TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Paunović, Ivan
AU  - Jovanović, Milan
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4787
AB  - Background
The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA).

Methods
The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS).

Results
This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition.

Conclusion
For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas
VL  - 63
SP  - 126658
DO  - 10.1016/j.jtemb.2020.126658
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Paunović, Ivan and Jovanović, Milan and Gavrović-Jankulović, Marija and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2021",
abstract = "Background
The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA).

Methods
The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS).

Results
This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition.

Conclusion
For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas",
volume = "63",
pages = "126658",
doi = "10.1016/j.jtemb.2020.126658"
}

Jagodić, J., Rovčanin, B., Paunović, I., Jovanović, M., Gavrović-Jankulović, M., Manojlović, D. D.,& Stojsavljević, A.. (2021). The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology
Elsevier., 63, 126658.
https://doi.org/10.1016/j.jtemb.2020.126658

Jagodić J, Rovčanin B, Paunović I, Jovanović M, Gavrović-Jankulović M, Manojlović DD, Stojsavljević A. The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology. 2021;63:126658.
doi:10.1016/j.jtemb.2020.126658 .

Jagodić, Jovana, Rovčanin, Branislav, Paunović, Ivan, Jovanović, Milan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., Stojsavljević, Aleksandar, "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas" in Journal of Trace Elements in Medicine and Biology, 63 (2021):126658,
https://doi.org/10.1016/j.jtemb.2020.126658 . .

TY  - CONF
AU  - Jagodić, J.
AU  - Rovčanin, B.
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, A.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4927
AB  - Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune disorder of the thyroid gland [1]. As a result of the continuous deterioration of the gland caused by HT, more than 90% of patients develop thyroid insufficiency and hypothyroidism [2]. It has been noted that genetic and/or environmental factors play an important role in the etiology of HT [3]. The most prevalent environmental and hazardous risk factors that were linked to the pathogenesis of HT include Se deficit, pollutants, and irradiation [4]. The focus of this research was to determine which trace elements could have a role in the pathophysiology of HT. In this regard, the essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main hazardous toxic trace elements (Ni, As, Pb, Cd, U) were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in the thyroid tissue, blood, and urine samples of patients with diagnosed HT. Control samples of blood and urine were collected from healthy donors. Moreover, the effects of relevant parameters on element profiles were examined and addressed in terms of environmental concerns. This investigation discovered a variation in the elemental profile of HT and control samples. Thyroid tissue and HT blood samples had significantly increased As and Pb levels. The obtained negative correlations between As and Pb and Se potentially indicates the antagonistic influence of As and Pb on the extrusion of essential Se from the HT tissue. The absence of Se in HT could be further explained by the obtained lower levels of Se in blood and higher Se in urine samples. Importantly, the findings could provide the understanding of the as-yet unresolved molecular basis of HT, and also highlight the role of these elements on thyroid homeostasis.
PB  - Belgrade : Serbian Chemical Society
C3  - Book of Abstracts 21st; European Meeting on Environmental Chemistry
T1  - Elemental Profile of Hashimoto’s Thyroiditis: Thyroid Tissue, Blood, and Urine Analysis
SP  - 155
EP  - 155
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4927
ER  - 

@conference{
author = "Jagodić, J. and Rovčanin, B. and Manojlović, Dragan D. and Stojsavljević, A.",
year = "2021",
abstract = "Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune disorder of the thyroid gland [1]. As a result of the continuous deterioration of the gland caused by HT, more than 90% of patients develop thyroid insufficiency and hypothyroidism [2]. It has been noted that genetic and/or environmental factors play an important role in the etiology of HT [3]. The most prevalent environmental and hazardous risk factors that were linked to the pathogenesis of HT include Se deficit, pollutants, and irradiation [4]. The focus of this research was to determine which trace elements could have a role in the pathophysiology of HT. In this regard, the essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main hazardous toxic trace elements (Ni, As, Pb, Cd, U) were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in the thyroid tissue, blood, and urine samples of patients with diagnosed HT. Control samples of blood and urine were collected from healthy donors. Moreover, the effects of relevant parameters on element profiles were examined and addressed in terms of environmental concerns. This investigation discovered a variation in the elemental profile of HT and control samples. Thyroid tissue and HT blood samples had significantly increased As and Pb levels. The obtained negative correlations between As and Pb and Se potentially indicates the antagonistic influence of As and Pb on the extrusion of essential Se from the HT tissue. The absence of Se in HT could be further explained by the obtained lower levels of Se in blood and higher Se in urine samples. Importantly, the findings could provide the understanding of the as-yet unresolved molecular basis of HT, and also highlight the role of these elements on thyroid homeostasis.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Book of Abstracts 21st; European Meeting on Environmental Chemistry",
title = "Elemental Profile of Hashimoto’s Thyroiditis: Thyroid Tissue, Blood, and Urine Analysis",
pages = "155-155",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4927"
}

Jagodić, J., Rovčanin, B., Manojlović, D. D.,& Stojsavljević, A.. (2021). Elemental Profile of Hashimoto’s Thyroiditis: Thyroid Tissue, Blood, and Urine Analysis. in Book of Abstracts 21st; European Meeting on Environmental Chemistry
Belgrade : Serbian Chemical Society., 155-155.
https://hdl.handle.net/21.15107/rcub_cherry_4927

Jagodić J, Rovčanin B, Manojlović DD, Stojsavljević A. Elemental Profile of Hashimoto’s Thyroiditis: Thyroid Tissue, Blood, and Urine Analysis. in Book of Abstracts 21st; European Meeting on Environmental Chemistry. 2021;:155-155.
https://hdl.handle.net/21.15107/rcub_cherry_4927 .

Jagodić, J., Rovčanin, B., Manojlović, Dragan D., Stojsavljević, A., "Elemental Profile of Hashimoto’s Thyroiditis: Thyroid Tissue, Blood, and Urine Analysis" in Book of Abstracts 21st; European Meeting on Environmental Chemistry (2021):155-155,
https://hdl.handle.net/21.15107/rcub_cherry_4927 .