TY  - JOUR
AU  - Grgurić-Šipka, Sanja
AU  - Stepanenko, Iryna N.
AU  - Lazić, Jelena
AU  - Bartel, Caroline
AU  - Jakupec, Michael A.
AU  - Arion, Vladimir B.
AU  - Keppler, Bernhard K.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/627
AB  - The light-protected reaction of [(eta(6)p-cymene)Ru(II)Cl(2)](2) with 1-(2-hydroxyethyl)piperazine in dry methanol, followed by addition of excess NH(4)PF(6), afforded the complex [(eta(6)-p-cymene)Ru(II)(NH(3))(2)Cl]-(PF(6)) (1) in 47% yield. Attempts to use the same protocol for the synthesis of [(eta(6)-pcymene)Os(II)(NH(3))(2)-Cl](PF(6)) led to the isolation of the binuclear triply methoxido-bridged arene-osmium compound [{(eta(6)-p-cymene)Os}(2)(mu-OCH(3))(3)](PF(6)) (3). Both compounds were characterised by X-ray crystallography and (1)H NMR spectroscopy, and the ruthenium complex also by spectroscopic techniques (IR and UV-vis spectroscopies). The antiproliferative activity of complex 1 in vitro was studied in A549 (non-small cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma) cells and compared to that of [(eta(6) p-cymene)Ru(II)(en)Cl](PF6) (2). In contrast to the latter compound, 1 is only modestly cytotoxic in all three cell lines (IC(50): 293-542 mu M), probably due to the instability of the diammine ruthenium complex in aqueous solution.
PB  - Royal Soc Chemistry, Cambridge
T2  - Dalton Transactions
T1  - Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin
IS  - 17
SP  - 3334
EP  - 3339
DO  - 10.1039/b822725j
ER  - 

@article{
author = "Grgurić-Šipka, Sanja and Stepanenko, Iryna N. and Lazić, Jelena and Bartel, Caroline and Jakupec, Michael A. and Arion, Vladimir B. and Keppler, Bernhard K.",
year = "2009",
abstract = "The light-protected reaction of [(eta(6)p-cymene)Ru(II)Cl(2)](2) with 1-(2-hydroxyethyl)piperazine in dry methanol, followed by addition of excess NH(4)PF(6), afforded the complex [(eta(6)-p-cymene)Ru(II)(NH(3))(2)Cl]-(PF(6)) (1) in 47% yield. Attempts to use the same protocol for the synthesis of [(eta(6)-pcymene)Os(II)(NH(3))(2)-Cl](PF(6)) led to the isolation of the binuclear triply methoxido-bridged arene-osmium compound [{(eta(6)-p-cymene)Os}(2)(mu-OCH(3))(3)](PF(6)) (3). Both compounds were characterised by X-ray crystallography and (1)H NMR spectroscopy, and the ruthenium complex also by spectroscopic techniques (IR and UV-vis spectroscopies). The antiproliferative activity of complex 1 in vitro was studied in A549 (non-small cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma) cells and compared to that of [(eta(6) p-cymene)Ru(II)(en)Cl](PF6) (2). In contrast to the latter compound, 1 is only modestly cytotoxic in all three cell lines (IC(50): 293-542 mu M), probably due to the instability of the diammine ruthenium complex in aqueous solution.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Dalton Transactions",
title = "Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin",
number = "17",
pages = "3334-3339",
doi = "10.1039/b822725j"
}

Grgurić-Šipka, S., Stepanenko, I. N., Lazić, J., Bartel, C., Jakupec, M. A., Arion, V. B.,& Keppler, B. K.. (2009). Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. in Dalton Transactions
Royal Soc Chemistry, Cambridge.(17), 3334-3339.
https://doi.org/10.1039/b822725j

Grgurić-Šipka S, Stepanenko IN, Lazić J, Bartel C, Jakupec MA, Arion VB, Keppler BK. Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. in Dalton Transactions. 2009;(17):3334-3339.
doi:10.1039/b822725j .

Grgurić-Šipka, Sanja, Stepanenko, Iryna N., Lazić, Jelena, Bartel, Caroline, Jakupec, Michael A., Arion, Vladimir B., Keppler, Bernhard K., "Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin" in Dalton Transactions, no. 17 (2009):3334-3339,
https://doi.org/10.1039/b822725j . .