TY  - JOUR
AU  - Međedović, Milica
AU  - Mijatović, Aleksandar
AU  - Baošić, Rada
AU  - Lazić, Dejan
AU  - Milanović, Žiko
AU  - Marković, Zoran
AU  - Milovanović, Jelena
AU  - Arsenijević, Dragana
AU  - Stojanović, Bojana
AU  - Arsenijević, Miloš
AU  - Milovanović, Marija
AU  - Petrović, Biljana
AU  - Rilak Simović, Ana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6353
AB  - In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed the highest DNA/BSA-activity, suggesting that the presence of the aromatic ring on the tetradentate Schiff base ligand contributes to increased activity. Moreover, these two compounds showed the highest cytotoxic effects toward human, A549 and murine LLC1 lung cancer cells. These complexes altered the ratio of anti- and pro-apoptotic molecules and induced apoptosis of A549 cells. Further, complexes 2 and 5 reduced the percentage of Mcl1 and Bcl2 expressing LLC1 cells, induced their apoptotic death and exerted an antiproliferative effect against LLC1. Finally, complex 5 reduced the volume of mouse primary heterotopic Lewis lung cancer, while complex 2 reduced the incidence and mean number of metastases per lung. Additionally, molecular docking with DNA revealed that the reduced number of aromatic rings or their absence causes lower intercalative properties of the complexes in order: 2 > 5 > 6 > 3 > 4 > 1. It was observed that conventional hydrogen bonds and hydrophobic interactions contribute to the stabilization of the structures of complex-DNA. A molecular docking study with BSA revealed a predominance of 1 – 6 in binding affinity to the active site III, a third D-shaped hydrophobic pocket within subdomain IB.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes
VL  - 248
SP  - 112363
DO  - 10.1016/j.jinorgbio.2023.112363
ER  - 

@article{
author = "Međedović, Milica and Mijatović, Aleksandar and Baošić, Rada and Lazić, Dejan and Milanović, Žiko and Marković, Zoran and Milovanović, Jelena and Arsenijević, Dragana and Stojanović, Bojana and Arsenijević, Miloš and Milovanović, Marija and Petrović, Biljana and Rilak Simović, Ana",
year = "2023",
abstract = "In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed the highest DNA/BSA-activity, suggesting that the presence of the aromatic ring on the tetradentate Schiff base ligand contributes to increased activity. Moreover, these two compounds showed the highest cytotoxic effects toward human, A549 and murine LLC1 lung cancer cells. These complexes altered the ratio of anti- and pro-apoptotic molecules and induced apoptosis of A549 cells. Further, complexes 2 and 5 reduced the percentage of Mcl1 and Bcl2 expressing LLC1 cells, induced their apoptotic death and exerted an antiproliferative effect against LLC1. Finally, complex 5 reduced the volume of mouse primary heterotopic Lewis lung cancer, while complex 2 reduced the incidence and mean number of metastases per lung. Additionally, molecular docking with DNA revealed that the reduced number of aromatic rings or their absence causes lower intercalative properties of the complexes in order: 2 > 5 > 6 > 3 > 4 > 1. It was observed that conventional hydrogen bonds and hydrophobic interactions contribute to the stabilization of the structures of complex-DNA. A molecular docking study with BSA revealed a predominance of 1 – 6 in binding affinity to the active site III, a third D-shaped hydrophobic pocket within subdomain IB.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes",
volume = "248",
pages = "112363",
doi = "10.1016/j.jinorgbio.2023.112363"
}

Međedović, M., Mijatović, A., Baošić, R., Lazić, D., Milanović, Ž., Marković, Z., Milovanović, J., Arsenijević, D., Stojanović, B., Arsenijević, M., Milovanović, M., Petrović, B.,& Rilak Simović, A.. (2023). Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes. in Journal of Inorganic Biochemistry
Elsevier., 248, 112363.
https://doi.org/10.1016/j.jinorgbio.2023.112363

Međedović M, Mijatović A, Baošić R, Lazić D, Milanović Ž, Marković Z, Milovanović J, Arsenijević D, Stojanović B, Arsenijević M, Milovanović M, Petrović B, Rilak Simović A. Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes. in Journal of Inorganic Biochemistry. 2023;248:112363.
doi:10.1016/j.jinorgbio.2023.112363 .

Međedović, Milica, Mijatović, Aleksandar, Baošić, Rada, Lazić, Dejan, Milanović, Žiko, Marković, Zoran, Milovanović, Jelena, Arsenijević, Dragana, Stojanović, Bojana, Arsenijević, Miloš, Milovanović, Marija, Petrović, Biljana, Rilak Simović, Ana, "Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes" in Journal of Inorganic Biochemistry, 248 (2023):112363,
https://doi.org/10.1016/j.jinorgbio.2023.112363 . .

