from 116 to 156 mV (Ep(1)) and -520 to -572 mV (Ep(2)) for Series I and from 148 to 228 mV (Ep(1)) and -569 to -638 mV (Ep(2)) for Series II. In general, slightly easier reduction of complexes belonging to Series I (higher cytotoxicity) could be due to less steric hindrance around the gold center. Reduction potentials and anticancer activity are not in correlation.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands
VL  - 11
IS  - 2
SP  - 1162
EP  - 1171
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2060
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Stanković, Dalibor and Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2016",
abstract = "Oxidation-reduction properties of eleven gold(III) complexes with (S,S)-R(2)edda-type ligands was studied by cyclic and differential pulse voltammetry in DMSO. Series I: [AuCl2{(S,S)-R(2)eddip}]PF6, (S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-butyl, n-pentyl, isobutyl, isoamyl, cyclopentyl, 1-5; II: [AuCl2{(S,S)-R(2)eddch}]PF6, (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = methyl, ethyl, n-propyl, n-butyl, isobutyl, isoamyl, 6-11. Voltammograms in DMSO showed two successive irreversible reduction steps, where Au-I species were the final reduction product. Reduction potential values are in range from 116 to 156 mV (Ep(1)) and -520 to -572 mV (Ep(2)) for Series I and from 148 to 228 mV (Ep(1)) and -569 to -638 mV (Ep(2)) for Series II. In general, slightly easier reduction of complexes belonging to Series I (higher cytotoxicity) could be due to less steric hindrance around the gold center. Reduction potentials and anticancer activity are not in correlation.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands",
volume = "11",
number = "2",
pages = "1162-1171",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2060"
}

Pantelić, N. Đ., Stanković, D., Zmejkovski, B. B., Kaluđerović, G. N.,& Sabo, T.. (2016). Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands. in International Journal of Electrochemical Science
Esg, Belgrade., 11(2), 1162-1171.
https://hdl.handle.net/21.15107/rcub_cherry_2060

Pantelić NĐ, Stanković D, Zmejkovski BB, Kaluđerović GN, Sabo T. Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands. in International Journal of Electrochemical Science. 2016;11(2):1162-1171.
https://hdl.handle.net/21.15107/rcub_cherry_2060 .

Pantelić, Nebojša Đ., Stanković, Dalibor, Zmejkovski, Bojana B., Kaluđerović, Goran N., Sabo, Tibor, "Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands" in International Journal of Electrochemical Science, 11, no. 2 (2016):1162-1171,
https://hdl.handle.net/21.15107/rcub_cherry_2060 .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Marković, Dragana D.
AU  - Vujić, Jelena M.
AU  - Stanojković, Tatjana
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2334
AB  - A novel gold(III) complex, [AuCl2{(S,S)-Et(2)eddl}]PF6, ((S,S)-Et(2)eddl = O,O-diethyl ester of ethylenediamine-N,N-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (H-1 and C-13), and 2D (H,H-COSY and H,H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R,R)-N,N diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S,S)-H(2)Et(2)eddl]Cl-2 and corresponding gold(III) complex was determined against tumor cell lines: human adenocarcinoma (HeLa), human colon carcinoma (LS174), human breast cancer (MCF7), non-small cell lung carcinoma cell line (A549), and non-cancerous cell line human embryonic lung fibroblast (MRC-5) using microculture tetrazolium test (MTT) assay. The results indicate that both ligand precursor and gold(III) complex have showed very good to moderate cytotoxic activity against all tested malignant cell lines. The highest activity was expressed by [AuCl2{(S,S)-Et(2)eddl}]PF6 against the LS174 cells, with IC50 value of 7.4 +/- 1.2 mu M.
PB  - Mdpi Ag, Basel
T2  - METALS
T1  - Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Acid
VL  - 6
IS  - 9
DO  - 10.3390/met6090226
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Marković, Dragana D. and Vujić, Jelena M. and Stanojković, Tatjana and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2016",
abstract = "A novel gold(III) complex, [AuCl2{(S,S)-Et(2)eddl}]PF6, ((S,S)-Et(2)eddl = O,O-diethyl ester of ethylenediamine-N,N-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (H-1 and C-13), and 2D (H,H-COSY and H,H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R,R)-N,N diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S,S)-H(2)Et(2)eddl]Cl-2 and corresponding gold(III) complex was determined against tumor cell lines: human adenocarcinoma (HeLa), human colon carcinoma (LS174), human breast cancer (MCF7), non-small cell lung carcinoma cell line (A549), and non-cancerous cell line human embryonic lung fibroblast (MRC-5) using microculture tetrazolium test (MTT) assay. The results indicate that both ligand precursor and gold(III) complex have showed very good to moderate cytotoxic activity against all tested malignant cell lines. The highest activity was expressed by [AuCl2{(S,S)-Et(2)eddl}]PF6 against the LS174 cells, with IC50 value of 7.4 +/- 1.2 mu M.",
publisher = "Mdpi Ag, Basel",
journal = "METALS",
title = "Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Acid",
volume = "6",
number = "9",
doi = "10.3390/met6090226"
}

Pantelić, N. Đ., Zmejkovski, B. B., Marković, D. D., Vujić, J. M., Stanojković, T., Sabo, T.,& Kaluđerović, G. N.. (2016). Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Acid. in METALS
Mdpi Ag, Basel., 6(9).
https://doi.org/10.3390/met6090226

