@article{
author = "Milosavljevic, S and Juranić, Ivan O. and Bulatović, V. and Macura, S. and Juranić, N. and Limbach, HH and Weisz, K and Vajs, Vlatka and Todorović, Nevena M.",
year = "2004",
abstract = "Conformational analysis of 9alpha-acetoxycumambrine A 1 and 8-O-isobutiryl-9alpha-acetoxycumambrine B 2 was carried out by low-temperature NMR studies. Results suggested that lactones 1 and 2 are mixtures of two distinctive conformers, I and II. Based on low-temperature H-1 NMR spectra, in four solvents, the thermodynamic parameters of I reversible arrow II exchange process were assessed. Energy of activation of I -- gt II reaction was obtained by dynamic NMR simulations for both compounds. Results revealed that conformational exchange of lactones 1 and 2 occurs due to "chair reversible arrow twisted chair" interconversion of a heptane ring. The same PM3 semiempirical method was applied for geometry optimization of lactones 1 and 2, as well as of 9alpha-hydroxycumambrine A 3, 9alpha-acetoxycumambrine B 4, and cumambrine B 5.",
publisher = "Kluwer Academic/Plenum Publ, New York",
journal = "Structural Chemistry",
title = "Conformational analysis of guaianolide-type sesquiterpene lactones by low-temperature NMR spectroscopy and semiempirical calculations",
volume = "15",
number = "3",
pages = "237-245",
doi = "10.1023/B:STUC.0000021533.65546.57"
}