TY  - JOUR
AU  - Krunić, Matija
AU  - Ristić, Biljana
AU  - Bošnjak, Mihajlo
AU  - Paunović, Verica
AU  - Tovilović-Kovačević, Gordana
AU  - Zagović, Nevena
AU  - Mirčić, Aleksandar
AU  - Marković, Zoran
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
AU  - Kleut, Duška
AU  - Mojović, Miloš
AU  - Nakarada, Đura
AU  - Marković, Olivera S.
AU  - Vuković, Irena
AU  - Harhaji-Trajković, Ljubica
AU  - Trajković, Vladimir
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5467
AB  - We investigated the ability of graphene quantum dot (GQD) nanoparticles to protect SH-SY5Y human neuro blastoma cells from oxidative/nitrosative stress induced by iron-nitrosyl complex sodium nitroprusside (SNP). 
GQD reduced SNP cytotoxicity by preventing mitochondrial depolarization, caspase-2 activation, and subsequent 
apoptotic death. Although GQD diminished the levels of nitric oxide (NO) in SNP-exposed cells, NO scavengers 
displayed only a slight protective effect, suggesting that NO quenching was not the main protective mechanism of 
GQD. GQD also reduced SNP-triggered increase in the intracellular levels of hydroxyl radical (
•
OH), superoxide 
anion (O2
•− ), and lipid peroxidation. Nonselective antioxidants, •
OH scavenging, and iron chelators, but not 
superoxide dismutase, mimicked GQD cytoprotective activity, indicating that GQD protect cells by neutralizing •
OH generated in the presence of SNP-released iron. Cellular internalization of GQD was required for optimal 
protection, since a removal of extracellular GQD by extensive washing only partly diminished their protective 
effect. Moreover, GQD cooperated with SNP to induce autophagy, as confirmed by the inhibition of autophagy limiting Akt/PRAS40/mTOR signaling and increase in autophagy gene transcription, protein levels of proauto phagic beclin-1 and LC3-II, formation of autophagic vesicles, and degradation of autophagic target p62. The 
antioxidant activity of GQD was not involved in autophagy induction, as antioxidants N-acetylcysteine and 
dimethyl sulfoxide failed to stimulate autophagy in SNP-exposed cells. Pharmacological inhibitors of early 
(wortmannin, 3-methyladenine) or late stages of autophagy (NH4Cl) efficiently reduced the protective effect of 
GQD. Therefore, the ability of GQD to prevent the in vitro neurotoxicity of SNP depends on both •
OH/NO 
scavenging and induction of cytoprotective autophagy.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Graphene quantum dot antioxidant and proautophagic actions protect  SH-SY5Y neuroblastoma cells from oxidative stress-mediated  apoptotic death
VL  - 177
SP  - 167
EP  - 180
DO  - 10.1016/j.freeradbiomed.2021.10.025
ER  - 

@article{
author = "Krunić, Matija and Ristić, Biljana and Bošnjak, Mihajlo and Paunović, Verica and Tovilović-Kovačević, Gordana and Zagović, Nevena and Mirčić, Aleksandar and Marković, Zoran and Todorović Marković, Biljana and Jovanović, Svetlana and Kleut, Duška and Mojović, Miloš and Nakarada, Đura and Marković, Olivera S. and Vuković, Irena and Harhaji-Trajković, Ljubica and Trajković, Vladimir",
year = "2021",
abstract = "We investigated the ability of graphene quantum dot (GQD) nanoparticles to protect SH-SY5Y human neuro blastoma cells from oxidative/nitrosative stress induced by iron-nitrosyl complex sodium nitroprusside (SNP). 
GQD reduced SNP cytotoxicity by preventing mitochondrial depolarization, caspase-2 activation, and subsequent 
apoptotic death. Although GQD diminished the levels of nitric oxide (NO) in SNP-exposed cells, NO scavengers 
displayed only a slight protective effect, suggesting that NO quenching was not the main protective mechanism of 
GQD. GQD also reduced SNP-triggered increase in the intracellular levels of hydroxyl radical (
•
OH), superoxide 
anion (O2
•− ), and lipid peroxidation. Nonselective antioxidants, •
OH scavenging, and iron chelators, but not 
superoxide dismutase, mimicked GQD cytoprotective activity, indicating that GQD protect cells by neutralizing •
OH generated in the presence of SNP-released iron. Cellular internalization of GQD was required for optimal 
protection, since a removal of extracellular GQD by extensive washing only partly diminished their protective 
effect. Moreover, GQD cooperated with SNP to induce autophagy, as confirmed by the inhibition of autophagy limiting Akt/PRAS40/mTOR signaling and increase in autophagy gene transcription, protein levels of proauto phagic beclin-1 and LC3-II, formation of autophagic vesicles, and degradation of autophagic target p62. The 
antioxidant activity of GQD was not involved in autophagy induction, as antioxidants N-acetylcysteine and 
dimethyl sulfoxide failed to stimulate autophagy in SNP-exposed cells. Pharmacological inhibitors of early 
(wortmannin, 3-methyladenine) or late stages of autophagy (NH4Cl) efficiently reduced the protective effect of 
GQD. Therefore, the ability of GQD to prevent the in vitro neurotoxicity of SNP depends on both •
OH/NO 
scavenging and induction of cytoprotective autophagy.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Graphene quantum dot antioxidant and proautophagic actions protect  SH-SY5Y neuroblastoma cells from oxidative stress-mediated  apoptotic death",
volume = "177",
pages = "167-180",
doi = "10.1016/j.freeradbiomed.2021.10.025"
}

