Avramović, Nataša

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  • Avramović, Nataša (3)
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Author's Bibliography

Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)

Ivanović, Stefan; Avramović, Nataša; Dojčinović, Biljana P.; Trifunović, Snežana S.; Novaković, Miroslav M.; Tešević, Vele; Mandić, Boris

(Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI), 2020)

TY  - JOUR
AU  - Ivanović, Stefan
AU  - Avramović, Nataša
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Snežana S.
AU  - Novaković, Miroslav M.
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3992
AB  - The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.
PB  - Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Foods
T1  - Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)
VL  - 9
IS  - 4
SP  - 430
DO  - 10.3390/foods9040430
ER  - 
@article{
author = "Ivanović, Stefan and Avramović, Nataša and Dojčinović, Biljana P. and Trifunović, Snežana S. and Novaković, Miroslav M. and Tešević, Vele and Mandić, Boris",
year = "2020",
abstract = "The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.",
publisher = "Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Foods",
title = "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)",
volume = "9",
number = "4",
pages = "430",
doi = "10.3390/foods9040430"
}
Ivanović, S., Avramović, N., Dojčinović, B. P., Trifunović, S. S., Novaković, M. M., Tešević, V.,& Mandić, B.. (2020). Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods
Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)., 9(4), 430.
https://doi.org/10.3390/foods9040430
Ivanović S, Avramović N, Dojčinović BP, Trifunović SS, Novaković MM, Tešević V, Mandić B. Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods. 2020;9(4):430.
doi:10.3390/foods9040430 .
Ivanović, Stefan, Avramović, Nataša, Dojčinović, Biljana P., Trifunović, Snežana S., Novaković, Miroslav M., Tešević, Vele, Mandić, Boris, "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)" in Foods, 9, no. 4 (2020):430,
https://doi.org/10.3390/foods9040430 . .
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Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

Avramović, Nataša; Mandić, Boris; Savić-Radojević, Ana; Simić, Tatjana

(2020)

TY  - JOUR
AU  - Avramović, Nataša
AU  - Mandić, Boris
AU  - Savić-Radojević, Ana
AU  - Simić, Tatjana
PY  - 2020
UR  - https://www.mdpi.com/1999-4923/12/4/298
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4021
AB  - Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
T2  - Pharmaceutics
T2  - Pharmaceutics
T1  - Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
VL  - 12
IS  - 4
SP  - 298
DO  - 10.3390/pharmaceutics12040298
ER  - 
@article{
author = "Avramović, Nataša and Mandić, Boris and Savić-Radojević, Ana and Simić, Tatjana",
year = "2020",
abstract = "Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.",
journal = "Pharmaceutics, Pharmaceutics",
title = "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy",
volume = "12",
number = "4",
pages = "298",
doi = "10.3390/pharmaceutics12040298"
}
Avramović, N., Mandić, B., Savić-Radojević, A.,& Simić, T.. (2020). Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics, 12(4), 298.
https://doi.org/10.3390/pharmaceutics12040298
Avramović N, Mandić B, Savić-Radojević A, Simić T. Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics. 2020;12(4):298.
doi:10.3390/pharmaceutics12040298 .
Avramović, Nataša, Mandić, Boris, Savić-Radojević, Ana, Simić, Tatjana, "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy" in Pharmaceutics, 12, no. 4 (2020):298,
https://doi.org/10.3390/pharmaceutics12040298 . .
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Platinum and ruthenium complexes as promising molecules in cancer therapy

Avramović, Nataša; Ignjatović, Nikola; Savić, Aleksandar

(Srpsko lekarsko društvo, 2019)

