Matović, Radomir

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orcid::0000-0001-7894-6654
  • Matović, Radomir (45)

Author's Bibliography

Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

Ferjancic, Zorana; Bihelovic, Filip; Vulovic, Bojan; Matovic, Radomir; Trmcic, Milena; Jankovic, Aleksandar; Pavlovic, Milos; Djurkovic, Filip; Prodanovic, Radivoje; Djurdjevic Djelmas, Aleksandra; Kalicanin, Nevena; Zlatovic, Mario; Sladic, Dusan; Vallet, Thomas; Vignuzzi, Marco; Saicic, Radomir N.

(Taylor and Francis Group, 2024)

TY  - JOUR
AU  - Ferjancic, Zorana
AU  - Bihelovic, Filip
AU  - Vulovic, Bojan
AU  - Matovic, Radomir
AU  - Trmcic, Milena
AU  - Jankovic, Aleksandar
AU  - Pavlovic, Milos
AU  - Djurkovic, Filip
AU  - Prodanovic, Radivoje
AU  - Djurdjevic Djelmas, Aleksandra
AU  - Kalicanin, Nevena
AU  - Zlatovic, Mario
AU  - Sladic, Dusan
AU  - Vallet, Thomas
AU  - Vignuzzi, Marco
AU  - Saicic, Radomir N.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6475
AB  - We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase, and mannosidase). Molecular modelling of the lead compounds, synthesis of the compounds with the highest docking scores, enzyme inhibition tests, and in vitro antiviral assays afforded rationally designed inhibitors. Two highly active α-glucosidase inhibitors were discovered, where one of them is the most potent iminosugar-based anti-SARS-CoV-2 agent to date (EC90 = 1.94 µM in A549-ACE2 cells against Omicron BA.1 strain). However, galactosidase inhibitors did not exhibit antiviral activity, whereas mannosidase inhibitors were both active and cytotoxic. As our iminosugar-based drug candidates act by a host-directed mechanism, they should be more resilient to drug resistance. Moreover, this strategy could be extended to identify potential drug candidates for other viral infections.
PB  - Taylor and Francis Group
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies
VL  - 39
IS  - 1
SP  - 2289007
DO  - 10.1080/14756366.2023.2289007
ER  - 
@article{
author = "Ferjancic, Zorana and Bihelovic, Filip and Vulovic, Bojan and Matovic, Radomir and Trmcic, Milena and Jankovic, Aleksandar and Pavlovic, Milos and Djurkovic, Filip and Prodanovic, Radivoje and Djurdjevic Djelmas, Aleksandra and Kalicanin, Nevena and Zlatovic, Mario and Sladic, Dusan and Vallet, Thomas and Vignuzzi, Marco and Saicic, Radomir N.",
year = "2024",
abstract = "We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase, and mannosidase). Molecular modelling of the lead compounds, synthesis of the compounds with the highest docking scores, enzyme inhibition tests, and in vitro antiviral assays afforded rationally designed inhibitors. Two highly active α-glucosidase inhibitors were discovered, where one of them is the most potent iminosugar-based anti-SARS-CoV-2 agent to date (EC90 = 1.94 µM in A549-ACE2 cells against Omicron BA.1 strain). However, galactosidase inhibitors did not exhibit antiviral activity, whereas mannosidase inhibitors were both active and cytotoxic. As our iminosugar-based drug candidates act by a host-directed mechanism, they should be more resilient to drug resistance. Moreover, this strategy could be extended to identify potential drug candidates for other viral infections.",
publisher = "Taylor and Francis Group",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies",
volume = "39",
number = "1",
pages = "2289007",
doi = "10.1080/14756366.2023.2289007"
}
Ferjancic, Z., Bihelovic, F., Vulovic, B., Matovic, R., Trmcic, M., Jankovic, A., Pavlovic, M., Djurkovic, F., Prodanovic, R., Djurdjevic Djelmas, A., Kalicanin, N., Zlatovic, M., Sladic, D., Vallet, T., Vignuzzi, M.,& Saicic, R. N.. (2024). Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor and Francis Group., 39(1), 2289007.
https://doi.org/10.1080/14756366.2023.2289007
Ferjancic Z, Bihelovic F, Vulovic B, Matovic R, Trmcic M, Jankovic A, Pavlovic M, Djurkovic F, Prodanovic R, Djurdjevic Djelmas A, Kalicanin N, Zlatovic M, Sladic D, Vallet T, Vignuzzi M, Saicic RN. Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2024;39(1):2289007.
doi:10.1080/14756366.2023.2289007 .
Ferjancic, Zorana, Bihelovic, Filip, Vulovic, Bojan, Matovic, Radomir, Trmcic, Milena, Jankovic, Aleksandar, Pavlovic, Milos, Djurkovic, Filip, Prodanovic, Radivoje, Djurdjevic Djelmas, Aleksandra, Kalicanin, Nevena, Zlatovic, Mario, Sladic, Dusan, Vallet, Thomas, Vignuzzi, Marco, Saicic, Radomir N., "Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies" in Journal of Enzyme Inhibition and Medicinal Chemistry, 39, no. 1 (2024):2289007,
https://doi.org/10.1080/14756366.2023.2289007 . .
4
1

Synthetic study on the angular triquinanes: Scientific paper

Stjepanovic, Mihailo; Janković, Aleksandar; Vulović, Bojan; Matović, Radomir; Saičić, Radomir

(Serbian Chemical Society, 2023)

TY  - JOUR
AU  - Stjepanovic, Mihailo
AU  - Janković, Aleksandar
AU  - Vulović, Bojan
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6389
AB  - The synthesis of an angular triquinane, which could serve as a suit­able platform for the synthesis of several natural products (panaginsene, sil­phi­nene, senoxydene) is described. The synthesis is based on two consecutive cyc­lo­pentene annulations, where alkenes were used as latent carbonyl function­alities (via Wacker reaction), and cyclopentenone annulation was effected by aldol condensation.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthetic study on the angular triquinanes: Scientific paper
VL  - 88
IS  - 10
SP  - 975
EP  - 983
DO  - 10.2298/JSC230627046S
ER  - 
@article{
author = "Stjepanovic, Mihailo and Janković, Aleksandar and Vulović, Bojan and Matović, Radomir and Saičić, Radomir",
year = "2023",
abstract = "The synthesis of an angular triquinane, which could serve as a suit­able platform for the synthesis of several natural products (panaginsene, sil­phi­nene, senoxydene) is described. The synthesis is based on two consecutive cyc­lo­pentene annulations, where alkenes were used as latent carbonyl function­alities (via Wacker reaction), and cyclopentenone annulation was effected by aldol condensation.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthetic study on the angular triquinanes: Scientific paper",
volume = "88",
number = "10",
pages = "975-983",
doi = "10.2298/JSC230627046S"
}
Stjepanovic, M., Janković, A., Vulović, B., Matović, R.,& Saičić, R.. (2023). Synthetic study on the angular triquinanes: Scientific paper. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 88(10), 975-983.
https://doi.org/10.2298/JSC230627046S
Stjepanovic M, Janković A, Vulović B, Matović R, Saičić R. Synthetic study on the angular triquinanes: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(10):975-983.
doi:10.2298/JSC230627046S .
Stjepanovic, Mihailo, Janković, Aleksandar, Vulović, Bojan, Matović, Radomir, Saičić, Radomir, "Synthetic study on the angular triquinanes: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 10 (2023):975-983,
https://doi.org/10.2298/JSC230627046S . .

Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation

Vulović, Bojan; Trmčić, Milena; Matović, Radomir; Saičić, Radomir

(ACS, 2019)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Trmčić, Milena
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3819
AB  - Unsaturated oxyallyl cations with a suitably positioned alkene bond undergo 5-exo-cyclization with the formation of vinylcyclopentane derivatives. Alkyne analogues provide allenes. The reaction proceeds with a moderate to excellent level of stereoselectivity and allows for asymmetric induction in the reaction with chiral substrate.
PB  - ACS
T2  - Organic Letters
T1  - Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation
VL  - 21
IS  - 23
SP  - 9618
EP  - 9621
DO  - 10.1021/acs.orglett.9b03791
ER  - 
@article{
author = "Vulović, Bojan and Trmčić, Milena and Matović, Radomir and Saičić, Radomir",
year = "2019",
abstract = "Unsaturated oxyallyl cations with a suitably positioned alkene bond undergo 5-exo-cyclization with the formation of vinylcyclopentane derivatives. Alkyne analogues provide allenes. The reaction proceeds with a moderate to excellent level of stereoselectivity and allows for asymmetric induction in the reaction with chiral substrate.",
publisher = "ACS",
journal = "Organic Letters",
title = "Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation",
volume = "21",
number = "23",
pages = "9618-9621",
doi = "10.1021/acs.orglett.9b03791"
}
Vulović, B., Trmčić, M., Matović, R.,& Saičić, R.. (2019). Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. in Organic Letters
ACS., 21(23), 9618-9621.
https://doi.org/10.1021/acs.orglett.9b03791
Vulović B, Trmčić M, Matović R, Saičić R. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. in Organic Letters. 2019;21(23):9618-9621.
doi:10.1021/acs.orglett.9b03791 .
Vulović, Bojan, Trmčić, Milena, Matović, Radomir, Saičić, Radomir, "Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation" in Organic Letters, 21, no. 23 (2019):9618-9621,
https://doi.org/10.1021/acs.orglett.9b03791 . .
5
1
6
2

Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791

Vulović, Bojan; Trmčić, Milena; Matović, Radomir; Saičić, Radomir

(ACS, 2019)

TY  - DATA
AU  - Vulović, Bojan
AU  - Trmčić, Milena
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3841
PB  - ACS
T2  - Organic Letters
T1  - Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3841
ER  - 
@misc{
author = "Vulović, Bojan and Trmčić, Milena and Matović, Radomir and Saičić, Radomir",
year = "2019",
publisher = "ACS",
journal = "Organic Letters",
title = "Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3841"
}
Vulović, B., Trmčić, M., Matović, R.,& Saičić, R.. (2019). Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791. in Organic Letters
ACS..
https://hdl.handle.net/21.15107/rcub_cherry_3841
Vulović B, Trmčić M, Matović R, Saičić R. Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791. in Organic Letters. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_3841 .
Vulović, Bojan, Trmčić, Milena, Matović, Radomir, Saičić, Radomir, "Supplementary data for the article: Vulovic, B.; Trmcic, M.; Matovic, R.; Saicic, R. N. Cyclization Reactions of Oxyallyl Cation. A Method for Cyclopentane Ring Formation. Organic Letters 2019, 21 (23), 9618–9621. https://doi.org/10.1021/acs.orglett.9b03791" in Organic Letters (2019),
https://hdl.handle.net/21.15107/rcub_cherry_3841 .

Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H

Vulović, Bojan; Kolarski, Dušan; Bihelović, Filip; Matović, Radomir; Gruden-Pavlović, Maja; Saičić, Radomir

(Amer Chemical Soc, Washington, 2016)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Kolarski, Dušan
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Gruden-Pavlović, Maja
AU  - Saičić, Radomir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2290
AB  - 1,6-Diynes with a t-butylcarbonate group in the propargylic position undergo gold(I)-catalyzed dominocyclization which affords alpha-hydroxycyclohexenones. The described sequence can be applied on functionalized, highly oxygenated substrates, as examplified in the synthesis of (-)-gabosine H and its epimer.
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H
VL  - 18
IS  - 15
SP  - 3886
EP  - 3889
DO  - 10.1021/acs.orglett.6b01898
ER  - 
@article{
author = "Vulović, Bojan and Kolarski, Dušan and Bihelović, Filip and Matović, Radomir and Gruden-Pavlović, Maja and Saičić, Radomir",
year = "2016",
abstract = "1,6-Diynes with a t-butylcarbonate group in the propargylic position undergo gold(I)-catalyzed dominocyclization which affords alpha-hydroxycyclohexenones. The described sequence can be applied on functionalized, highly oxygenated substrates, as examplified in the synthesis of (-)-gabosine H and its epimer.",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H",
volume = "18",
number = "15",
pages = "3886-3889",
doi = "10.1021/acs.orglett.6b01898"
}
Vulović, B., Kolarski, D., Bihelović, F., Matović, R., Gruden-Pavlović, M.,& Saičić, R.. (2016). Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H. in Organic Letters
Amer Chemical Soc, Washington., 18(15), 3886-3889.
https://doi.org/10.1021/acs.orglett.6b01898
Vulović B, Kolarski D, Bihelović F, Matović R, Gruden-Pavlović M, Saičić R. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H. in Organic Letters. 2016;18(15):3886-3889.
doi:10.1021/acs.orglett.6b01898 .
Vulović, Bojan, Kolarski, Dušan, Bihelović, Filip, Matović, Radomir, Gruden-Pavlović, Maja, Saičić, Radomir, "Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H" in Organic Letters, 18, no. 15 (2016):3886-3889,
https://doi.org/10.1021/acs.orglett.6b01898 . .
10
17
11
17
14

Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016)

Vulović, Bojan; Kolarski, Dušan; Bihelović, Filip; Matović, Radomir; Gruden-Pavlović, Maja; Saičić, Radomir