Krunić, M., Ristić, B., Bošnjak, M., Paunović, V., Tovilović-Kovačević, G., Zagović, N., Mirčić, A., Marković, Z., Todorović Marković, B., Jovanović, S., Kleut, D., Mojović, M., Nakarada, Đ., Marković, O. S., Vuković, I., Harhaji-Trajković, L.,& Trajković, V.. (2021). Graphene quantum dot antioxidant and proautophagic actions protect  SH-SY5Y neuroblastoma cells from oxidative stress-mediated  apoptotic death. in Free Radical Biology and Medicine
Elsevier., 177, 167-180.
https://doi.org/10.1016/j.freeradbiomed.2021.10.025

Krunić M, Ristić B, Bošnjak M, Paunović V, Tovilović-Kovačević G, Zagović N, Mirčić A, Marković Z, Todorović Marković B, Jovanović S, Kleut D, Mojović M, Nakarada Đ, Marković OS, Vuković I, Harhaji-Trajković L, Trajković V. Graphene quantum dot antioxidant and proautophagic actions protect  SH-SY5Y neuroblastoma cells from oxidative stress-mediated  apoptotic death. in Free Radical Biology and Medicine. 2021;177:167-180.
doi:10.1016/j.freeradbiomed.2021.10.025 .

Krunić, Matija, Ristić, Biljana, Bošnjak, Mihajlo, Paunović, Verica, Tovilović-Kovačević, Gordana, Zagović, Nevena, Mirčić, Aleksandar, Marković, Zoran, Todorović Marković, Biljana, Jovanović, Svetlana, Kleut, Duška, Mojović, Miloš, Nakarada, Đura, Marković, Olivera S., Vuković, Irena, Harhaji-Trajković, Ljubica, Trajković, Vladimir, "Graphene quantum dot antioxidant and proautophagic actions protect  SH-SY5Y neuroblastoma cells from oxidative stress-mediated  apoptotic death" in Free Radical Biology and Medicine, 177 (2021):167-180,
https://doi.org/10.1016/j.freeradbiomed.2021.10.025 . .

TY  - JOUR
AU  - Božanić, Milenka Lj.
AU  - Dojčinović, Biljana P.
AU  - Živić, Miroslav
AU  - Marković, Zoran 
AU  - Manojlović, Dragan D.
AU  - Živić, Ivana
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4051
AB  - Trout farms are one of the major sources of pollution of highland streams and rivers. Since river sediment burdened with organic pollution binds greater amounts of heavy metals we investigated the influence of the trout farm on the accumulation of metals in the sediment, water and Ephemera danica larvae. Research was conducted seasonally (April, July, and October of 2015 and January of 2016) at one control locality (SK1) and three localities downstream from the farm (SK2-SK4). In agreement with the hypothesis the fish farm discharge induced localized and statistically significant increase of concentrations of Fe, Cu, Cr, Ni, Pb and Cd in sediment and E. danica larvae, but not in water at locality SK2 just below the fish farm indicating that sediment is the main source of heavy metals for this organism. However, according to the values of Biota sediment accumulation factor (BSAF) only metals with low sediment concentrations (As, Cd and Cu) accumulated in the larvae. Moreover, BASF values for toxic metals (As, Cd and Cr) showed negative correlation with their concentrations in sediment indicating existence of defense mechanisms in E. danica against assimilation of these metals in high concentrations lethal for it. On the other hand, BSAF values for essential microelements (Cu and Fe) were positively correlated with their sediment concentrations. In conclusion the trout farm induced accumulation of heavy metals in river sediment and E. danica larvae proved to be a good bioindicators of the pollution of river systems by As, Cd and Cu.
PB  - EDP Sciences
T2  - Knowledge & Management of Aquatic Ecosystems
T1  - Bioaccumulation of heavy metals in Ephemera danica larvae under influence of a trout farm outlet waters
IS  - 420
SP  - 50
DO  - 10.1051/kmae/2019040
ER  - 

