Ćirić, Ana

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orcid::0000-0002-9478-5448
  • Ćirić, Ana (4)

Author's Bibliography

Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity

Vesović, Nikola; Nenadić, Marija; Soković, Marina; Ćirić, Ana; Vujisić, Ljubodrag V.; Todosijević, Marina; Stevanović, Nataša; Perić-Mataruga, Vesna; Ilijin, Larisa; Ćurčić, Srećko

(SpringerLink, 2022)

TY  - JOUR
AU  - Vesović, Nikola
AU  - Nenadić, Marija
AU  - Soković, Marina
AU  - Ćirić, Ana
AU  - Vujisić, Ljubodrag V.
AU  - Todosijević, Marina
AU  - Stevanović, Nataša
AU  - Perić-Mataruga, Vesna
AU  - Ilijin, Larisa
AU  - Ćurčić, Srećko
PY  - 2022
UR  - https://doi.org/10.1007/s00114-022-01790-0
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5183
AB  - Pygidial gland secretions are used as repellent defensive allomones in ground beetles. We provide the first precise data on the chemical composition and antimicrobial potency of the secretion of the blue ground beetle, as well as on the morphology of its pygidial glands. The latter structures were not previously studied chemoecologically and morphologically, and we hypothesized that their secretion may have some antimicrobial action, as is the case with certain Carabus species. Gas chromatography-mass spectrometry (GC-MS) was used to identify methacrylic and angelic acids as dominant chemicals in the secretion from individuals of three populations of the blue ground beetle in Serbia. We tested its secretion against selected strains of medically important microorganisms. The secretion exibits antimicrobial action against certain bacterial species and all tested micromycetes. The most significant antifungal effect of the secretion was against Penicillium ochrochloron, which is more sensitive to the secretion than to commercial antifungal drugs ketoconazole and bifonazole. Bifonazole achieved minimum inhibitory concentrations against Trichoderma viride at more than three times higher value than did the secretion, indicating a significant antifungal effect of the secretion against this micromycete as well. Additionally, we tested commercially available standards of two dominant chemicals in the secretion to investigate their interaction and antimicrobial role in the secretion. Finally, we describe all glandular morpho-functional units of the blue ground beetle. Our results suggest that the secretion of the blue ground beetle may serve not only defensive but also antimicrobial functions, which likely aid the survival of this beetle in the microbial-rich forest litter habitat.
PB  - SpringerLink
T2  - The Science of Nature
T1  - Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity
VL  - 109
IS  - 2
SP  - 19
DO  - 10.1007/s00114-022-01790-0
ER  - 
@article{
author = "Vesović, Nikola and Nenadić, Marija and Soković, Marina and Ćirić, Ana and Vujisić, Ljubodrag V. and Todosijević, Marina and Stevanović, Nataša and Perić-Mataruga, Vesna and Ilijin, Larisa and Ćurčić, Srećko",
year = "2022",
abstract = "Pygidial gland secretions are used as repellent defensive allomones in ground beetles. We provide the first precise data on the chemical composition and antimicrobial potency of the secretion of the blue ground beetle, as well as on the morphology of its pygidial glands. The latter structures were not previously studied chemoecologically and morphologically, and we hypothesized that their secretion may have some antimicrobial action, as is the case with certain Carabus species. Gas chromatography-mass spectrometry (GC-MS) was used to identify methacrylic and angelic acids as dominant chemicals in the secretion from individuals of three populations of the blue ground beetle in Serbia. We tested its secretion against selected strains of medically important microorganisms. The secretion exibits antimicrobial action against certain bacterial species and all tested micromycetes. The most significant antifungal effect of the secretion was against Penicillium ochrochloron, which is more sensitive to the secretion than to commercial antifungal drugs ketoconazole and bifonazole. Bifonazole achieved minimum inhibitory concentrations against Trichoderma viride at more than three times higher value than did the secretion, indicating a significant antifungal effect of the secretion against this micromycete as well. Additionally, we tested commercially available standards of two dominant chemicals in the secretion to investigate their interaction and antimicrobial role in the secretion. Finally, we describe all glandular morpho-functional units of the blue ground beetle. Our results suggest that the secretion of the blue ground beetle may serve not only defensive but also antimicrobial functions, which likely aid the survival of this beetle in the microbial-rich forest litter habitat.",
publisher = "SpringerLink",
journal = "The Science of Nature",
title = "Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity",
volume = "109",
number = "2",
pages = "19",
doi = "10.1007/s00114-022-01790-0"
}
Vesović, N., Nenadić, M., Soković, M., Ćirić, A., Vujisić, L. V., Todosijević, M., Stevanović, N., Perić-Mataruga, V., Ilijin, L.,& Ćurčić, S.. (2022). Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity. in The Science of Nature
SpringerLink., 109(2), 19.
https://doi.org/10.1007/s00114-022-01790-0
Vesović N, Nenadić M, Soković M, Ćirić A, Vujisić LV, Todosijević M, Stevanović N, Perić-Mataruga V, Ilijin L, Ćurčić S. Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity. in The Science of Nature. 2022;109(2):19.
doi:10.1007/s00114-022-01790-0 .
Vesović, Nikola, Nenadić, Marija, Soković, Marina, Ćirić, Ana, Vujisić, Ljubodrag V., Todosijević, Marina, Stevanović, Nataša, Perić-Mataruga, Vesna, Ilijin, Larisa, Ćurčić, Srećko, "Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity" in The Science of Nature, 109, no. 2 (2022):19,
https://doi.org/10.1007/s00114-022-01790-0 . .

Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources

Aničić, Neda; Gašić, Uroš M.; Lu, Feng; Ćirić, Ana; Ivanov, Marija; Jevtić, Bojan; Dimitrijević, Milena; Anđelković, Boban D.; Skorić, Marijana; Nestorović Živković, Jasmina; Mao, Yingle; Liu, Jia; Tang, Chunping; Soković, Marina; Ye, Yang; Mišić, Danijela

(MDPI, 2021)

TY  - JOUR
AU  - Aničić, Neda
AU  - Gašić, Uroš M.
AU  - Lu, Feng
AU  - Ćirić, Ana
AU  - Ivanov, Marija
AU  - Jevtić, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban D.
AU  - Skorić, Marijana
AU  - Nestorović Živković, Jasmina
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Mišić, Danijela
PY  - 2021
UR  - https://www.mdpi.com/1424-8247/14/5/414
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4444
AB  - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
PB  - MDPI
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
VL  - 14
IS  - 5
SP  - 414
DO  - 10.3390/ph14050414
ER  - 
@article{
author = "Aničić, Neda and Gašić, Uroš M. and Lu, Feng and Ćirić, Ana and Ivanov, Marija and Jevtić, Bojan and Dimitrijević, Milena and Anđelković, Boban D. and Skorić, Marijana and Nestorović Živković, Jasmina and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Mišić, Danijela",
year = "2021",
abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.",
publisher = "MDPI",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources",
volume = "14",
number = "5",
pages = "414",
doi = "10.3390/ph14050414"
}
Aničić, N., Gašić, U. M., Lu, F., Ćirić, A., Ivanov, M., Jevtić, B., Dimitrijević, M., Anđelković, B. D., Skorić, M., Nestorović Živković, J., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Mišić, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals
MDPI., 14(5), 414.
https://doi.org/10.3390/ph14050414
Aničić N, Gašić UM, Lu F, Ćirić A, Ivanov M, Jevtić B, Dimitrijević M, Anđelković BD, Skorić M, Nestorović Živković J, Mao Y, Liu J, Tang C, Soković M, Ye Y, Mišić D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5):414.
doi:10.3390/ph14050414 .
Aničić, Neda, Gašić, Uroš M., Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban D., Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021):414,
https://doi.org/10.3390/ph14050414 . .
1
7
2
6

Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.

Aničić, Neda; Gašić, Uroš M.; Lu, Feng; Ćirić, Ana; Ivanov, Marija; Jevtić, Bojan; Dimitrijević, Milena; Anđelković, Boban D.; Skorić, Marijana; Nestorović Živković, Jasmina; Mao, Yingle; Liu, Jia; Tang, Chunping; Soković, Marina; Ye, Yang; Mišić, Danijela

(MDPI, 2021)