Pantelić NĐ, Zmejkovski BB, Marković DD, Vujić JM, Stanojković T, Sabo T, Kaluđerović GN. Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Acid. in METALS. 2016;6(9).
doi:10.3390/met6090226 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Marković, Dragana D., Vujić, Jelena M., Stanojković, Tatjana, Sabo, Tibor, Kaluđerović, Goran N., "Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O-Diethyl Ester of Ethylenediamine-N,N-Di-2-(4-Methyl)Pentanoic Acid" in METALS, 6, no. 9 (2016),
https://doi.org/10.3390/met6090226 . .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Stanojković, Tatjana
AU  - Zmejkovski, Bojana B.
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1651
AB  - Five novel gold(III) complexes of general formulas [AuCl2{(S,S)-R(2)eddip}]PF6, ((S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-Bu, n-Pe, i-Bu, i-Am, cPe; 1-5, respectively) were synthesized and characterized by UV/Vis, IR and NMR spectroscopy and mass spectrometry. DFT calculations indicated that (R,R)-N,N'-configuration diastereoisomers were the most stable for 1-5. 3 is stable in DMSO for at least 24 h, but immediate hydrolysis in PBS occurs. 3 is readily reduced with ascorbic acid and forms adducts with bovine serum albumin (BSA). In vitro anticancer activity of the gold(III) complexes against human cervix adenocarcinoma HeLa, human myelogenous leukemia K562, human melanoma Fem-x tumor cell lines, as well as against non-cancerous human embryonic lung fibroblast cell line MRC5 was determined using MIT assay. Complex 4 showed highest activity and selectivity (IC50(Femx) = 1.3 +/- 0.2; IC50(MRC-5)/IC50(Fem-x) = 72.5 +/- 12.4), 4 times more active and 28 times more selective than cisplatin. Complexes induced apoptotic mode of death in a time-dependent manner in HeLa cells.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic acid
VL  - 90
SP  - 766
EP  - 774
DO  - 10.1016/j.ejmech.2014.12.019
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Stanojković, Tatjana and Zmejkovski, Bojana B. and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2015",
abstract = "Five novel gold(III) complexes of general formulas [AuCl2{(S,S)-R(2)eddip}]PF6, ((S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-Bu, n-Pe, i-Bu, i-Am, cPe; 1-5, respectively) were synthesized and characterized by UV/Vis, IR and NMR spectroscopy and mass spectrometry. DFT calculations indicated that (R,R)-N,N'-configuration diastereoisomers were the most stable for 1-5. 3 is stable in DMSO for at least 24 h, but immediate hydrolysis in PBS occurs. 3 is readily reduced with ascorbic acid and forms adducts with bovine serum albumin (BSA). In vitro anticancer activity of the gold(III) complexes against human cervix adenocarcinoma HeLa, human myelogenous leukemia K562, human melanoma Fem-x tumor cell lines, as well as against non-cancerous human embryonic lung fibroblast cell line MRC5 was determined using MIT assay. Complex 4 showed highest activity and selectivity (IC50(Femx) = 1.3 +/- 0.2; IC50(MRC-5)/IC50(Fem-x) = 72.5 +/- 12.4), 4 times more active and 28 times more selective than cisplatin. Complexes induced apoptotic mode of death in a time-dependent manner in HeLa cells.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic acid",
volume = "90",
pages = "766-774",
doi = "10.1016/j.ejmech.2014.12.019"
}

Pantelić, N. Đ., Stanojković, T., Zmejkovski, B. B., Sabo, T.,& Kaluđerović, G. N.. (2015). In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic acid. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 90, 766-774.
https://doi.org/10.1016/j.ejmech.2014.12.019

Pantelić NĐ, Stanojković T, Zmejkovski BB, Sabo T, Kaluđerović GN. In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic acid. in European Journal of Medicinal Chemistry. 2015;90:766-774.
doi:10.1016/j.ejmech.2014.12.019 .

Pantelić, Nebojša Đ., Stanojković, Tatjana, Zmejkovski, Bojana B., Sabo, Tibor, Kaluđerović, Goran N., "In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-2-propanoic acid" in European Journal of Medicinal Chemistry, 90 (2015):766-774,
https://doi.org/10.1016/j.ejmech.2014.12.019 . .

TY  - DATA
AU  - Pantelić, Nebojša Đ.
AU  - Stanojković, Tatjana
AU  - Zmejkovski, Bojana B.
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3378
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Supplementary data for article: Pantelic, N.; Stanojkovic, T. P.; Zmejkovski, B. B.; Sabo, T. J.; Kaluerovic, G. N. In Vitro Anticancer Activity of Gold(III) Complexes with Some Esters of (S, S)-Ethylenediamine-N, N G2-Di-2-Propanoic Acid. European Journal of Medicinal Chemistry 2015, 90, 766–774. https://doi.org/10.1016/j.ejmech.2014.12.019
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3378
ER  - 

@misc{
author = "Pantelić, Nebojša Đ. and Stanojković, Tatjana and Zmejkovski, Bojana B. and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2015",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Supplementary data for article: Pantelic, N.; Stanojkovic, T. P.; Zmejkovski, B. B.; Sabo, T. J.; Kaluerovic, G. N. In Vitro Anticancer Activity of Gold(III) Complexes with Some Esters of (S, S)-Ethylenediamine-N, N G2-Di-2-Propanoic Acid. European Journal of Medicinal Chemistry 2015, 90, 766–774. https://doi.org/10.1016/j.ejmech.2014.12.019",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3378"
}

Pantelić, N. Đ., Stanojković, T., Zmejkovski, B. B., Sabo, T.,& Kaluđerović, G. N.. (2015). Supplementary data for article: Pantelic, N.; Stanojkovic, T. P.; Zmejkovski, B. B.; Sabo, T. J.; Kaluerovic, G. N. In Vitro Anticancer Activity of Gold(III) Complexes with Some Esters of (S, S)-Ethylenediamine-N, N G2-Di-2-Propanoic Acid. European Journal of Medicinal Chemistry 2015, 90, 766–774. https://doi.org/10.1016/j.ejmech.2014.12.019. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux..
https://hdl.handle.net/21.15107/rcub_cherry_3378

Pantelić NĐ, Stanojković T, Zmejkovski BB, Sabo T, Kaluđerović GN. Supplementary data for article: Pantelic, N.; Stanojkovic, T. P.; Zmejkovski, B. B.; Sabo, T. J.; Kaluerovic, G. N. In Vitro Anticancer Activity of Gold(III) Complexes with Some Esters of (S, S)-Ethylenediamine-N, N G2-Di-2-Propanoic Acid. European Journal of Medicinal Chemistry 2015, 90, 766–774. https://doi.org/10.1016/j.ejmech.2014.12.019. in European Journal of Medicinal Chemistry. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3378 .