@article{
author = "Božanić, Milenka Lj. and Dojčinović, Biljana P. and Živić, Miroslav and Marković, Zoran  and Manojlović, Dragan D. and Živić, Ivana",
year = "2019",
abstract = "Trout farms are one of the major sources of pollution of highland streams and rivers. Since river sediment burdened with organic pollution binds greater amounts of heavy metals we investigated the influence of the trout farm on the accumulation of metals in the sediment, water and Ephemera danica larvae. Research was conducted seasonally (April, July, and October of 2015 and January of 2016) at one control locality (SK1) and three localities downstream from the farm (SK2-SK4). In agreement with the hypothesis the fish farm discharge induced localized and statistically significant increase of concentrations of Fe, Cu, Cr, Ni, Pb and Cd in sediment and E. danica larvae, but not in water at locality SK2 just below the fish farm indicating that sediment is the main source of heavy metals for this organism. However, according to the values of Biota sediment accumulation factor (BSAF) only metals with low sediment concentrations (As, Cd and Cu) accumulated in the larvae. Moreover, BASF values for toxic metals (As, Cd and Cr) showed negative correlation with their concentrations in sediment indicating existence of defense mechanisms in E. danica against assimilation of these metals in high concentrations lethal for it. On the other hand, BSAF values for essential microelements (Cu and Fe) were positively correlated with their sediment concentrations. In conclusion the trout farm induced accumulation of heavy metals in river sediment and E. danica larvae proved to be a good bioindicators of the pollution of river systems by As, Cd and Cu.",
publisher = "EDP Sciences",
journal = "Knowledge & Management of Aquatic Ecosystems",
title = "Bioaccumulation of heavy metals in Ephemera danica larvae under influence of a trout farm outlet waters",
number = "420",
pages = "50",
doi = "10.1051/kmae/2019040"
}

Božanić, M. Lj., Dojčinović, B. P., Živić, M., Marković, Z., Manojlović, D. D.,& Živić, I.. (2019). Bioaccumulation of heavy metals in Ephemera danica larvae under influence of a trout farm outlet waters. in Knowledge & Management of Aquatic Ecosystems
EDP Sciences.(420), 50.
https://doi.org/10.1051/kmae/2019040

Božanić ML, Dojčinović BP, Živić M, Marković Z, Manojlović DD, Živić I. Bioaccumulation of heavy metals in Ephemera danica larvae under influence of a trout farm outlet waters. in Knowledge & Management of Aquatic Ecosystems. 2019;(420):50.
doi:10.1051/kmae/2019040 .

Božanić, Milenka Lj., Dojčinović, Biljana P., Živić, Miroslav, Marković, Zoran , Manojlović, Dragan D., Živić, Ivana, "Bioaccumulation of heavy metals in Ephemera danica larvae under influence of a trout farm outlet waters" in Knowledge & Management of Aquatic Ecosystems, no. 420 (2019):50,
https://doi.org/10.1051/kmae/2019040 . .

TY  - JOUR
AU  - Jakovljević, Katarina
AU  - Joksović, Milan D.
AU  - Botta, Bruno
AU  - Jovanović, Ljiljana S.
AU  - Avdović, Edina
AU  - Marković, Zoran
AU  - Mihailović, Vladimir
AU  - Andrić, Marijana
AU  - Trifunović, Snežana S.
AU  - Marković, Violeta
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3738
AB  - A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole amide derivative 3a were prepared to compare the effects of the structural changes on the radical-scavenging activity. The obtained compounds were examined for their antioxidative potential by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. In addition, selected compounds were studied by density functional theory (DFT) and cyclic voltammetry experiments. The tested compounds showed high potential to scavenging DPPH radical and ABTS radical cation compared with the referent antioxidants ascorbic acid and nordihydroguaiaretic acid (NDGA). On the basis of the calculated thermodynamic parameters, it can be concluded that the sequential proton loss electron transfer (SPLET) mechanism represents the most probable reaction path in a polar solvent for DPPH radical–scavenging activity. On the other hand, the single electron transfer followed by proton transfer (SET-PT) can be a likely mechanistic pathway in the case of an ABTS radical cation.
PB  - Elsevier
T2  - Comptes Rendus Chimie
T1  - Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies
VL  - 22
IS  - 8
SP  - 585
EP  - 598
DO  - 10.1016/j.crci.2019.06.001
ER  - 

@article{
author = "Jakovljević, Katarina and Joksović, Milan D. and Botta, Bruno and Jovanović, Ljiljana S. and Avdović, Edina and Marković, Zoran and Mihailović, Vladimir and Andrić, Marijana and Trifunović, Snežana S. and Marković, Violeta",
year = "2019",
abstract = "A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole amide derivative 3a were prepared to compare the effects of the structural changes on the radical-scavenging activity. The obtained compounds were examined for their antioxidative potential by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. In addition, selected compounds were studied by density functional theory (DFT) and cyclic voltammetry experiments. The tested compounds showed high potential to scavenging DPPH radical and ABTS radical cation compared with the referent antioxidants ascorbic acid and nordihydroguaiaretic acid (NDGA). On the basis of the calculated thermodynamic parameters, it can be concluded that the sequential proton loss electron transfer (SPLET) mechanism represents the most probable reaction path in a polar solvent for DPPH radical–scavenging activity. On the other hand, the single electron transfer followed by proton transfer (SET-PT) can be a likely mechanistic pathway in the case of an ABTS radical cation.",
publisher = "Elsevier",
journal = "Comptes Rendus Chimie",
title = "Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies",
volume = "22",
number = "8",
pages = "585-598",
doi = "10.1016/j.crci.2019.06.001"
}

