TY  - JOUR
AU  - Ilic-Tomić, Tatjana
AU  - Soković, Marina
AU  - Vojnović, Sandra
AU  - Ćirić, Ana D.
AU  - Veljić, Milan
AU  - Nikodinović-Runić, Jasmina
AU  - Novaković, Miroslav M.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2395
AB  - Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa
VL  - 83
IS  - 01-02
SP  - 117
EP  - 125
DO  - 10.1055/s-0042-107674
ER  - 

@article{
author = "Ilic-Tomić, Tatjana and Soković, Marina and Vojnović, Sandra and Ćirić, Ana D. and Veljić, Milan and Nikodinović-Runić, Jasmina and Novaković, Miroslav M.",
year = "2017",
abstract = "Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa",
volume = "83",
number = "01-02",
pages = "117-125",
doi = "10.1055/s-0042-107674"
}

Ilic-Tomić, T., Soković, M., Vojnović, S., Ćirić, A. D., Veljić, M., Nikodinović-Runić, J.,& Novaković, M. M.. (2017). Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 83(01-02), 117-125.
https://doi.org/10.1055/s-0042-107674

Ilic-Tomić T, Soković M, Vojnović S, Ćirić AD, Veljić M, Nikodinović-Runić J, Novaković MM. Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica. 2017;83(01-02):117-125.
doi:10.1055/s-0042-107674 .

Ilic-Tomić, Tatjana, Soković, Marina, Vojnović, Sandra, Ćirić, Ana D., Veljić, Milan, Nikodinović-Runić, Jasmina, Novaković, Miroslav M., "Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa" in Planta Medica, 83, no. 01-02 (2017):117-125,
https://doi.org/10.1055/s-0042-107674 . .

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Apostolović, Danijela
AU  - Mandić, Boris
AU  - Veljić, Milan
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1793
AB  - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL  - 11
IS  - 6
SP  - 872
EP  - 885
DO  - 10.1002/cbdv.201300277
ER  - 

@article{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Apostolović, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277"
}

Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Apostolović, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277

Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Apostolović D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277 .

Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Apostolović, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry and Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 . .

TY  - JOUR
AU  - Bukvicki, Danka
AU  - Gottardi, Davide
AU  - Tyagi, Arnit Kumar
AU  - Veljić, Milan
AU  - Mann, Petar D.
AU  - Vujisić, Ljubodrag V.
AU  - Guerzoni, Maria Elisabetta
AU  - Vannini, Lucia
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1489
AB  - This study was focused on chemical characterisation of liverwort Scapania nemorea extracts and their antimicrobial activity against pathogenic and food-spoiling yeasts and bacteria. The chemical composition of three different extracts of the liverwort S. nemorea was determined by solid phase microextraction gas chromatography-mass spectrometry (SPME GC MS). The dominant compounds in extracts were sesquiterpenes beta-bazzanene (11%, 17.9% and 14.6%), isobazzanene (10.2%, 15.8% and 11.7%) and aromadendrene (8.8%, 12.9% and 10.6%) in the methanol, ethanol and ethyl acetate extracts, respectively. Antimicrobial potential of S. nemorea extracts against food spoiling yeasts and bacteria was determined in vitro by microdilution method. The Minimum Inhibitory Concentration (MIC) varied from 0.5 to 3 mg/mL for bacteria, and from 0.2 to 1 mg/mL for yeasts. Moreover, the combined effects of dry methanol extract of S. nemorea and heat processing on the survival and growth of a spoilage yeast in an apple/orange-based beverage, have been assessed through a Central Composite Design. Changes in color and flavor of the beverages were considered acceptable also after one week of storage at 25 degrees C. The results provide evidence of antimicrobial potential of S. nemorea extracts and suggest its potential as natural antimicrobial agent for food preservation. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - LWT -food Science and Technology ( Lebensmittel - Wissenschaft und Technologie)
T1  - Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice
VL  - 55
IS  - 2
SP  - 452
EP  - 458
DO  - 10.1016/j.lwt.2013.09.029
ER  - 

