TY  - JOUR
AU  - Zukic, Selma
AU  - Veljović, Elma
AU  - Špirtović-Halilović, Selma
AU  - Muratovic, Samija
AU  - Osmanović, Amar
AU  - Trifunović, Snežana S.
AU  - Novaković, Irena T.
AU  - Završnik, Davorka
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2231
AB  - Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.
PB  - Croatian Chemical Soc, Zagreb
T2  - Croatica Chemica Acta
T1  - Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives
VL  - 91
IS  - 1
SP  - 1
EP  - 9
DO  - 10.5562/cca3225
ER  - 

@article{
author = "Zukic, Selma and Veljović, Elma and Špirtović-Halilović, Selma and Muratovic, Samija and Osmanović, Amar and Trifunović, Snežana S. and Novaković, Irena T. and Završnik, Davorka",
year = "2018",
abstract = "Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.",
publisher = "Croatian Chemical Soc, Zagreb",
journal = "Croatica Chemica Acta",
title = "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives",
volume = "91",
number = "1",
pages = "1-9",
doi = "10.5562/cca3225"
}

Zukic, S., Veljović, E., Špirtović-Halilović, S., Muratovic, S., Osmanović, A., Trifunović, S. S., Novaković, I. T.,& Završnik, D.. (2018). Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. in Croatica Chemica Acta
Croatian Chemical Soc, Zagreb., 91(1), 1-9.
https://doi.org/10.5562/cca3225

Zukic S, Veljović E, Špirtović-Halilović S, Muratovic S, Osmanović A, Trifunović SS, Novaković IT, Završnik D. Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. in Croatica Chemica Acta. 2018;91(1):1-9.
doi:10.5562/cca3225 .

Zukic, Selma, Veljović, Elma, Špirtović-Halilović, Selma, Muratovic, Samija, Osmanović, Amar, Trifunović, Snežana S., Novaković, Irena T., Završnik, Davorka, "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives" in Croatica Chemica Acta, 91, no. 1 (2018):1-9,
https://doi.org/10.5562/cca3225 . .

TY  - JOUR
AU  - Veljović, Elma
AU  - Špirtović-Halilović, Selma
AU  - Muratovic, Samija
AU  - Zulj, Lidija Valek
AU  - Roca, Sunčica
AU  - Trifunović, Snežana S.
AU  - Osmanović, Amar
AU  - Završnik, Davorka
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1743
AB  - Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.
PB  - Croatian Chemical Soc, Zagreb
T2  - Croatica Chemica Acta
T1  - 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation
VL  - 88
IS  - 2
SP  - 121
EP  - 127
DO  - 10.5562/cca2595
ER  - 

@article{
author = "Veljović, Elma and Špirtović-Halilović, Selma and Muratovic, Samija and Zulj, Lidija Valek and Roca, Sunčica and Trifunović, Snežana S. and Osmanović, Amar and Završnik, Davorka",
year = "2015",
abstract = "Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.",
publisher = "Croatian Chemical Soc, Zagreb",
journal = "Croatica Chemica Acta",
title = "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation",
volume = "88",
number = "2",
pages = "121-127",
doi = "10.5562/cca2595"
}

Veljović, E., Špirtović-Halilović, S., Muratovic, S., Zulj, L. V., Roca, S., Trifunović, S. S., Osmanović, A.,& Završnik, D.. (2015). 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. in Croatica Chemica Acta
Croatian Chemical Soc, Zagreb., 88(2), 121-127.
https://doi.org/10.5562/cca2595

Veljović E, Špirtović-Halilović S, Muratovic S, Zulj LV, Roca S, Trifunović SS, Osmanović A, Završnik D. 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. in Croatica Chemica Acta. 2015;88(2):121-127.
doi:10.5562/cca2595 .

Veljović, Elma, Špirtović-Halilović, Selma, Muratovic, Samija, Zulj, Lidija Valek, Roca, Sunčica, Trifunović, Snežana S., Osmanović, Amar, Završnik, Davorka, "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation" in Croatica Chemica Acta, 88, no. 2 (2015):121-127,
https://doi.org/10.5562/cca2595 . .