Novaković, Miroslav M.

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Authority KeyName Variants
orcid::0000-0002-4984-041X
  • Novaković, Miroslav M. (60)
Projects
Natural products of wild, cultivated and edible plants: structure and bioactivity determination Microbial diversity study and characterization of beneficial environmental microorganisms
Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research
The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors Characterization and application of fungal metabolites and assessment of new biofungicides potential
Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders
Modulation of antioxidative metabolism in plants for improvement of plant abiotic stress tolerance and identification of new biomarkers for application in remediation and monitoring of degraded biotopes Content of bioactive components in small and stone fruits as affected by cultivar specificities and growing conditions, and obtaining biologically valuable products by improved and newly developed technologies
Bioactive natural products as potential sources of new pharmaceuticals and food supplements Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) Biomarkers in neurodegenerative and malignant processes
Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost Morphological, chemical, pharmacological and agronomic characterization of the Pannonian Thyme (Thymus pannonicus All., Lamiaceae), with the purpose of sustainable production in intensive cropping system
“Agricultural Adaptation to Climate Change – Networking, Education, Research and Extension” (Norwegian Programme in Higher Education, Research and Development in Western Balkans) Centre of Excellence in Bioinformatics “BIO-ICT” (Higher Education and Research for Innovation and Competitiveness project, Contract No. 01- 1001)
Department of Agricultural and Food Sciences, University of Bologna, Italy Evaluation of ecophysiological and genetic plant diversity in forest ecosystems
Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija
Regulacija antioksidativnog metabolizma biljaka u toku rastenja, infekcije patogenima i delovanja abiotičkog stresa: mehanizmi transporta, signalizacije i otpornosti Biljni proizvodi u preventivi i terapiji nezaraznih hroničnih oboljenja kod ljudi
“INGAF” (Ministry of Science of Montenegro) Matsumae International Foundation

Author's Bibliography

Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)

Ivanović, Stefan; Avramović, Nataša; Dojčinović, Biljana P.; Trifunović, Snežana S.; Novaković, Miroslav M.; Tešević, Vele; Mandić, Boris

(Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI), 2020)

TY  - JOUR
AU  - Ivanović, Stefan
AU  - Avramović, Nataša
AU  - Dojčinović, Biljana P.
AU  - Trifunović, Snežana S.
AU  - Novaković, Miroslav M.
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3992
AB  - The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.
PB  - Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Foods
T1  - Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)
VL  - 9
IS  - 4
SP  - 430
DO  - 10.3390/foods9040430
ER  - 
@article{
author = "Ivanović, Stefan and Avramović, Nataša and Dojčinović, Biljana P. and Trifunović, Snežana S. and Novaković, Miroslav M. and Tešević, Vele and Mandić, Boris",
year = "2020",
abstract = "The present study evaluates natural composition of Serbian roasted hazelnut skins (HS) with potential role in application as functional nutrient of various food products. Total phenols (TPC) and flavonoids contents (TFC) in HS extracts obtained with dierent ethanol concentrations (10%—I, 50%—II and 96%—III) and their antioxidant activities were investigated. The highest total phenols content (706.0  9.7 mgGAE/gextract) was observed in 96% ethanol HS extract. Ethanol HS extracts showed very high antioxidant activity with eective concentrations (EC50) ranged between 0.052 and 0.066 mg/mL. The phenol and flavonoid content of roasted HS extracts I–III was determined by HPLC-ESI-MS/MS analyses. Contents of lipids, proteins, carbohydrates, metals, and C, H, N, S elements in roasted HS were also determined. Relatively high C/N, C/P and C/N/P ratios, rich metal contents and fatty acids composition indicated that hazelnut skin might be a good candidate for use as either human or fungal functional nutrient. In addition, possible application of phenolic HS extracts as UV booster was studied by recording UV spectra (220–440 nm) of 10 mg/L of HS extracts I–III combined with 10 mg/L of chemical sunscreen agent benzophenone-3 and in vitro sun protection factor (SPF) was calculated.",
publisher = "Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Foods",
title = "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)",
volume = "9",
number = "4",
pages = "430",
doi = "10.3390/foods9040430"
}
Ivanović, S., Avramović, N., Dojčinović, B. P., Trifunović, S. S., Novaković, M. M., Tešević, V.,& Mandić, B.. (2020). Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods
Multidisciplinary Digital Publishing Institute(Multidisciplinary Digital Publishing Institute (MDPI)., 9(4), 430.
https://doi.org/10.3390/foods9040430
Ivanović S, Avramović N, Dojčinović BP, Trifunović SS, Novaković MM, Tešević V, Mandić B. Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.). in Foods. 2020;9(4):430.
doi:10.3390/foods9040430 .
Ivanović, Stefan, Avramović, Nataša, Dojčinović, Biljana P., Trifunović, Snežana S., Novaković, Miroslav M., Tešević, Vele, Mandić, Boris, "Chemical Composition, Total Phenols and Flavonoids Contents and Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins (Corylus avellana L.)" in Foods, 9, no. 4 (2020):430,
https://doi.org/10.3390/foods9040430 . .
7
6
6

Bisaurones – enzymatic production and biological evaluation

Novaković, Miroslav M.; Ilić-Tomić, Tatjana; Tešević, Vele; Simić, Katarina; Ivanović, Stefan; Simić, Stefan; Opsenica, Igor; Nikodinović-Runić, Jasmina

(Royal Society of Chemistry, 2020)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Ilić-Tomić, Tatjana
AU  - Tešević, Vele
AU  - Simić, Katarina
AU  - Ivanović, Stefan
AU  - Simić, Stefan
AU  - Opsenica, Igor
AU  - Nikodinović-Runić, Jasmina
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4052
AB  - The Trametes versicolor laccase catalyzed oxidation of chalcone butein afforded four dimers of aurone sulfuretin (i.e. two regioisomeric pairs of diasteromers, 1-4) as the major products. The formation of the dimers was explained by a two step process involving the initial cyclization of butein into aurone sulfuretin, followed by the combination of two molecules of sulfuretin. The coupling process occurred between the 2,10-double bond of one molecule of sulfuretin and the (3′,4′) catechol group of the other to yield a dimeric structure. This was confirmed by the experiment involving the laccase catalyzed oxidation of sulfuretin yielding the same dimeric bisaurones. Compounds 1, 3 and 4, were isolated using semipreparative HPLC and characterized by the detailed analysis of the NMR, MS, IR, and UV-vis data. The structure of compound 2, isolated as a mixture containing ca. 25% of compound 1, was proposed by the comparison of 1H NMR data to compound 1 and by using LC-ESIMS analysis. The starting chalcone butein and the products of the biocatalytic transformation, aurone sulfuretin and sulfuretin dimers 1, 3 and 4, were evaluated for their cytotoxic and antioxidative properties in vitro using a healthy human fibroblast (MRC5) cell line. The biotransformation products showed lower cytotoxicity but higher antioxidative properties. The C. coggygria bark methanol extract rich in butein and sulfuretin was also biotransformed by laccase. The transformed extract exhibited significantly improved antioxidative activities.
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T1  - Bisaurones – enzymatic production and biological evaluation
VL  - 44
IS  - 23
SP  - 9647
EP  - 9655
DO  - 10.1039/d0nj00758g
ER  - 
@article{
author = "Novaković, Miroslav M. and Ilić-Tomić, Tatjana and Tešević, Vele and Simić, Katarina and Ivanović, Stefan and Simić, Stefan and Opsenica, Igor and Nikodinović-Runić, Jasmina",
year = "2020",
abstract = "The Trametes versicolor laccase catalyzed oxidation of chalcone butein afforded four dimers of aurone sulfuretin (i.e. two regioisomeric pairs of diasteromers, 1-4) as the major products. The formation of the dimers was explained by a two step process involving the initial cyclization of butein into aurone sulfuretin, followed by the combination of two molecules of sulfuretin. The coupling process occurred between the 2,10-double bond of one molecule of sulfuretin and the (3′,4′) catechol group of the other to yield a dimeric structure. This was confirmed by the experiment involving the laccase catalyzed oxidation of sulfuretin yielding the same dimeric bisaurones. Compounds 1, 3 and 4, were isolated using semipreparative HPLC and characterized by the detailed analysis of the NMR, MS, IR, and UV-vis data. The structure of compound 2, isolated as a mixture containing ca. 25% of compound 1, was proposed by the comparison of 1H NMR data to compound 1 and by using LC-ESIMS analysis. The starting chalcone butein and the products of the biocatalytic transformation, aurone sulfuretin and sulfuretin dimers 1, 3 and 4, were evaluated for their cytotoxic and antioxidative properties in vitro using a healthy human fibroblast (MRC5) cell line. The biotransformation products showed lower cytotoxicity but higher antioxidative properties. The C. coggygria bark methanol extract rich in butein and sulfuretin was also biotransformed by laccase. The transformed extract exhibited significantly improved antioxidative activities.",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry",
title = "Bisaurones – enzymatic production and biological evaluation",
volume = "44",
number = "23",
pages = "9647-9655",
doi = "10.1039/d0nj00758g"
}
Novaković, M. M., Ilić-Tomić, T., Tešević, V., Simić, K., Ivanović, S., Simić, S., Opsenica, I.,& Nikodinović-Runić, J.. (2020). Bisaurones – enzymatic production and biological evaluation. in New Journal of Chemistry
Royal Society of Chemistry., 44(23), 9647-9655.
https://doi.org/10.1039/d0nj00758g
Novaković MM, Ilić-Tomić T, Tešević V, Simić K, Ivanović S, Simić S, Opsenica I, Nikodinović-Runić J. Bisaurones – enzymatic production and biological evaluation. in New Journal of Chemistry. 2020;44(23):9647-9655.
doi:10.1039/d0nj00758g .
Novaković, Miroslav M., Ilić-Tomić, Tatjana, Tešević, Vele, Simić, Katarina, Ivanović, Stefan, Simić, Stefan, Opsenica, Igor, Nikodinović-Runić, Jasmina, "Bisaurones – enzymatic production and biological evaluation" in New Journal of Chemistry, 44, no. 23 (2020):9647-9655,
https://doi.org/10.1039/d0nj00758g . .

Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G

Novaković, Miroslav M.; Ilić-Tomić, Tatjana; Tešević, Vele; Simić, Katarina; Ivanović, Stefan; Simić, Stefan; Opsenica, Igor; Nikodinović-Runić, Jasmina

(Royal Society of Chemistry, 2020)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Ilić-Tomić, Tatjana
AU  - Tešević, Vele
AU  - Simić, Katarina
AU  - Ivanović, Stefan
AU  - Simić, Stefan
AU  - Opsenica, Igor
AU  - Nikodinović-Runić, Jasmina
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4078
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T1  - Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G
ER  - 
@misc{
author = "Novaković, Miroslav M. and Ilić-Tomić, Tatjana and Tešević, Vele and Simić, Katarina and Ivanović, Stefan and Simić, Stefan and Opsenica, Igor and Nikodinović-Runić, Jasmina",
year = "2020",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry",
title = "Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G"
}
Novaković, M. M., Ilić-Tomić, T., Tešević, V., Simić, K., Ivanović, S., Simić, S., Opsenica, I.,& Nikodinović-Runić, J.. (2020). Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G. in New Journal of Chemistry
Royal Society of Chemistry..
Novaković MM, Ilić-Tomić T, Tešević V, Simić K, Ivanović S, Simić S, Opsenica I, Nikodinović-Runić J. Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G. in New Journal of Chemistry. 2020;..
Novaković, Miroslav M., Ilić-Tomić, Tatjana, Tešević, Vele, Simić, Katarina, Ivanović, Stefan, Simić, Stefan, Opsenica, Igor, Nikodinović-Runić, Jasmina, "Supplementary data for the article: Novakovic, M.; Ilic-Tomic, T.; Tesevic, V.; Simic, K.; Ivanovic, S.; Simic, S.; Opsenica, I.; Nikodinovic-Runic, J. Bisaurones – Enzymatic Production and Biological Evaluation. New J. Chem. 2020, 44 (23), 9647–9655. https://doi.org/10.1039/D0NJ00758G" in New Journal of Chemistry (2020).

Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives

Novaković, Miroslav M.; Simić, Stefan; Koračak, Ljiljana; Zlatović, Mario; Ilić-Tomič, Tatjana; Asakawa, Yoshinori; Nikodinović-Runić, Jasmina; Opsenica, Igor

(Elsevier, 2020)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Simić, Stefan
AU  - Koračak, Ljiljana
AU  - Zlatović, Mario
AU  - Ilić-Tomič, Tatjana
AU  - Asakawa, Yoshinori
AU  - Nikodinović-Runić, Jasmina
AU  - Opsenica, Igor
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3867
AB  - Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. All tested esters were less cytotoxic in comparison to marchantin A, but they also exhibited lower cytotoxicity against healthy cells. Monoesters displayed higher cytotoxic activities than the corresponding peresterified products, presumably due to the presence of free catechol group. Monohexanoyl ester ME3 displayed the same IC50 like marchantin A against MDA-MB-231 cells, but the selectivity was higher. In this way, regioselective enzymatic monoesterification enhanced selectivity of marchantin A. ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A.
PB  - Elsevier
T2  - Fitoterapia
T1  - Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives
VL  - 142
SP  - 104520
DO  - 10.1016/j.fitote.2020.104520
ER  - 
@article{
author = "Novaković, Miroslav M. and Simić, Stefan and Koračak, Ljiljana and Zlatović, Mario and Ilić-Tomič, Tatjana and Asakawa, Yoshinori and Nikodinović-Runić, Jasmina and Opsenica, Igor",
year = "2020",
abstract = "Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. All tested esters were less cytotoxic in comparison to marchantin A, but they also exhibited lower cytotoxicity against healthy cells. Monoesters displayed higher cytotoxic activities than the corresponding peresterified products, presumably due to the presence of free catechol group. Monohexanoyl ester ME3 displayed the same IC50 like marchantin A against MDA-MB-231 cells, but the selectivity was higher. In this way, regioselective enzymatic monoesterification enhanced selectivity of marchantin A. ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A.",
publisher = "Elsevier",
journal = "Fitoterapia",
title = "Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives",
volume = "142",
pages = "104520",
doi = "10.1016/j.fitote.2020.104520"
}
Novaković, M. M., Simić, S., Koračak, L., Zlatović, M., Ilić-Tomič, T., Asakawa, Y., Nikodinović-Runić, J.,& Opsenica, I.. (2020). Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives. in Fitoterapia
Elsevier., 142, 104520.
https://doi.org/10.1016/j.fitote.2020.104520
Novaković MM, Simić S, Koračak L, Zlatović M, Ilić-Tomič T, Asakawa Y, Nikodinović-Runić J, Opsenica I. Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives. in Fitoterapia. 2020;142:104520.
doi:10.1016/j.fitote.2020.104520 .
Novaković, Miroslav M., Simić, Stefan, Koračak, Ljiljana, Zlatović, Mario, Ilić-Tomič, Tatjana, Asakawa, Yoshinori, Nikodinović-Runić, Jasmina, Opsenica, Igor, "Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives" in Fitoterapia, 142 (2020):104520,
https://doi.org/10.1016/j.fitote.2020.104520 . .
1
1
1
1

Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867

Novaković, Miroslav M.; Simić, Stefan; Koračak, Ljiljana; Zlatović, Mario; Ilić-Tomič, Tatjana; Asakawa, Yoshinori; Nikodinović-Runić, Jasmina; Opsenica, Igor

(Elsevier, 2020)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Simić, Stefan
AU  - Koračak, Ljiljana
AU  - Zlatović, Mario
AU  - Ilić-Tomič, Tatjana
AU  - Asakawa, Yoshinori
AU  - Nikodinović-Runić, Jasmina
AU  - Opsenica, Igor
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3889
PB  - Elsevier
T2  - Fitoterapia
T1  - Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867
ER  - 
@misc{
author = "Novaković, Miroslav M. and Simić, Stefan and Koračak, Ljiljana and Zlatović, Mario and Ilić-Tomič, Tatjana and Asakawa, Yoshinori and Nikodinović-Runić, Jasmina and Opsenica, Igor",
year = "2020",
publisher = "Elsevier",
journal = "Fitoterapia",
title = "Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867"
}
Novaković, M. M., Simić, S., Koračak, L., Zlatović, M., Ilić-Tomič, T., Asakawa, Y., Nikodinović-Runić, J.,& Opsenica, I.. (2020). Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867. in Fitoterapia
Elsevier..
Novaković MM, Simić S, Koračak L, Zlatović M, Ilić-Tomič T, Asakawa Y, Nikodinović-Runić J, Opsenica I. Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867. in Fitoterapia. 2020;..
Novaković, Miroslav M., Simić, Stefan, Koračak, Ljiljana, Zlatović, Mario, Ilić-Tomič, Tatjana, Asakawa, Yoshinori, Nikodinović-Runić, Jasmina, Opsenica, Igor, "Supplementary data for the article: Novakovic, M.; Simić, S.; Koračak, L.; Zlatović, M.; Ilic-Tomic, T.; Asakawa, Y.; Nikodinovic-Runic, J.; Opsenica, I. Chemo- and Biocatalytic Esterification of Marchantin A and Cytotoxic Activity of Ester Derivatives. Fitoterapia 2020, 142. https://doi.org/10.1016/j.fitote.2020.104520.oxic activity of ester derivatives http://cherry.chem.bg.ac.rs/handle/123456789/3867" in Fitoterapia (2020).

Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives

Novaković, Miroslav M.; Simić, Stefan; Koračak, Ljiljana; Zlatović, Mario; Ilić-Tomič, Tatjana; Asakawa, Yoshinori; Nikodinović-Runić, Jasmina; Opsenica, Igor

(Elsevier, 2020)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Simić, Stefan
AU  - Koračak, Ljiljana
AU  - Zlatović, Mario
AU  - Ilić-Tomič, Tatjana
AU  - Asakawa, Yoshinori
AU  - Nikodinović-Runić, Jasmina
AU  - Opsenica, Igor
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3890
AB  - Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. All tested esters were less cytotoxic in comparison to marchantin A, but they also exhibited lower cytotoxicity against healthy cells. Monoesters displayed higher cytotoxic activities than the corresponding peresterified products, presumably due to the presence of free catechol group. Monohexanoyl ester ME3 displayed the same IC50 like marchantin A against MDA-MB-231 cells, but the selectivity was higher. In this way, regioselective enzymatic monoesterification enhanced selectivity of marchantin A. ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A.
PB  - Elsevier
T2  - Fitoterapia
T1  - Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives
VL  - 142
SP  - 104520
DO  - 10.1016/j.fitote.2020.104520
ER  - 
@article{
author = "Novaković, Miroslav M. and Simić, Stefan and Koračak, Ljiljana and Zlatović, Mario and Ilić-Tomič, Tatjana and Asakawa, Yoshinori and Nikodinović-Runić, Jasmina and Opsenica, Igor",
year = "2020",
abstract = "Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. All tested esters were less cytotoxic in comparison to marchantin A, but they also exhibited lower cytotoxicity against healthy cells. Monoesters displayed higher cytotoxic activities than the corresponding peresterified products, presumably due to the presence of free catechol group. Monohexanoyl ester ME3 displayed the same IC50 like marchantin A against MDA-MB-231 cells, but the selectivity was higher. In this way, regioselective enzymatic monoesterification enhanced selectivity of marchantin A. ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A.",
publisher = "Elsevier",
journal = "Fitoterapia",
title = "Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives",
volume = "142",
pages = "104520",
doi = "10.1016/j.fitote.2020.104520"
}
Novaković, M. M., Simić, S., Koračak, L., Zlatović, M., Ilić-Tomič, T., Asakawa, Y., Nikodinović-Runić, J.,& Opsenica, I.. (2020). Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives. in Fitoterapia
Elsevier., 142, 104520.
https://doi.org/10.1016/j.fitote.2020.104520
Novaković MM, Simić S, Koračak L, Zlatović M, Ilić-Tomič T, Asakawa Y, Nikodinović-Runić J, Opsenica I. Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives. in Fitoterapia. 2020;142:104520.
doi:10.1016/j.fitote.2020.104520 .
Novaković, Miroslav M., Simić, Stefan, Koračak, Ljiljana, Zlatović, Mario, Ilić-Tomič, Tatjana, Asakawa, Yoshinori, Nikodinović-Runić, Jasmina, Opsenica, Igor, "Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives" in Fitoterapia, 142 (2020):104520,
https://doi.org/10.1016/j.fitote.2020.104520 . .
1
1
1
1

Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa

Stanković, Jovana; Gođevac, Dejan; Tešević, Vele; Dajić-Stevanović, Zora; Ćirić, Ana D.; Soković, Marina; Novaković, Miroslav M.

(American Chemical Society, 2019)

TY  - JOUR
AU  - Stanković, Jovana
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Dajić-Stevanović, Zora
AU  - Ćirić, Ana D.
AU  - Soković, Marina
AU  - Novaković, Miroslav M.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3725
AB  - A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-d-glucuronopyranosyl-(1→2)-β-d-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-d-glucopyranosyl-3-O-(2-O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-d-glucopyranosyl-3-O-(2-O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-d-glucopyranosyl-3-O-(β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-α-l-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-d-apiofuranosyl-(1'→2″)-β-d-glucopyranoside (5) and patuletin 3-O-5'-O-feruloyl-β-d-apiofuranosyl-(1'→2″)-β-d-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.
PB  - American Chemical Society
T2  - Journal of Natural Products
T1  - Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa
VL  - 82
IS  - 6
SP  - 1487
EP  - 1495
DO  - 10.1021/acs.jnatprod.8b00970
ER  - 
@article{
author = "Stanković, Jovana and Gođevac, Dejan and Tešević, Vele and Dajić-Stevanović, Zora and Ćirić, Ana D. and Soković, Marina and Novaković, Miroslav M.",
year = "2019",
abstract = "A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-d-glucuronopyranosyl-(1→2)-β-d-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-d-glucopyranosyl-3-O-(2-O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-d-glucopyranosyl-3-O-(2-O-sulfo-β-d-galactopyranosyl)-(1→2)-α-l-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-d-glucopyranosyl-3-O-(β-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-(1→2)-α-l-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-d-apiofuranosyl-(1'→2″)-β-d-glucopyranoside (5) and patuletin 3-O-5'-O-feruloyl-β-d-apiofuranosyl-(1'→2″)-β-d-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.",
publisher = "American Chemical Society",
journal = "Journal of Natural Products",
title = "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa",
volume = "82",
number = "6",
pages = "1487-1495",
doi = "10.1021/acs.jnatprod.8b00970"
}
Stanković, J., Gođevac, D., Tešević, V., Dajić-Stevanović, Z., Ćirić, A. D., Soković, M.,& Novaković, M. M.. (2019). Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa. in Journal of Natural Products
American Chemical Society., 82(6), 1487-1495.
https://doi.org/10.1021/acs.jnatprod.8b00970
Stanković J, Gođevac D, Tešević V, Dajić-Stevanović Z, Ćirić AD, Soković M, Novaković MM. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa. in Journal of Natural Products. 2019;82(6):1487-1495.
doi:10.1021/acs.jnatprod.8b00970 .
Stanković, Jovana, Gođevac, Dejan, Tešević, Vele, Dajić-Stevanović, Zora, Ćirić, Ana D., Soković, Marina, Novaković, Miroslav M., "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa" in Journal of Natural Products, 82, no. 6 (2019):1487-1495,
https://doi.org/10.1021/acs.jnatprod.8b00970 . .
4
5
5
4

Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970

Stanković, Jovana; Gođevac, Dejan; Tešević, Vele; Dajić-Stevanović, Zora; Ćirić, Ana D.; Soković, Marina; Novaković, Miroslav M.

(American Chemical Society, 2019)

TY  - DATA
AU  - Stanković, Jovana
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Dajić-Stevanović, Zora
AU  - Ćirić, Ana D.
AU  - Soković, Marina
AU  - Novaković, Miroslav M.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3726
PB  - American Chemical Society
T2  - Journal of Natural Products
T1  - Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970
ER  - 
@misc{
author = "Stanković, Jovana and Gođevac, Dejan and Tešević, Vele and Dajić-Stevanović, Zora and Ćirić, Ana D. and Soković, Marina and Novaković, Miroslav M.",
year = "2019",
publisher = "American Chemical Society",
journal = "Journal of Natural Products",
title = "Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970"
}
Stanković, J., Gođevac, D., Tešević, V., Dajić-Stevanović, Z., Ćirić, A. D., Soković, M.,& Novaković, M. M.. (2019). Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970. in Journal of Natural Products
American Chemical Society..
Stanković J, Gođevac D, Tešević V, Dajić-Stevanović Z, Ćirić AD, Soković M, Novaković MM. Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970. in Journal of Natural Products. 2019;..
Stanković, Jovana, Gođevac, Dejan, Tešević, Vele, Dajić-Stevanović, Zora, Ćirić, Ana D., Soković, Marina, Novaković, Miroslav M., "Supplementary data for the article: Stanković, J.; Godevac, D.; Tešević, V.; Dajić-Stevanović, Z.; Ćirić, A.; Soković, M.; Novaković, M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex Tatarica against Pseudomonas Aeruginosa. Journal of Natural Products 2019, 82 (6), 1487–1495. https://doi.org/10.1021/acs.jnatprod.8b00970" in Journal of Natural Products (2019).

Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.)

Ninić-Todorović, Jelena; Novaković, Miroslav M.; Čukanović, Jelena; Sofrenić, Ivana V.; Todorović, Ivan; Todorović, Dragan; Tešević, Vele

(2019)

TY  - JOUR
AU  - Ninić-Todorović, Jelena
AU  - Novaković, Miroslav M.
AU  - Čukanović, Jelena
AU  - Sofrenić, Ivana V.
AU  - Todorović, Ivan
AU  - Todorović, Dragan
AU  - Tešević, Vele
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3929
AB  - Five genotypes of Turkish hazelnuts (Corylus colurna L.) were analyzed for chemical composition, including total oil content, fatty acid and sterol composition. The oil yields from these kernels varied from 36.5% to 60.8% and the main fatty acids were oleic acid (79.34-83.0%) and linoleic acid (7.52-10.81%). The polyunsaturated/saturated fatty acid ratio was low, ranging from 0.87 to 1.25. To-tal phytosterol content ranged from 4.52 to 6.50 mg g -1 of oil. Among the eleven sterols identified and quantified, b-sitosterol was the major one with a mean percentage of 65.09% while fucosterol and campesterol were the second and the third components of the group with mean values of 10.91% and 4.36%, respectively. The radical scavenging activity was evaluated using 2.2-diphenyl-1 picrylhy-drazyl (DPPH) assay.
T2  - Lekovite sirovine
T1  - Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.)
IS  - 39
SP  - 18
EP  - 22
DO  - 10.5937/leksir1939018N
ER  - 
@article{
author = "Ninić-Todorović, Jelena and Novaković, Miroslav M. and Čukanović, Jelena and Sofrenić, Ivana V. and Todorović, Ivan and Todorović, Dragan and Tešević, Vele",
year = "2019",
abstract = "Five genotypes of Turkish hazelnuts (Corylus colurna L.) were analyzed for chemical composition, including total oil content, fatty acid and sterol composition. The oil yields from these kernels varied from 36.5% to 60.8% and the main fatty acids were oleic acid (79.34-83.0%) and linoleic acid (7.52-10.81%). The polyunsaturated/saturated fatty acid ratio was low, ranging from 0.87 to 1.25. To-tal phytosterol content ranged from 4.52 to 6.50 mg g -1 of oil. Among the eleven sterols identified and quantified, b-sitosterol was the major one with a mean percentage of 65.09% while fucosterol and campesterol were the second and the third components of the group with mean values of 10.91% and 4.36%, respectively. The radical scavenging activity was evaluated using 2.2-diphenyl-1 picrylhy-drazyl (DPPH) assay.",
journal = "Lekovite sirovine",
title = "Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.)",
number = "39",
pages = "18-22",
doi = "10.5937/leksir1939018N"
}
Ninić-Todorović, J., Novaković, M. M., Čukanović, J., Sofrenić, I. V., Todorović, I., Todorović, D.,& Tešević, V.. (2019). Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.). in Lekovite sirovine(39), 18-22.
https://doi.org/10.5937/leksir1939018N
Ninić-Todorović J, Novaković MM, Čukanović J, Sofrenić IV, Todorović I, Todorović D, Tešević V. Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.). in Lekovite sirovine. 2019;(39):18-22.
doi:10.5937/leksir1939018N .
Ninić-Todorović, Jelena, Novaković, Miroslav M., Čukanović, Jelena, Sofrenić, Ivana V., Todorović, Ivan, Todorović, Dragan, Tešević, Vele, "Lipid composition and DPPH activities of the seed oil of five Turkish hazelnut genotypes (Corylus colurna L.)" in Lekovite sirovine, no. 39 (2019):18-22,
https://doi.org/10.5937/leksir1939018N . .

Tetracyclic triterpenoids from Euphorbia nicaeensis All

Krstić, Gordana B.; Novaković, Miroslav M.; Jadranin, Milka; Tešević, Vele

(2019)

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Novaković, Miroslav M.
AU  - Jadranin, Milka
AU  - Tešević, Vele
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3931
AB  - In this study, three tetracyclic triterpenes: (3S,24S)-tirucall-7-ene-3,24,25-triol (1), (3S,24R)-tirucall-7-ene-3,24,25-triol (2) and inoterpene C (3), were isolated from the milkweed Euphorbia nicaeensis All. using dry-column flash silica gel chromatography and semipreparative normal-phase HPLC. Their structures were determined on the basis of 1D and 2D NMR spectra and literature review. Although these three compounds have previously been isolated from other plant species, this is the first time that they have been isolated from E. nicaeensis.
T2  - Advanced Technologies
T1  - Tetracyclic triterpenoids from Euphorbia nicaeensis All
VL  - 8
IS  - 2
SP  - 37
EP  - 45
DO  - 10.5937/savteh1902037K
ER  - 
@article{
author = "Krstić, Gordana B. and Novaković, Miroslav M. and Jadranin, Milka and Tešević, Vele",
year = "2019",
abstract = "In this study, three tetracyclic triterpenes: (3S,24S)-tirucall-7-ene-3,24,25-triol (1), (3S,24R)-tirucall-7-ene-3,24,25-triol (2) and inoterpene C (3), were isolated from the milkweed Euphorbia nicaeensis All. using dry-column flash silica gel chromatography and semipreparative normal-phase HPLC. Their structures were determined on the basis of 1D and 2D NMR spectra and literature review. Although these three compounds have previously been isolated from other plant species, this is the first time that they have been isolated from E. nicaeensis.",
journal = "Advanced Technologies",
title = "Tetracyclic triterpenoids from Euphorbia nicaeensis All",
volume = "8",
number = "2",
pages = "37-45",
doi = "10.5937/savteh1902037K"
}
Krstić, G. B., Novaković, M. M., Jadranin, M.,& Tešević, V.. (2019). Tetracyclic triterpenoids from Euphorbia nicaeensis All. in Advanced Technologies, 8(2), 37-45.
https://doi.org/10.5937/savteh1902037K
Krstić GB, Novaković MM, Jadranin M, Tešević V. Tetracyclic triterpenoids from Euphorbia nicaeensis All. in Advanced Technologies. 2019;8(2):37-45.
doi:10.5937/savteh1902037K .
Krstić, Gordana B., Novaković, Miroslav M., Jadranin, Milka, Tešević, Vele, "Tetracyclic triterpenoids from Euphorbia nicaeensis All" in Advanced Technologies, 8, no. 2 (2019):37-45,
https://doi.org/10.5937/savteh1902037K . .

Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata

Novaković, Miroslav M.; Bukvicki, Danka; Anđelković, Boban D.; Ilić-Tomić, Tatjana; Veljić, Milan; Tešević, Vele; Asakawa, Yoshinori

(American Chemical Society and American Society of Pharmacognosy, 2019)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Bukvicki, Danka
AU  - Anđelković, Boban D.
AU  - Ilić-Tomić, Tatjana
AU  - Veljić, Milan
AU  - Tešević, Vele
AU  - Asakawa, Yoshinori
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3096
AB  - Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively.
PB  - American Chemical Society and American Society of Pharmacognosy
T2  - Journal of Natural Products
T1  - Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
VL  - 82
IS  - 4
SP  - 694
EP  - 701
DO  - 10.1021/acs.jnatprod.8b00390
ER  - 
@article{
author = "Novaković, Miroslav M. and Bukvicki, Danka and Anđelković, Boban D. and Ilić-Tomić, Tatjana and Veljić, Milan and Tešević, Vele and Asakawa, Yoshinori",
year = "2019",
abstract = "Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively.",
publisher = "American Chemical Society and American Society of Pharmacognosy",
journal = "Journal of Natural Products",
title = "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata",
volume = "82",
number = "4",
pages = "694-701",
doi = "10.1021/acs.jnatprod.8b00390"
}
Novaković, M. M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y.. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products
American Chemical Society and American Society of Pharmacognosy., 82(4), 694-701.
https://doi.org/10.1021/acs.jnatprod.8b00390
Novaković MM, Bukvicki D, Anđelković BD, Ilić-Tomić T, Veljić M, Tešević V, Asakawa Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products. 2019;82(4):694-701.
doi:10.1021/acs.jnatprod.8b00390 .
Novaković, Miroslav M., Bukvicki, Danka, Anđelković, Boban D., Ilić-Tomić, Tatjana, Veljić, Milan, Tešević, Vele, Asakawa, Yoshinori, "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata" in Journal of Natural Products, 82, no. 4 (2019):694-701,
https://doi.org/10.1021/acs.jnatprod.8b00390 . .
1
6
5
6