@article{
author = "Bukvicki, Danka and Gottardi, Davide and Tyagi, Arnit Kumar and Veljić, Milan and Mann, Petar D. and Vujisić, Ljubodrag V. and Guerzoni, Maria Elisabetta and Vannini, Lucia",
year = "2014",
abstract = "This study was focused on chemical characterisation of liverwort Scapania nemorea extracts and their antimicrobial activity against pathogenic and food-spoiling yeasts and bacteria. The chemical composition of three different extracts of the liverwort S. nemorea was determined by solid phase microextraction gas chromatography-mass spectrometry (SPME GC MS). The dominant compounds in extracts were sesquiterpenes beta-bazzanene (11%, 17.9% and 14.6%), isobazzanene (10.2%, 15.8% and 11.7%) and aromadendrene (8.8%, 12.9% and 10.6%) in the methanol, ethanol and ethyl acetate extracts, respectively. Antimicrobial potential of S. nemorea extracts against food spoiling yeasts and bacteria was determined in vitro by microdilution method. The Minimum Inhibitory Concentration (MIC) varied from 0.5 to 3 mg/mL for bacteria, and from 0.2 to 1 mg/mL for yeasts. Moreover, the combined effects of dry methanol extract of S. nemorea and heat processing on the survival and growth of a spoilage yeast in an apple/orange-based beverage, have been assessed through a Central Composite Design. Changes in color and flavor of the beverages were considered acceptable also after one week of storage at 25 degrees C. The results provide evidence of antimicrobial potential of S. nemorea extracts and suggest its potential as natural antimicrobial agent for food preservation. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "LWT -food Science and Technology ( Lebensmittel - Wissenschaft und Technologie)",
title = "Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice",
volume = "55",
number = "2",
pages = "452-458",
doi = "10.1016/j.lwt.2013.09.029"
}

Bukvicki, D., Gottardi, D., Tyagi, A. K., Veljić, M., Mann, P. D., Vujisić, L. V., Guerzoni, M. E.,& Vannini, L.. (2014). Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice. in LWT -food Science and Technology ( Lebensmittel - Wissenschaft und Technologie)
Elsevier Science Bv, Amsterdam., 55(2), 452-458.
https://doi.org/10.1016/j.lwt.2013.09.029

Bukvicki D, Gottardi D, Tyagi AK, Veljić M, Mann PD, Vujisić LV, Guerzoni ME, Vannini L. Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice. in LWT -food Science and Technology ( Lebensmittel - Wissenschaft und Technologie). 2014;55(2):452-458.
doi:10.1016/j.lwt.2013.09.029 .

Bukvicki, Danka, Gottardi, Davide, Tyagi, Arnit Kumar, Veljić, Milan, Mann, Petar D., Vujisić, Ljubodrag V., Guerzoni, Maria Elisabetta, Vannini, Lucia, "Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice" in LWT -food Science and Technology ( Lebensmittel - Wissenschaft und Technologie), 55, no. 2 (2014):452-458,
https://doi.org/10.1016/j.lwt.2013.09.029 . .

TY  - JOUR
AU  - Bojović, Srđan R.
AU  - Sarac, Zorica
AU  - Nikolić, Biljana
AU  - Tešević, Vele
AU  - Todosijević, Marina
AU  - Veljić, Milan
AU  - Marin, Petar D.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1563
AB  - This is the first report on the composition and variability of the needle-wax n-alkanes in natural populations of Pinus nigra in Serbia. Samples of 195 trees from seven populations belonging to several infraspecific taxa (ssp. nigra, var. gocensis, ssp. pallasiana, and var. banatica) were analyzed. In general, the size of the n-alkanes ranged from C16 to C33, with the exception of ssp. nigra, for which it ranged from C18 to C33. The most abundant were C23-, C25-, C27-, and C29-alkanes. The needle waxes of Populations IIII and V were characterized by a higher content of C23-, C25-, and C27-alkanes and a lower content of C24-, C26-, C28-, and C30-alkanes, compared to the other populations, and the trees of these populations could be assigned to ssp. nigra. The samples of Population VI were characterized by higher amounts of C22-, C24-, C30-, and C32-alkanes and lower amounts of C25- and C27-alkanes, and the trees could be considered as ssp. pallasiana. The samples of Population VII, consisting of trees belonging to var. banatica, were richer in C29-, C31-, and C33-alkanes. The wax compositions of Populations IV and V, both composed of trees previously determined as P. nigra var. gocensis, showed a tendency of splitting. Indeed, the alkane composition of Population IV was closer to that of ssp. pallasiana pines, while that of Population V was more similar to that of ssp. nigra pines. From the results presented here, it is obvious that in the central part of the Balkan Peninsula, significant diversification and differentiation of the populations of black pine exists, and these populations could be defined as different intraspecific taxa. Our results also indicate the validity of n-alkanes as chemotaxonomic characters within this aggregate.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Composition of n-Alkanes in Natural Populations of Pinus nigra from Serbia - Chemotaxonomic Implications
VL  - 9
IS  - 12
SP  - 2761
EP  - 2774
DO  - 10.1002/cbdv.201200051
ER  - 

