TY  - JOUR
AU  - Gandra, Upendar Reddy
AU  - Sinopoli, Alessandro
AU  - Moncho, Salvador
AU  - Nanda Kumar, Manjula
AU  - Ninković, Dragan
AU  - Zarić, Snežana D.
AU  - Sohail, Muhammad
AU  - Al-Meer, Saeed
AU  - Brothers, Edward N.
AU  - Mazloum, Nayef A.
AU  - Al-Hashimi, Mohammed
AU  - Bazzi, Hassan S.
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3636
AB  - Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.
PB  - American Chemical Society
T2  - ACS Applied Materials and Interfaces
T1  - Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization
VL  - 11
IS  - 37
SP  - 34376
EP  - 34384
DO  - 10.1021/acsami.9b12628
ER  - 

@article{
author = "Gandra, Upendar Reddy and Sinopoli, Alessandro and Moncho, Salvador and Nanda Kumar, Manjula and Ninković, Dragan and Zarić, Snežana D. and Sohail, Muhammad and Al-Meer, Saeed and Brothers, Edward N. and Mazloum, Nayef A. and Al-Hashimi, Mohammed and Bazzi, Hassan S.",
year = "2019",
abstract = "Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.",
publisher = "American Chemical Society",
journal = "ACS Applied Materials and Interfaces",
title = "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization",
volume = "11",
number = "37",
pages = "34376-34384",
doi = "10.1021/acsami.9b12628"
}

Gandra, U. R., Sinopoli, A., Moncho, S., Nanda Kumar, M., Ninković, D., Zarić, S. D., Sohail, M., Al-Meer, S., Brothers, E. N., Mazloum, N. A., Al-Hashimi, M.,& Bazzi, H. S.. (2019). Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces
American Chemical Society., 11(37), 34376-34384.
https://doi.org/10.1021/acsami.9b12628

Gandra UR, Sinopoli A, Moncho S, Nanda Kumar M, Ninković D, Zarić SD, Sohail M, Al-Meer S, Brothers EN, Mazloum NA, Al-Hashimi M, Bazzi HS. Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces. 2019;11(37):34376-34384.
doi:10.1021/acsami.9b12628 .

Gandra, Upendar Reddy, Sinopoli, Alessandro, Moncho, Salvador, Nanda Kumar, Manjula, Ninković, Dragan, Zarić, Snežana D., Sohail, Muhammad, Al-Meer, Saeed, Brothers, Edward N., Mazloum, Nayef A., Al-Hashimi, Mohammed, Bazzi, Hassan S., "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization" in ACS Applied Materials and Interfaces, 11, no. 37 (2019):34376-34384,
https://doi.org/10.1021/acsami.9b12628 . .