TY  - JOUR
AU  - Odovic, Jadranka
AU  - Aleksic, Mirjana
AU  - Stojimirovic, Biljana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav Lj.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1004
AB  - The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the R(M) values and the composition 0 of employed mobile phase was obtained. The hydrophobicity parameters R(M)(0) and C(0) were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
AB  - Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites
T1  - Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita
VL  - 74
IS  - 6
SP  - 677
EP  - 688
DO  - 10.2298/JSC0906677O
ER  - 

@article{
author = "Odovic, Jadranka and Aleksic, Mirjana and Stojimirovic, Biljana and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.",
year = "2009",
abstract = "The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the R(M) values and the composition 0 of employed mobile phase was obtained. The hydrophobicity parameters R(M)(0) and C(0) were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography., Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites, Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita",
volume = "74",
number = "6",
pages = "677-688",
doi = "10.2298/JSC0906677O"
}

Odovic, J., Aleksic, M., Stojimirovic, B., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2009). Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(6), 677-688.
https://doi.org/10.2298/JSC0906677O

Odovic J, Aleksic M, Stojimirovic B, Milojković-Opsenica D, Tešić ŽL. Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society. 2009;74(6):677-688.
doi:10.2298/JSC0906677O .

Odovic, Jadranka, Aleksic, Mirjana, Stojimirovic, Biljana, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites" in Journal of the Serbian Chemical Society, 74, no. 6 (2009):677-688,
https://doi.org/10.2298/JSC0906677O . .

TY  - JOUR
AU  - Odovic, Jadranka
AU  - Stojimirovic, Biljana
AU  - Aleksic, Mirjana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav Lj.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/801
AB  - The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water ethanol and water-acetone as binary solvent systems. The relationship between the R-M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organic modifier in the employed solvent systems led to a decrease of the R-M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R-M(0) and c(0) were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values.
AB  - Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites
T1  - Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita
VL  - 71
IS  - 6
SP  - 621
EP  - 628
DO  - 10.2298/JSC0606621O
ER  - 

@article{
author = "Odovic, Jadranka and Stojimirovic, Biljana and Aleksic, Mirjana and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.",
year = "2006",
abstract = "The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water ethanol and water-acetone as binary solvent systems. The relationship between the R-M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organic modifier in the employed solvent systems led to a decrease of the R-M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R-M(0) and c(0) were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values., Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites, Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita",
volume = "71",
number = "6",
pages = "621-628",
doi = "10.2298/JSC0606621O"
}

Odovic, J., Stojimirovic, B., Aleksic, M., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2006). Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 71(6), 621-628.
https://doi.org/10.2298/JSC0606621O

Odovic J, Stojimirovic B, Aleksic M, Milojković-Opsenica D, Tešić ŽL. Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society. 2006;71(6):621-628.
doi:10.2298/JSC0606621O .

Odovic, Jadranka, Stojimirovic, Biljana, Aleksic, Mirjana, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites" in Journal of the Serbian Chemical Society, 71, no. 6 (2006):621-628,
https://doi.org/10.2298/JSC0606621O . .