Pantelić, Nebojša Đ., Stanojković, Tatjana, Zmejkovski, Bojana B., Sabo, Tibor, Kaluđerović, Goran N., "Supplementary data for article: Pantelic, N.; Stanojkovic, T. P.; Zmejkovski, B. B.; Sabo, T. J.; Kaluerovic, G. N. In Vitro Anticancer Activity of Gold(III) Complexes with Some Esters of (S, S)-Ethylenediamine-N, N G2-Di-2-Propanoic Acid. European Journal of Medicinal Chemistry 2015, 90, 766–774. https://doi.org/10.1016/j.ejmech.2014.12.019" in European Journal of Medicinal Chemistry (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3378 .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Stanojković, Tatjana
AU  - Jevtic, Verica V.
AU  - Radic, Gordana P.
AU  - Trifunović, Srećko R.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1800
AB  - A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters
VL  - 79
IS  - 6
SP  - 649
EP  - 658
DO  - 10.2298/JSC130512022P
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Stanojković, Tatjana and Jevtic, Verica V. and Radic, Gordana P. and Trifunović, Srećko R. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2014",
abstract = "A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters",
volume = "79",
number = "6",
pages = "649-658",
doi = "10.2298/JSC130512022P"
}

Pantelić, N. Đ., Zmejkovski, B. B., Stanojković, T., Jevtic, V. V., Radic, G. P., Trifunović, S. R., Kaluđerović, G. N.,& Sabo, T.. (2014). Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(6), 649-658.
https://doi.org/10.2298/JSC130512022P

Pantelić NĐ, Zmejkovski BB, Stanojković T, Jevtic VV, Radic GP, Trifunović SR, Kaluđerović GN, Sabo T. Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in Journal of the Serbian Chemical Society. 2014;79(6):649-658.
doi:10.2298/JSC130512022P .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Stanojković, Tatjana, Jevtic, Verica V., Radic, Gordana P., Trifunović, Srećko R., Kaluđerović, Goran N., Sabo, Tibor, "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters" in Journal of the Serbian Chemical Society, 79, no. 6 (2014):649-658,
https://doi.org/10.2298/JSC130512022P . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Savić, Aleksandar
AU  - Poljarević, Jelena
AU  - Pantelić, Nebojša Đ.
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1840
AB  - Six palladium(II) complexes with (S,S)-R(2)edda-type esters ((S,S)-R2edda-type; (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1-3; (S,S)-pddch = (S,S)-propylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N'-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1-4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N'-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N' configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 +/- 3.9, 29.5 +/- 1.3 and 34.3 +/- 3.2, respectively). (C) 2014 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters
VL  - 80
SP  - 106
EP  - 111
DO  - 10.1016/j.poly.2014.02.026
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Savić, Aleksandar and Poljarević, Jelena and Pantelić, Nebojša Đ. and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2014",
abstract = "Six palladium(II) complexes with (S,S)-R(2)edda-type esters ((S,S)-R2edda-type; (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1-3; (S,S)-pddch = (S,S)-propylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N'-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1-4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N'-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N' configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 +/- 3.9, 29.5 +/- 1.3 and 34.3 +/- 3.2, respectively). (C) 2014 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters",
volume = "80",
pages = "106-111",
doi = "10.1016/j.poly.2014.02.026"
}

Zmejkovski, B. B., Savić, A., Poljarević, J., Pantelić, N. Đ., Aranđelović, S., Radulović, S., Grgurić-Šipka, S., Kaluđerović, G. N.,& Sabo, T.. (2014). Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 80, 106-111.
https://doi.org/10.1016/j.poly.2014.02.026

Zmejkovski BB, Savić A, Poljarević J, Pantelić NĐ, Aranđelović S, Radulović S, Grgurić-Šipka S, Kaluđerović GN, Sabo T. Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters. in Polyhedron. 2014;80:106-111.
doi:10.1016/j.poly.2014.02.026 .

Zmejkovski, Bojana B., Savić, Aleksandar, Poljarević, Jelena, Pantelić, Nebojša Đ., Aranđelović, Sandra, Radulović, Siniša, Grgurić-Šipka, Sanja, Kaluđerović, Goran N., Sabo, Tibor, "Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters" in Polyhedron, 80 (2014):106-111,
https://doi.org/10.1016/j.poly.2014.02.026 . .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Trifunović-Macedoljan, Jelena
AU  - Savić, Aleksandar
AU  - Stanković, Dalibor
AU  - Damjanović, Ana
AU  - Juranić, Zorica D.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1422
AB  - Six novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by complexes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate
VL  - 128
SP  - 146
EP  - 153
DO  - 10.1016/j.jinorgbio.2013.08.002
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Trifunović-Macedoljan, Jelena and Savić, Aleksandar and Stanković, Dalibor and Damjanović, Ana and Juranić, Zorica D. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2013",
abstract = "Six novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by complexes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate",
volume = "128",
pages = "146-153",
doi = "10.1016/j.jinorgbio.2013.08.002"
}

Pantelić, N. Đ., Zmejkovski, B. B., Trifunović-Macedoljan, J., Savić, A., Stanković, D., Damjanović, A., Juranić, Z. D., Kaluđerović, G. N.,& Sabo, T.. (2013). Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 128, 146-153.
https://doi.org/10.1016/j.jinorgbio.2013.08.002

Pantelić NĐ, Zmejkovski BB, Trifunović-Macedoljan J, Savić A, Stanković D, Damjanović A, Juranić ZD, Kaluđerović GN, Sabo T. Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate. in Journal of Inorganic Biochemistry. 2013;128:146-153.
doi:10.1016/j.jinorgbio.2013.08.002 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Trifunović-Macedoljan, Jelena, Savić, Aleksandar, Stanković, Dalibor, Damjanović, Ana, Juranić, Zorica D., Kaluđerović, Goran N., Sabo, Tibor, "Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate" in Journal of Inorganic Biochemistry, 128 (2013):146-153,
https://doi.org/10.1016/j.jinorgbio.2013.08.002 . .

TY  - DATA
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Trifunović-Macedoljan, Jelena
AU  - Savić, Aleksandar
AU  - Stanković, Dalibor
AU  - Damjanović, Ana
AU  - Juranić, Zorica D.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3497
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3497
ER  - 

@misc{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Trifunović-Macedoljan, Jelena and Savić, Aleksandar and Stanković, Dalibor and Damjanović, Ana and Juranić, Zorica D. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2013",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3497"
}

Pantelić, N. Đ., Zmejkovski, B. B., Trifunović-Macedoljan, J., Savić, A., Stanković, D., Damjanović, A., Juranić, Z. D., Kaluđerović, G. N.,& Sabo, T.. (2013). Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York..
https://hdl.handle.net/21.15107/rcub_cherry_3497