Jakovljević, K., Joksović, M. D., Botta, B., Jovanović, L. S., Avdović, E., Marković, Z., Mihailović, V., Andrić, M., Trifunović, S. S.,& Marković, V.. (2019). Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies. in Comptes Rendus Chimie
Elsevier., 22(8), 585-598.
https://doi.org/10.1016/j.crci.2019.06.001

Jakovljević K, Joksović MD, Botta B, Jovanović LS, Avdović E, Marković Z, Mihailović V, Andrić M, Trifunović SS, Marković V. Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies. in Comptes Rendus Chimie. 2019;22(8):585-598.
doi:10.1016/j.crci.2019.06.001 .

Jakovljević, Katarina, Joksović, Milan D., Botta, Bruno, Jovanović, Ljiljana S., Avdović, Edina, Marković, Zoran, Mihailović, Vladimir, Andrić, Marijana, Trifunović, Snežana S., Marković, Violeta, "Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies" in Comptes Rendus Chimie, 22, no. 8 (2019):585-598,
https://doi.org/10.1016/j.crci.2019.06.001 . .

TY  - DATA
AU  - Jakovljević, Katarina
AU  - Joksović, Milan D.
AU  - Botta, Bruno
AU  - Jovanović, Ljiljana S.
AU  - Avdović, Edina
AU  - Marković, Zoran
AU  - Mihailović, Vladimir
AU  - Andrić, Marijana
AU  - Trifunović, Snežana S.
AU  - Marković, Violeta
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3739
PB  - Elsevier
T2  - Comptes Rendus Chimie
T1  - Supplementary data for the article: Jakovljević, K.; Joksović, M. D.; Botta, B.; Jovanović, L. S.; Avdović, E.; Marković, Z.; Mihailović, V.; Andrić, M.; Trifunović, S.; Marković, V. Novel 1,3,4-Thiadiazole Conjugates Derived from Protocatechuic Acid: Synthesis, Antioxidant Activity, and Computational and Electrochemical Studies. Comptes Rendus Chimie 2019, 22 (8), 585–598. https://doi.org/10.1016/j.crci.2019.06.001
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3739
ER  - 

@misc{
author = "Jakovljević, Katarina and Joksović, Milan D. and Botta, Bruno and Jovanović, Ljiljana S. and Avdović, Edina and Marković, Zoran and Mihailović, Vladimir and Andrić, Marijana and Trifunović, Snežana S. and Marković, Violeta",
year = "2019",
publisher = "Elsevier",
journal = "Comptes Rendus Chimie",
title = "Supplementary data for the article: Jakovljević, K.; Joksović, M. D.; Botta, B.; Jovanović, L. S.; Avdović, E.; Marković, Z.; Mihailović, V.; Andrić, M.; Trifunović, S.; Marković, V. Novel 1,3,4-Thiadiazole Conjugates Derived from Protocatechuic Acid: Synthesis, Antioxidant Activity, and Computational and Electrochemical Studies. Comptes Rendus Chimie 2019, 22 (8), 585–598. https://doi.org/10.1016/j.crci.2019.06.001",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3739"
}

Jakovljević, K., Joksović, M. D., Botta, B., Jovanović, L. S., Avdović, E., Marković, Z., Mihailović, V., Andrić, M., Trifunović, S. S.,& Marković, V.. (2019). Supplementary data for the article: Jakovljević, K.; Joksović, M. D.; Botta, B.; Jovanović, L. S.; Avdović, E.; Marković, Z.; Mihailović, V.; Andrić, M.; Trifunović, S.; Marković, V. Novel 1,3,4-Thiadiazole Conjugates Derived from Protocatechuic Acid: Synthesis, Antioxidant Activity, and Computational and Electrochemical Studies. Comptes Rendus Chimie 2019, 22 (8), 585–598. https://doi.org/10.1016/j.crci.2019.06.001. in Comptes Rendus Chimie
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_3739

Jakovljević K, Joksović MD, Botta B, Jovanović LS, Avdović E, Marković Z, Mihailović V, Andrić M, Trifunović SS, Marković V. Supplementary data for the article: Jakovljević, K.; Joksović, M. D.; Botta, B.; Jovanović, L. S.; Avdović, E.; Marković, Z.; Mihailović, V.; Andrić, M.; Trifunović, S.; Marković, V. Novel 1,3,4-Thiadiazole Conjugates Derived from Protocatechuic Acid: Synthesis, Antioxidant Activity, and Computational and Electrochemical Studies. Comptes Rendus Chimie 2019, 22 (8), 585–598. https://doi.org/10.1016/j.crci.2019.06.001. in Comptes Rendus Chimie. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_3739 .