Supplementary data for article: Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390

Novaković, Miroslav M.; Bukvicki, Danka; Anđelković, Boban D.; Ilić-Tomić, Tatjana; Veljić, Milan; Tešević, Vele; Asakawa, Yoshinori

(American Chemical Society and American Society of Pharmacognosy, 2019)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Bukvicki, Danka
AU  - Anđelković, Boban D.
AU  - Ilić-Tomić, Tatjana
AU  - Veljić, Milan
AU  - Tešević, Vele
AU  - Asakawa, Yoshinori
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3097
PB  - American Chemical Society and American Society of Pharmacognosy
T2  - Journal of Natural Products
T1  - Supplementary data for article:   	Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390
ER  - 
@misc{
author = "Novaković, Miroslav M. and Bukvicki, Danka and Anđelković, Boban D. and Ilić-Tomić, Tatjana and Veljić, Milan and Tešević, Vele and Asakawa, Yoshinori",
year = "2019",
publisher = "American Chemical Society and American Society of Pharmacognosy",
journal = "Journal of Natural Products",
title = "Supplementary data for article:   	Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390"
}
Novaković, M. M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y.. (2019). Supplementary data for article:   	Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390. in Journal of Natural Products
American Chemical Society and American Society of Pharmacognosy..
Novaković MM, Bukvicki D, Anđelković BD, Ilić-Tomić T, Veljić M, Tešević V, Asakawa Y. Supplementary data for article:   	Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390. in Journal of Natural Products. 2019;..
Novaković, Miroslav M., Bukvicki, Danka, Anđelković, Boban D., Ilić-Tomić, Tatjana, Veljić, Milan, Tešević, Vele, Asakawa, Yoshinori, "Supplementary data for article:   	Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390" in Journal of Natural Products (2019).

Effects of soil properties and fertilization on quality and biological activity of Swiss chard

Topalović, Ana; Knežević, Mirko; Trifunović, Snežana S.; Novaković, Miroslav M.; Pešić, Milica; Ðurović, Dijana

(International Society for Horticultural Science, 2018)

TY  - JOUR
AU  - Topalović, Ana
AU  - Knežević, Mirko
AU  - Trifunović, Snežana S.
AU  - Novaković, Miroslav M.
AU  - Pešić, Milica
AU  - Ðurović, Dijana
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2886
AB  - Swiss chard (Beta vulgaris L. var. cicla) is a leafy vegetable highly consumed in many parts of the world as a very popular ingredient of different diets. The purpose of this study was to evaluate effects of soil properties and fertilization on yield, mineral composition, total phenolics, antioxidant and biological activity of Swiss chard. The mineral composition of Swiss chard was generally affected by soil properties. The fertilization at 50% of recommended level (110 kg ha -1 N, 90 kg ha -1 P 2 O 5 and 100 kg ha -1 K 2 O per season) affected negatively yield and on the other hand affected positively antioxidant activity, while fertilization at 150% of recommended level had a contrary effect. The available K in soil affected the yield positively. Total phenolics were in negative correlation with the yield. The positive relationship of total phenolics and content of Mn in chard was noticed. The greatest efficacy in human colorectal carcinoma cell lines was obtained by Swiss chard extract from plants fertilized at 150% of recommended level.
PB  - International Society for Horticultural Science
T2  - European Journal of Horticultural Science
T1  - Effects of soil properties and fertilization on quality and biological activity of Swiss chard
VL  - 83
IS  - 6
SP  - 374
EP  - 381
DO  - 10.17660/eJHS.2018/83.6.5
ER  - 
@article{
author = "Topalović, Ana and Knežević, Mirko and Trifunović, Snežana S. and Novaković, Miroslav M. and Pešić, Milica and Ðurović, Dijana",
year = "2018",
abstract = "Swiss chard (Beta vulgaris L. var. cicla) is a leafy vegetable highly consumed in many parts of the world as a very popular ingredient of different diets. The purpose of this study was to evaluate effects of soil properties and fertilization on yield, mineral composition, total phenolics, antioxidant and biological activity of Swiss chard. The mineral composition of Swiss chard was generally affected by soil properties. The fertilization at 50% of recommended level (110 kg ha -1 N, 90 kg ha -1 P 2 O 5 and 100 kg ha -1 K 2 O per season) affected negatively yield and on the other hand affected positively antioxidant activity, while fertilization at 150% of recommended level had a contrary effect. The available K in soil affected the yield positively. Total phenolics were in negative correlation with the yield. The positive relationship of total phenolics and content of Mn in chard was noticed. The greatest efficacy in human colorectal carcinoma cell lines was obtained by Swiss chard extract from plants fertilized at 150% of recommended level.",
publisher = "International Society for Horticultural Science",
journal = "European Journal of Horticultural Science",
title = "Effects of soil properties and fertilization on quality and biological activity of Swiss chard",
volume = "83",
number = "6",
pages = "374-381",
doi = "10.17660/eJHS.2018/83.6.5"
}
Topalović, A., Knežević, M., Trifunović, S. S., Novaković, M. M., Pešić, M.,& Ðurović, D.. (2018). Effects of soil properties and fertilization on quality and biological activity of Swiss chard. in European Journal of Horticultural Science
International Society for Horticultural Science., 83(6), 374-381.
https://doi.org/10.17660/eJHS.2018/83.6.5
Topalović A, Knežević M, Trifunović SS, Novaković MM, Pešić M, Ðurović D. Effects of soil properties and fertilization on quality and biological activity of Swiss chard. in European Journal of Horticultural Science. 2018;83(6):374-381.
doi:10.17660/eJHS.2018/83.6.5 .
Topalović, Ana, Knežević, Mirko, Trifunović, Snežana S., Novaković, Miroslav M., Pešić, Milica, Ðurović, Dijana, "Effects of soil properties and fertilization on quality and biological activity of Swiss chard" in European Journal of Horticultural Science, 83, no. 6 (2018):374-381,
https://doi.org/10.17660/eJHS.2018/83.6.5 . .
2
1
1
2

An insight into chemical composition and biological activity of Montenegrin Vranac red wine

Đorđević, Neda O.; Novaković, Miroslav M.; Pejin, Boris; Živković, Mirjana B.; Savić, Aleksandar; Mutić, Jelena; Tešević, Vele

(Elsevier Science Bv, Amsterdam, 2018)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Živković, Mirjana B.
AU  - Savić, Aleksandar
AU  - Mutić, Jelena
AU  - Tešević, Vele
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2072
AB  - This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.
PB  - Elsevier Science Bv, Amsterdam
T2  - Scientia Horticulturae
T1  - An insight into chemical composition and biological activity of Montenegrin Vranac red wine
VL  - 230
SP  - 142
EP  - 148
DO  - 10.1016/j.scienta.2017.11.033
UR  - Kon_3403
ER  - 
@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Živković, Mirjana B. and Savić, Aleksandar and Mutić, Jelena and Tešević, Vele",
year = "2018",
abstract = "This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Scientia Horticulturae",
title = "An insight into chemical composition and biological activity of Montenegrin Vranac red wine",
volume = "230",
pages = "142-148",
doi = "10.1016/j.scienta.2017.11.033",
url = "Kon_3403"
}
Đorđević, N. O., Novaković, M. M., Pejin, B., Živković, M. B., Savić, A., Mutić, J.,& Tešević, V.. (2018). An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae
Elsevier Science Bv, Amsterdam., 230, 142-148.
https://doi.org/10.1016/j.scienta.2017.11.033
Kon_3403
Đorđević NO, Novaković MM, Pejin B, Živković MB, Savić A, Mutić J, Tešević V. An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae. 2018;230:142-148.
doi:10.1016/j.scienta.2017.11.033
Kon_3403 .
Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Živković, Mirjana B., Savić, Aleksandar, Mutić, Jelena, Tešević, Vele, "An insight into chemical composition and biological activity of Montenegrin Vranac red wine" in Scientia Horticulturae, 230 (2018):142-148,
https://doi.org/10.1016/j.scienta.2017.11.033 .,
Kon_3403 .
5
5
5

Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger

Novaković, Miroslav M.; Bukvicki, Danka; Vajs, Vlatka; Tešević, Vele; Milosavljević, Slobodan M.; Marin, Petar D.; Asakawa, Yoshinori

(Natural Products Inc, Westerville, 2018)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Bukvicki, Danka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2150
AB  - A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger
VL  - 13
IS  - 4
SP  - 479
EP  - 482
UR  - Kon_3481
ER  - 
@article{
author = "Novaković, Miroslav M. and Bukvicki, Danka and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan M. and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger",
volume = "13",
number = "4",
pages = "479-482",
url = "Kon_3481"
}
Novaković, M. M., Bukvicki, D., Vajs, V., Tešević, V., Milosavljević, S. M., Marin, P. D.,& Asakawa, Y.. (2018). Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications
Natural Products Inc, Westerville., 13(4), 479-482.
Kon_3481
Novaković MM, Bukvicki D, Vajs V, Tešević V, Milosavljević SM, Marin PD, Asakawa Y. Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications. 2018;13(4):479-482.
Kon_3481 .
Novaković, Miroslav M., Bukvicki, Danka, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan M., Marin, Petar D., Asakawa, Yoshinori, "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger" in Natural Product Communications, 13, no. 4 (2018):479-482,
Kon_3481 .
1
1

Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil

Marin, Marija; Novaković, Miroslav M.; Vučković, Ivan M.; Tešević, Vele; Kolarević, Stoimir; Vuković-Gačić, Branka

(Taylor & Francis Ltd, Abingdon, 2018)

TY  - JOUR
AU  - Marin, Marija
AU  - Novaković, Miroslav M.
AU  - Vučković, Ivan M.
AU  - Tešević, Vele
AU  - Kolarević, Stoimir
AU  - Vuković-Gačić, Branka
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2143
AB  - The composition of the essential oil (EO) obtained by hydrodistillation from the leaves of Thymus capitatus Hoff. et Link. growing wild in Sythonia (Greece) was analysed by GC-FID, GC-MS and quantitative H-1 NMR spectroscopy. Thirty nine compounds were identified, representing approximately 99.0 % of the oil. Major component determined by GC-FID was carvacrol (81.8 %), followed by linalool (3.5 %) and (E)-caryophyllenc (3.5 %). Abundance of carvacrol determined by quantitative H-1 NMR spectroscopy was 74.9 % and was in reasonable agreement with GC-FID result. The oil was tested for the antioxidant activity in DPPH assay and showed a dose dependent free radical scavenging activity with EC50 value of 1.03 mu g/ml. Antimicrobial effect of the EO was tested against Gram negative, Gram positive bacteria, and fungi. The tested EO showed significant activity against fungi, especially S. cerevisiae. The most sensitive bacteria were E. coil ATCC 25922, E. fecalis and S. epidermidis. Human pathogen Burkholderia cepacia, ATCC 25416 was used in the investigation of T capitatus for the fast time.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Essential Oil Bearing Plants
T1  - Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil
VL  - 21
IS  - 2
SP  - 388
EP  - 399
DO  - 10.1080/0972060X.2018.1449668
UR  - Kon_3474
ER  - 
@article{
author = "Marin, Marija and Novaković, Miroslav M. and Vučković, Ivan M. and Tešević, Vele and Kolarević, Stoimir and Vuković-Gačić, Branka",
year = "2018",
abstract = "The composition of the essential oil (EO) obtained by hydrodistillation from the leaves of Thymus capitatus Hoff. et Link. growing wild in Sythonia (Greece) was analysed by GC-FID, GC-MS and quantitative H-1 NMR spectroscopy. Thirty nine compounds were identified, representing approximately 99.0 % of the oil. Major component determined by GC-FID was carvacrol (81.8 %), followed by linalool (3.5 %) and (E)-caryophyllenc (3.5 %). Abundance of carvacrol determined by quantitative H-1 NMR spectroscopy was 74.9 % and was in reasonable agreement with GC-FID result. The oil was tested for the antioxidant activity in DPPH assay and showed a dose dependent free radical scavenging activity with EC50 value of 1.03 mu g/ml. Antimicrobial effect of the EO was tested against Gram negative, Gram positive bacteria, and fungi. The tested EO showed significant activity against fungi, especially S. cerevisiae. The most sensitive bacteria were E. coil ATCC 25922, E. fecalis and S. epidermidis. Human pathogen Burkholderia cepacia, ATCC 25416 was used in the investigation of T capitatus for the fast time.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Essential Oil Bearing Plants",
title = "Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil",
volume = "21",
number = "2",
pages = "388-399",
doi = "10.1080/0972060X.2018.1449668",
url = "Kon_3474"
}
Marin, M., Novaković, M. M., Vučković, I. M., Tešević, V., Kolarević, S.,& Vuković-Gačić, B.. (2018). Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil. in Journal of Essential Oil Bearing Plants
Taylor & Francis Ltd, Abingdon., 21(2), 388-399.
https://doi.org/10.1080/0972060X.2018.1449668
Kon_3474
Marin M, Novaković MM, Vučković IM, Tešević V, Kolarević S, Vuković-Gačić B. Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil. in Journal of Essential Oil Bearing Plants. 2018;21(2):388-399.
doi:10.1080/0972060X.2018.1449668
Kon_3474 .
Marin, Marija, Novaković, Miroslav M., Vučković, Ivan M., Tešević, Vele, Kolarević, Stoimir, Vuković-Gačić, Branka, "Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil" in Journal of Essential Oil Bearing Plants, 21, no. 2 (2018):388-399,
https://doi.org/10.1080/0972060X.2018.1449668 .,
Kon_3474 .
10
9
10

Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana

Vidaković, Vera; Novaković, Miroslav M.; Popović, Zorica; Janković, Milan; Matić, Rada; Tešević, Vele; Bojović, Srđan R.

(Walter De Gruyter Gmbh, Berlin, 2018)

TY  - JOUR
AU  - Vidaković, Vera
AU  - Novaković, Miroslav M.
AU  - Popović, Zorica
AU  - Janković, Milan
AU  - Matić, Rada
AU  - Tešević, Vele
AU  - Bojović, Srđan R.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2574
AB  - Diarylheptanoids are a group of secondary metabolites widely distributed in the Betulaceae family and characteristic for Alnus species. In this study, the chemotaxonomic power of diarylheptanoids, such as hirsutanonol-5-O-beta-d-glucopyranoside, rubranoside A, oregonin, platyphylloside, alnuside A and hirsutanonol, has been investigated in combination with principal component analysis (PCA) for differentiation of Alnus species. Concentrations of six diarylheptanoids in the bark extracts of two natural populations of Alnus glutinosa (black alder) and Alnus incana (gray alder) were determined by -ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). PCA clearly shows the separation of three groups. Populations I (A. glutinosa) and II (A. incana) both consisted of individuals of the corresponding species. Four individuals from both sampled populations formed a separate group (population III), which possibly represents a hybrid group. Accordingly, diarylheptanoids may serve in combination with PCA as chemotaxonomic markers at the species level, which may also reveal hybrid species.
PB  - Walter De Gruyter Gmbh, Berlin
T2  - Holzforschung
T1  - Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana
VL  - 72
IS  - 1
SP  - 9
EP  - 16
DO  - 10.1515/hf-2017-0074
UR  - Kon_3390
ER  - 
@article{
author = "Vidaković, Vera and Novaković, Miroslav M. and Popović, Zorica and Janković, Milan and Matić, Rada and Tešević, Vele and Bojović, Srđan R.",
year = "2018",
abstract = "Diarylheptanoids are a group of secondary metabolites widely distributed in the Betulaceae family and characteristic for Alnus species. In this study, the chemotaxonomic power of diarylheptanoids, such as hirsutanonol-5-O-beta-d-glucopyranoside, rubranoside A, oregonin, platyphylloside, alnuside A and hirsutanonol, has been investigated in combination with principal component analysis (PCA) for differentiation of Alnus species. Concentrations of six diarylheptanoids in the bark extracts of two natural populations of Alnus glutinosa (black alder) and Alnus incana (gray alder) were determined by -ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). PCA clearly shows the separation of three groups. Populations I (A. glutinosa) and II (A. incana) both consisted of individuals of the corresponding species. Four individuals from both sampled populations formed a separate group (population III), which possibly represents a hybrid group. Accordingly, diarylheptanoids may serve in combination with PCA as chemotaxonomic markers at the species level, which may also reveal hybrid species.",
publisher = "Walter De Gruyter Gmbh, Berlin",
journal = "Holzforschung",
title = "Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana",
volume = "72",
number = "1",
pages = "9-16",
doi = "10.1515/hf-2017-0074",
url = "Kon_3390"
}
Vidaković, V., Novaković, M. M., Popović, Z., Janković, M., Matić, R., Tešević, V.,& Bojović, S. R.. (2018). Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana. in Holzforschung
Walter De Gruyter Gmbh, Berlin., 72(1), 9-16.
https://doi.org/10.1515/hf-2017-0074
Kon_3390
Vidaković V, Novaković MM, Popović Z, Janković M, Matić R, Tešević V, Bojović SR. Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana. in Holzforschung. 2018;72(1):9-16.
doi:10.1515/hf-2017-0074
Kon_3390 .
Vidaković, Vera, Novaković, Miroslav M., Popović, Zorica, Janković, Milan, Matić, Rada, Tešević, Vele, Bojović, Srđan R., "Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana" in Holzforschung, 72, no. 1 (2018):9-16,
https://doi.org/10.1515/hf-2017-0074 .,
Kon_3390 .
7
6
7

Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171

Đorđević, Neda O.; Pejin, Boris; Novaković, Miroslav M.; Stanković, Dalibor; Mutić, Jelena; Pajović, Snezana B.; Tešević, Vele

(Taylor & Francis Ltd, Abingdon, 2018)

TY  - DATA
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor
AU  - Mutić, Jelena
AU  - Pajović, Snezana B.
AU  - Tešević, Vele
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3016
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171
UR  - Kon_3379
ER  - 
@misc{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor and Mutić, Jelena and Pajović, Snezana B. and Tešević, Vele",
year = "2018",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171",
url = "Kon_3379"
}
Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D., Mutić, J., Pajović, S. B.,& Tešević, V.. (2018). Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
Kon_3379
Đorđević NO, Pejin B, Novaković MM, Stanković D, Mutić J, Pajović SB, Tešević V. Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171. in Natural Product Research. 2018;.
Kon_3379 .
Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor, Mutić, Jelena, Pajović, Snezana B., Tešević, Vele, "Supplementary material for the article: Đorđević, N. O.; Pejin, B.; Novaković, M. M.; Stanković, D. M.; Mutić, J. J.; Pajović, S. B.; Tešević, V. V. Multielement Analysis and Antioxidant Capacity of Merlot Wine Clones Developed in Montenegro. Nat. Prod. Res. 2018, 32 (3), 247–251. https://doi.org/10.1080/14786419.2017.1347171" in Natural Product Research (2018),
Kon_3379 .

Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro

Đorđević, Neda O.; Pejin, Boris; Novaković, Miroslav M.; Stanković, Dalibor; Mutić, Jelena; Pajović, Snezana B.; Tešević, Vele

(Taylor & Francis Ltd, Abingdon, 2018)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor
AU  - Mutić, Jelena
AU  - Pajović, Snezana B.
AU  - Tešević, Vele
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2563
AB  - The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro
VL  - 32
IS  - 3
SP  - 247
EP  - 251
DO  - 10.1080/14786419.2017.1347171
UR  - Kon_3379
ER  - 
@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor and Mutić, Jelena and Pajović, Snezana B. and Tešević, Vele",
year = "2018",
abstract = "The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro",
volume = "32",
number = "3",
pages = "247-251",
doi = "10.1080/14786419.2017.1347171",
url = "Kon_3379"
}
Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D., Mutić, J., Pajović, S. B.,& Tešević, V.. (2018). Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(3), 247-251.
https://doi.org/10.1080/14786419.2017.1347171
Kon_3379
Đorđević NO, Pejin B, Novaković MM, Stanković D, Mutić J, Pajović SB, Tešević V. Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research. 2018;32(3):247-251.
doi:10.1080/14786419.2017.1347171
Kon_3379 .
Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor, Mutić, Jelena, Pajović, Snezana B., Tešević, Vele, "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro" in Natural Product Research, 32, no. 3 (2018):247-251,
https://doi.org/10.1080/14786419.2017.1347171 .,
Kon_3379 .
6
6
6

Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana

Vidaković, Vera; Stefanović, Milena; Novaković, Miroslav M.; Jadranin, Milka; Popović, Zorica; Matić, Rada; Tešević, Vele; Bojović, Srđan R.

(2018)

TY  - JOUR
AU  - Vidaković, Vera
AU  - Stefanović, Milena
AU  - Novaković, Miroslav M.
AU  - Jadranin, Milka
AU  - Popović, Zorica
AU  - Matić, Rada
AU  - Tešević, Vele
AU  - Bojović, Srđan R.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/338
AB  - The reliability of diarylheptanoids as chemotaxonomic markers at inter- and intraspecific levels has been investigated. Six diarylheptanoids were quantified in bark ethanol extracts of four Alnus spp. populations by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The populations described here as locus classicus Alnus glutinosa (I) and locus classicus Alnus incana (III) are clearly differentiated. Compared to population I, individuals in population III have higher extract yields and hirsutanonol-5-O-β-D-glucopyranoside content and lower contents of hirsutanonol, rubranoside A and oregonin. Individuals from neighboring populations of A. glutinosa (II) and A. incana (IV) share similar contents of hirsutanonol. All the studied populations exhibit a high intrapopulation variability of the selected diarylheptanoids; they have a heterogeneous chemotype and they partially overlap. The geographical proximity of populations II and IV increases their chemical similarity. Principal component analysis (PCA) clearly shows that the biggest dispersion of individuals lies within population IV. The reason for its heterogeneity might be its physical proximity to population II, i.e. the appearance of hybrids. Also, geometric morphometrics of leaves was performed as a screening criterion for spontaneous hybrids. © Walter de Gruyter GmbH, Berlin/Boston 2018.
T2  - Holzforschung
T1  - Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana
DO  - 10.1515/hf-2018-0019
UR  - Kon_1309
ER  - 
@article{
author = "Vidaković, Vera and Stefanović, Milena and Novaković, Miroslav M. and Jadranin, Milka and Popović, Zorica and Matić, Rada and Tešević, Vele and Bojović, Srđan R.",
year = "2018",
abstract = "The reliability of diarylheptanoids as chemotaxonomic markers at inter- and intraspecific levels has been investigated. Six diarylheptanoids were quantified in bark ethanol extracts of four Alnus spp. populations by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The populations described here as locus classicus Alnus glutinosa (I) and locus classicus Alnus incana (III) are clearly differentiated. Compared to population I, individuals in population III have higher extract yields and hirsutanonol-5-O-β-D-glucopyranoside content and lower contents of hirsutanonol, rubranoside A and oregonin. Individuals from neighboring populations of A. glutinosa (II) and A. incana (IV) share similar contents of hirsutanonol. All the studied populations exhibit a high intrapopulation variability of the selected diarylheptanoids; they have a heterogeneous chemotype and they partially overlap. The geographical proximity of populations II and IV increases their chemical similarity. Principal component analysis (PCA) clearly shows that the biggest dispersion of individuals lies within population IV. The reason for its heterogeneity might be its physical proximity to population II, i.e. the appearance of hybrids. Also, geometric morphometrics of leaves was performed as a screening criterion for spontaneous hybrids. © Walter de Gruyter GmbH, Berlin/Boston 2018.",
journal = "Holzforschung",
title = "Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana",
doi = "10.1515/hf-2018-0019",
url = "Kon_1309"
}
Vidaković, V., Stefanović, M., Novaković, M. M., Jadranin, M., Popović, Z., Matić, R., Tešević, V.,& Bojović, S. R.. (2018). Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana. in Holzforschung.
https://doi.org/10.1515/hf-2018-0019
Kon_1309
Vidaković V, Stefanović M, Novaković MM, Jadranin M, Popović Z, Matić R, Tešević V, Bojović SR. Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana. in Holzforschung. 2018;.
doi:10.1515/hf-2018-0019
Kon_1309 .
Vidaković, Vera, Stefanović, Milena, Novaković, Miroslav M., Jadranin, Milka, Popović, Zorica, Matić, Rada, Tešević, Vele, Bojović, Srđan R., "Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana" in Holzforschung (2018),
https://doi.org/10.1515/hf-2018-0019 .,
Kon_1309 .
1

Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark

Novaković, Miroslav M.; Nikodinović-Runić, Jasmina; Veselinović, Jovana; Ilić-Tomić, Tatjana; Vidaković, Vera; Tešević, Vele; Milosavljević, Slobodan M.