Pantelić NĐ, Zmejkovski BB, Trifunović-Macedoljan J, Savić A, Stanković D, Damjanović A, Juranić ZD, Kaluđerović GN, Sabo T. Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002. in Journal of Inorganic Biochemistry. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3497 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Trifunović-Macedoljan, Jelena, Savić, Aleksandar, Stanković, Dalibor, Damjanović, Ana, Juranić, Zorica D., Kaluđerović, Goran N., Sabo, Tibor, "Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002" in Journal of Inorganic Biochemistry (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3497 .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1424
AB  - A new R(2)edda-type ester, O,O'-diisopropyl ester of N,N'-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate, [(S,S)-H(2)iPr(2)eddl]Cl-2 center dot 2H(2)O, 1, and its palladium(II) complex, dichlorido(O,O'-diisopropyl-N,N'-1,2-ethanediylbis-L-leucinate)palladium(II) hemihydrate, [PdCl2{(S,S)-iPr(2)eddl}]center dot 0.5H(2)O, 2, were synthesized and characterized by elemental analysis, and IR and NMR spectroscopy. As expected, the palladium(II) complex was found in two from three possible diastereoisomeric forms (R,R), (S,S) and (R,S) equivalent to (S,R).
AB  - Nov estar R2dda-tipa 0,0'-diizopropil estar N,N'-1,2-etandiilbis-L-leucina, dihidrohlorid dihidrat [(S,S)-H2iPr2eddl]Cl2-2H2O (1) i njegov kompleks paladijuma(II), dihlorido(0,0'-diizopropil-N,N'-1,2-etandiilbis-L-leucinat)paladijum(II)- -hemihidrat [PdCl2{(S,SHPr2eddl}]-0.5H2O (2) su sintetisani i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Kalijum-tetrahloridopaladat(II), reagujući sa [(S,S)-H2iPr2eddl]Cl2-2H2O, očekivano daje paladijumov kompleks 2 u obliku dva od moguća tri dijastereoizomera, (R,R), (S,S) i (R,S) = (S,R), što je potvrđeno uz pomoć NMR spektroskopije, a u saglasnosti je sa ranije urađenim DFT proračunima. PR Projekat Ministarstva nauke Republike Srbije, br. 172035.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Palladium(II) complexes with R(2)edda derived ligands. Part VI. O,O '-Diisopropyl ester of N,N '-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate and its palladium(II) complex: synthesis and characterization
T1  - Kompleksi paladijuma(II) sa ligandima R2edda tipa. Deo VI. 0,0'-diizopropil estar N,N'-1,2-etandiilbis-L-leucina, dihidrohlorid dihidrat i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija
VL  - 78
IS  - 8
SP  - 1171
EP  - 1176
DO  - 10.2298/JSC130113021Z
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Sabo, Tibor and Kaluđerović, Goran N.",
year = "2013",
abstract = "A new R(2)edda-type ester, O,O'-diisopropyl ester of N,N'-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate, [(S,S)-H(2)iPr(2)eddl]Cl-2 center dot 2H(2)O, 1, and its palladium(II) complex, dichlorido(O,O'-diisopropyl-N,N'-1,2-ethanediylbis-L-leucinate)palladium(II) hemihydrate, [PdCl2{(S,S)-iPr(2)eddl}]center dot 0.5H(2)O, 2, were synthesized and characterized by elemental analysis, and IR and NMR spectroscopy. As expected, the palladium(II) complex was found in two from three possible diastereoisomeric forms (R,R), (S,S) and (R,S) equivalent to (S,R)., Nov estar R2dda-tipa 0,0'-diizopropil estar N,N'-1,2-etandiilbis-L-leucina, dihidrohlorid dihidrat [(S,S)-H2iPr2eddl]Cl2-2H2O (1) i njegov kompleks paladijuma(II), dihlorido(0,0'-diizopropil-N,N'-1,2-etandiilbis-L-leucinat)paladijum(II)- -hemihidrat [PdCl2{(S,SHPr2eddl}]-0.5H2O (2) su sintetisani i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Kalijum-tetrahloridopaladat(II), reagujući sa [(S,S)-H2iPr2eddl]Cl2-2H2O, očekivano daje paladijumov kompleks 2 u obliku dva od moguća tri dijastereoizomera, (R,R), (S,S) i (R,S) = (S,R), što je potvrđeno uz pomoć NMR spektroskopije, a u saglasnosti je sa ranije urađenim DFT proračunima. PR Projekat Ministarstva nauke Republike Srbije, br. 172035.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Palladium(II) complexes with R(2)edda derived ligands. Part VI. O,O '-Diisopropyl ester of N,N '-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate and its palladium(II) complex: synthesis and characterization, Kompleksi paladijuma(II) sa ligandima R2edda tipa. Deo VI. 0,0'-diizopropil estar N,N'-1,2-etandiilbis-L-leucina, dihidrohlorid dihidrat i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija",
volume = "78",
number = "8",
pages = "1171-1176",
doi = "10.2298/JSC130113021Z"
}

Zmejkovski, B. B., Sabo, T.,& Kaluđerović, G. N.. (2013). Palladium(II) complexes with R(2)edda derived ligands. Part VI. O,O '-Diisopropyl ester of N,N '-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate and its palladium(II) complex: synthesis and characterization. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 78(8), 1171-1176.
https://doi.org/10.2298/JSC130113021Z

Zmejkovski BB, Sabo T, Kaluđerović GN. Palladium(II) complexes with R(2)edda derived ligands. Part VI. O,O '-Diisopropyl ester of N,N '-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate and its palladium(II) complex: synthesis and characterization. in Journal of the Serbian Chemical Society. 2013;78(8):1171-1176.
doi:10.2298/JSC130113021Z .

Zmejkovski, Bojana B., Sabo, Tibor, Kaluđerović, Goran N., "Palladium(II) complexes with R(2)edda derived ligands. Part VI. O,O '-Diisopropyl ester of N,N '-1,2-ethanediylbis-L-leucine, dihydrochloride dihydrate and its palladium(II) complex: synthesis and characterization" in Journal of the Serbian Chemical Society, 78, no. 8 (2013):1171-1176,
https://doi.org/10.2298/JSC130113021Z . .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatovic, Sanja A.
AU  - Zmejkovski, Bojana B.
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojic, Marija K.
AU  - Steinborn, Dirk
AU  - Miljkovic, Djordje M.
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava D.
AU  - Sabo, Tibor
AU  - Maksimovic-Ivanic, Danijela D.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1523
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
VL  - 4
IS  - 9
SP  - 979
EP  - 987
DO  - 10.1039/c2mt20058a
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatovic, Sanja A. and Zmejkovski, Bojana B. and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojic, Marija K. and Steinborn, Dirk and Miljkovic, Djordje M. and Schmidt, Harry and Stošić-Grujičić, Stanislava D. and Sabo, Tibor and Maksimovic-Ivanic, Danijela D.",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
volume = "4",
number = "9",
pages = "979-987",
doi = "10.1039/c2mt20058a"
}

Kaluđerović, G. N., Mijatovic, S. A., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojic, M. K., Steinborn, D., Miljkovic, D. M., Schmidt, H., Stošić-Grujičić, S. D., Sabo, T.,& Maksimovic-Ivanic, D. D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics
Royal Soc Chemistry, Cambridge., 4(9), 979-987.
https://doi.org/10.1039/c2mt20058a

Kaluđerović GN, Mijatovic SA, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojic MK, Steinborn D, Miljkovic DM, Schmidt H, Stošić-Grujičić SD, Sabo T, Maksimovic-Ivanic DD. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):979-987.
doi:10.1039/c2mt20058a .