Jakovljević, Katarina, Joksović, Milan D., Botta, Bruno, Jovanović, Ljiljana S., Avdović, Edina, Marković, Zoran, Mihailović, Vladimir, Andrić, Marijana, Trifunović, Snežana S., Marković, Violeta, "Supplementary data for the article: Jakovljević, K.; Joksović, M. D.; Botta, B.; Jovanović, L. S.; Avdović, E.; Marković, Z.; Mihailović, V.; Andrić, M.; Trifunović, S.; Marković, V. Novel 1,3,4-Thiadiazole Conjugates Derived from Protocatechuic Acid: Synthesis, Antioxidant Activity, and Computational and Electrochemical Studies. Comptes Rendus Chimie 2019, 22 (8), 585–598. https://doi.org/10.1016/j.crci.2019.06.001" in Comptes Rendus Chimie (2019),
https://hdl.handle.net/21.15107/rcub_cherry_3739 .

TY  - JOUR
AU  - Dulić, Zorka
AU  - Živić, Ivana
AU  - Pergal, Marija V.
AU  - Živić, Miroslav
AU  - Stanković, Marko
AU  - Manojlović, Dragan D.
AU  - Marković, Zoran
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2098
AB  - The aim of this study was to assess the accumulation and seasonal variations of 20 toxic and trace elements in the abdominal and dorsal muscle (DM), liver and gut contents (GCs) of Cyprinus carpio, and in the sediments and zooplankton from semi-intensive aquaculture ponds during a six-month production season (from May to October). Sediments showed the highest concentrations of the measured elements, followed by zooplankton, fish GCs and livers, while the lowest levels were present in fish muscles. Correspondence analysis revealed that the elemental composition of the fish GCs was mostly similar to that of the sediment and zooplankton. The element concentrations of carp liver and muscles were more similar to each other. Overall, the results indicate that fish liver was the main target organ accumulating Cu, Se and Zn, regardless of their initial amounts in the environment. A seasonal decrease of a range of elements in fish liver (Al, Co, Fe, Li, Mn, Ni, Pb and Sr) was evident towards the end of the investigation period. In addition, the fish DM showed a seasonal accumulation of Sr and Li. However, toxic elements i.e. As, B, Ba Hg and V did not show such a seasonal variation, and were evenly distributed between fish liver and muscles. The concentrations of some elements, such as As, in fish tissues were similar or even higher than in literature data from polluted sites, but none of them exceeded the maximum acceptable concentrations prescribed by Serbian legislation or by FAO or EU regulation.
PB  - Edp Sciences S A, Les Ulis Cedex A
T2  - Annales de Limnologie = International Journal of Limnology
T1  - Accumulation and seasonal variation of toxic and trace elements in tissues of Cyprinus carpio from semi-intensive aquaculture ponds
VL  - 54
DO  - 10.1051/limn/2017036
ER  - 

@article{
author = "Dulić, Zorka and Živić, Ivana and Pergal, Marija V. and Živić, Miroslav and Stanković, Marko and Manojlović, Dragan D. and Marković, Zoran",
year = "2018",
abstract = "The aim of this study was to assess the accumulation and seasonal variations of 20 toxic and trace elements in the abdominal and dorsal muscle (DM), liver and gut contents (GCs) of Cyprinus carpio, and in the sediments and zooplankton from semi-intensive aquaculture ponds during a six-month production season (from May to October). Sediments showed the highest concentrations of the measured elements, followed by zooplankton, fish GCs and livers, while the lowest levels were present in fish muscles. Correspondence analysis revealed that the elemental composition of the fish GCs was mostly similar to that of the sediment and zooplankton. The element concentrations of carp liver and muscles were more similar to each other. Overall, the results indicate that fish liver was the main target organ accumulating Cu, Se and Zn, regardless of their initial amounts in the environment. A seasonal decrease of a range of elements in fish liver (Al, Co, Fe, Li, Mn, Ni, Pb and Sr) was evident towards the end of the investigation period. In addition, the fish DM showed a seasonal accumulation of Sr and Li. However, toxic elements i.e. As, B, Ba Hg and V did not show such a seasonal variation, and were evenly distributed between fish liver and muscles. The concentrations of some elements, such as As, in fish tissues were similar or even higher than in literature data from polluted sites, but none of them exceeded the maximum acceptable concentrations prescribed by Serbian legislation or by FAO or EU regulation.",
publisher = "Edp Sciences S A, Les Ulis Cedex A",
journal = "Annales de Limnologie = International Journal of Limnology",
title = "Accumulation and seasonal variation of toxic and trace elements in tissues of Cyprinus carpio from semi-intensive aquaculture ponds",
volume = "54",
doi = "10.1051/limn/2017036"
}

Dulić, Z., Živić, I., Pergal, M. V., Živić, M., Stanković, M., Manojlović, D. D.,& Marković, Z.. (2018). Accumulation and seasonal variation of toxic and trace elements in tissues of Cyprinus carpio from semi-intensive aquaculture ponds. in Annales de Limnologie = International Journal of Limnology
Edp Sciences S A, Les Ulis Cedex A., 54.
https://doi.org/10.1051/limn/2017036

Dulić Z, Živić I, Pergal MV, Živić M, Stanković M, Manojlović DD, Marković Z. Accumulation and seasonal variation of toxic and trace elements in tissues of Cyprinus carpio from semi-intensive aquaculture ponds. in Annales de Limnologie = International Journal of Limnology. 2018;54.
doi:10.1051/limn/2017036 .