TY  - JOUR
AU  - Avramović, Nataša
AU  - Ignjatović, Nikola
AU  - Savić, Aleksandar
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3304
AB  - Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer cases are expected in the next two decades worldwide. The development of new chemotherapeutic agents with improved properties is presently the main challenge in the medicinal chemistry. Cisplatin was introduced to oncology in 1978 as first chemotherapeutic agent regarding its specific interaction with DNA, leading to its damage and causing the cell death. Since the first application of cisplatin in cancer therapy, there has been a growing interest in new metal-based compounds, in particular platinum and ruthenium complexes, with better anticancer activity and less side-effects compared to cisplatin. Carboplatin and oxaliplatin have shown promising action against some types of cancer, which are resistant to cisplatin. With the aim to overcome cross-resistance to these Pt(II) drugs, bioavailable platinum complexes (satraplatin and picoplatin) firstly found application as orally administered drugs, as well as some combined therapies of Pt(II) drugs (cisplatin, picoplatin) with specific resistant modulators. In recent years, novel polymer and liposomal formulations of platinum drugs (prolindac, lipoplatin, lipoxal, aroplatin) have been designed with strategy to improve drug delivery to target cancer cells and reduce toxicity. Complexes based on ruthenium have great potential to become leading candidates for the medical use in anticancer therapy. Some of these compounds have shown good anticancer activity, both in vitro and in vivo and two of them (KP1019 and NAMI-A) have passed clinical trials and given promising results.
PB  - Srpsko lekarsko društvo
T2  - Srpski Arhiv za Celokupno Lekarstvo
T1  - Platinum and ruthenium complexes as promising molecules in cancer therapy
VL  - 147
IS  - 1-2
SP  - 105
EP  - 109
DO  - 10.2298/SARH180706075A
ER  - 
@article{
author = "Avramović, Nataša and Ignjatović, Nikola and Savić, Aleksandar",
year = "2019",
abstract = "Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer cases are expected in the next two decades worldwide. The development of new chemotherapeutic agents with improved properties is presently the main challenge in the medicinal chemistry. Cisplatin was introduced to oncology in 1978 as first chemotherapeutic agent regarding its specific interaction with DNA, leading to its damage and causing the cell death. Since the first application of cisplatin in cancer therapy, there has been a growing interest in new metal-based compounds, in particular platinum and ruthenium complexes, with better anticancer activity and less side-effects compared to cisplatin. Carboplatin and oxaliplatin have shown promising action against some types of cancer, which are resistant to cisplatin. With the aim to overcome cross-resistance to these Pt(II) drugs, bioavailable platinum complexes (satraplatin and picoplatin) firstly found application as orally administered drugs, as well as some combined therapies of Pt(II) drugs (cisplatin, picoplatin) with specific resistant modulators. In recent years, novel polymer and liposomal formulations of platinum drugs (prolindac, lipoplatin, lipoxal, aroplatin) have been designed with strategy to improve drug delivery to target cancer cells and reduce toxicity. Complexes based on ruthenium have great potential to become leading candidates for the medical use in anticancer therapy. Some of these compounds have shown good anticancer activity, both in vitro and in vivo and two of them (KP1019 and NAMI-A) have passed clinical trials and given promising results.",
publisher = "Srpsko lekarsko društvo",
journal = "Srpski Arhiv za Celokupno Lekarstvo",
title = "Platinum and ruthenium complexes as promising molecules in cancer therapy",
volume = "147",
number = "1-2",
pages = "105-109",
doi = "10.2298/SARH180706075A"
}
Avramović, N., Ignjatović, N.,& Savić, A.. (2019). Platinum and ruthenium complexes as promising molecules in cancer therapy. in Srpski Arhiv za Celokupno Lekarstvo
Srpsko lekarsko društvo., 147(1-2), 105-109.
https://doi.org/10.2298/SARH180706075A
Avramović N, Ignjatović N, Savić A. Platinum and ruthenium complexes as promising molecules in cancer therapy. in Srpski Arhiv za Celokupno Lekarstvo. 2019;147(1-2):105-109.
doi:10.2298/SARH180706075A .
Avramović, Nataša, Ignjatović, Nikola, Savić, Aleksandar, "Platinum and ruthenium complexes as promising molecules in cancer therapy" in Srpski Arhiv za Celokupno Lekarstvo, 147, no. 1-2 (2019):105-109,
https://doi.org/10.2298/SARH180706075A . .
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