Kaluđerović, Goran N., Mijatovic, Sanja A., Zmejkovski, Bojana B., Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojic, Marija K., Steinborn, Dirk, Miljkovic, Djordje M., Schmidt, Harry, Stošić-Grujičić, Stanislava D., Sabo, Tibor, Maksimovic-Ivanic, Danijela D., "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012):979-987,
https://doi.org/10.1039/c2mt20058a . .

TY  - JOUR
AU  - Vujić, Jelena M.
AU  - Cvijović, Milica
AU  - Kaluđerović, Goran N.
AU  - Milovanović, Marija
AU  - Zmejkovski, Bojana B.
AU  - Volarevic, Vladislav
AU  - Arsenijević, Nebojša
AU  - Sabo, Tibor
AU  - Trifunović, Srećko R.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1112
AB  - Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. (C) 2010 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti
VL  - 45
IS  - 9
SP  - 3601
EP  - 3606
DO  - 10.1016/j.ejmech.2010.05.005
ER  - 

@article{
author = "Vujić, Jelena M. and Cvijović, Milica and Kaluđerović, Goran N. and Milovanović, Marija and Zmejkovski, Bojana B. and Volarevic, Vladislav and Arsenijević, Nebojša and Sabo, Tibor and Trifunović, Srećko R.",
year = "2010",
abstract = "Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. (C) 2010 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti",
volume = "45",
number = "9",
pages = "3601-3606",
doi = "10.1016/j.ejmech.2010.05.005"
}

Vujić, J. M., Cvijović, M., Kaluđerović, G. N., Milovanović, M., Zmejkovski, B. B., Volarevic, V., Arsenijević, N., Sabo, T.,& Trifunović, S. R.. (2010). Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 45(9), 3601-3606.
https://doi.org/10.1016/j.ejmech.2010.05.005

Vujić JM, Cvijović M, Kaluđerović GN, Milovanović M, Zmejkovski BB, Volarevic V, Arsenijević N, Sabo T, Trifunović SR. Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti. in European Journal of Medicinal Chemistry. 2010;45(9):3601-3606.
doi:10.1016/j.ejmech.2010.05.005 .

Vujić, Jelena M., Cvijović, Milica, Kaluđerović, Goran N., Milovanović, Marija, Zmejkovski, Bojana B., Volarevic, Vladislav, Arsenijević, Nebojša, Sabo, Tibor, Trifunović, Srećko R., "Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral acti" in European Journal of Medicinal Chemistry, 45, no. 9 (2010):3601-3606,
https://doi.org/10.1016/j.ejmech.2010.05.005 . .

TY  - THES
AU  - Zmejkovski, Bojana B.
PY  - 2010
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=1150
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:7943/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=39270927
UR  - http://nardus.mpn.gov.rs/123456789/3497
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2649
AB  - U ovom radu su opisane sinteze, karakterizacija i antiproliferativna aktivnost liganada u obliku hidrohloridnih soli, estara etilendiamin-N,N’-di-3-propanske kiseline (H2eddp),  (S,S)-etilendiamin-N,N’-di-2-propanske kiseline ((S,S)-H2eddip) i (S,S)-etilendiamin-N,N’-di-2-(4-metil)-pentanske kiseline ((S,S)-H2eddl), kao i odgovarajućih kompleksa sa platinom(IV), platinom(II) i paladijumom(II).Sintetisano je osam novih estara, a to su izopropil i izobutil estri svih navedenih kiselina, a sa (S,S)-H2eddip dobijeni su i ciklopentil i cikloheksil estri. Ova jedinjenja su dobijena refluktovanjem suspenzije kiseline u odgovarajućem apsolutnom alkoholu kome je prethodno ukapan tionil-hlorid. Svi estri su dobijeni u obliku dihidrohlorida: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2 i [(S,S)-H2iBu2eddl]Cl2. Estri su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom, a [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 i [(S,S)-H2iBu2eddl]Cl2 urađena je i rendgenostrukturna analiza. U pokušaju sinteze ciklopentil estra (S,S)-etilendiamin-N,N'-di-2-(3-metil)-butanske kiseline (S,S)-H2eddv, dobijeni su neočekivani monokristali sastava [(S,S)-H4eddv]Br0,17Cl1,83.4C5H9OH.Kompleksi platine(IV) dobijeni su u reakciji natrijum- ili kalijum-heksahloroplatinata(IV) sa navedenim estrima. Sintetisano je pet novih kompleksa platine(IV): [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] i [PtCl4(iBu2eddp)]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom. Kristalna struktura određena je kompleksima [PtCl4{(S,S)-iPr2eddip}]  i [PtCl4{(S,S)-cPe2eddip}]. Kompleksi platine(II) dobijeni su  u reakciji kalijum-tetrahloroplatinata(II) sa estrima. Sintetisano je tri nova kompleksa platine(II): [PtCl2{(S,S)-iPr2eddip}], [PtCl2{(S,S)-iBu2eddip}] i [PtCl2{(S,S)-cPe2eddip}]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom.Sedam novih kompleksa paladijuma(II): [PdCl2{(S,S)-iPr2eddip}], [PdCl{(S,S)-iPreddip}], [PdCl2{(S,S)-iBu2eddip}], [PdCl2{(S,S)-cPe2eddip}], [PdCl2{(S,S)-Cy2eddip}], [PdCl2{(S,S)-iPr2eddl}] i [PdCl2{(S,S)-iBu2eddl}] dobijeno je u reakciji kalijum-tetrahloropaladata(II) sa estrima. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom...
AB  - This work describes synthesis, characterization and antiproliferative activity of ligands precursors, esters of ethylenediamine-N,N’-di-3-propanoic acid (H2eddp),  (S,S)-ethylenediamine-N,N’-di-2-propanoic acid ((S,S)-H2eddip) and (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)-pentanoic acid ((S,S)-H2eddl), as well as their complexes with platinum(IV), platinum(II) and palladium(II).Eight novel esters are synthesized, isopropyl and isobutyl esters of the mentioned acids, and cyclopentyl and cyclohexyl esters of (S,S)-H2eddip. Thionyl-chloride was intoduced into a flask containing absolute alcohol. The corresponding acid is added forming a suspension which was reflucted. All of the esters were obtained as dihydrochlorides: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2, [(S,S)-H2iBu2eddl]Cl2. Esters were characterized by elemental analysis, IR and NMR spectroscopy. Crystal structures of [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 and [(S,S)-H2iBu2eddl]Cl2 are solved by X-ray analyses. While trying to synthesize the cyclopentyl ester of (S,S)-ethylenediamine-N,N'-di-2-(3-methyl)-butanoic acid (S,S)-H2eddv, unexpected crystals suitable for X-ray analysis were obtained and determined - [(S,S)-H4eddv]Br0.17Cl1.83.4C5H9OH.Complexes of platinum(IV) are synthesized in a reaction of potassium-hexachloroplatinate(IV) with esters. Five novel platinum(IV) complexes are obtained: [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] and [PtCl4(iBu2eddip)]. These complexes are characterized by elemental analysis, IR and NMR spectroscopy...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa
T1  - Synthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type esters
UR  - https://hdl.handle.net/21.15107/rcub_nardus_3497
ER  - 