Dulić, Zorka, Živić, Ivana, Pergal, Marija V., Živić, Miroslav, Stanković, Marko, Manojlović, Dragan D., Marković, Zoran, "Accumulation and seasonal variation of toxic and trace elements in tissues of Cyprinus carpio from semi-intensive aquaculture ponds" in Annales de Limnologie = International Journal of Limnology, 54 (2018),
https://doi.org/10.1051/limn/2017036 . .

TY  - JOUR
AU  - Trbovic, Dejana
AU  - Marković, Zoran
AU  - Milojković-Opsenica, Dušanka
AU  - Petronijevic, Radivoj
AU  - Spiric, Danka
AU  - Đinović-Stojanović, Jasna
AU  - Spiric, Aurelija
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1443
AB  - The most marketed species of fish in Serbia is common carp (Cyprinus carpio), which accounts for more than 80% of the national aquaculture. This study aimed to investigate the influence of two supplementary fish feeds (maize and extruded feed) on the proximate and fatty acid composition of carp. The results show that the protein, lipid, and ash contents were higher (P  lt = 0.001) in the extruded feed compared with maize. The carp fed extruded feed exhibited significantly higher protein and moisture contents (P  lt = 0.001 and P  lt = 0.01, respectively), whereas the total lipid content was significantly higher (P  lt = 0.001) in carp fed maize. The analysis of the fatty acid profiles showed that the saturated fatty acid (SFA) content in carp fed maize (23.94%) was lower than that in carp fed extruded feed (25.36%). The monounsaturated fatty acid (MUFA) content in carp fed maize (61.83%) was considerably higher compared with carp fed extruded feed (41.95%), whereas the polyunsaturated fatty acid (PUFA) content in carp fed maize (13.66%) was lower than that in carp fed extruded feed (30.91%). The principal component analysis (PCA) of the fatty acid profile resulted in a two-principal-component model that described 75.94% of the total data variance. The most influential factors were determined from the loading plot governing this distinction. The n-6/n-3 ratio in carp fed extruded feed (5.8) was found to be more nutritionally beneficial than that in carp fed maize (13.8), which indicates the better nutritional properties of carp fed extruded feed.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Food Composition and Analysis
T1  - Influence of diet on proximate composition and fatty acid profile in common carp (Cyprinus carpio)
VL  - 31
IS  - 1
SP  - 75
EP  - 81
DO  - 10.1016/j.jfca.2013.04.002
ER  - 

@article{
author = "Trbovic, Dejana and Marković, Zoran and Milojković-Opsenica, Dušanka and Petronijevic, Radivoj and Spiric, Danka and Đinović-Stojanović, Jasna and Spiric, Aurelija",
year = "2013",
abstract = "The most marketed species of fish in Serbia is common carp (Cyprinus carpio), which accounts for more than 80% of the national aquaculture. This study aimed to investigate the influence of two supplementary fish feeds (maize and extruded feed) on the proximate and fatty acid composition of carp. The results show that the protein, lipid, and ash contents were higher (P  lt = 0.001) in the extruded feed compared with maize. The carp fed extruded feed exhibited significantly higher protein and moisture contents (P  lt = 0.001 and P  lt = 0.01, respectively), whereas the total lipid content was significantly higher (P  lt = 0.001) in carp fed maize. The analysis of the fatty acid profiles showed that the saturated fatty acid (SFA) content in carp fed maize (23.94%) was lower than that in carp fed extruded feed (25.36%). The monounsaturated fatty acid (MUFA) content in carp fed maize (61.83%) was considerably higher compared with carp fed extruded feed (41.95%), whereas the polyunsaturated fatty acid (PUFA) content in carp fed maize (13.66%) was lower than that in carp fed extruded feed (30.91%). The principal component analysis (PCA) of the fatty acid profile resulted in a two-principal-component model that described 75.94% of the total data variance. The most influential factors were determined from the loading plot governing this distinction. The n-6/n-3 ratio in carp fed extruded feed (5.8) was found to be more nutritionally beneficial than that in carp fed maize (13.8), which indicates the better nutritional properties of carp fed extruded feed.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Food Composition and Analysis",
title = "Influence of diet on proximate composition and fatty acid profile in common carp (Cyprinus carpio)",
volume = "31",
number = "1",
pages = "75-81",
doi = "10.1016/j.jfca.2013.04.002"
}