TY  - DATA
AU  - Aničić, Neda
AU  - Gašić, Uroš M.
AU  - Lu, Feng
AU  - Ćirić, Ana
AU  - Ivanov, Marija
AU  - Jevtić, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban D.
AU  - Skorić, Marijana
AU  - Nestorović Živković, Jasmina
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Mišić, Danijela
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4445
PB  - MDPI
T2  - Pharmaceuticals
T2  - Pharmaceuticals
T1  - Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.
VL  - 14
IS  - 5
SP  - 414
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4445
ER  - 
@misc{
author = "Aničić, Neda and Gašić, Uroš M. and Lu, Feng and Ćirić, Ana and Ivanov, Marija and Jevtić, Bojan and Dimitrijević, Milena and Anđelković, Boban D. and Skorić, Marijana and Nestorović Živković, Jasmina and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Mišić, Danijela",
year = "2021",
publisher = "MDPI",
journal = "Pharmaceuticals, Pharmaceuticals",
title = "Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.",
volume = "14",
number = "5",
pages = "414",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4445"
}
Aničić, N., Gašić, U. M., Lu, F., Ćirić, A., Ivanov, M., Jevtić, B., Dimitrijević, M., Anđelković, B. D., Skorić, M., Nestorović Živković, J., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Mišić, D.. (2021). Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.. in Pharmaceuticals
MDPI., 14(5), 414.
https://hdl.handle.net/21.15107/rcub_cherry_4445
Aničić N, Gašić UM, Lu F, Ćirić A, Ivanov M, Jevtić B, Dimitrijević M, Anđelković BD, Skorić M, Nestorović Živković J, Mao Y, Liu J, Tang C, Soković M, Ye Y, Mišić D. Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414.. in Pharmaceuticals. 2021;14(5):414.
https://hdl.handle.net/21.15107/rcub_cherry_4445 .
Aničić, Neda, Gašić, Uroš M., Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban D., Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela, "Supplementary data for the article: Aničić, N.; Gašić, U.; Lu, F.; Ćirić, A.; Ivanov, M.; Jevtić, B.; Dimitrijević, M.; Anđelković, B.; Skorić, M.; Nestorović Živković, J.; Mao, Y.; Liu, J.; Tang, C.; Soković, M.; Ye, Y.; Mišić, D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. Pharmaceuticals 2021, 14 (5), 414. https://doi.org/10.3390/ph14050414." in Pharmaceuticals, 14, no. 5 (2021):414,
https://hdl.handle.net/21.15107/rcub_cherry_4445 .

Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential

Sofrenić, Ivana V.; Ljujić, Jovana; Simić, Katarina; Ivanović, Stefan; Stanković-Jeremić, Jovana; Ćirić, Ana; Soković, Marina; Anđelković, Boban D.

(Serbian Chemical Society, 2021)