@phdthesis{
author = "Zmejkovski, Bojana B.",
year = "2010",
abstract = "U ovom radu su opisane sinteze, karakterizacija i antiproliferativna aktivnost liganada u obliku hidrohloridnih soli, estara etilendiamin-N,N’-di-3-propanske kiseline (H2eddp),  (S,S)-etilendiamin-N,N’-di-2-propanske kiseline ((S,S)-H2eddip) i (S,S)-etilendiamin-N,N’-di-2-(4-metil)-pentanske kiseline ((S,S)-H2eddl), kao i odgovarajućih kompleksa sa platinom(IV), platinom(II) i paladijumom(II).Sintetisano je osam novih estara, a to su izopropil i izobutil estri svih navedenih kiselina, a sa (S,S)-H2eddip dobijeni su i ciklopentil i cikloheksil estri. Ova jedinjenja su dobijena refluktovanjem suspenzije kiseline u odgovarajućem apsolutnom alkoholu kome je prethodno ukapan tionil-hlorid. Svi estri su dobijeni u obliku dihidrohlorida: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2 i [(S,S)-H2iBu2eddl]Cl2. Estri su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom, a [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 i [(S,S)-H2iBu2eddl]Cl2 urađena je i rendgenostrukturna analiza. U pokušaju sinteze ciklopentil estra (S,S)-etilendiamin-N,N'-di-2-(3-metil)-butanske kiseline (S,S)-H2eddv, dobijeni su neočekivani monokristali sastava [(S,S)-H4eddv]Br0,17Cl1,83.4C5H9OH.Kompleksi platine(IV) dobijeni su u reakciji natrijum- ili kalijum-heksahloroplatinata(IV) sa navedenim estrima. Sintetisano je pet novih kompleksa platine(IV): [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] i [PtCl4(iBu2eddp)]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom. Kristalna struktura određena je kompleksima [PtCl4{(S,S)-iPr2eddip}]  i [PtCl4{(S,S)-cPe2eddip}]. Kompleksi platine(II) dobijeni su  u reakciji kalijum-tetrahloroplatinata(II) sa estrima. Sintetisano je tri nova kompleksa platine(II): [PtCl2{(S,S)-iPr2eddip}], [PtCl2{(S,S)-iBu2eddip}] i [PtCl2{(S,S)-cPe2eddip}]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom.Sedam novih kompleksa paladijuma(II): [PdCl2{(S,S)-iPr2eddip}], [PdCl{(S,S)-iPreddip}], [PdCl2{(S,S)-iBu2eddip}], [PdCl2{(S,S)-cPe2eddip}], [PdCl2{(S,S)-Cy2eddip}], [PdCl2{(S,S)-iPr2eddl}] i [PdCl2{(S,S)-iBu2eddl}] dobijeno je u reakciji kalijum-tetrahloropaladata(II) sa estrima. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom..., This work describes synthesis, characterization and antiproliferative activity of ligands precursors, esters of ethylenediamine-N,N’-di-3-propanoic acid (H2eddp),  (S,S)-ethylenediamine-N,N’-di-2-propanoic acid ((S,S)-H2eddip) and (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)-pentanoic acid ((S,S)-H2eddl), as well as their complexes with platinum(IV), platinum(II) and palladium(II).Eight novel esters are synthesized, isopropyl and isobutyl esters of the mentioned acids, and cyclopentyl and cyclohexyl esters of (S,S)-H2eddip. Thionyl-chloride was intoduced into a flask containing absolute alcohol. The corresponding acid is added forming a suspension which was reflucted. All of the esters were obtained as dihydrochlorides: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2, [(S,S)-H2iBu2eddl]Cl2. Esters were characterized by elemental analysis, IR and NMR spectroscopy. Crystal structures of [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 and [(S,S)-H2iBu2eddl]Cl2 are solved by X-ray analyses. While trying to synthesize the cyclopentyl ester of (S,S)-ethylenediamine-N,N'-di-2-(3-methyl)-butanoic acid (S,S)-H2eddv, unexpected crystals suitable for X-ray analysis were obtained and determined - [(S,S)-H4eddv]Br0.17Cl1.83.4C5H9OH.Complexes of platinum(IV) are synthesized in a reaction of potassium-hexachloroplatinate(IV) with esters. Five novel platinum(IV) complexes are obtained: [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] and [PtCl4(iBu2eddip)]. These complexes are characterized by elemental analysis, IR and NMR spectroscopy...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa, Synthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type esters",
url = "https://hdl.handle.net/21.15107/rcub_nardus_3497"
}

Zmejkovski, B. B.. (2010). Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_3497

Zmejkovski BB. Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa. in Универзитет у Београду. 2010;.
https://hdl.handle.net/21.15107/rcub_nardus_3497 .

