TY  - CHAP
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Nevenka
AU  - Jovanović, Katarina K.
AU  - Grgurić-Šipka, Sanja
AU  - Radulović, Siniša
PY  - 2017
UR  - https://www.worldcat.org/title/ruthenium-chemistry/oclc/1032703727&referer=brief_results
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5074
PB  - Pan Stanford Publishing Pte. Ltd.
T2  - Ruthenium chemistry
T1  - The Development of Ru(II)-p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents
SP  - 215
EP  - 258
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5074
ER  - 

@inbook{
author = "Gligorijević, Nevenka and Aranđelović, Nevenka and Jovanović, Katarina K. and Grgurić-Šipka, Sanja and Radulović, Siniša",
year = "2017",
publisher = "Pan Stanford Publishing Pte. Ltd.",
journal = "Ruthenium chemistry",
booktitle = "The Development of Ru(II)-p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents",
pages = "215-258",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5074"
}

Gligorijević, N., Aranđelović, N., Jovanović, K. K., Grgurić-Šipka, S.,& Radulović, S.. (2017). The Development of Ru(II)-p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents. in Ruthenium chemistry
Pan Stanford Publishing Pte. Ltd.., 215-258.
https://hdl.handle.net/21.15107/rcub_cherry_5074

Gligorijević N, Aranđelović N, Jovanović KK, Grgurić-Šipka S, Radulović S. The Development of Ru(II)-p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents. in Ruthenium chemistry. 2017;:215-258.
https://hdl.handle.net/21.15107/rcub_cherry_5074 .

Gligorijević, Nevenka, Aranđelović, Nevenka, Jovanović, Katarina K., Grgurić-Šipka, Sanja, Radulović, Siniša, "The Development of Ru(II)-p-Cymene Complexes with Pyridine Derivatives as Anti-Cancer Agents" in Ruthenium chemistry (2017):215-258,
https://hdl.handle.net/21.15107/rcub_cherry_5074 .

TY  - JOUR
AU  - Jovanović, Katarina K.
AU  - Tanić, Miljana
AU  - Ivanović, Ivanka
AU  - Gligorijević, Nevenka
AU  - Dojčinović, Biljana P.
AU  - Radulović, Siniša
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6318
AB  - Ruthenium(II)arene complexes are promising drug candidates for the therapy of solid tumors. Inprevious work, seven new compounds of the general formula [Ru(η6-p-cymene)(L1–7)Cl] were synthesized and characterized, of which the complex with L=isoquinoline-3-carboxylic acid (RuT7) was two times as active on HeLa cells compared to normal cell line MRC-5, as indicated by IC50 values determined after48 h of incubation (45.4±3.0 vs. 84.2±5.7 μM, respectively). In the present study, cell cycle analysis of HeLa cells treated with RuT7 showed S phase arrest and an increase in sub-G1 population.The apoptotic potential of the title compound was confirmed with the Annexin V-FITC/PI assay together with a morphological evaluation of cells using fluorescent microscopy. Analysis of the intracellular accumulation of ruthenium showed 8.9 ng Ru / 10 6 cells after 6 h of incubation.To gain further insight in the molecular mechanism of action of RuT7 on HeLa cells, a whole-transcriptome microarray gene expression analysis was performed. Analysis of functional categories and signaling and biochemical pathways associated with the response of HeLa cells to treatment with RuT7 showed that it leads the cells through the intrinsic (mitochondrial) apoptotic pathway, via indirect DNA damage due to the action of reactive oxygens pecies, and through direct DNA binding of RuT7. Statistical analysis for enrichment of gene sets associated with known drug-induced toxicities identified fewer associated toxicity profiles in RuT7-treated cells compared to cisplatin treatment. Altogether these results provide the basis for further development of RuT7 in animal and pre-clinical studies as a potential drug candidate.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand
VL  - 163
SP  - 362
EP  - 373
DO  - 10.1016/j.jinorgbio.2016.04.011
ER  - 