(Amer Chemical Soc, Washington, 2017)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Nikodinović-Runić, Jasmina
AU  - Veselinović, Jovana
AU  - Ilić-Tomić, Tatjana
AU  - Vidaković, Vera
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2466
AB  - Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
VL  - 80
IS  - 5
SP  - 1255
EP  - 1263
DO  - 10.1021/acs.jnatprod.6b00805
UR  - Kon_3282
ER  - 
@article{
author = "Novaković, Miroslav M. and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2017",
abstract = "Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark",
volume = "80",
number = "5",
pages = "1255-1263",
doi = "10.1021/acs.jnatprod.6b00805",
url = "Kon_3282"
}
Novaković, M. M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S. M.. (2017). Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products
Amer Chemical Soc, Washington., 80(5), 1255-1263.
https://doi.org/10.1021/acs.jnatprod.6b00805
Kon_3282
Novaković MM, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević SM. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products. 2017;80(5):1255-1263.
doi:10.1021/acs.jnatprod.6b00805
Kon_3282 .
Novaković, Miroslav M., Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan M., "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark" in Journal of Natural Products, 80, no. 5 (2017):1255-1263,
https://doi.org/10.1021/acs.jnatprod.6b00805 .,
Kon_3282 .
7
6
6

Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

Ilic-Tomić, Tatjana; Soković, Marina; Vojnović, Sandra; Ćirić, Ana D.; Veljić, Milan; Nikodinović-Runić, Jasmina; Novaković, Miroslav M.

(Georg Thieme Verlag Kg, Stuttgart, 2017)

TY  - JOUR
AU  - Ilic-Tomić, Tatjana
AU  - Soković, Marina
AU  - Vojnović, Sandra
AU  - Ćirić, Ana D.
AU  - Veljić, Milan
AU  - Nikodinović-Runić, Jasmina
AU  - Novaković, Miroslav M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2395
AB  - Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa
VL  - 83
IS  - 01-02
SP  - 117
EP  - 125
DO  - 10.1055/s-0042-107674
UR  - Kon_3211
ER  - 
@article{
author = "Ilic-Tomić, Tatjana and Soković, Marina and Vojnović, Sandra and Ćirić, Ana D. and Veljić, Milan and Nikodinović-Runić, Jasmina and Novaković, Miroslav M.",
year = "2017",
abstract = "Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa",
volume = "83",
number = "01-02",
pages = "117-125",
doi = "10.1055/s-0042-107674",
url = "Kon_3211"
}
Ilic-Tomić, T., Soković, M., Vojnović, S., Ćirić, A. D., Veljić, M., Nikodinović-Runić, J.,& Novaković, M. M.. (2017). Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 83(01-02), 117-125.
https://doi.org/10.1055/s-0042-107674
Kon_3211
Ilic-Tomić T, Soković M, Vojnović S, Ćirić AD, Veljić M, Nikodinović-Runić J, Novaković MM. Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa. in Planta Medica. 2017;83(01-02):117-125.
doi:10.1055/s-0042-107674
Kon_3211 .
Ilic-Tomić, Tatjana, Soković, Marina, Vojnović, Sandra, Ćirić, Ana D., Veljić, Milan, Nikodinović-Runić, Jasmina, Novaković, Miroslav M., "Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa" in Planta Medica, 83, no. 01-02 (2017):117-125,
https://doi.org/10.1055/s-0042-107674 .,
Kon_3211 .
2
12
11
15

Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674

Ilić-Tomić, Tatjana; Soković, Marina; Vojnović, Sandra; Cirić, Ana D.; Veljić, Milan; Nikodinović-Runić, Jasmina; Novaković, Miroslav M.

(Georg Thieme Verlag Kg, Stuttgart, 2017)

TY  - DATA
AU  - Ilić-Tomić, Tatjana
AU  - Soković, Marina
AU  - Vojnović, Sandra
AU  - Cirić, Ana D.
AU  - Veljić, Milan
AU  - Nikodinović-Runić, Jasmina
AU  - Novaković, Miroslav M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3034
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674
ER  - 
@misc{
author = "Ilić-Tomić, Tatjana and Soković, Marina and Vojnović, Sandra and Cirić, Ana D. and Veljić, Milan and Nikodinović-Runić, Jasmina and Novaković, Miroslav M.",
year = "2017",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674"
}
Ilić-Tomić, T., Soković, M., Vojnović, S., Cirić, A. D., Veljić, M., Nikodinović-Runić, J.,& Novaković, M. M.. (2017). Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart..
Ilić-Tomić T, Soković M, Vojnović S, Cirić AD, Veljić M, Nikodinović-Runić J, Novaković MM. Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674. in Planta Medica. 2017;..
Ilić-Tomić, Tatjana, Soković, Marina, Vojnović, Sandra, Cirić, Ana D., Veljić, Milan, Nikodinović-Runić, Jasmina, Novaković, Miroslav M., "Supplementary data for article: Ilic-Tomic, T.; Sokovic, M.; Vojnovic, S.; Ciric, A.; Veljic, M.; Nikodinovic-Runic, J.; Novakovic, M. Diarylheptanoids from Alnus Viridis Ssp Viridis and Alnus Glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas Aeruginosa. Planta Medica 2017, 83 (1–2), 117–125. https://doi.org/10.1055/s-0042-107674" in Planta Medica (2017).

Supplementary data for article: Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805

Novaković, Miroslav M.; Nikodinović-Runić, Jasmina; Veselinović, Jovana; Ilić-Tomić, Tatjana; Vidaković, Vera; Tešević, Vele; Milosavljević, Slobodan M.

(Amer Chemical Soc, Washington, 2017)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Nikodinović-Runić, Jasmina
AU  - Veselinović, Jovana
AU  - Ilić-Tomić, Tatjana
AU  - Vidaković, Vera
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3088
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805
ER  - 
@misc{
author = "Novaković, Miroslav M. and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2017",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805"
}
Novaković, M. M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S. M.. (2017). Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805. in Journal of Natural Products
Amer Chemical Soc, Washington..
Novaković MM, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević SM. Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805. in Journal of Natural Products. 2017;..
Novaković, Miroslav M., Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan M., "Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805" in Journal of Natural Products (2017).

Comparative analytical study of the selected wine varieties grown in Montenegro

Đorđević, Neda O.; Novaković, Miroslav M.; Pejin, Boris; Mutić, Jelena; Vajs, Vlatka; Pajović, Snezana B.; Tešević, Vele

(Taylor & Francis Ltd, Abingdon, 2017)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Mutić, Jelena
AU  - Vajs, Vlatka
AU  - Pajović, Snezana B.
AU  - Tešević, Vele
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2481
AB  - Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Comparative analytical study of the selected wine varieties grown in Montenegro
VL  - 31
IS  - 15
SP  - 1825
EP  - 1830
DO  - 10.1080/14786419.2017.1289209
UR  - Kon_3297
ER  - 
@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Mutić, Jelena and Vajs, Vlatka and Pajović, Snezana B. and Tešević, Vele",
year = "2017",
abstract = "Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Comparative analytical study of the selected wine varieties grown in Montenegro",
volume = "31",
number = "15",
pages = "1825-1830",
doi = "10.1080/14786419.2017.1289209",
url = "Kon_3297"
}
Đorđević, N. O., Novaković, M. M., Pejin, B., Mutić, J., Vajs, V., Pajović, S. B.,& Tešević, V.. (2017). Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(15), 1825-1830.
https://doi.org/10.1080/14786419.2017.1289209
Kon_3297
Đorđević NO, Novaković MM, Pejin B, Mutić J, Vajs V, Pajović SB, Tešević V. Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research. 2017;31(15):1825-1830.
doi:10.1080/14786419.2017.1289209
Kon_3297 .
Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Mutić, Jelena, Vajs, Vlatka, Pajović, Snezana B., Tešević, Vele, "Comparative analytical study of the selected wine varieties grown in Montenegro" in Natural Product Research, 31, no. 15 (2017):1825-1830,
https://doi.org/10.1080/14786419.2017.1289209 .,
Kon_3297 .
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