Zmejkovski, Bojana B., "Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa" in Универзитет у Београду (2010),
https://hdl.handle.net/21.15107/rcub_nardus_3497 .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/621
AB  - In the crystal structure of the title compound, C(12)H(26)N(2)O(4)(2+)center dot-2(Br(0.085)Cl(0.915))(-)center dot 4C(5)H(9)OH, the complete cation is generated by crystallographic twofold symmetry. Contamination of the chloride counter-anion with bromide occured during the preparation, due to the use of 1,2-dibromoethane. One of the solvent molecules is disordered, with occupancies 0.53 (3): 0.47 (3). The crystal packing is stabilized by an infinite two dimensional center dot center dot center dot X center dot center dot center dot H-N-H center dot center dot center dot X center dot center dot center dot hydrogen-bonding network (X: Br(-)/Cl(-) similar or equal to 1:12). In addition, O-H center dot center dot center dot X and O-H center dot center dot center dot O hydrogen bonds involving solvent molecules are observed.
PB  - Wiley-Blackwell Publishing, Inc, Malden
T2  - Acta Crystallographica. Section E: Structure Reports Online
T1  - (S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12)
VL  - 65
DO  - 10.1107/S1600536809006679
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Sabo, Tibor",
year = "2009",
abstract = "In the crystal structure of the title compound, C(12)H(26)N(2)O(4)(2+)center dot-2(Br(0.085)Cl(0.915))(-)center dot 4C(5)H(9)OH, the complete cation is generated by crystallographic twofold symmetry. Contamination of the chloride counter-anion with bromide occured during the preparation, due to the use of 1,2-dibromoethane. One of the solvent molecules is disordered, with occupancies 0.53 (3): 0.47 (3). The crystal packing is stabilized by an infinite two dimensional center dot center dot center dot X center dot center dot center dot H-N-H center dot center dot center dot X center dot center dot center dot hydrogen-bonding network (X: Br(-)/Cl(-) similar or equal to 1:12). In addition, O-H center dot center dot center dot X and O-H center dot center dot center dot O hydrogen bonds involving solvent molecules are observed.",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Acta Crystallographica. Section E: Structure Reports Online",
title = "(S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12)",
volume = "65",
doi = "10.1107/S1600536809006679"
}

Zmejkovski, B. B., Kaluđerović, G. N., Gomez-Ruiz, S.,& Sabo, T.. (2009). (S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12). in Acta Crystallographica. Section E: Structure Reports Online
Wiley-Blackwell Publishing, Inc, Malden., 65.
https://doi.org/10.1107/S1600536809006679

Zmejkovski BB, Kaluđerović GN, Gomez-Ruiz S, Sabo T. (S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12). in Acta Crystallographica. Section E: Structure Reports Online. 2009;65.
doi:10.1107/S1600536809006679 .

Zmejkovski, Bojana B., Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Sabo, Tibor, "(S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12)" in Acta Crystallographica. Section E: Structure Reports Online, 65 (2009),
https://doi.org/10.1107/S1600536809006679 . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Žižak, Željko S.
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Paschke, Reinhard
AU  - Juranić, Zorica D.
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1005
AB  - New R(2)eddip-type esters (R = cyclopentyl, L3 center dot 2HCl 1.5H(2)O; cyclohexyl, L4 center dot 2HCl center dot H2O) and corresponding palladium(II) complexes, [PdCl(2)L3] (3) and [PdCl2L4]center dot H2O (4), as well as [PdCl2L2] (2: L2 diisobutyl ester of eddip) were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopies and elemental analysis. The crystal structure of L3 center dot 2HCl center dot 2CHCl(3) was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl(2)L1] (1). In vitro anti proliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test. (C) 2009 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes
VL  - 44
IS  - 9
SP  - 3452
EP  - 3458
DO  - 10.1016/j.ejmech.2009.02.002
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Žižak, Željko S. and Steinborn, Dirk and Schmidt, Harry and Paschke, Reinhard and Juranić, Zorica D. and Sabo, Tibor",
year = "2009",
abstract = "New R(2)eddip-type esters (R = cyclopentyl, L3 center dot 2HCl 1.5H(2)O; cyclohexyl, L4 center dot 2HCl center dot H2O) and corresponding palladium(II) complexes, [PdCl(2)L3] (3) and [PdCl2L4]center dot H2O (4), as well as [PdCl2L2] (2: L2 diisobutyl ester of eddip) were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopies and elemental analysis. The crystal structure of L3 center dot 2HCl center dot 2CHCl(3) was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl(2)L1] (1). In vitro anti proliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test. (C) 2009 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes",
volume = "44",
number = "9",
pages = "3452-3458",
doi = "10.1016/j.ejmech.2009.02.002"
}

Zmejkovski, B. B., Kaluđerović, G. N., Gomez-Ruiz, S., Žižak, Ž. S., Steinborn, D., Schmidt, H., Paschke, R., Juranić, Z. D.,& Sabo, T.. (2009). Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 44(9), 3452-3458.
https://doi.org/10.1016/j.ejmech.2009.02.002

Zmejkovski BB, Kaluđerović GN, Gomez-Ruiz S, Žižak ŽS, Steinborn D, Schmidt H, Paschke R, Juranić ZD, Sabo T. Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry. 2009;44(9):3452-3458.
doi:10.1016/j.ejmech.2009.02.002 .

