@article{
author = "Matijašević Joković, Suzana and Dobrijević, Zorana and Kotarac, Nevena and Filipović, Lidija and Popović, Milica M. and Korać, Aleksandra and Vuković, Ivan and Savić-Pavićević, Dušanka and Brajušković, Goran",
year = "2022",
abstract = "MiR-21 and miR-375 have been reported as dysregulated in prostate cancer (PCa) in
multiple previous studies. Still, variable or even opposing data for the expression of these microRNAs
in PCa were found, and their potential biomarker properties remain elusive. In an attempt to clarify
their significance as PCa biomarkers, as well as to compare different types of specimens as a source
of relevant microRNAs, we used plasma and matching plasma-derived exosomes from patients with
PCa and patients with benign prostatic hyperplasia (BPH). Plasma and exosomes were obtained
from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and
miR-375 were determined by RT-qPCR. We found no significant difference in the level of expression
of these microRNAs in plasma and exosomes between patients with PCa and BPH. The level of
exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients
with aggressive PCa, while for plasma samples, the results remained insignificant. For miR-375, we
did not find an association with the values of standard prognostic parameters of PCa, nor with cancer
aggressiveness. Therefore, our results support the potential prognostic role of exosomal miR-21
expression levels in PCa.",
publisher = "MDPI",
journal = "Genes",
title = "MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes",
volume = "13",
number = "12",
pages = "2320",
doi = "10.3390/genes13122320"
}