(Amer Chemical Soc, Washington, 2016)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Kolarski, Dušan
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Gruden-Pavlović, Maja
AU  - Saičić, Radomir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2327
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016)
VL  - 18
IS  - 19
SP  - 5186
EP  - 5187
DO  - 10.1021/acs.orglett.6b02509
ER  - 
@article{
author = "Vulović, Bojan and Kolarski, Dušan and Bihelović, Filip and Matović, Radomir and Gruden-Pavlović, Maja and Saičić, Radomir",
year = "2016",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016)",
volume = "18",
number = "19",
pages = "5186-5187",
doi = "10.1021/acs.orglett.6b02509"
}
Vulović, B., Kolarski, D., Bihelović, F., Matović, R., Gruden-Pavlović, M.,& Saičić, R.. (2016). Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016). in Organic Letters
Amer Chemical Soc, Washington., 18(19), 5186-5187.
https://doi.org/10.1021/acs.orglett.6b02509
Vulović B, Kolarski D, Bihelović F, Matović R, Gruden-Pavlović M, Saičić R. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016). in Organic Letters. 2016;18(19):5186-5187.
doi:10.1021/acs.orglett.6b02509 .
Vulović, Bojan, Kolarski, Dušan, Bihelović, Filip, Matović, Radomir, Gruden-Pavlović, Maja, Saičić, Radomir, "Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H (vol 18, pg 3886, 2016)" in Organic Letters, 18, no. 19 (2016):5186-5187,
https://doi.org/10.1021/acs.orglett.6b02509 . .
1
2
1

Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898

Vulović, Bojan; Kolarski, Dušan; Bihelović, Filip; Matović, Radomir; Gruden-Pavlović, Maja; Saičić, Radomir

(Amer Chemical Soc, Washington, 2016)

TY  - DATA
AU  - Vulović, Bojan
AU  - Kolarski, Dušan
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Gruden-Pavlović, Maja
AU  - Saičić, Radomir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3520
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3520
ER  - 
@misc{
author = "Vulović, Bojan and Kolarski, Dušan and Bihelović, Filip and Matović, Radomir and Gruden-Pavlović, Maja and Saičić, Radomir",
year = "2016",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3520"
}
Vulović, B., Kolarski, D., Bihelović, F., Matović, R., Gruden-Pavlović, M.,& Saičić, R.. (2016). Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898. in Organic Letters
Amer Chemical Soc, Washington..
https://hdl.handle.net/21.15107/rcub_cherry_3520
Vulović B, Kolarski D, Bihelović F, Matović R, Gruden-Pavlović M, Saičić R. Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898. in Organic Letters. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3520 .
Vulović, Bojan, Kolarski, Dušan, Bihelović, Filip, Matović, Radomir, Gruden-Pavlović, Maja, Saičić, Radomir, "Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898" in Organic Letters (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3520 .

Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V

Vulović, Bojan; Marić, Ivana; Matović, Radomir; Saičić, Radomir

(Serbian Chemical Soc, Belgrade, 2016)

TY  - DATA
AU  - Vulović, Bojan
AU  - Marić, Ivana
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3629
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3629
ER  - 
@misc{
author = "Vulović, Bojan and Marić, Ivana and Matović, Radomir and Saičić, Radomir",
year = "2016",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3629"
}
Vulović, B., Marić, I., Matović, R.,& Saičić, R.. (2016). Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade..
https://hdl.handle.net/21.15107/rcub_cherry_3629
Vulović B, Marić I, Matović R, Saičić R. Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V. in Journal of the Serbian Chemical Society. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3629 .
Vulović, Bojan, Marić, Ivana, Matović, Radomir, Saičić, Radomir, "Supplementary data for the article: Vulović, B.; Marić, I.; Matović, R.; Saicíć, R. N. Synthesis of Vinyldihydropyran by Cooperative Catalysis. Journal of the Serbian Chemical Society 2016, 81 (12), 1335–1343. https://doi.org/10.2298/JSC161102103V" in Journal of the Serbian Chemical Society (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3629 .

Synthesis of vinyldihydropyran by cooperative catalysis

Vulović, Bojan; Marić, Ivana; Matović, Radomir; Saičić, Radomir

(Serbian Chemical Soc, Belgrade, 2016)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Marić, Ivana
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2388
AB  - Delta(5)-Unsaturated aldehydes with a suitably positioned allylic halide, or phosphate, leaving group undergo doubly-catalyzed cyclization to give dihydropyran derivatives. The cyclization proceeds under the synergetic action of diazabicycloundecene and Pd(PPh3)(4). This type of transformation was also accomplished with an aryl ketone.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis of vinyldihydropyran by cooperative catalysis
VL  - 81
IS  - 12
SP  - 1335
EP  - 1343
DO  - 10.2298/JSC161102103V
ER  - 
@article{
author = "Vulović, Bojan and Marić, Ivana and Matović, Radomir and Saičić, Radomir",
year = "2016",
abstract = "Delta(5)-Unsaturated aldehydes with a suitably positioned allylic halide, or phosphate, leaving group undergo doubly-catalyzed cyclization to give dihydropyran derivatives. The cyclization proceeds under the synergetic action of diazabicycloundecene and Pd(PPh3)(4). This type of transformation was also accomplished with an aryl ketone.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis of vinyldihydropyran by cooperative catalysis",
volume = "81",
number = "12",
pages = "1335-1343",
doi = "10.2298/JSC161102103V"
}
Vulović, B., Marić, I., Matović, R.,& Saičić, R.. (2016). Synthesis of vinyldihydropyran by cooperative catalysis. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 81(12), 1335-1343.
https://doi.org/10.2298/JSC161102103V
Vulović B, Marić I, Matović R, Saičić R. Synthesis of vinyldihydropyran by cooperative catalysis. in Journal of the Serbian Chemical Society. 2016;81(12):1335-1343.
doi:10.2298/JSC161102103V .
Vulović, Bojan, Marić, Ivana, Matović, Radomir, Saičić, Radomir, "Synthesis of vinyldihydropyran by cooperative catalysis" in Journal of the Serbian Chemical Society, 81, no. 12 (2016):1335-1343,
https://doi.org/10.2298/JSC161102103V . .
1
1
2
1

Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen

Novković, Luka P.; Trmčić, Milena; Rodić, Marko; Bihelović, Filip; Zlatar, Matija; Matović, Radomir; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2015)