@article{
author = "Bojović, Srđan R. and Sarac, Zorica and Nikolić, Biljana and Tešević, Vele and Todosijević, Marina and Veljić, Milan and Marin, Petar D.",
year = "2012",
abstract = "This is the first report on the composition and variability of the needle-wax n-alkanes in natural populations of Pinus nigra in Serbia. Samples of 195 trees from seven populations belonging to several infraspecific taxa (ssp. nigra, var. gocensis, ssp. pallasiana, and var. banatica) were analyzed. In general, the size of the n-alkanes ranged from C16 to C33, with the exception of ssp. nigra, for which it ranged from C18 to C33. The most abundant were C23-, C25-, C27-, and C29-alkanes. The needle waxes of Populations IIII and V were characterized by a higher content of C23-, C25-, and C27-alkanes and a lower content of C24-, C26-, C28-, and C30-alkanes, compared to the other populations, and the trees of these populations could be assigned to ssp. nigra. The samples of Population VI were characterized by higher amounts of C22-, C24-, C30-, and C32-alkanes and lower amounts of C25- and C27-alkanes, and the trees could be considered as ssp. pallasiana. The samples of Population VII, consisting of trees belonging to var. banatica, were richer in C29-, C31-, and C33-alkanes. The wax compositions of Populations IV and V, both composed of trees previously determined as P. nigra var. gocensis, showed a tendency of splitting. Indeed, the alkane composition of Population IV was closer to that of ssp. pallasiana pines, while that of Population V was more similar to that of ssp. nigra pines. From the results presented here, it is obvious that in the central part of the Balkan Peninsula, significant diversification and differentiation of the populations of black pine exists, and these populations could be defined as different intraspecific taxa. Our results also indicate the validity of n-alkanes as chemotaxonomic characters within this aggregate.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Composition of n-Alkanes in Natural Populations of Pinus nigra from Serbia - Chemotaxonomic Implications",
volume = "9",
number = "12",
pages = "2761-2774",
doi = "10.1002/cbdv.201200051"
}

Bojović, S. R., Sarac, Z., Nikolić, B., Tešević, V., Todosijević, M., Veljić, M.,& Marin, P. D.. (2012). Composition of n-Alkanes in Natural Populations of Pinus nigra from Serbia - Chemotaxonomic Implications. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 9(12), 2761-2774.
https://doi.org/10.1002/cbdv.201200051

Bojović SR, Sarac Z, Nikolić B, Tešević V, Todosijević M, Veljić M, Marin PD. Composition of n-Alkanes in Natural Populations of Pinus nigra from Serbia - Chemotaxonomic Implications. in Chemistry and Biodiversity. 2012;9(12):2761-2774.
doi:10.1002/cbdv.201200051 .

Bojović, Srđan R., Sarac, Zorica, Nikolić, Biljana, Tešević, Vele, Todosijević, Marina, Veljić, Milan, Marin, Petar D., "Composition of n-Alkanes in Natural Populations of Pinus nigra from Serbia - Chemotaxonomic Implications" in Chemistry and Biodiversity, 9, no. 12 (2012):2761-2774,
https://doi.org/10.1002/cbdv.201200051 . .