TY  - CONF
AU  - Mrđan, Gorana
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
AU  - Rašeta, Milena
AU  - Verbić, Tatjana
AU  - Marković, Olivera S.
AU  - Matijević, Borko
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5963
AB  - Carbohydrazones and their thio analogs represent compounds obtained
by condensation of carbohydrazide and thiocarbohydrazide with carbonyl
compounds. Due to their structure, relatively simple synthesis, and high reactivity,
mentioned derivatives have a wide range of applications in all fields. In this study,
ionization constants of four newly synthesized mono(thio)carbohydrazones were
determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption
spectra was investigated and quantified using the linear solvation energy relationships
method and Catalan’s model. Finally, by applying the DPPH assay, the
antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone
derivatives proved to be significantly more active when compared
to carbohydrazones.
C3  - XIV International Scientific Conference Contemporary Materials 2021 Programme and the Book of Abstracts, Banja Luka, September 9th to 10th, 2021
T1  - Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives
SP  - 40
EP  - 40
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5963
ER  - 

@conference{
author = "Mrđan, Gorana and Vaštag, Đenđi and Apostolov, Suzana and Rašeta, Milena and Verbić, Tatjana and Marković, Olivera S. and Matijević, Borko",
year = "2021",
abstract = "Carbohydrazones and their thio analogs represent compounds obtained
by condensation of carbohydrazide and thiocarbohydrazide with carbonyl
compounds. Due to their structure, relatively simple synthesis, and high reactivity,
mentioned derivatives have a wide range of applications in all fields. In this study,
ionization constants of four newly synthesized mono(thio)carbohydrazones were
determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption
spectra was investigated and quantified using the linear solvation energy relationships
method and Catalan’s model. Finally, by applying the DPPH assay, the
antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone
derivatives proved to be significantly more active when compared
to carbohydrazones.",
journal = "XIV International Scientific Conference Contemporary Materials 2021 Programme and the Book of Abstracts, Banja Luka, September 9th to 10th, 2021",
title = "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives",
pages = "40-40",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5963"
}

Mrđan, G., Vaštag, Đ., Apostolov, S., Rašeta, M., Verbić, T., Marković, O. S.,& Matijević, B.. (2021). Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in XIV International Scientific Conference Contemporary Materials 2021 Programme and the Book of Abstracts, Banja Luka, September 9th to 10th, 2021, 40-40.
https://hdl.handle.net/21.15107/rcub_cherry_5963

Mrđan G, Vaštag Đ, Apostolov S, Rašeta M, Verbić T, Marković OS, Matijević B. Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in XIV International Scientific Conference Contemporary Materials 2021 Programme and the Book of Abstracts, Banja Luka, September 9th to 10th, 2021. 2021;:40-40.
https://hdl.handle.net/21.15107/rcub_cherry_5963 .

Mrđan, Gorana, Vaštag, Đenđi, Apostolov, Suzana, Rašeta, Milena, Verbić, Tatjana, Marković, Olivera S., Matijević, Borko, "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives" in XIV International Scientific Conference Contemporary Materials 2021 Programme and the Book of Abstracts, Banja Luka, September 9th to 10th, 2021 (2021):40-40,
https://hdl.handle.net/21.15107/rcub_cherry_5963 .

TY  - CONF
AU  - Mrđan, Gorana
AU  - Verbić, Tatjana
AU  - Marković, Olivera S.
AU  - Matijević, Borko
AU  - Vaštag, Đenđi
AU  - Apostolov, Suzana
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5960
AB  - Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized com-pounds.
One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a com-pound, which may indicate further potential application of newly synthesized deri-vatives.
In this work, ionization constants of twenty monocarbohydrazone deriva-tives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
C3  - XIII International Scientific Conference Contemporary Materials 2020  Programme  and the Book of Abstracts, Banja Luka, 11th September, 2020
T1  - Determination of ionization constants of selected monocarbohydrazone derivatives
SP  - 50
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5960
ER  - 

@conference{
author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera S. and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana",
year = "2020",
abstract = "Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized com-pounds.
One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a com-pound, which may indicate further potential application of newly synthesized deri-vatives.
In this work, ionization constants of twenty monocarbohydrazone deriva-tives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.",
journal = "XIII International Scientific Conference Contemporary Materials 2020  Programme  and the Book of Abstracts, Banja Luka, 11th September, 2020",
title = "Determination of ionization constants of selected monocarbohydrazone derivatives",
pages = "50-50",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5960"
}

Mrđan, G., Verbić, T., Marković, O. S., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatives. in XIII International Scientific Conference Contemporary Materials 2020  Programme  and the Book of Abstracts, Banja Luka, 11th September, 2020, 50-50.
https://hdl.handle.net/21.15107/rcub_cherry_5960

Mrđan G, Verbić T, Marković OS, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatives. in XIII International Scientific Conference Contemporary Materials 2020  Programme  and the Book of Abstracts, Banja Luka, 11th September, 2020. 2020;:50-50.
https://hdl.handle.net/21.15107/rcub_cherry_5960 .

Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera S., Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatives" in XIII International Scientific Conference Contemporary Materials 2020  Programme  and the Book of Abstracts, Banja Luka, 11th September, 2020 (2020):50-50,
https://hdl.handle.net/21.15107/rcub_cherry_5960 .