@article{
author = "Jovanović, Katarina K. and Tanić, Miljana and Ivanović, Ivanka and Gligorijević, Nevenka and Dojčinović, Biljana P. and Radulović, Siniša",
year = "2016",
abstract = "Ruthenium(II)arene complexes are promising drug candidates for the therapy of solid tumors. Inprevious work, seven new compounds of the general formula [Ru(η6-p-cymene)(L1–7)Cl] were synthesized and characterized, of which the complex with L=isoquinoline-3-carboxylic acid (RuT7) was two times as active on HeLa cells compared to normal cell line MRC-5, as indicated by IC50 values determined after48 h of incubation (45.4±3.0 vs. 84.2±5.7 μM, respectively). In the present study, cell cycle analysis of HeLa cells treated with RuT7 showed S phase arrest and an increase in sub-G1 population.The apoptotic potential of the title compound was confirmed with the Annexin V-FITC/PI assay together with a morphological evaluation of cells using fluorescent microscopy. Analysis of the intracellular accumulation of ruthenium showed 8.9 ng Ru / 10 6 cells after 6 h of incubation.To gain further insight in the molecular mechanism of action of RuT7 on HeLa cells, a whole-transcriptome microarray gene expression analysis was performed. Analysis of functional categories and signaling and biochemical pathways associated with the response of HeLa cells to treatment with RuT7 showed that it leads the cells through the intrinsic (mitochondrial) apoptotic pathway, via indirect DNA damage due to the action of reactive oxygens pecies, and through direct DNA binding of RuT7. Statistical analysis for enrichment of gene sets associated with known drug-induced toxicities identified fewer associated toxicity profiles in RuT7-treated cells compared to cisplatin treatment. Altogether these results provide the basis for further development of RuT7 in animal and pre-clinical studies as a potential drug candidate.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand",
volume = "163",
pages = "362-373",
doi = "10.1016/j.jinorgbio.2016.04.011"
}

Jovanović, K. K., Tanić, M., Ivanović, I., Gligorijević, N., Dojčinović, B. P.,& Radulović, S.. (2016). Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand. in Journal of Inorganic Biochemistry
Elsevier., 163, 362-373.
https://doi.org/10.1016/j.jinorgbio.2016.04.011

Jovanović KK, Tanić M, Ivanović I, Gligorijević N, Dojčinović BP, Radulović S. Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand. in Journal of Inorganic Biochemistry. 2016;163:362-373.
doi:10.1016/j.jinorgbio.2016.04.011 .

Jovanović, Katarina K., Tanić, Miljana, Ivanović, Ivanka, Gligorijević, Nevenka, Dojčinović, Biljana P., Radulović, Siniša, "Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand" in Journal of Inorganic Biochemistry, 163 (2016):362-373,
https://doi.org/10.1016/j.jinorgbio.2016.04.011 . .

TY  - JOUR
AU  - Ivanović, Ivanka
AU  - Jovanović, Katarina K.
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Arion, Vladimir B.
AU  - Sheweshein, Khalil Salem A. M.
AU  - Tešić, Živoslav Lj.
AU  - Grgurić-Šipka, Sanja
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1451
AB  - A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All rights reserved.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Organometallic Chemistry
T1  - Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity
VL  - 749
SP  - 343
EP  - 349
DO  - 10.1016/j.jorganchem.2013.10.023
ER  - 

@article{
author = "Ivanović, Ivanka and Jovanović, Katarina K. and Gligorijević, Nevenka and Radulović, Siniša and Arion, Vladimir B. and Sheweshein, Khalil Salem A. M. and Tešić, Živoslav Lj. and Grgurić-Šipka, Sanja",
year = "2014",
abstract = "A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All rights reserved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Organometallic Chemistry",
title = "Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity",
volume = "749",
pages = "343-349",
doi = "10.1016/j.jorganchem.2013.10.023"
}

Ivanović, I., Jovanović, K. K., Gligorijević, N., Radulović, S., Arion, V. B., Sheweshein, K. S. A. M., Tešić, Ž. Lj.,& Grgurić-Šipka, S.. (2014). Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity. in Journal of Organometallic Chemistry
Elsevier Science Sa, Lausanne., 749, 343-349.
https://doi.org/10.1016/j.jorganchem.2013.10.023

Ivanović I, Jovanović KK, Gligorijević N, Radulović S, Arion VB, Sheweshein KSAM, Tešić ŽL, Grgurić-Šipka S. Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity. in Journal of Organometallic Chemistry. 2014;749:343-349.
doi:10.1016/j.jorganchem.2013.10.023 .

Ivanović, Ivanka, Jovanović, Katarina K., Gligorijević, Nevenka, Radulović, Siniša, Arion, Vladimir B., Sheweshein, Khalil Salem A. M., Tešić, Živoslav Lj., Grgurić-Šipka, Sanja, "Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity" in Journal of Organometallic Chemistry, 749 (2014):343-349,
https://doi.org/10.1016/j.jorganchem.2013.10.023 . .