TY  - JOUR
AU  - Sofrenić, Ivana V.
AU  - Ljujić, Jovana
AU  - Simić, Katarina
AU  - Ivanović, Stefan
AU  - Stanković-Jeremić, Jovana
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Anđelković, Boban D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4940
AB  - The objective of this study was to test four-dimensional LC-ESI-MS/MS chromatography in analysis of complex mixture such as ethanol extracts of different propolis samples. In total more than 1200 picks were identified and only for 185 literature conformation was found. The given data represent the result of tentative identification, and summarized results are given in the text. Comparing the samples, from different altitudes, 96 components were detected as characteristic in high altitude samples and 18 in samples collected at low altitudes. Antimicrobial activity of ethanol extracts of propolis (EEP) and pro­pyl­ene glycol extracts of propolis (PGEP) were carried out on S. aureus, B. cereus, M. flavus, L. monocytogenes, P. aeruginosa, S. typhimurium, E. coli and E. cloacae bacterial strains and compared with broad-spectrum antibiotics, streptomycin and ampicillin. Anti-quorum sensing activity was performed on P. aeruginosa by testing the effect of representative propolis extracts on bio­film formation, twitching and motility activity and production of pyocyanin. We demonstrated that the majority of explored propolis extracts have greater or equal minimal inhibitory concentration and minimum bactericidal concen­tra­tion values compared to antibiotics, independently of the solvent used for the extraction. The samples collected from the highest altitude emerged as least active antimicrobial agents but with the greatest potential as anti-quorum sen­sing agents.
AB  - Циљ овог истраживања је билo тестирање четвородимензионалне LC–ESI-MS/MS хроматографије у анализи комплексних смеша, као што су етанолни екстракти различитих узорака прополиса. Укупно је идентификовано више од 1200 пикова, а самo за 185 смо нашли литературну потврду. Приказани подаци представљају тентативну идентификацију и сумирани резултат је дат у тексту. Поређењем узорака са различитих надморских висина, за 96 једињења је утврђено да се налазе само у узорцима са високе надморске висине и 18 само у узорцима прикупљеним на нижим надморским висинама. Антибактеријске активности етанолних и пропиленгликолних екстрактата прополиса (EEP и PGEP, редом) тестиране су на S. aureus, B. cereus, M. flavus, L. monocytogenes, P. aeruginosa, S. typhimurium, E. coli и E. cloacae бактеријским линијама и поређене са анти- биотицима широког спектра деловања, стрептомицином и ампицилином. Anti-quorum sensing активност је тестирана на P. aeruginosa испитивањем ефекта репрезентативних екстраката прополиса на формирање биофилма, тестовима покретљивости руба коло- није (twitching и mobility) и производње пиоцианина. Показали смо да највећи број, коришћених екстраката прополиса, има истe и/или мање MIC и MBC вредности, у поре- ђењу са атибиотицима, независно од растварача коришћеног за екстракцију. Узорци прикупљени на високим надморским висинама су се показали као најмање активни антибактерициди али имају велики anti-quorum sensing потенцијал.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential
T1  - Примена lc–ms/ms технике са јонском покретљивошћу за хемијску анализу екстраката прополиса са антимикробним потенцијалом.
IS  - 12
SP  - 1205
EP  - 1218
DO  - 10.2298/JSC210812086S
ER  - 
@article{
author = "Sofrenić, Ivana V. and Ljujić, Jovana and Simić, Katarina and Ivanović, Stefan and Stanković-Jeremić, Jovana and Ćirić, Ana and Soković, Marina and Anđelković, Boban D.",
year = "2021",
abstract = "The objective of this study was to test four-dimensional LC-ESI-MS/MS chromatography in analysis of complex mixture such as ethanol extracts of different propolis samples. In total more than 1200 picks were identified and only for 185 literature conformation was found. The given data represent the result of tentative identification, and summarized results are given in the text. Comparing the samples, from different altitudes, 96 components were detected as characteristic in high altitude samples and 18 in samples collected at low altitudes. Antimicrobial activity of ethanol extracts of propolis (EEP) and pro­pyl­ene glycol extracts of propolis (PGEP) were carried out on S. aureus, B. cereus, M. flavus, L. monocytogenes, P. aeruginosa, S. typhimurium, E. coli and E. cloacae bacterial strains and compared with broad-spectrum antibiotics, streptomycin and ampicillin. Anti-quorum sensing activity was performed on P. aeruginosa by testing the effect of representative propolis extracts on bio­film formation, twitching and motility activity and production of pyocyanin. We demonstrated that the majority of explored propolis extracts have greater or equal minimal inhibitory concentration and minimum bactericidal concen­tra­tion values compared to antibiotics, independently of the solvent used for the extraction. The samples collected from the highest altitude emerged as least active antimicrobial agents but with the greatest potential as anti-quorum sen­sing agents., Циљ овог истраживања је билo тестирање четвородимензионалне LC–ESI-MS/MS хроматографије у анализи комплексних смеша, као што су етанолни екстракти различитих узорака прополиса. Укупно је идентификовано више од 1200 пикова, а самo за 185 смо нашли литературну потврду. Приказани подаци представљају тентативну идентификацију и сумирани резултат је дат у тексту. Поређењем узорака са различитих надморских висина, за 96 једињења је утврђено да се налазе само у узорцима са високе надморске висине и 18 само у узорцима прикупљеним на нижим надморским висинама. Антибактеријске активности етанолних и пропиленгликолних екстрактата прополиса (EEP и PGEP, редом) тестиране су на S. aureus, B. cereus, M. flavus, L. monocytogenes, P. aeruginosa, S. typhimurium, E. coli и E. cloacae бактеријским линијама и поређене са анти- биотицима широког спектра деловања, стрептомицином и ампицилином. Anti-quorum sensing активност је тестирана на P. aeruginosa испитивањем ефекта репрезентативних екстраката прополиса на формирање биофилма, тестовима покретљивости руба коло- није (twitching и mobility) и производње пиоцианина. Показали смо да највећи број, коришћених екстраката прополиса, има истe и/или мање MIC и MBC вредности, у поре- ђењу са атибиотицима, независно од растварача коришћеног за екстракцију. Узорци прикупљени на високим надморским висинама су се показали као најмање активни антибактерициди али имају велики anti-quorum sensing потенцијал.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential, Примена lc–ms/ms технике са јонском покретљивошћу за хемијску анализу екстраката прополиса са антимикробним потенцијалом.",
number = "12",
pages = "1205-1218",
doi = "10.2298/JSC210812086S"
}
Sofrenić, I. V., Ljujić, J., Simić, K., Ivanović, S., Stanković-Jeremić, J., Ćirić, A., Soković, M.,& Anđelković, B. D.. (2021). Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential. in Journal of the Serbian Chemical Society
Serbian Chemical Society.(12), 1205-1218.
https://doi.org/10.2298/JSC210812086S
Sofrenić IV, Ljujić J, Simić K, Ivanović S, Stanković-Jeremić J, Ćirić A, Soković M, Anđelković BD. Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential. in Journal of the Serbian Chemical Society. 2021;(12):1205-1218.
doi:10.2298/JSC210812086S .
Sofrenić, Ivana V., Ljujić, Jovana, Simić, Katarina, Ivanović, Stefan, Stanković-Jeremić, Jovana, Ćirić, Ana, Soković, Marina, Anđelković, Boban D., "Application of LC-MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential" in Journal of the Serbian Chemical Society, no. 12 (2021):1205-1218,
https://doi.org/10.2298/JSC210812086S . .