TY  - DATA
AU  - Matijević, Borko M.
AU  - Vaštag, Đenđi Đ.
AU  - Apostolov, Suzana L.
AU  - Milčić, Miloš K.
AU  - Marinković, Aleksandar
AU  - Petrović, Slobodan D.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3386
T2  - Arabian Journal of Chemistry
T1  - Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3386
ER  - 

@misc{
author = "Matijević, Borko M. and Vaštag, Đenđi Đ. and Apostolov, Suzana L. and Milčić, Miloš K. and Marinković, Aleksandar and Petrović, Slobodan D.",
year = "2015",
journal = "Arabian Journal of Chemistry",
title = "Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3386"
}

Matijević, B. M., Vaštag, Đ. Đ., Apostolov, S. L., Milčić, M. K., Marinković, A.,& Petrović, S. D.. (2015). Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008. in Arabian Journal of Chemistry.
https://hdl.handle.net/21.15107/rcub_cherry_3386

Matijević BM, Vaštag ĐĐ, Apostolov SL, Milčić MK, Marinković A, Petrović SD. Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008. in Arabian Journal of Chemistry. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3386 .

Matijević, Borko M., Vaštag, Đenđi Đ., Apostolov, Suzana L., Milčić, Miloš K., Marinković, Aleksandar, Petrović, Slobodan D., "Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008" in Arabian Journal of Chemistry (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3386 .

TY  - JOUR
AU  - Matijević, Borko M.
AU  - Vaštag, Đenđi Đ.
AU  - Apostolov, Suzana L.
AU  - Milčić, Miloš K.
AU  - Marinković, Aleksandar
AU  - Petrović, Slobodan D.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/293
AB  - The UV absorption spectra of twelve. N-(substituted phenyl)-2-chloroacetamides were recorded in eighteen solvents. The effect of specific and non-specific solvent-solute interactions on the absorption maxima shifts was evaluated by using the Kamlet-Taft solvent parameter set,. i.e. applying linear solvation energy relationships (LSER) principles. Optimized geometries and experimental results were interpreted by using DFT (B3LYP/6-311+G(d,p) method) and time-dependent density functional (TD-DFT) method. Overall electron density in both ground and excited state was obtained by the use of Quantum Theory of Atoms in Molecules,. i.e. Bader's analysis. It was found that both solvent and substituents cause appropriate change of the extent of conjugation in the molecules that further affect their intra-molecular charge transfer (ICT) character. Linear free energy relationships (LFERs) were applied to the substituent-induced NMR chemical shifts (SCS) using single substituent parameter (SSP) and dual substituent parameter (DSP) model. Transmission mode of the electronic effects of substituent was discussed according to the results of theoretical calculations and results of LFER correlations. Comparative analysis of presented results with the ones published for structurally similar series of amide which contained cyano group, instead chlorine, provides additional information on the impact of present group to the properties of investigated compound.
T2  - Arabian Journal of Chemistry
T1  - N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study
DO  - 10.1016/j.arabjc.2015.09.008
ER  - 

@article{
author = "Matijević, Borko M. and Vaštag, Đenđi Đ. and Apostolov, Suzana L. and Milčić, Miloš K. and Marinković, Aleksandar and Petrović, Slobodan D.",
year = "2015",
abstract = "The UV absorption spectra of twelve. N-(substituted phenyl)-2-chloroacetamides were recorded in eighteen solvents. The effect of specific and non-specific solvent-solute interactions on the absorption maxima shifts was evaluated by using the Kamlet-Taft solvent parameter set,. i.e. applying linear solvation energy relationships (LSER) principles. Optimized geometries and experimental results were interpreted by using DFT (B3LYP/6-311+G(d,p) method) and time-dependent density functional (TD-DFT) method. Overall electron density in both ground and excited state was obtained by the use of Quantum Theory of Atoms in Molecules,. i.e. Bader's analysis. It was found that both solvent and substituents cause appropriate change of the extent of conjugation in the molecules that further affect their intra-molecular charge transfer (ICT) character. Linear free energy relationships (LFERs) were applied to the substituent-induced NMR chemical shifts (SCS) using single substituent parameter (SSP) and dual substituent parameter (DSP) model. Transmission mode of the electronic effects of substituent was discussed according to the results of theoretical calculations and results of LFER correlations. Comparative analysis of presented results with the ones published for structurally similar series of amide which contained cyano group, instead chlorine, provides additional information on the impact of present group to the properties of investigated compound.",
journal = "Arabian Journal of Chemistry",
title = "N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study",
doi = "10.1016/j.arabjc.2015.09.008"
}

Matijević, B. M., Vaštag, Đ. Đ., Apostolov, S. L., Milčić, M. K., Marinković, A.,& Petrović, S. D.. (2015). N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study. in Arabian Journal of Chemistry.
https://doi.org/10.1016/j.arabjc.2015.09.008

Matijević BM, Vaštag ĐĐ, Apostolov SL, Milčić MK, Marinković A, Petrović SD. N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study. in Arabian Journal of Chemistry. 2015;.
doi:10.1016/j.arabjc.2015.09.008 .

Matijević, Borko M., Vaštag, Đenđi Đ., Apostolov, Suzana L., Milčić, Miloš K., Marinković, Aleksandar, Petrović, Slobodan D., "N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study" in Arabian Journal of Chemistry (2015),
https://doi.org/10.1016/j.arabjc.2015.09.008 . .