Trbovic, D., Marković, Z., Milojković-Opsenica, D., Petronijevic, R., Spiric, D., Đinović-Stojanović, J.,& Spiric, A.. (2013). Influence of diet on proximate composition and fatty acid profile in common carp (Cyprinus carpio). in Journal of Food Composition and Analysis
Academic Press Inc Elsevier Science, San Diego., 31(1), 75-81.
https://doi.org/10.1016/j.jfca.2013.04.002

Trbovic D, Marković Z, Milojković-Opsenica D, Petronijevic R, Spiric D, Đinović-Stojanović J, Spiric A. Influence of diet on proximate composition and fatty acid profile in common carp (Cyprinus carpio). in Journal of Food Composition and Analysis. 2013;31(1):75-81.
doi:10.1016/j.jfca.2013.04.002 .

Trbovic, Dejana, Marković, Zoran, Milojković-Opsenica, Dušanka, Petronijevic, Radivoj, Spiric, Danka, Đinović-Stojanović, Jasna, Spiric, Aurelija, "Influence of diet on proximate composition and fatty acid profile in common carp (Cyprinus carpio)" in Journal of Food Composition and Analysis, 31, no. 1 (2013):75-81,
https://doi.org/10.1016/j.jfca.2013.04.002 . .

TY  - JOUR
AU  - Marković, Zoran
AU  - Šolaja, Bogdan A.
AU  - Milić, Dragana
AU  - Juranić, Ivan O.
AU  - Gasic, MJ
PY  - 2000
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/437
AB  - The MO study showed that the radical oxidation of phenols into quinols occurs readily. Further radical oxidation (in the m-CPBA/(BzO)(2)/hv system) of quinols occurs through appropriate biradical species with an activation energy of 79.5 kJ/mol yielding syn-epoxyquinols. The stereochemical outcome presented in this study is in full agreement with the experimental results.
AB  - Molekulsko-orbitalnim proučavanjem potvrđeno je da lako dolazi do radikalske oksidacije fenola u odgovarajuće hinole. Daljom oksidacijom sistemom m-CPBA/(BzO)2/hν hinoli se preko biradikalskih reakcionih vrsta oksiduju u odgovarajuće epoksihinole. Izračunato je da aktivaciona energija ove reakcije iznosi 79.5 kJ/mol. Stereohemijske posledice naših izračunavanja su u potpunom skladu sa eksperimentalnim rezultatima.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Molecular orbital study of the oxidation of steroidal phenols into quinols and epoxyquinols
T1  - Molekulsko-orbitalno proučavanje oksidacije fenola u hinole i epoksihinole
VL  - 65
IS  - 7
SP  - 491
EP  - 496
DO  - 10.2298/JSC0007491M
ER  - 

@article{
author = "Marković, Zoran and Šolaja, Bogdan A. and Milić, Dragana and Juranić, Ivan O. and Gasic, MJ",
year = "2000",
abstract = "The MO study showed that the radical oxidation of phenols into quinols occurs readily. Further radical oxidation (in the m-CPBA/(BzO)(2)/hv system) of quinols occurs through appropriate biradical species with an activation energy of 79.5 kJ/mol yielding syn-epoxyquinols. The stereochemical outcome presented in this study is in full agreement with the experimental results., Molekulsko-orbitalnim proučavanjem potvrđeno je da lako dolazi do radikalske oksidacije fenola u odgovarajuće hinole. Daljom oksidacijom sistemom m-CPBA/(BzO)2/hν hinoli se preko biradikalskih reakcionih vrsta oksiduju u odgovarajuće epoksihinole. Izračunato je da aktivaciona energija ove reakcije iznosi 79.5 kJ/mol. Stereohemijske posledice naših izračunavanja su u potpunom skladu sa eksperimentalnim rezultatima.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Molecular orbital study of the oxidation of steroidal phenols into quinols and epoxyquinols, Molekulsko-orbitalno proučavanje oksidacije fenola u hinole i epoksihinole",
volume = "65",
number = "7",
pages = "491-496",
doi = "10.2298/JSC0007491M"
}

Marković, Z., Šolaja, B. A., Milić, D., Juranić, I. O.,& Gasic, M.. (2000). Molecular orbital study of the oxidation of steroidal phenols into quinols and epoxyquinols. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 65(7), 491-496.
https://doi.org/10.2298/JSC0007491M

Marković Z, Šolaja BA, Milić D, Juranić IO, Gasic M. Molecular orbital study of the oxidation of steroidal phenols into quinols and epoxyquinols. in Journal of the Serbian Chemical Society. 2000;65(7):491-496.
doi:10.2298/JSC0007491M .

Marković, Zoran, Šolaja, Bogdan A., Milić, Dragana, Juranić, Ivan O., Gasic, MJ, "Molecular orbital study of the oxidation of steroidal phenols into quinols and epoxyquinols" in Journal of the Serbian Chemical Society, 65, no. 7 (2000):491-496,
https://doi.org/10.2298/JSC0007491M . .