TY  - JOUR
AU  - Novković, Luka P.
AU  - Trmčić, Milena
AU  - Rodić, Marko
AU  - Bihelović, Filip
AU  - Zlatar, Matija
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2000
AB  - Domino reactions of ketones with molecular oxygen in the presence of potassium hydroxide and potassium t-butoxide afford cyclic hydroperoxy acetals (3,5-dihydroxy-1,2-dioxanes). Mixed endoperoxides can also be obtained in a three-component reaction of two ketones and oxygen.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen
VL  - 5
IS  - 120
SP  - 99577
EP  - 99584
DO  - 10.1039/c5ra13476e
ER  - 
@article{
author = "Novković, Luka P. and Trmčić, Milena and Rodić, Marko and Bihelović, Filip and Zlatar, Matija and Matović, Radomir and Saičić, Radomir",
year = "2015",
abstract = "Domino reactions of ketones with molecular oxygen in the presence of potassium hydroxide and potassium t-butoxide afford cyclic hydroperoxy acetals (3,5-dihydroxy-1,2-dioxanes). Mixed endoperoxides can also be obtained in a three-component reaction of two ketones and oxygen.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen",
volume = "5",
number = "120",
pages = "99577-99584",
doi = "10.1039/c5ra13476e"
}
Novković, L. P., Trmčić, M., Rodić, M., Bihelović, F., Zlatar, M., Matović, R.,& Saičić, R.. (2015). Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen. in RSC Advances
Royal Soc Chemistry, Cambridge., 5(120), 99577-99584.
https://doi.org/10.1039/c5ra13476e
Novković LP, Trmčić M, Rodić M, Bihelović F, Zlatar M, Matović R, Saičić R. Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen. in RSC Advances. 2015;5(120):99577-99584.
doi:10.1039/c5ra13476e .
Novković, Luka P., Trmčić, Milena, Rodić, Marko, Bihelović, Filip, Zlatar, Matija, Matović, Radomir, Saičić, Radomir, "Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen" in RSC Advances, 5, no. 120 (2015):99577-99584,
https://doi.org/10.1039/c5ra13476e . .
10
6
9
10

Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e

Novković, Luka P.; Trmčić, Milena; Rodić, Marko; Bihelović, Filip; Zlatar, Matija; Matović, Radomir; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2015)

TY  - DATA
AU  - Novković, Luka P.
AU  - Trmčić, Milena
AU  - Rodić, Marko
AU  - Bihelović, Filip
AU  - Zlatar, Matija
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3442
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3442
ER  - 
@misc{
author = "Novković, Luka P. and Trmčić, Milena and Rodić, Marko and Bihelović, Filip and Zlatar, Matija and Matović, Radomir and Saičić, Radomir",
year = "2015",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3442"
}
Novković, L. P., Trmčić, M., Rodić, M., Bihelović, F., Zlatar, M., Matović, R.,& Saičić, R.. (2015). Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e. in RSC Advances
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3442
Novković LP, Trmčić M, Rodić M, Bihelović F, Zlatar M, Matović R, Saičić R. Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e. in RSC Advances. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3442 .
Novković, Luka P., Trmčić, Milena, Rodić, Marko, Bihelović, Filip, Zlatar, Matija, Matović, Radomir, Saičić, Radomir, "Supplementary data for article: Novkovic, L.; Trmcic, M.; Rodic, M.; Bihelovic, F.; Zlatar, M.; Matovic, R.; Saicic, R. N. Synthesis of Endoperoxides by Domino Reactions of Ketones and Molecular Oxygen. RSC Advances 2015, 5 (120), 99577–99584. https://doi.org/10.1039/c5ra13476e" in RSC Advances (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3442 .

Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides

Ferjančić, Zorana; Matović, Radomir; Bihelović, Filip

(Serbian Chemical Soc, Belgrade, 2014)

TY  - JOUR
AU  - Ferjančić, Zorana
AU  - Matović, Radomir
AU  - Bihelović, Filip
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1799
AB  - Intermolecular Nozaki-Hiyama-Kishi coupling between alkenylchromium(III) reagents, derived from either (E)-(2-bromoethenyl)benzene or (E)-1-iodo-1-pentadecene, and the conformationally rigid Garner's aldehyde resulted in the stereoselective formation of Felkin-type allylic alcohols in good yields, thus providing an easy access to sphingosines. In addition, when the protecting group in the Garner's aldehyde was changed (from Boc to N-octanoyl), a reversal of stereoselectivity was observed in the reaction with (E)-1-pentadecenylchromium(III), probably as the result of hydrophobic interactions between the long carbon chains of the reaction partners.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides
VL  - 79
IS  - 6
SP  - 627
EP  - 636
DO  - 10.2298/JSC130611067F
ER  - 
@article{
author = "Ferjančić, Zorana and Matović, Radomir and Bihelović, Filip",
year = "2014",
abstract = "Intermolecular Nozaki-Hiyama-Kishi coupling between alkenylchromium(III) reagents, derived from either (E)-(2-bromoethenyl)benzene or (E)-1-iodo-1-pentadecene, and the conformationally rigid Garner's aldehyde resulted in the stereoselective formation of Felkin-type allylic alcohols in good yields, thus providing an easy access to sphingosines. In addition, when the protecting group in the Garner's aldehyde was changed (from Boc to N-octanoyl), a reversal of stereoselectivity was observed in the reaction with (E)-1-pentadecenylchromium(III), probably as the result of hydrophobic interactions between the long carbon chains of the reaction partners.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides",
volume = "79",
number = "6",
pages = "627-636",
doi = "10.2298/JSC130611067F"
}
Ferjančić, Z., Matović, R.,& Bihelović, F.. (2014). Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(6), 627-636.
https://doi.org/10.2298/JSC130611067F
Ferjančić Z, Matović R, Bihelović F. Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides. in Journal of the Serbian Chemical Society. 2014;79(6):627-636.
doi:10.2298/JSC130611067F .
Ferjančić, Zorana, Matović, Radomir, Bihelović, Filip, "Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides" in Journal of the Serbian Chemical Society, 79, no. 6 (2014):627-636,
https://doi.org/10.2298/JSC130611067F . .
2
2
2
1

Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

Matović, Radomir; Bihelović, Filip; Gruden-Pavlović, Maja; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2014)

TY  - JOUR
AU  - Matović, Radomir
AU  - Bihelović, Filip
AU  - Gruden-Pavlović, Maja
AU  - Saičić, Radomir
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1860
AB  - The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki-Hiyama-Kishi cyclization as the key steps. The synthetic analogue retained its antibacterial activity against methicillin-resistant S. aureus strains, whereas its cytotoxicity decreased for three orders of magnitude, as compared to atrop-abyssomicin C.
PB  - Royal Soc Chemistry, Cambridge
T2  - Organic and Biomolecular Chemistry
T1  - Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C
VL  - 12
IS  - 39
SP  - 7682
EP  - 7685
DO  - 10.1039/c4ob01436g
ER  - 
@article{
author = "Matović, Radomir and Bihelović, Filip and Gruden-Pavlović, Maja and Saičić, Radomir",
year = "2014",
abstract = "The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki-Hiyama-Kishi cyclization as the key steps. The synthetic analogue retained its antibacterial activity against methicillin-resistant S. aureus strains, whereas its cytotoxicity decreased for three orders of magnitude, as compared to atrop-abyssomicin C.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Organic and Biomolecular Chemistry",
title = "Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C",
volume = "12",
number = "39",
pages = "7682-7685",
doi = "10.1039/c4ob01436g"
}
Matović, R., Bihelović, F., Gruden-Pavlović, M.,& Saičić, R.. (2014). Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C. in Organic and Biomolecular Chemistry
Royal Soc Chemistry, Cambridge., 12(39), 7682-7685.
https://doi.org/10.1039/c4ob01436g
Matović R, Bihelović F, Gruden-Pavlović M, Saičić R. Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C. in Organic and Biomolecular Chemistry. 2014;12(39):7682-7685.
doi:10.1039/c4ob01436g .
Matović, Radomir, Bihelović, Filip, Gruden-Pavlović, Maja, Saičić, Radomir, "Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C" in Organic and Biomolecular Chemistry, 12, no. 39 (2014):7682-7685,
https://doi.org/10.1039/c4ob01436g . .
14
12
12
14

Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates

Vulović, Bojan; Gruden-Pavlović, Maja; Matović, Radomir; Saičić, Radomir

(Amer Chemical Soc, Washington, 2014)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Gruden-Pavlović, Maja
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1475
AB  - Organocatalyzed Tsuji-Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations.
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates
VL  - 16
IS  - 1
SP  - 34
EP  - 37
DO  - 10.1021/ol4028557
ER  - 
@article{
author = "Vulović, Bojan and Gruden-Pavlović, Maja and Matović, Radomir and Saičić, Radomir",
year = "2014",
abstract = "Organocatalyzed Tsuji-Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations.",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates",
volume = "16",
number = "1",
pages = "34-37",
doi = "10.1021/ol4028557"
}
Vulović, B., Gruden-Pavlović, M., Matović, R.,& Saičić, R.. (2014). Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates. in Organic Letters
Amer Chemical Soc, Washington., 16(1), 34-37.
https://doi.org/10.1021/ol4028557
Vulović B, Gruden-Pavlović M, Matović R, Saičić R. Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates. in Organic Letters. 2014;16(1):34-37.
doi:10.1021/ol4028557 .
Vulović, Bojan, Gruden-Pavlović, Maja, Matović, Radomir, Saičić, Radomir, "Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates" in Organic Letters, 16, no. 1 (2014):34-37,
https://doi.org/10.1021/ol4028557 . .
12
8
10
10

Total synthesis and biological evaluation of (-)-atrop-abyssomicin C

Bihelović, Filip; Karadžić, Ivanka M.; Matović, Radomir; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2013)

TY  - JOUR
AU  - Bihelović, Filip
AU  - Karadžić, Ivanka M.
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1388
AB  - Enantioselective synthesis of a marine antibiotic (-)-atrop-abyssomicin C was accomplished in 21 steps, in 1.8% overall yield (4%, based on the recovered starting material). The key steps of the synthesis are the formation of the functionalized cyclohexane core by an organocatalyzed Tsuji-Trost reaction, the formation of a tricyclic spirotetronate unit by a gold-catalyzed reaction sequence and the highly efficient eleven-membered ring closure by a Nozaki-Hiyama-Kishi reaction. Biological tests showed all abyssomicin derivatives to possess strong antibacterial activity against methicillin resistant S. aureus strains; however, they also proved to be cytotoxic, both to malignant and to normal somatic cells.
PB  - Royal Soc Chemistry, Cambridge
T2  - Organic and Biomolecular Chemistry
T1  - Total synthesis and biological evaluation of (-)-atrop-abyssomicin C
VL  - 11
IS  - 33
SP  - 5413
EP  - 5424
DO  - 10.1039/c3ob40692j
ER  - 
@article{
author = "Bihelović, Filip and Karadžić, Ivanka M. and Matović, Radomir and Saičić, Radomir",
year = "2013",
abstract = "Enantioselective synthesis of a marine antibiotic (-)-atrop-abyssomicin C was accomplished in 21 steps, in 1.8% overall yield (4%, based on the recovered starting material). The key steps of the synthesis are the formation of the functionalized cyclohexane core by an organocatalyzed Tsuji-Trost reaction, the formation of a tricyclic spirotetronate unit by a gold-catalyzed reaction sequence and the highly efficient eleven-membered ring closure by a Nozaki-Hiyama-Kishi reaction. Biological tests showed all abyssomicin derivatives to possess strong antibacterial activity against methicillin resistant S. aureus strains; however, they also proved to be cytotoxic, both to malignant and to normal somatic cells.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Organic and Biomolecular Chemistry",
title = "Total synthesis and biological evaluation of (-)-atrop-abyssomicin C",
volume = "11",
number = "33",
pages = "5413-5424",
doi = "10.1039/c3ob40692j"
}
Bihelović, F., Karadžić, I. M., Matović, R.,& Saičić, R.. (2013). Total synthesis and biological evaluation of (-)-atrop-abyssomicin C. in Organic and Biomolecular Chemistry
Royal Soc Chemistry, Cambridge., 11(33), 5413-5424.
https://doi.org/10.1039/c3ob40692j
Bihelović F, Karadžić IM, Matović R, Saičić R. Total synthesis and biological evaluation of (-)-atrop-abyssomicin C. in Organic and Biomolecular Chemistry. 2013;11(33):5413-5424.
doi:10.1039/c3ob40692j .
Bihelović, Filip, Karadžić, Ivanka M., Matović, Radomir, Saičić, Radomir, "Total synthesis and biological evaluation of (-)-atrop-abyssomicin C" in Organic and Biomolecular Chemistry, 11, no. 33 (2013):5413-5424,
https://doi.org/10.1039/c3ob40692j . .
1
29
26
28
30

Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j

Bihelović, Filip; Karadžić, Ivanka M.; Matović, Radomir; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2013)

TY  - DATA
AU  - Bihelović, Filip
AU  - Karadžić, Ivanka M.
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3557
PB  - Royal Soc Chemistry, Cambridge
T2  - Organic and Biomolecular Chemistry
T1  - Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3557
ER  - 
@misc{
author = "Bihelović, Filip and Karadžić, Ivanka M. and Matović, Radomir and Saičić, Radomir",
year = "2013",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Organic and Biomolecular Chemistry",
title = "Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3557"
}
Bihelović, F., Karadžić, I. M., Matović, R.,& Saičić, R.. (2013). Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j. in Organic and Biomolecular Chemistry
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3557
Bihelović F, Karadžić IM, Matović R, Saičić R. Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j. in Organic and Biomolecular Chemistry. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3557 .
Bihelović, Filip, Karadžić, Ivanka M., Matović, Radomir, Saičić, Radomir, "Supplementary data for article: Bihelović, F.; Karadžić, I.; Matović, R.; Saičić, R. Total Synthesis and Biological Evaluation of (-)-Atrop-Abyssomicin C. Organic and Biomolecular Chemistry 2013, 11 (33), 5413–5424. https://doi.org/10.1039/c3ob40692j" in Organic and Biomolecular Chemistry (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3557 .

Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716

Marjanović-Trajković, Jasna; Divjaković, Vladimir; Matović, Radomir; Ferjančić, Zorana; Saičić, Radomir

(Wiley-V C H Verlag Gmbh, Weinheim, 2013)

TY  - DATA
AU  - Marjanović-Trajković, Jasna
AU  - Divjaković, Vladimir
AU  - Matović, Radomir
AU  - Ferjančić, Zorana
AU  - Saičić, Radomir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3489
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Organic Chemistry
T1  - Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3489
ER  - 
@misc{
author = "Marjanović-Trajković, Jasna and Divjaković, Vladimir and Matović, Radomir and Ferjančić, Zorana and Saičić, Radomir",
year = "2013",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Organic Chemistry",
title = "Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3489"
}
Marjanović-Trajković, J., Divjaković, V., Matović, R., Ferjančić, Z.,& Saičić, R.. (2013). Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716. in European Journal of Organic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim..
https://hdl.handle.net/21.15107/rcub_cherry_3489
Marjanović-Trajković J, Divjaković V, Matović R, Ferjančić Z, Saičić R. Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716. in European Journal of Organic Chemistry. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3489 .
Marjanović-Trajković, Jasna, Divjaković, Vladimir, Matović, Radomir, Ferjančić, Zorana, Saičić, Radomir, "Supplementary data for article: Marjanović-Trajković, J.; Divjakovic, V.; Matovic, R.; Ferjančić, Z.; Saičić, R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-Epi-Hyacinthacine A(2) and (-)-3-Epi-Hyacinthacine A(1). European Journal of Organic Chemistry 2013, 2013 (25), 5555–5560. https://doi.org/10.1002/ejoc.201300716" in European Journal of Organic Chemistry (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3489 .

Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1)

Marjanović-Trajković, Jasna; Divjaković, Vladimir; Matović, Radomir; Ferjančić, Zorana; Saičić, Radomir

(Wiley-V C H Verlag Gmbh, Weinheim, 2013)

TY  - JOUR
AU  - Marjanović-Trajković, Jasna
AU  - Divjaković, Vladimir
AU  - Matović, Radomir
AU  - Ferjančić, Zorana
AU  - Saičić, Radomir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1389
AB  - The stereodivergent synthesis of two hyacinthacine analogues, which relies on an organocatalyzed aldol addition, is described. The aldol addition of dioxanone to an -N-carbobenzyloxy-substituted chiral aldehyde, promoted by both (R)- and (S)-proline, proceeds in reasonable yields with acceptable diastereomeric ratios. The success of the reaction may be due to the use of an acyclic aldehyde acceptor, which allows reagent control of the stereochemical outcome of the key aldolization step in both the matched and mismatched cases.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Organic Chemistry
T1  - Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1)
VL  - 2013
IS  - 25
SP  - 5555
EP  - 5560
DO  - 10.1002/ejoc.201300716
ER  - 
@article{
author = "Marjanović-Trajković, Jasna and Divjaković, Vladimir and Matović, Radomir and Ferjančić, Zorana and Saičić, Radomir",
year = "2013",
abstract = "The stereodivergent synthesis of two hyacinthacine analogues, which relies on an organocatalyzed aldol addition, is described. The aldol addition of dioxanone to an -N-carbobenzyloxy-substituted chiral aldehyde, promoted by both (R)- and (S)-proline, proceeds in reasonable yields with acceptable diastereomeric ratios. The success of the reaction may be due to the use of an acyclic aldehyde acceptor, which allows reagent control of the stereochemical outcome of the key aldolization step in both the matched and mismatched cases.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Organic Chemistry",
title = "Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1)",
volume = "2013",
number = "25",
pages = "5555-5560",
doi = "10.1002/ejoc.201300716"
}
Marjanović-Trajković, J., Divjaković, V., Matović, R., Ferjančić, Z.,& Saičić, R.. (2013). Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1). in European Journal of Organic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim., 2013(25), 5555-5560.
https://doi.org/10.1002/ejoc.201300716
Marjanović-Trajković J, Divjaković V, Matović R, Ferjančić Z, Saičić R. Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1). in European Journal of Organic Chemistry. 2013;2013(25):5555-5560.
doi:10.1002/ejoc.201300716 .
Marjanović-Trajković, Jasna, Divjaković, Vladimir, Matović, Radomir, Ferjančić, Zorana, Saičić, Radomir, "Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1)" in European Journal of Organic Chemistry, 2013, no. 25 (2013):5555-5560,
https://doi.org/10.1002/ejoc.201300716 . .
1
17
18
21
17

Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f

Trmčić, Milena; Matović, Radomir; Tovilović, Gordana; Ristić, Biljana Z.; Trajković, Vladimir S.; Ferjančić, Zorana; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2012)

TY  - DATA
AU  - Trmčić, Milena
AU  - Matović, Radomir
AU  - Tovilović, Gordana
AU  - Ristić, Biljana Z.
AU  - Trajković, Vladimir S.
AU  - Ferjančić, Zorana
AU  - Saičić, Radomir
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3673
PB  - Royal Soc Chemistry, Cambridge
T2  - Organic and Biomolecular Chemistry
T1  - Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3673
ER  - 
@misc{
author = "Trmčić, Milena and Matović, Radomir and Tovilović, Gordana and Ristić, Biljana Z. and Trajković, Vladimir S. and Ferjančić, Zorana and Saičić, Radomir",
year = "2012",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Organic and Biomolecular Chemistry",
title = "Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3673"
}
Trmčić, M., Matović, R., Tovilović, G., Ristić, B. Z., Trajković, V. S., Ferjančić, Z.,& Saičić, R.. (2012). Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f. in Organic and Biomolecular Chemistry
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3673
Trmčić M, Matović R, Tovilović G, Ristić BZ, Trajković VS, Ferjančić Z, Saičić R. Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f. in Organic and Biomolecular Chemistry. 2012;.
https://hdl.handle.net/21.15107/rcub_cherry_3673 .
Trmčić, Milena, Matović, Radomir, Tovilović, Gordana, Ristić, Biljana Z., Trajković, Vladimir S., Ferjančić, Zorana, Saičić, Radomir, "Supplementary data for article:Trmčić, M.; Matović, R. V.; Tovilović, G.; Ristic, B. Z.; Trajković, V. S.; Ferjančić, Z.; Saičić, R. A Novel C,D-Spirolactone Analogue of Paclitaxel: Autophagy Instead of Apoptosis as a Previously Unknown Mechanism of Cytotoxic Action for Taxoids. Organic and Biomolecular Chemistry 2012, 10 (25), 4933–4942. https://doi.org/10.1039/c2ob25514f" in Organic and Biomolecular Chemistry (2012),
https://hdl.handle.net/21.15107/rcub_cherry_3673 .

