@article{
author = "Gandra, Upendar Reddy and Sinopoli, Alessandro and Moncho, Salvador and Nanda Kumar, Manjula and Ninković, Dragan and Zarić, Snežana D. and Sohail, Muhammad and Al-Meer, Saeed and Brothers, Edward N. and Mazloum, Nayef A. and Al-Hashimi, Mohammed and Bazzi, Hassan S.",
year = "2019",
abstract = "Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.",
publisher = "American Chemical Society",
journal = "ACS Applied Materials and Interfaces",
title = "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization",
volume = "11",
number = "37",
pages = "34376-34384",
doi = "10.1021/acsami.9b12628"
}