Zmejkovski, Bojana B., Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Žižak, Željko S., Steinborn, Dirk, Schmidt, Harry, Paschke, Reinhard, Juranić, Zorica D., Sabo, Tibor, "Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes" in European Journal of Medicinal Chemistry, 44, no. 9 (2009):3452-3458,
https://doi.org/10.1016/j.ejmech.2009.02.002 . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1035
AB  - A new R(2)edda-type ester, diisobutyl (SS)-2,2'-(1,2-ethane-diyldiimino)di(4-methylpentanoate) dihydrochloride, [(S,S)-H(2)iBu(2)eddl]Cl-2, 1, and its palladium(II) complex, dichloro(diisobutyl (SS)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate))palladium(II), [PdCl2{(S,S)-iBu(2)eddl}], 2, were synthesized and characterized by elemental analysis, as well as IR and NMR spectroscopy. It was found that complex 2 was obtained as mixture of two diastereoisomers, observed in NMR spectra. The crystal structure of compound I was determined by X-ray diffraction studies and is described. The isolated crystals consisted of one dicationic species [(SS)-H(2)iBu(2)eddl](2+) and two Cl-. The crystal system was tetragonal with the space group P4(2). Hydrogen bonds significant for the manner of packing are N-H1N center dot center dot center dot Cl, 3.049(3) angstrom, 159(3)degrees and N-H2N center dot center dot center dot Cl, 3.100(3) angstrom, 164(3)degrees. An infinite chain was formed building a one layer structure, usual for these types of compounds. The C-2 symmetry axis of the compound passes through the Cl-Cl-i bond vector and lies perpendicular to the plane N2Cl2.
AB  - Novi estar R2edda-tipa diizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpen-tanoat)-dihidrohlorid [(S,S)-H2iBu2eddl]Cl2,1, i njegov kompleks paladijuma(II), dihlorodiizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpentanoat)-paladijum(II) [PdCl2{(S,S)-iBu2eddl}], 2, sintetisani su i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Nađeno je da je kompleks 2 dobijen kao smeša dva dijastereoizomera, što je primećeno u NMR spektrima. Kristalna struktura 1 je rešena i opisana. Izolovani kristali se sastoje iz jedne dikatjonske vrste [(S,S)-H2iBu2eddl]2+ i dva Cl-. Kristalni sistem je tetragonalan sa prostornim grupom P42. Značajne vodonične veze za način pakovanja su N-H1N•••Cl, 3,049(3) Å, 159(3)°i N-H2N...Cl, 3,100(3) Å, 164(3)°. Time se formira beskonačan lanac i jednoslojna struktura, koji su uobičajeni za ove tipove struktura. Osa simetrije C2 jedinjenja prolazi kroz C1-C1i vektor veze i leži normalno na N2Cl2 ravan. PR Projekat Ministarstva nauke Republike Srbije, br. 142010.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Palladium(II) complexes with R(2)edda derived ligands. Part III. Diisobutyl (S,S)-2,2 '-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: synthesis and characterization
T1  - Kompleksi paladijuma(II) sa ligandima R2edda tipa, deo III - diizobutil-(s,s)-2,2'-(1,2,-etandiildiimino)-di(4-metilpentanoat)-dihidrohlorid i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija
VL  - 74
IS  - 11
SP  - 1249
EP  - 1258
DO  - 10.2298/JSC0911249Z
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Sabo, Tibor",
year = "2009",
abstract = "A new R(2)edda-type ester, diisobutyl (SS)-2,2'-(1,2-ethane-diyldiimino)di(4-methylpentanoate) dihydrochloride, [(S,S)-H(2)iBu(2)eddl]Cl-2, 1, and its palladium(II) complex, dichloro(diisobutyl (SS)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate))palladium(II), [PdCl2{(S,S)-iBu(2)eddl}], 2, were synthesized and characterized by elemental analysis, as well as IR and NMR spectroscopy. It was found that complex 2 was obtained as mixture of two diastereoisomers, observed in NMR spectra. The crystal structure of compound I was determined by X-ray diffraction studies and is described. The isolated crystals consisted of one dicationic species [(SS)-H(2)iBu(2)eddl](2+) and two Cl-. The crystal system was tetragonal with the space group P4(2). Hydrogen bonds significant for the manner of packing are N-H1N center dot center dot center dot Cl, 3.049(3) angstrom, 159(3)degrees and N-H2N center dot center dot center dot Cl, 3.100(3) angstrom, 164(3)degrees. An infinite chain was formed building a one layer structure, usual for these types of compounds. The C-2 symmetry axis of the compound passes through the Cl-Cl-i bond vector and lies perpendicular to the plane N2Cl2., Novi estar R2edda-tipa diizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpen-tanoat)-dihidrohlorid [(S,S)-H2iBu2eddl]Cl2,1, i njegov kompleks paladijuma(II), dihlorodiizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpentanoat)-paladijum(II) [PdCl2{(S,S)-iBu2eddl}], 2, sintetisani su i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Nađeno je da je kompleks 2 dobijen kao smeša dva dijastereoizomera, što je primećeno u NMR spektrima. Kristalna struktura 1 je rešena i opisana. Izolovani kristali se sastoje iz jedne dikatjonske vrste [(S,S)-H2iBu2eddl]2+ i dva Cl-. Kristalni sistem je tetragonalan sa prostornim grupom P42. Značajne vodonične veze za način pakovanja su N-H1N•••Cl, 3,049(3) Å, 159(3)°i N-H2N...Cl, 3,100(3) Å, 164(3)°. Time se formira beskonačan lanac i jednoslojna struktura, koji su uobičajeni za ove tipove struktura. Osa simetrije C2 jedinjenja prolazi kroz C1-C1i vektor veze i leži normalno na N2Cl2 ravan. PR Projekat Ministarstva nauke Republike Srbije, br. 142010.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Palladium(II) complexes with R(2)edda derived ligands. Part III. Diisobutyl (S,S)-2,2 '-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: synthesis and characterization, Kompleksi paladijuma(II) sa ligandima R2edda tipa, deo III - diizobutil-(s,s)-2,2'-(1,2,-etandiildiimino)-di(4-metilpentanoat)-dihidrohlorid i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija",
volume = "74",
number = "11",
pages = "1249-1258",
doi = "10.2298/JSC0911249Z"
}

Zmejkovski, B. B., Kaluđerović, G. N., Gomez-Ruiz, S.,& Sabo, T.. (2009). Palladium(II) complexes with R(2)edda derived ligands. Part III. Diisobutyl (S,S)-2,2 '-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: synthesis and characterization. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(11), 1249-1258.
https://doi.org/10.2298/JSC0911249Z

Zmejkovski BB, Kaluđerović GN, Gomez-Ruiz S, Sabo T. Palladium(II) complexes with R(2)edda derived ligands. Part III. Diisobutyl (S,S)-2,2 '-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: synthesis and characterization. in Journal of the Serbian Chemical Society. 2009;74(11):1249-1258.
doi:10.2298/JSC0911249Z .

Zmejkovski, Bojana B., Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Sabo, Tibor, "Palladium(II) complexes with R(2)edda derived ligands. Part III. Diisobutyl (S,S)-2,2 '-(1,2-ethanediyldiimino)di(4-methylpentanoate) and its palladium(II) complex: synthesis and characterization" in Journal of the Serbian Chemical Society, 74, no. 11 (2009):1249-1258,
https://doi.org/10.2298/JSC0911249Z . .