A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids

Trmčić, Milena; Matović, Radomir; Tovilović, Gordana; Ristić, Biljana Z.; Trajković, Vladimir S.; Ferjančić, Zorana; Saičić, Radomir

(Royal Soc Chemistry, Cambridge, 2012)

TY  - JOUR
AU  - Trmčić, Milena
AU  - Matović, Radomir
AU  - Tovilović, Gordana
AU  - Ristić, Biljana Z.
AU  - Trajković, Vladimir S.
AU  - Ferjančić, Zorana
AU  - Saičić, Radomir
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1304
AB  - The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.
PB  - Royal Soc Chemistry, Cambridge
T2  - Organic and Biomolecular Chemistry
T1  - A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
VL  - 10
IS  - 25
SP  - 4933
EP  - 4942
DO  - 10.1039/c2ob25514f
ER  - 
@article{
author = "Trmčić, Milena and Matović, Radomir and Tovilović, Gordana and Ristić, Biljana Z. and Trajković, Vladimir S. and Ferjančić, Zorana and Saičić, Radomir",
year = "2012",
abstract = "The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Organic and Biomolecular Chemistry",
title = "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids",
volume = "10",
number = "25",
pages = "4933-4942",
doi = "10.1039/c2ob25514f"
}
Trmčić, M., Matović, R., Tovilović, G., Ristić, B. Z., Trajković, V. S., Ferjančić, Z.,& Saičić, R.. (2012). A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic and Biomolecular Chemistry
Royal Soc Chemistry, Cambridge., 10(25), 4933-4942.
https://doi.org/10.1039/c2ob25514f
Trmčić M, Matović R, Tovilović G, Ristić BZ, Trajković VS, Ferjančić Z, Saičić R. A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic and Biomolecular Chemistry. 2012;10(25):4933-4942.
doi:10.1039/c2ob25514f .
Trmčić, Milena, Matović, Radomir, Tovilović, Gordana, Ristić, Biljana Z., Trajković, Vladimir S., Ferjančić, Zorana, Saičić, Radomir, "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids" in Organic and Biomolecular Chemistry, 10, no. 25 (2012):4933-4942,
https://doi.org/10.1039/c2ob25514f . .
12
12
14
12

Synthetic studies towards D-modified paclitaxel analogues

Ferjančić, Zorana; Matović, Radomir; Saičić, Radomir

(Serbian Chemical Soc, Belgrade, 2012)

TY  - JOUR
AU  - Ferjančić, Zorana
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1568
AB  - A synthetic sequence has been developed for the preparation of 9,10-di-O-diacetyl-4-desmethylene-4 beta-(3-butenyl)-4 alpha-hydroxy-5-O-mesyltaxicin I-1,2-carbonate 3, an intermediate in an attempted synthesis of a cyclobutane paclitaxel analogue. A series of reactions of 3 were investigated, including the protection of the sterically hindered C-4 alpha-hydroxy group and the oxidative cleavage of the terminal double bond. Cyclization of 13 to the cyclobutane-containing intermediate failed due to the unexpected instability of the dimethylsilane protecting group under basic conditions.
AB  - Razvijena je sintetička sekvenca za dobijanje 9,10-di-O-acetil-4-desmetilen-4β-(3-butenil)-4α-hidroksi-5-O-meziltaksicin I-1,2-karbonata (3), intermedijera u pokušanoj sintezi ciklobutanskog analoga paklitaksela. Ispitivana je mogućnost dalje hemijske transformacije jedinjenja 3, kao što je zaštita sterno izrazito zaštićene C-4α hidroksilne grupe i oksidativna fragmentacija terminalne dvostruke veze. Ciklizacija jedinjenja 13 nije dala željeni rezultat - intermedijer sa ciklobutanovim prstenom, što je posledica neočekivane nestabilnosti DMS-zaštitne grupe u baznim reakcionim uslovima.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthetic studies towards D-modified paclitaxel analogues
T1  - Sintetičke studije analoga paklitaksela sa modifikovanim D-prstenom
VL  - 77
IS  - 11
SP  - 1529
EP  - 1539
DO  - 10.2298/JSC120626094F
ER  - 
@article{
author = "Ferjančić, Zorana and Matović, Radomir and Saičić, Radomir",
year = "2012",
abstract = "A synthetic sequence has been developed for the preparation of 9,10-di-O-diacetyl-4-desmethylene-4 beta-(3-butenyl)-4 alpha-hydroxy-5-O-mesyltaxicin I-1,2-carbonate 3, an intermediate in an attempted synthesis of a cyclobutane paclitaxel analogue. A series of reactions of 3 were investigated, including the protection of the sterically hindered C-4 alpha-hydroxy group and the oxidative cleavage of the terminal double bond. Cyclization of 13 to the cyclobutane-containing intermediate failed due to the unexpected instability of the dimethylsilane protecting group under basic conditions., Razvijena je sintetička sekvenca za dobijanje 9,10-di-O-acetil-4-desmetilen-4β-(3-butenil)-4α-hidroksi-5-O-meziltaksicin I-1,2-karbonata (3), intermedijera u pokušanoj sintezi ciklobutanskog analoga paklitaksela. Ispitivana je mogućnost dalje hemijske transformacije jedinjenja 3, kao što je zaštita sterno izrazito zaštićene C-4α hidroksilne grupe i oksidativna fragmentacija terminalne dvostruke veze. Ciklizacija jedinjenja 13 nije dala željeni rezultat - intermedijer sa ciklobutanovim prstenom, što je posledica neočekivane nestabilnosti DMS-zaštitne grupe u baznim reakcionim uslovima.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthetic studies towards D-modified paclitaxel analogues, Sintetičke studije analoga paklitaksela sa modifikovanim D-prstenom",
volume = "77",
number = "11",
pages = "1529-1539",
doi = "10.2298/JSC120626094F"
}
Ferjančić, Z., Matović, R.,& Saičić, R.. (2012). Synthetic studies towards D-modified paclitaxel analogues. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 77(11), 1529-1539.
https://doi.org/10.2298/JSC120626094F
Ferjančić Z, Matović R, Saičić R. Synthetic studies towards D-modified paclitaxel analogues. in Journal of the Serbian Chemical Society. 2012;77(11):1529-1539.
doi:10.2298/JSC120626094F .
Ferjančić, Zorana, Matović, Radomir, Saičić, Radomir, "Synthetic studies towards D-modified paclitaxel analogues" in Journal of the Serbian Chemical Society, 77, no. 11 (2012):1529-1539,
https://doi.org/10.2298/JSC120626094F . .

Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009)

Vulović, Bojan; Bihelović, Filip; Matović, Radomir; Saičić, Radomir

(Pergamon-Elsevier Science Ltd, Oxford, 2010)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1073
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron
T1  - Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009)
VL  - 66
IS  - 17
SP  - 3275
EP  - 3275
DO  - 10.1016/j.tet.2010.03.013
ER  - 
@article{
author = "Vulović, Bojan and Bihelović, Filip and Matović, Radomir and Saičić, Radomir",
year = "2010",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron",
title = "Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009)",
volume = "66",
number = "17",
pages = "3275-3275",
doi = "10.1016/j.tet.2010.03.013"
}
Vulović, B., Bihelović, F., Matović, R.,& Saičić, R.. (2010). Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009). in Tetrahedron
Pergamon-Elsevier Science Ltd, Oxford., 66(17), 3275-3275.
https://doi.org/10.1016/j.tet.2010.03.013
Vulović B, Bihelović F, Matović R, Saičić R. Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009). in Tetrahedron. 2010;66(17):3275-3275.
doi:10.1016/j.tet.2010.03.013 .
Vulović, Bojan, Bihelović, Filip, Matović, Radomir, Saičić, Radomir, "Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings (vol 65, pg 10485, 2009)" in Tetrahedron, 66, no. 17 (2010):3275-3275,
https://doi.org/10.1016/j.tet.2010.03.013 . .
4
7
3
4

Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings

Vulović, Bojan; Bihelović, Filip; Matović, Radomir; Saičić, Radomir

(Pergamon-Elsevier Science Ltd, Oxford, 2009)

TY  - JOUR
AU  - Vulović, Bojan
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Saičić, Radomir
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1031
AB  - A combination of organotransition metal catalysis and organocatalysis allows for Tsuji-Trost 5-exo- and 6-exo-cyclizations of aldehydes. This transformation can also be accomplished as a catalytic asymmetric reaction, which affords vinylcyclopentane derivatives with up to 98%ee. (C) 2009 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron
T1  - Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings
VL  - 65
IS  - 50
SP  - 10485
EP  - 10494
DO  - 10.1016/j.tet.2009.10.006
ER  - 
@article{
author = "Vulović, Bojan and Bihelović, Filip and Matović, Radomir and Saičić, Radomir",
year = "2009",
abstract = "A combination of organotransition metal catalysis and organocatalysis allows for Tsuji-Trost 5-exo- and 6-exo-cyclizations of aldehydes. This transformation can also be accomplished as a catalytic asymmetric reaction, which affords vinylcyclopentane derivatives with up to 98%ee. (C) 2009 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron",
title = "Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings",
volume = "65",
number = "50",
pages = "10485-10494",
doi = "10.1016/j.tet.2009.10.006"
}
Vulović, B., Bihelović, F., Matović, R.,& Saičić, R.. (2009). Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings. in Tetrahedron
Pergamon-Elsevier Science Ltd, Oxford., 65(50), 10485-10494.
https://doi.org/10.1016/j.tet.2009.10.006
Vulović B, Bihelović F, Matović R, Saičić R. Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings. in Tetrahedron. 2009;65(50):10485-10494.
doi:10.1016/j.tet.2009.10.006 .
Vulović, Bojan, Bihelović, Filip, Matović, Radomir, Saičić, Radomir, "Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings" in Tetrahedron, 65, no. 50 (2009):10485-10494,
https://doi.org/10.1016/j.tet.2009.10.006 . .
64
44
61
64

Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings

Bihelović, Filip; Matović, Radomir; Vulović, Bojan; Saičić, Radomir

(American Chemical Society (ACS), 2007)

TY  - JOUR
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Vulović, Bojan
AU  - Saičić, Radomir
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4357
AB  - Synergic combination of organotransition metal catalysis and organocatalysis allows, for the first time, the Tsuji-Trost cyclization of aldehydes. A catalytic asymmetric variant of the reaction is also possible.
PB  - American Chemical Society (ACS)
T2  - Organic Letters
T1  - Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings
VL  - 9
IS  - 24
SP  - 5063
EP  - 5066
DO  - 10.1021/ol7023554
ER  - 
@article{
author = "Bihelović, Filip and Matović, Radomir and Vulović, Bojan and Saičić, Radomir",
year = "2007",
abstract = "Synergic combination of organotransition metal catalysis and organocatalysis allows, for the first time, the Tsuji-Trost cyclization of aldehydes. A catalytic asymmetric variant of the reaction is also possible.",
publisher = "American Chemical Society (ACS)",
journal = "Organic Letters",
title = "Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings",
volume = "9",
number = "24",
pages = "5063-5066",
doi = "10.1021/ol7023554"
}
Bihelović, F., Matović, R., Vulović, B.,& Saičić, R.. (2007). Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings. in Organic Letters
American Chemical Society (ACS)., 9(24), 5063-5066.
https://doi.org/10.1021/ol7023554
Bihelović F, Matović R, Vulović B, Saičić R. Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings. in Organic Letters. 2007;9(24):5063-5066.
doi:10.1021/ol7023554 .
Bihelović, Filip, Matović, Radomir, Vulović, Bojan, Saičić, Radomir, "Organocatalyzed cyclizations of π-allylpalladium complexes: A new method for the construction of five- and six-membered rings" in Organic Letters, 9, no. 24 (2007):5063-5066,
https://doi.org/10.1021/ol7023554 . .
119
96
107
118

Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings

Bihelović, Filip; Matović, Radomir; Vulović, Bojan; Saičić, Radomir

(Amer Chemical Soc, Washington, 2007)

TY  - JOUR
AU  - Bihelović, Filip
AU  - Matović, Radomir
AU  - Vulović, Bojan
AU  - Saičić, Radomir
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/890
AB  - Synergic combination of organotransition metal catalysis and organocatalysis allows, for the first time, the Tsuji-Trost cyclization of aldehydes. A catalytic asymmetric variant of the reaction is also possible.
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings
VL  - 9
IS  - 24
SP  - 5063
EP  - 5066
DO  - 10.1021/ol7023554
ER  - 
@article{
author = "Bihelović, Filip and Matović, Radomir and Vulović, Bojan and Saičić, Radomir",
year = "2007",
abstract = "Synergic combination of organotransition metal catalysis and organocatalysis allows, for the first time, the Tsuji-Trost cyclization of aldehydes. A catalytic asymmetric variant of the reaction is also possible.",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings",
volume = "9",
number = "24",
pages = "5063-5066",
doi = "10.1021/ol7023554"
}
Bihelović, F., Matović, R., Vulović, B.,& Saičić, R.. (2007). Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings. in Organic Letters
Amer Chemical Soc, Washington., 9(24), 5063-5066.
https://doi.org/10.1021/ol7023554
Bihelović F, Matović R, Vulović B, Saičić R. Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings. in Organic Letters. 2007;9(24):5063-5066.
doi:10.1021/ol7023554 .
Bihelović, Filip, Matović, Radomir, Vulović, Bojan, Saičić, Radomir, "Organocatalyzed cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings" in Organic Letters, 9, no. 24 (2007):5063-5066,
https://doi.org/10.1021/ol7023554 . .
119
96
107
118